Imiquimod (hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.114845
COL6A3 collagen, type VI, alpha 3 0.112715
STC1 stanniocalcin 1 0.109724
FNDC3B fibronectin type III domain containing 3B 0.089176
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0813014
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0744944
DGKD diacylglycerol kinase, delta 130kDa 0.074202
NDRG1 N-myc downstream regulated 1 0.0733972
SMAD3 SMAD family member 3 0.0703653
EGFR epidermal growth factor receptor 0.0694297
LOX lysyl oxidase 0.0678426
LOXL2 lysyl oxidase-like 2 0.0630717
CXCL8 chemokine (C-X-C motif) ligand 8 0.0555639
MYH9 myosin, heavy chain 9, non-muscle 0.0553703
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0546031
MACF1 microtubule-actin crosslinking factor 1 0.0543203
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0519566
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0490913
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0480792
ATP13A3 ATPase type 13A3 0.0455663
ERRFI1 ERBB receptor feedback inhibitor 1 0.0448711
TRIO trio Rho guanine nucleotide exchange factor 0.0419439
COL5A1 collagen, type V, alpha 1 0.0416658
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0406696
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0400853
EEF2 eukaryotic translation elongation factor 2 0.0399532
CALD1 caldesmon 1 0.0389272
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0378546
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0374672
FLNA filamin A, alpha 0.0371159
ASPH aspartate beta-hydroxylase 0.0370025
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0363025
SAMD4A sterile alpha motif domain containing 4A 0.0359992
RPL3 ribosomal protein L3 0.0359304
NFE2L1 nuclear factor, erythroid 2-like 1 0.0352215
TLN1 talin 1 0.0347952
MYOF myoferlin 0.0343909
NAMPT nicotinamide phosphoribosyltransferase 0.0331738
ELL2 elongation factor, RNA polymerase II, 2 0.0327252
TNIP1 TNFAIP3 interacting protein 1 0.0316937
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0315205
ANO6 anoctamin 6 0.0315161
ZNF841 zinc finger protein 841 0.0311605
GOLGB1 golgin B1 0.03021
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.029581
HDAC9 histone deacetylase 9 0.0293343
WWTR1 WW domain containing transcription regulator 1 0.0289401
MSN moesin 0.0289318
HSPA8 heat shock 70kDa protein 8 0.0285469
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.028368
HELZ helicase with zinc finger 0.0282663
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0279618
SRP54 signal recognition particle 54kDa 0.0267357
ANKRD36 ankyrin repeat domain 36 0.0265162
CLTC clathrin, heavy chain (Hc) 0.0261478
ACTN1 actinin, alpha 1 0.0260487
AFF1 AF4/FMR2 family, member 1 0.026039
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0259994
TXNIP thioredoxin interacting protein 0.0256512
RPL4 ribosomal protein L4 0.0254769
CORO1C coronin, actin binding protein, 1C 0.0254495
SHB Src homology 2 domain containing adaptor protein B 0.0251587
DOCK5 dedicator of cytokinesis 5 0.0251021
OGA O-GlcNAcase 0.0247151
FAM13A family with sequence similarity 13, member A 0.0246794
PCBP3 poly(rC) binding protein 3 0.0243489
LOC112694756 uncharaterized LOC112694756 0.0241905
PRELID2 PRELI domain containing 2 0.023969
PHF3 PHD finger protein 3 0.0239495
PMM2 phosphomannomutase 2 0.023564
INSIG2 insulin induced gene 2 0.0233951
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0229915
ZNF451 zinc finger protein 451 0.0229302
FAM219A family with sequence similarity 219, member A 0.022925
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0228774
UBA6 ubiquitin-like modifier activating enzyme 6 0.0227658
YEATS2 YEATS domain containing 2 0.0225831
AHNAK AHNAK nucleoprotein 0.0223698
TTC3 tetratricopeptide repeat domain 3 0.0220208
CALU calumenin 0.0218533
VMP1 vacuole membrane protein 1 0.0217371
PLEC plectin 0.0215341
MARCHF6 membrane associated ring-CH-type finger 6 0.0214419
TPM3 tropomyosin 3 0.0214132
HYOU1 hypoxia up-regulated 1 0.0213976
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0213864
NAV2 neuron navigator 2 0.0213021
NOTCH2 notch 2 0.0212421
PKM pyruvate kinase, muscle 0.0212026
NPC1 Niemann-Pick disease, type C1 0.0211035
ZNF638 zinc finger protein 638 0.0211033
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0209303
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0208342
SPTBN1 spectrin, beta, non-erythrocytic 1 0.020712
TNNC1 troponin C type 1 (slow) 0.0205188
BACE2 beta-site APP-cleaving enzyme 2 0.0204631
DSCAM Down syndrome cell adhesion molecule 0.020215
AVL9 AVL9 homolog (S. cerevisiase) 0.0201872
FAM114A1 family with sequence similarity 114, member A1 0.0199488
RTN4 reticulon 4 0.0199474

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.154953
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138665
VIM vimentin -0.133903
FTL ferritin, light polypeptide -0.104537
NALF1 NALCN channel auxiliary factor 1 -0.0888814
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0809707
MT2A metallothionein 2A -0.0773266
B2M beta-2-microglobulin -0.0755333
PTMA prothymosin, alpha -0.0737194
RPS6 ribosomal protein S6 -0.0696499
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.06881
RPL35A ribosomal protein L35a -0.0637844
RPS8 ribosomal protein S8 -0.0632441
RPLP1 ribosomal protein, large, P1 -0.061024
HLA-B major histocompatibility complex, class I, B -0.0576326
FN1 fibronectin 1 -0.0516362
GRB10 growth factor receptor-bound protein 10 -0.0513333
RPS19 ribosomal protein S19 -0.0474643
TPT1 tumor protein, translationally-controlled 1 -0.047026
RPL37A ribosomal protein L37a -0.0456546
RPL28 ribosomal protein L28 -0.0425209
RPL34 ribosomal protein L34 -0.0414978
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0392434
NLGN1 neuroligin 1 -0.0362836
RPL12 ribosomal protein L12 -0.0349607
RPLP2 ribosomal protein, large, P2 -0.0332936
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0331866
GNAS GNAS complex locus -0.0322467
RPS13 ribosomal protein S13 -0.0320067
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0318565
SEC61G Sec61 gamma subunit -0.0295503
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.028508
RPL9 ribosomal protein L9 -0.0283323
PDE4D phosphodiesterase 4D, cAMP-specific -0.0279804
EIF1 eukaryotic translation initiation factor 1 -0.0279364
RPS23 ribosomal protein S23 -0.0275622
S100A6 S100 calcium binding protein A6 -0.0275209
S100A10 S100 calcium binding protein A10 -0.0270999
RPL31 ribosomal protein L31 -0.0269462
RPS25 ribosomal protein S25 -0.0264211
RPL36 ribosomal protein L36 -0.0264075
RPL19 ribosomal protein L19 -0.0252362
RPL32 ribosomal protein L32 -0.024725
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0246469
IGF2 insulin-like growth factor 2 -0.024624
S100A9 S100 calcium binding protein A9 -0.0244634
RPL23 ribosomal protein L23 -0.0243905
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0242274
RPS27A ribosomal protein S27a -0.0242013
ACTG1 actin gamma 1 -0.024051
RPS24 ribosomal protein S24 -0.023662
AHR aryl hydrocarbon receptor -0.0235893
PTCHD4 patched domain containing 4 -0.0235138
CLMP CXADR-like membrane protein -0.0233504
HIP1 huntingtin interacting protein 1 -0.0233079
RPL35 ribosomal protein L35 -0.0230171
RPS5 ribosomal protein S5 -0.0230136
RPS12 ribosomal protein S12 -0.0228218
PRSS23 protease, serine, 23 -0.0226372
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0223706
PTPRG protein tyrosine phosphatase, receptor type, G -0.0217834
RPS27 ribosomal protein S27 -0.0216867
GDF15 growth differentiation factor 15 -0.0215863
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0214978
RPL37 ribosomal protein L37 -0.021234
RPS21 ribosomal protein S21 -0.0212247
ASTN2 astrotactin 2 -0.0210679
RPS3 ribosomal protein S3 -0.0210647
RPS16 ribosomal protein S16 -0.0210357
RPS11 ribosomal protein S11 -0.0210059
TPM4 tropomyosin 4 -0.0209413
SEPTIN7 septin 7 -0.0208127
NDUFA4 NDUFA4, mitochondrial complex associated -0.0205051
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0197573
PTK2 protein tyrosine kinase 2 -0.0196001
NAP1L1 nucleosome assembly protein 1-like 1 -0.0194996
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0193537
RPL7A ribosomal protein L7a -0.0193448
CBX3 chromobox homolog 3 -0.0190869
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0190734
ZNF804A zinc finger protein 804A -0.0188747
RPS17 ribosomal protein S17 -0.0188525
HMGB1 high mobility group box 1 -0.0188362
VDAC1 voltage-dependent anion channel 1 -0.0184933
WSB1 WD repeat and SOCS box containing 1 -0.0183986
SMC4 structural maintenance of chromosomes 4 -0.0183152
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0181841
FBXO11 F-box protein 11 -0.0180133
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0178621
RPLP0 ribosomal protein, large, P0 -0.0177533
GARS1 glycyl-tRNA synthetase 1 -0.0173512
GPHN gephyrin -0.0173009
RPS20 ribosomal protein S20 -0.0172026
RPL26 ribosomal protein L26 -0.0171604
TMSB4X thymosin beta 4, X-linked -0.0170094
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0169405
CD99 CD99 molecule -0.0169024
ENO1 enolase 1, (alpha) -0.0168759
MT1X metallothionein 1X -0.0167799
LAMB1 laminin, beta 1 -0.0167131