Imiquimod (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0725764
PLEC plectin 0.0711385
FLNB filamin B, beta 0.0578352
CORO1C coronin, actin binding protein, 1C 0.0432609
ITPRID2 ITPR interacting domain containing 2 0.0420291
MYH9 myosin, heavy chain 9, non-muscle 0.0410963
TPM3 tropomyosin 3 0.0401864
SMAD3 SMAD family member 3 0.0384458
VCL vinculin 0.0332174
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0300981
SLMAP sarcolemma associated protein 0.0296145
UBA6 ubiquitin-like modifier activating enzyme 6 0.0292177
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0284065
RCOR1 REST corepressor 1 0.0279901
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0274395
PICALM phosphatidylinositol binding clathrin assembly protein 0.027069
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0270077
AHNAK AHNAK nucleoprotein 0.0269437
MCL1 myeloid cell leukemia 1 0.0262631
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.025703
ERRFI1 ERBB receptor feedback inhibitor 1 0.0252536
GRB10 growth factor receptor-bound protein 10 0.0251403
ITGA6 integrin, alpha 6 0.0237312
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0236502
UBC ubiquitin C 0.0236472
NCOR2 nuclear receptor corepressor 2 0.0235458
HSPA8 heat shock 70kDa protein 8 0.0235087
HAPSTR1 HUWE1 associated protein modifying stress responses 0.02336
CTBP2 C-terminal binding protein 2 0.0233315
ANXA11 annexin A11 0.0229291
EEF2 eukaryotic translation elongation factor 2 0.0225994
ARRDC3 arrestin domain containing 3 0.022504
CCNL1 cyclin L1 0.0224643
LAMC2 laminin, gamma 2 0.0224286
NCKAP1 NCK-associated protein 1 0.0222254
TNIP1 TNFAIP3 interacting protein 1 0.0222081
DHFR dihydrofolate reductase 0.0215103
LMO7 LIM domain 7 0.020842
RPL3 ribosomal protein L3 0.0205378
GLS2 glutaminase 2 (liver, mitochondrial) 0.0204006
MPRIP myosin phosphatase Rho interacting protein 0.020299
SPTBN1 spectrin, beta, non-erythrocytic 1 0.020268
DSPP dentin sialophosphoprotein 0.020154
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0200993
ARHGAP42 Rho GTPase activating protein 42 0.0198023
CHD1 chromodomain helicase DNA binding protein 1 0.0197343
STK39 serine threonine kinase 39 0.0192122
PDLIM5 PDZ and LIM domain 5 0.0187592
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0182641
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0182027
KIAA0040 KIAA0040 0.0178952
APLP2 amyloid beta (A4) precursor-like protein 2 0.0177369
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0175939
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0175582
ZEB1 zinc finger E-box binding homeobox 1 0.017515
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0175143
NIBAN2 niban apoptosis regulator 2 0.0169806
MSN moesin 0.0167979
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0167274
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0166721
SESTD1 SEC14 and spectrin domains 1 0.0164482
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0161423
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0160579
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0159768
IGFBP3 insulin-like growth factor binding protein 3 0.0157646
RALB v-ral simian leukemia viral oncogene homolog B 0.0157085
SETX senataxin 0.015605
BCAR3 breast cancer anti-estrogen resistance 3 0.0155261
SLC35F3 solute carrier family 35, member F3 0.0153031
PPARD peroxisome proliferator-activated receptor delta 0.0153013
ANO6 anoctamin 6 0.0150867
SKAP2 src kinase associated phosphoprotein 2 0.0148445
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0145556
CAPRIN2 caprin family member 2 0.0145406
NCOA3 nuclear receptor coactivator 3 0.0145289
KMT2C lysine (K)-specific methyltransferase 2C 0.0142945
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0142196
RASA3 RAS p21 protein activator 3 0.0141689
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0140971
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0140639
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0137688
EPHA2 EPH receptor A2 0.0137043
KIF16B kinesin family member 16B 0.0136076
CDHR2 cadherin-related family member 2 0.0135637
CD46 CD46 molecule, complement regulatory protein 0.013547
FAT1 FAT atypical cadherin 1 0.0134169
SERTAD2 SERTA domain containing 2 0.0129531
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0127262
SLTM SAFB-like, transcription modulator 0.0126677
ATP13A3 ATPase type 13A3 0.0126223
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0126184
DIAPH1 diaphanous-related formin 1 0.0124321
ADAM17 ADAM metallopeptidase domain 17 0.012366
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0123607
EGFR epidermal growth factor receptor 0.0122475
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0120417
SEPTIN9 septin 9 0.0118021
AKAP13 A kinase (PRKA) anchor protein 13 0.0116901
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0116782
ADAM9 ADAM metallopeptidase domain 9 0.0116727

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.286252
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.177583
VIM vimentin -0.146596
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146484
S100A10 S100 calcium binding protein A10 -0.125202
TPT1 tumor protein, translationally-controlled 1 -0.121438
PTMA prothymosin, alpha -0.113182
S100A6 S100 calcium binding protein A6 -0.0790881
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.070323
RPL35A ribosomal protein L35a -0.068499
FTL ferritin, light polypeptide -0.0677288
LAMB3 laminin, beta 3 -0.0677089
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0651138
RPLP1 ribosomal protein, large, P1 -0.0648495
RPS8 ribosomal protein S8 -0.0645428
ACTG1 actin gamma 1 -0.0641019
RPL12 ribosomal protein L12 -0.0622827
RPL37A ribosomal protein L37a -0.0620755
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0610838
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0609546
EIF1 eukaryotic translation initiation factor 1 -0.0595838
ANXA2 annexin A2 -0.0579779
RPL34 ribosomal protein L34 -0.0572665
RPS3 ribosomal protein S3 -0.0568892
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0555548
RPS6 ribosomal protein S6 -0.0532961
RPL31 ribosomal protein L31 -0.0532799
RPLP2 ribosomal protein, large, P2 -0.0514378
TXNRD1 thioredoxin reductase 1 -0.0499145
HMGA1 high mobility group AT-hook 1 -0.0485141
S100A11 S100 calcium binding protein A11 -0.04571
RPS12 ribosomal protein S12 -0.0454935
S100A4 S100 calcium binding protein A4 -0.0435082
RPS27A ribosomal protein S27a -0.0430691
RPS24 ribosomal protein S24 -0.0428383
POTEF POTE ankyrin domain family, member F -0.0427302
RPS20 ribosomal protein S20 -0.0413438
RPL11 ribosomal protein L11 -0.0411801
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0410882
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0401987
RPS13 ribosomal protein S13 -0.0401215
RPL26 ribosomal protein L26 -0.0397833
RPS21 ribosomal protein S21 -0.0390775
EMP1 epithelial membrane protein 1 -0.0385363
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0385099
RPL37 ribosomal protein L37 -0.0384238
RPL8 ribosomal protein L8 -0.0380412
RPS19 ribosomal protein S19 -0.0378963
RPLP0 ribosomal protein, large, P0 -0.0373281
KLF6 Kruppel-like factor 6 -0.0370118
RPS14 ribosomal protein S14 -0.036985
RAB1A RAB1A, member RAS oncogene family -0.036365
RPL19 ribosomal protein L19 -0.0359434
GNAS GNAS complex locus -0.0355515
MYL12B myosin, light chain 12B, regulatory -0.0345452
RPL9 ribosomal protein L9 -0.0342222
SEPTIN7 septin 7 -0.0340148
RPL36A ribosomal protein L36a -0.0338102
RPS29 ribosomal protein S29 -0.0332006
RPS27 ribosomal protein S27 -0.0330948
RPS23 ribosomal protein S23 -0.0330593
B2M beta-2-microglobulin -0.032329
RPL5 ribosomal protein L5 -0.0322501
RPL23 ribosomal protein L23 -0.0321607
RPL36 ribosomal protein L36 -0.0316002
SQSTM1 sequestosome 1 -0.0315046
IER3 immediate early response 3 -0.0313275
ASPH aspartate beta-hydroxylase -0.031273
RPL28 ribosomal protein L28 -0.0309885
RPS25 ribosomal protein S25 -0.030872
PGK1 phosphoglycerate kinase 1 -0.0308169
PFN1 profilin 1 -0.0306976
RPL30 ribosomal protein L30 -0.030504
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0296498
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0288085
SEM1 SEM1 26S proteasome subunit -0.0283475
LY6E lymphocyte antigen 6 complex, locus E -0.0281619
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0281191
RPS16 ribosomal protein S16 -0.0277987
FTH1 ferritin, heavy polypeptide 1 -0.0273264
RAB2A RAB2A, member RAS oncogene family -0.0273222
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0270691
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0263997
SDC4 syndecan 4 -0.0262828
FBXO11 F-box protein 11 -0.0262556
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0262445
VDAC1 voltage-dependent anion channel 1 -0.0258193
LOC112694756 uncharaterized LOC112694756 -0.0252839
RPL32 ribosomal protein L32 -0.0250286
RPS28 ribosomal protein S28 -0.024999
CSTB cystatin B (stefin B) -0.0249841
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0249559
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0248126
RPL27A ribosomal protein L27a -0.0247733
KRT19 keratin 19, type I -0.0242667
SLC38A2 solute carrier family 38, member 2 -0.0240787
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0238948
RACK1 receptor for activated C kinase 1 -0.0237236
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0233929
NOP58 NOP58 ribonucleoprotein -0.0230923