Imiquimod (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.102862
ZNF608 zinc finger protein 608 0.0913046
NEBL nebulette 0.089623
ADGRG6 adhesion G protein-coupled receptor G6 0.080558
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0801209
TENM3 teneurin transmembrane protein 3 0.0689139
NPAS3 neuronal PAS domain protein 3 0.055427
NFIA nuclear factor I/A 0.054314
DST dystonin 0.0533776
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0496965
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0473461
SLIT2 slit homolog 2 (Drosophila) 0.04625
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0458942
KMT2C lysine (K)-specific methyltransferase 2C 0.0456829
RPL3 ribosomal protein L3 0.0433528
TOX thymocyte selection-associated high mobility group box 0.0403952
FMNL2 formin-like 2 0.0386994
EEF2 eukaryotic translation elongation factor 2 0.0369662
ATP11A ATPase, class VI, type 11A 0.0356314
ZNF638 zinc finger protein 638 0.035411
YEATS2 YEATS domain containing 2 0.0353503
NUP58 nucleoporin 58 0.035145
SMYD3 SET and MYND domain containing 3 0.0346969
EFNA5 ephrin-A5 0.0341032
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0337861
SOX5 SRY (sex determining region Y)-box 5 0.0331963
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0325399
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0323183
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0312458
VCL vinculin 0.0311009
SLF1 SMC5-SMC6 complex localization factor 1 0.0306456
PHF21A PHD finger protein 21A 0.0296138
GJA1 gap junction protein, alpha 1, 43kDa 0.0284255
USP9X ubiquitin specific peptidase 9, X-linked 0.0282272
PIAS2 protein inhibitor of activated STAT, 2 0.027841
NGLY1 N-glycanase 1 0.0275522
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0275098
ARFGEF3 ARFGEF family member 3 0.0263224
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0260349
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0256248
GYS1 glycogen synthase 1 (muscle) 0.0253955
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0249766
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0249428
ARB2A ARB2 cotranscriptional regulator A 0.0243884
GSK3B glycogen synthase kinase 3 beta 0.0243669
TOP2B topoisomerase (DNA) II beta 180kDa 0.0242017
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0236851
KIAA1958 KIAA1958 0.0233793
COL5A2 collagen, type V, alpha 2 0.0232222
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0230788
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0230162
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0229777
OSBPL10 oxysterol binding protein-like 10 0.0229713
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0228193
ANKRD36 ankyrin repeat domain 36 0.0224005
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0223826
EP300 E1A binding protein p300 0.0221168
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0220206
TTC28 tetratricopeptide repeat domain 28 0.0215935
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0215527
LCOR ligand dependent nuclear receptor corepressor 0.0214071
DHFR dihydrofolate reductase 0.0212779
KDM3A lysine (K)-specific demethylase 3A 0.0212258
PGK1 phosphoglycerate kinase 1 0.0208817
NUMA1 nuclear mitotic apparatus protein 1 0.0205436
UBE3C ubiquitin protein ligase E3C 0.0204799
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0203777
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0202569
NCKAP1 NCK-associated protein 1 0.0202066
HSPA8 heat shock 70kDa protein 8 0.020111
PCNX1 pecanex 1 0.0200336
ADAM10 ADAM metallopeptidase domain 10 0.0200262
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0199869
GRID2 glutamate receptor, ionotropic, delta 2 0.0199003
ZNF544 zinc finger protein 544 0.0196359
CABIN1 calcineurin binding protein 1 0.0195079
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0194209
SMAD2 SMAD family member 2 0.019405
ATG10 autophagy related 10 0.0193693
AGTPBP1 ATP/GTP binding protein 1 0.0193028
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0192996
CAMTA1 calmodulin binding transcription activator 1 0.0191967
HELZ helicase with zinc finger 0.0191508
ZZZ3 zinc finger, ZZ-type containing 3 0.0189054
PTCH1 patched 1 0.0188948
KLC1 kinesin light chain 1 0.0187162
EXOC6B exocyst complex component 6B 0.018632
ZFAND3 zinc finger, AN1-type domain 3 0.018594
AK2 adenylate kinase 2 0.0185518
SRSF1 serine/arginine-rich splicing factor 1 0.0185012
EWSR1 EWS RNA-binding protein 1 0.0184266
DENND5A DENN/MADD domain containing 5A 0.018374
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0182774
DENND1A DENN/MADD domain containing 1A 0.0182694
SBF2 SET binding factor 2 0.018232
ATRN attractin 0.0181963
TPD52 tumor protein D52 0.018144
AFDN afadin, adherens junction formation factor 0.0178544
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0178176
PRELID2 PRELI domain containing 2 0.0177791

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.148968
RPS6 ribosomal protein S6 -0.117525
PTMA prothymosin, alpha -0.113442
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112308
RPLP1 ribosomal protein, large, P1 -0.0892172
RPS8 ribosomal protein S8 -0.0851688
TMSB10 thymosin beta 10 -0.0782016
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.065796
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0633857
RPL11 ribosomal protein L11 -0.0598609
RPS21 ribosomal protein S21 -0.0563544
RPL26 ribosomal protein L26 -0.0532521
VIM vimentin -0.0532303
ACTG1 actin gamma 1 -0.0514158
RPL35A ribosomal protein L35a -0.0508797
RPL34 ribosomal protein L34 -0.0506421
RPL19 ribosomal protein L19 -0.0502
RPS19 ribosomal protein S19 -0.0482279
RPL37A ribosomal protein L37a -0.0453951
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0447717
RPL5 ribosomal protein L5 -0.0443273
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0442743
RPL31 ribosomal protein L31 -0.0441895
RPS12 ribosomal protein S12 -0.0438391
RPL23 ribosomal protein L23 -0.0432206
RPS24 ribosomal protein S24 -0.0429568
RPLP2 ribosomal protein, large, P2 -0.0422241
RPS29 ribosomal protein S29 -0.0417102
RPL9 ribosomal protein L9 -0.0414591
RPL12 ribosomal protein L12 -0.0410163
TPT1 tumor protein, translationally-controlled 1 -0.040991
RPS3 ribosomal protein S3 -0.0404271
IFI6 interferon, alpha-inducible protein 6 -0.0402674
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0388331
NAP1L1 nucleosome assembly protein 1-like 1 -0.0386749
GNAS GNAS complex locus -0.0386035
HMGB1 high mobility group box 1 -0.03779
RPL28 ribosomal protein L28 -0.0377289
RPS25 ribosomal protein S25 -0.0368599
RPLP0 ribosomal protein, large, P0 -0.0365817
RPS14 ribosomal protein S14 -0.0357374
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0351519
RPS16 ribosomal protein S16 -0.0338858
RPS17 ribosomal protein S17 -0.0336776
PFN1 profilin 1 -0.0332688
RPS15 ribosomal protein S15 -0.0328737
FTL ferritin, light polypeptide -0.0328668
RPL36 ribosomal protein L36 -0.0326856
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0326282
CENPF centromere protein F, 350/400kDa -0.03233
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0319191
EIF5B eukaryotic translation initiation factor 5B -0.0317415
SERBP1 SERPINE1 mRNA binding protein 1 -0.0307565
B2M beta-2-microglobulin -0.0298644
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.029772
RPS5 ribosomal protein S5 -0.027955
MT2A metallothionein 2A -0.0278214
RPS27A ribosomal protein S27a -0.0275335
RPL35 ribosomal protein L35 -0.0274664
S100A9 S100 calcium binding protein A9 -0.0272551
RPS10 ribosomal protein S10 -0.0272319
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0271449
NOP58 NOP58 ribonucleoprotein -0.0269182
WSB1 WD repeat and SOCS box containing 1 -0.0264424
RPL38 ribosomal protein L38 -0.0263688
KPNB1 karyopherin (importin) beta 1 -0.0258727
RPL8 ribosomal protein L8 -0.025555
RPS27 ribosomal protein S27 -0.0251736
SRSF11 serine/arginine-rich splicing factor 11 -0.0250677
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0250218
RPS28 ribosomal protein S28 -0.0249828
RPS13 ribosomal protein S13 -0.0248396
RPL27 ribosomal protein L27 -0.0247788
RPS11 ribosomal protein S11 -0.024675
RPS23 ribosomal protein S23 -0.024424
RPS20 ribosomal protein S20 -0.0240694
SOX4 SRY (sex determining region Y)-box 4 -0.0240317
VDAC1 voltage-dependent anion channel 1 -0.0240105
RPL27A ribosomal protein L27a -0.0239926
HMGA1 high mobility group AT-hook 1 -0.0237456
PABPN1 poly(A) binding protein, nuclear 1 -0.0236291
EGR1 early growth response 1 -0.0233937
FN1 fibronectin 1 -0.0232385
RPS2 ribosomal protein S2 -0.0228989
ATP5F1E ATP synthase F1 subunit epsilon -0.0228461
MYL12B myosin, light chain 12B, regulatory -0.0228414
RPL32 ribosomal protein L32 -0.0224865
EIF1 eukaryotic translation initiation factor 1 -0.0224346
RPL18 ribosomal protein L18 -0.0223837
YBX1 Y box binding protein 1 -0.0221629
ISG15 ISG15 ubiquitin-like modifier -0.0219649
LDHB lactate dehydrogenase B -0.0218992
S100A10 S100 calcium binding protein A10 -0.0216636
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0216202
RPL36A ribosomal protein L36a -0.0214012
GOLGA4 golgin A4 -0.0212452
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0202554
PDIA3 protein disulfide isomerase family A, member 3 -0.0201329
DEK DEK proto-oncogene -0.0197162
HLA-B major histocompatibility complex, class I, B -0.01962