Imiquimod (hydrochloride)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0392338
DSCAM Down syndrome cell adhesion molecule 0.0383968
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0353134
NRIP1 nuclear receptor interacting protein 1 0.0337397
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0314561
MLPH melanophilin 0.0299733
RNF149 ring finger protein 149 0.0296431
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0290093
MYH9 myosin, heavy chain 9, non-muscle 0.0277593
NDRG1 N-myc downstream regulated 1 0.0258191
FNIP1 folliculin interacting protein 1 0.0251384
ZMYM2 zinc finger, MYM-type 2 0.0245989
STK24 serine/threonine kinase 24 0.0245243
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0244199
ERRFI1 ERBB receptor feedback inhibitor 1 0.0240098
SRRM2 serine/arginine repetitive matrix 2 0.0236357
MBNL2 muscleblind-like splicing regulator 2 0.0233081
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0228154
IFNGR1 interferon gamma receptor 1 0.0225108
RNF43 ring finger protein 43 0.0222212
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0210661
TM9SF2 transmembrane 9 superfamily member 2 0.0197813
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0193498
DHFR dihydrofolate reductase 0.0192322
SREBF2 sterol regulatory element binding transcription factor 2 0.0189759
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0189343
PHF3 PHD finger protein 3 0.0188572
OARD1 O-acyl-ADP-ribose deacylase 1 0.0185115
ABHD2 abhydrolase domain containing 2 0.0184665
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0178037
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0176419
SPRED1 sprouty-related, EVH1 domain containing 1 0.0175307
TXNIP thioredoxin interacting protein 0.0174166
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0172454
MKI67 marker of proliferation Ki-67 0.0170474
UBC ubiquitin C 0.0167424
RBM26 RNA binding motif protein 26 0.0167327
IL20RA interleukin 20 receptor, alpha 0.0167104
COG6 component of oligomeric golgi complex 6 0.0162246
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0154796
USP3 ubiquitin specific peptidase 3 0.0154463
TMEM62 transmembrane protein 62 0.0153113
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.015273
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0152612
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0151572
ARHGAP5 Rho GTPase activating protein 5 0.0150628
PDZD8 PDZ domain containing 8 0.0149373
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0149001
PRELID2 PRELI domain containing 2 0.0148937
LRRC1 leucine rich repeat containing 1 0.0148302
YEATS2 YEATS domain containing 2 0.0146773
ZFC3H1 zinc finger, C3H1-type containing 0.0146308
PUM2 pumilio RNA-binding family member 2 0.0145314
PTEN phosphatase and tensin homolog 0.0143132
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0142832
GIGYF2 GRB10 interacting GYF protein 2 0.0141694
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0139439
CD46 CD46 molecule, complement regulatory protein 0.0136475
RPL3 ribosomal protein L3 0.0135615
HDLBP high density lipoprotein binding protein 0.0134155
SPRED2 sprouty-related, EVH1 domain containing 2 0.0131686
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0131621
CERT1 ceramide transporter 1 0.013162
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.013039
TMEM51 transmembrane protein 51 0.0129319
KDM3A lysine (K)-specific demethylase 3A 0.0128727
DSPP dentin sialophosphoprotein 0.0128692
NPEPPS aminopeptidase puromycin sensitive 0.0128601
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0128026
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.012775
WDR26 WD repeat domain 26 0.0127523
ARRDC3 arrestin domain containing 3 0.0126477
KDM6A lysine (K)-specific demethylase 6A 0.0125305
PNPLA7 patatin-like phospholipase domain containing 7 0.0124208
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0123702
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0123661
FAT1 FAT atypical cadherin 1 0.0122047
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0121044
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0119349
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0118911
PTBP3 polypyrimidine tract binding protein 3 0.0118816
FOXO3 forkhead box O3 0.0118507
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.011731
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0117075
NCOR2 nuclear receptor corepressor 2 0.0116417
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0116209
MINK1 misshapen-like kinase 1 0.0115944
SLF2 SMC5-SMC6 complex localization factor 2 0.0115445
DNMBP dynamin binding protein 0.0115392
ESRP1 epithelial splicing regulatory protein 1 0.0114863
DIDO1 death inducer-obliterator 1 0.0114728
PRRC1 proline-rich coiled-coil 1 0.0114509
ARCN1 archain 1 0.0113589
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0113406
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0113344
MCTP2 multiple C2 domains, transmembrane 2 0.0113231
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0113133
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0112924
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0112575
RC3H2 ring finger and CCCH-type domains 2 0.0112432

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.105797
B2M beta-2-microglobulin -0.0952487
TPT1 tumor protein, translationally-controlled 1 -0.0879892
LMO7 LIM domain 7 -0.0853603
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0825528
RNF213 ring finger protein 213 -0.0730035
EGR1 early growth response 1 -0.0717401
ANXA2 annexin A2 -0.0710147
RIGI RNA sensor RIG-I -0.0698885
GMDS GDP-mannose 4,6-dehydratase -0.0698211
LCN2 lipocalin 2 -0.0636215
MX1 MX dynamin-like GTPase 1 -0.0634636
INTS6 integrator complex subunit 6 -0.0623615
SP100 SP100 nuclear antigen -0.0596759
IFI6 interferon, alpha-inducible protein 6 -0.0534363
SQSTM1 sequestosome 1 -0.0528155
MX2 MX dynamin-like GTPase 2 -0.0527723
STS steroid sulfatase (microsomal), isozyme S -0.0513393
RAB7A RAB7A, member RAS oncogene family -0.0508487
EZR ezrin -0.0489444
GCLC glutamate-cysteine ligase, catalytic subunit -0.047763
LOC102724023 ES1 protein homolog, mitochondrial -0.0464046
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0441887
IFI27 interferon, alpha-inducible protein 27 -0.0439159
PTMA prothymosin, alpha -0.0436696
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0413834
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0411277
NPSR1 neuropeptide S receptor 1 -0.0404375
AREG amphiregulin -0.0398213
PLSCR1 phospholipid scramblase 1 -0.0395832
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.039163
FTL ferritin, light polypeptide -0.0378491
TSHZ2 teashirt zinc finger homeobox 2 -0.0369061
IRF1 interferon regulatory factor 1 -0.0355528
TMSB10 thymosin beta 10 -0.0350747
LYZ lysozyme -0.034978
PRKCA protein kinase C, alpha -0.0345694
XAF1 XIAP associated factor 1 -0.0344741
RPS6 ribosomal protein S6 -0.0343882
HLA-B major histocompatibility complex, class I, B -0.0340658
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0333315
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0333191
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0330612
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0326431
ACTG1 actin gamma 1 -0.0326386
RPL35A ribosomal protein L35a -0.032432
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0320244
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.031509
EFNB2 ephrin-B2 -0.0314805
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0310565
RABGAP1L RAB GTPase activating protein 1-like -0.0309134
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0301604
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.030095
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0300297
PLSCR2 phospholipid scramblase 2 -0.0297853
MAML2 mastermind-like 2 (Drosophila) -0.0295005
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.029405
JUN jun proto-oncogene -0.0293211
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0292821
MT2A metallothionein 2A -0.0276409
VCL vinculin -0.0273564
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0272955
ARHGAP26 Rho GTPase activating protein 26 -0.0272672
ASPH aspartate beta-hydroxylase -0.0266595
S100A6 S100 calcium binding protein A6 -0.0266225
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0262452
EXT1 exostosin glycosyltransferase 1 -0.0259285
AKAP13 A kinase (PRKA) anchor protein 13 -0.025928
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0257345
MCL1 myeloid cell leukemia 1 -0.0256956
PERP PERP, TP53 apoptosis effector -0.025683
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0256664
TJP1 tight junction protein 1 -0.0256197
ITGA6 integrin, alpha 6 -0.0249905
TMC5 transmembrane channel-like 5 -0.0249138
LAMA4 laminin, alpha 4 -0.0244828
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0242771
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0240827
RPS8 ribosomal protein S8 -0.0237456
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0232062
MCU mitochondrial calcium uniporter -0.0230614
MCTP1 multiple C2 domains, transmembrane 1 -0.0228259
BAIAP2L1 BAI1-associated protein 2-like 1 -0.022728
C6ORF132 chromosome 6 open reading frame 132 -0.0221919
PMP22 peripheral myelin protein 22 -0.0220318
FTH1 ferritin, heavy polypeptide 1 -0.0217967
SLC38A1 solute carrier family 38, member 1 -0.02176
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0216977
RPL34 ribosomal protein L34 -0.021539
CATSPERB catsper channel auxiliary subunit beta -0.0210985
ANXA1 annexin A1 -0.0210669
FNDC3B fibronectin type III domain containing 3B -0.0209566
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0208798
IGFBP3 insulin-like growth factor binding protein 3 -0.0207437
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.020568
NABP1 nucleic acid binding protein 1 -0.0205282
CXCL8 chemokine (C-X-C motif) ligand 8 -0.020256
ZNF292 zinc finger protein 292 -0.0200529
EPHB2 EPH receptor B2 -0.01999
TM4SF1 transmembrane 4 L six family member 1 -0.0199294