Imiquimod (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.185584
DSCAM Down syndrome cell adhesion molecule 0.0976563
ERRFI1 ERBB receptor feedback inhibitor 1 0.0973263
PRELID2 PRELI domain containing 2 0.0920672
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0833383
MYH9 myosin, heavy chain 9, non-muscle 0.0765815
TBC1D22A TBC1 domain family, member 22A 0.0730451
EEF2 eukaryotic translation elongation factor 2 0.0628285
FAT1 FAT atypical cadherin 1 0.0605131
HDLBP high density lipoprotein binding protein 0.0561797
CTNND1 catenin (cadherin-associated protein), delta 1 0.0551492
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0448151
KDM4C lysine (K)-specific demethylase 4C 0.0438566
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.043612
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0429327
RPL3 ribosomal protein L3 0.0420927
MBD5 methyl-CpG binding domain protein 5 0.0415617
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0414814
NDRG1 N-myc downstream regulated 1 0.0412681
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0411124
EZR ezrin 0.0397996
ZNF638 zinc finger protein 638 0.0389335
YEATS2 YEATS domain containing 2 0.0375715
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0373894
TXNRD1 thioredoxin reductase 1 0.037297
RBM39 RNA binding motif protein 39 0.0364514
LOC112694756 uncharaterized LOC112694756 0.0342896
COPA coatomer protein complex, subunit alpha 0.03414
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0340148
CLTC clathrin, heavy chain (Hc) 0.033984
ZFC3H1 zinc finger, C3H1-type containing 0.0338549
TM9SF3 transmembrane 9 superfamily member 3 0.0335328
ZNF654 zinc finger protein 654 0.0333593
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0331329
ARCN1 archain 1 0.0328522
ACTN4 actinin, alpha 4 0.0324564
MCL1 myeloid cell leukemia 1 0.0322162
PATJ PATJ crumbs cell polarity complex component 0.0318824
MARCHF6 membrane associated ring-CH-type finger 6 0.0317643
YME1L1 YME1-like 1 ATPase 0.0314516
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0312689
ZC3H11A zinc finger CCCH-type containing 11A 0.0308344
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0306042
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0298633
GOLGB1 golgin B1 0.0298585
SCARB1 scavenger receptor class B, member 1 0.0295448
ATXN1 ataxin 1 0.0294237
ZNF292 zinc finger protein 292 0.0285413
AFF4 AF4/FMR2 family, member 4 0.0279129
ADGRG6 adhesion G protein-coupled receptor G6 0.0277858
VCL vinculin 0.0277837
EP300 E1A binding protein p300 0.0276578
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0274527
PCM1 pericentriolar material 1 0.0274331
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0271203
CSDE1 cold shock domain containing E1, RNA-binding 0.0269784
NF1 neurofibromin 1 0.0267009
TPM4 tropomyosin 4 0.0265194
FXR1 fragile X mental retardation, autosomal homolog 1 0.0263699
SBF2 SET binding factor 2 0.0258467
ARF4 ADP-ribosylation factor 4 0.0256312
SPRED2 sprouty-related, EVH1 domain containing 2 0.0255998
HELZ helicase with zinc finger 0.0254692
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0253567
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252258
PFKP phosphofructokinase, platelet 0.0250115
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0249657
PLAUR plasminogen activator, urokinase receptor 0.02489
WDR26 WD repeat domain 26 0.0247902
SON SON DNA binding protein 0.0247291
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0246423
SETD5 SET domain containing 5 0.0243773
WAC WW domain containing adaptor with coiled-coil 0.024277
KLF6 Kruppel-like factor 6 0.0241768
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0238768
PAPOLA poly(A) polymerase alpha 0.0233496
APLP2 amyloid beta (A4) precursor-like protein 2 0.0233416
RPL4 ribosomal protein L4 0.023269
CSNK1A1 casein kinase 1, alpha 1 0.0232316
STRN3 striatin, calmodulin binding protein 3 0.0231667
WDFY3 WD repeat and FYVE domain containing 3 0.0230236
FNBP4 formin binding protein 4 0.0229779
KMT2C lysine (K)-specific methyltransferase 2C 0.0229605
MED13 mediator complex subunit 13 0.0227814
VMP1 vacuole membrane protein 1 0.0226152
ANXA2 annexin A2 0.0225994
TOR1AIP2 torsin A interacting protein 2 0.0225183
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0225117
SEC31A SEC31 homolog A (S. cerevisiae) 0.0224694
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.022347
ICAM1 intercellular adhesion molecule 1 0.022325
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0222442
GOLGA2 golgin A2 0.0221619
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0221581
SHB Src homology 2 domain containing adaptor protein B 0.0217145
CDK19 cyclin-dependent kinase 19 0.021702
UBAP2L ubiquitin associated protein 2-like 0.0216566
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0215006
ATM ATM serine/threonine kinase 0.0214924
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0214074

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.168265
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.148744
RPS6 ribosomal protein S6 -0.0812225
TMSB10 thymosin beta 10 -0.0794193
TPT1 tumor protein, translationally-controlled 1 -0.0761122
RPS8 ribosomal protein S8 -0.0745245
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0733108
RPL35A ribosomal protein L35a -0.0673717
FTL ferritin, light polypeptide -0.056887
POTEF POTE ankyrin domain family, member F -0.0486233
RPL37A ribosomal protein L37a -0.0432121
RPLP1 ribosomal protein, large, P1 -0.0426061
RPS19 ribosomal protein S19 -0.0421047
ACTG1 actin gamma 1 -0.0394546
RPS25 ribosomal protein S25 -0.0382144
RPL34 ribosomal protein L34 -0.0375121
RPS17 ribosomal protein S17 -0.0359107
RPLP2 ribosomal protein, large, P2 -0.0347939
LDHB lactate dehydrogenase B -0.0327507
RPL31 ribosomal protein L31 -0.032686
RPL23 ribosomal protein L23 -0.0312031
RPL11 ribosomal protein L11 -0.030717
RPS13 ribosomal protein S13 -0.0303483
RPS29 ribosomal protein S29 -0.0301426
RPL36 ribosomal protein L36 -0.0299737
RPS15 ribosomal protein S15 -0.0295725
HLA-B major histocompatibility complex, class I, B -0.0294055
RPL5 ribosomal protein L5 -0.0290321
NAP1L1 nucleosome assembly protein 1-like 1 -0.0289453
B2M beta-2-microglobulin -0.0287964
RPS10 ribosomal protein S10 -0.0283807
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0282642
RPL26 ribosomal protein L26 -0.0280875
S100A10 S100 calcium binding protein A10 -0.0278869
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0278256
RPS24 ribosomal protein S24 -0.0272275
RPL28 ribosomal protein L28 -0.0269009
SMC4 structural maintenance of chromosomes 4 -0.0265356
RPS14 ribosomal protein S14 -0.0262278
RPL19 ribosomal protein L19 -0.0258666
S100A9 S100 calcium binding protein A9 -0.0253205
EIF5B eukaryotic translation initiation factor 5B -0.0253052
RPL12 ribosomal protein L12 -0.0252197
VEGFA vascular endothelial growth factor A -0.0248471
RPL7A ribosomal protein L7a -0.0248349
RPS16 ribosomal protein S16 -0.0246651
RPL37 ribosomal protein L37 -0.024609
GNAS GNAS complex locus -0.0245474
HLA-A major histocompatibility complex, class I, A -0.02442
KTN1 kinectin 1 (kinesin receptor) -0.024413
RPL38 ribosomal protein L38 -0.0243848
RPS3 ribosomal protein S3 -0.0242076
RPS11 ribosomal protein S11 -0.0240156
RPL32 ribosomal protein L32 -0.0239913
RPS27 ribosomal protein S27 -0.0236708
HMGB1 high mobility group box 1 -0.0236693
HILPDA hypoxia inducible lipid droplet-associated -0.0234968
RPS21 ribosomal protein S21 -0.02326
PDIA3 protein disulfide isomerase family A, member 3 -0.022859
VIM vimentin -0.0228533
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0227939
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0223402
RPS20 ribosomal protein S20 -0.0222918
MORF4L2 mortality factor 4 like 2 -0.0221575
RPLP0 ribosomal protein, large, P0 -0.0219167
WWOX WW domain containing oxidoreductase -0.0214513
RPS2 ribosomal protein S2 -0.0213808
YBX1 Y box binding protein 1 -0.0213377
KPNB1 karyopherin (importin) beta 1 -0.0212862
RPL27 ribosomal protein L27 -0.0211239
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0211053
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.02107
S100A6 S100 calcium binding protein A6 -0.0208893
LMNA lamin A/C -0.0206239
TUBA1B tubulin, alpha 1b -0.0199801
CCND1 cyclin D1 -0.0199296
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0199149
RPL9 ribosomal protein L9 -0.0195509
PFN1 profilin 1 -0.019521
SRPK2 SRSF protein kinase 2 -0.019442
IFITM3 interferon induced transmembrane protein 3 -0.0192616
SMC3 structural maintenance of chromosomes 3 -0.0191662
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0191353
PKM pyruvate kinase, muscle -0.0190117
TUBB4B tubulin, beta 4B class IVb -0.0184777
PA2G4 proliferation-associated 2G4, 38kDa -0.0184118
RPS27A ribosomal protein S27a -0.018338
CEMIP2 cell migration inducing hyaluronidase 2 -0.0183032
FBL fibrillarin -0.0179818
CBX3 chromobox homolog 3 -0.0178909
LRRC23 leucine rich repeat containing 23 -0.0175934
ENO2 enolase 2 (gamma, neuronal) -0.0175877
GMDS GDP-mannose 4,6-dehydratase -0.017452
RPS12 ribosomal protein S12 -0.0172703
PRDX2 peroxiredoxin 2 -0.0172511
MIDN midnolin -0.0171816
RAN RAN, member RAS oncogene family -0.0169114
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0168922
HMGA2 high mobility group AT-hook 2 -0.0168715
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0164524