Imiquimod (hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.115191
ERRFI1 ERBB receptor feedback inhibitor 1 0.0646035
ELL2 elongation factor, RNA polymerase II, 2 0.0557147
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0507603
TRIO trio Rho guanine nucleotide exchange factor 0.0501505
SEPTIN9 septin 9 0.0384419
COL5A1 collagen, type V, alpha 1 0.0336046
COL6A1 collagen, type VI, alpha 1 0.0331115
FAM13A family with sequence similarity 13, member A 0.0310731
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0301693
COL6A3 collagen, type VI, alpha 3 0.0299684
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0291799
LOXL2 lysyl oxidase-like 2 0.0269475
EGR1 early growth response 1 0.0267449
TNS1 tensin 1 0.0265166
HPCAL1 hippocalcin-like 1 0.0257415
PPARD peroxisome proliferator-activated receptor delta 0.0253392
LOX lysyl oxidase 0.0251816
JARID2 jumonji, AT rich interactive domain 2 0.0238367
NDRG1 N-myc downstream regulated 1 0.0218296
VCL vinculin 0.0214473
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0211838
RASA3 RAS p21 protein activator 3 0.0206723
FLNA filamin A, alpha 0.0196737
MCL1 myeloid cell leukemia 1 0.0196465
PLEC plectin 0.0195368
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0193291
IGF2 insulin-like growth factor 2 0.019204
FNDC3B fibronectin type III domain containing 3B 0.0184812
COL6A2 collagen, type VI, alpha 2 0.0181146
SMAD3 SMAD family member 3 0.0175724
MSN moesin 0.0169786
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.016668
CDH13 cadherin 13 0.015484
COL7A1 collagen, type VII, alpha 1 0.0152877
IGFBP3 insulin-like growth factor binding protein 3 0.0152619
CD109 CD109 molecule 0.0150412
RPL3 ribosomal protein L3 0.0149878
ATP13A3 ATPase type 13A3 0.0149133
SHB Src homology 2 domain containing adaptor protein B 0.0146762
ARRDC3 arrestin domain containing 3 0.0146099
SPRED2 sprouty-related, EVH1 domain containing 2 0.0145571
HELZ helicase with zinc finger 0.0142089
GRB10 growth factor receptor-bound protein 10 0.0141889
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0136624
NUP58 nucleoporin 58 0.0133226
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0131995
MYH9 myosin, heavy chain 9, non-muscle 0.0131738
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0127904
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0125941
INSIG2 insulin induced gene 2 0.0123179
CORO1C coronin, actin binding protein, 1C 0.0122526
TRAM2 translocation associated membrane protein 2 0.0121383
AMPD3 adenosine monophosphate deaminase 3 0.0120691
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0120629
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0114687
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0111435
CHIC2 cysteine-rich hydrophobic domain 2 0.0110278
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0107958
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0107745
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0107277
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0107245
SEC24A SEC24 family member A 0.0103864
ACTN1 actinin, alpha 1 0.0103837
CAPRIN2 caprin family member 2 0.0103288
ADARB1 adenosine deaminase, RNA-specific, B1 0.0103016
ZMIZ1 zinc finger, MIZ-type containing 1 0.0102923
MIMS1 mitochondrial inner membrane scaffold 1 0.0102417
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0102135
COL4A2 collagen, type IV, alpha 2 0.0101454
FERMT2 fermitin family member 2 0.0100062
THBS2 thrombospondin 2 0.00991204
TENM2 teneurin transmembrane protein 2 0.00990284
AKAP12 A kinase (PRKA) anchor protein 12 0.00983893
KLF7 Kruppel-like factor 7 (ubiquitous) 0.00982065
PDE10A phosphodiesterase 10A 0.00979439
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.00974891
HJURP Holliday junction recognition protein 0.00967616
LHFPL2 lipoma HMGIC fusion partner-like 2 0.00957214
FBXO42 F-box protein 42 0.00955725
TFRC transferrin receptor 0.00939832
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00936662
PCBP3 poly(rC) binding protein 3 0.00920112
MTCL1 microtubule crosslinking factor 1 0.00912695
PICALM phosphatidylinositol binding clathrin assembly protein 0.0091222
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.00902421
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.00900607
UBA6 ubiquitin-like modifier activating enzyme 6 0.00893261
USP3 ubiquitin specific peptidase 3 0.00893127
TNNC1 troponin C type 1 (slow) 0.00883276
SMTN smoothelin 0.00878782
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.00873536
ZNF185 zinc finger protein 185 (LIM domain) 0.00867155
STC1 stanniocalcin 1 0.00864
TNIP1 TNFAIP3 interacting protein 1 0.00863334
FAM219A family with sequence similarity 219, member A 0.00858586
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00845373
EFNA5 ephrin-A5 0.00841091
L1CAM L1 cell adhesion molecule 0.00840221
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.00830844

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.485079
VIM vimentin -0.413148
TMSB10 thymosin beta 10 -0.182555
MT2A metallothionein 2A -0.144656
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.114711
PTMA prothymosin, alpha -0.106676
ENO1 enolase 1, (alpha) -0.101814
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0829599
CD44 CD44 molecule (Indian blood group) -0.0799506
RPS6 ribosomal protein S6 -0.0749278
TPT1 tumor protein, translationally-controlled 1 -0.0709227
RPLP1 ribosomal protein, large, P1 -0.0697015
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0695086
RPS27A ribosomal protein S27a -0.0624208
ASPH aspartate beta-hydroxylase -0.0579492
RPL12 ribosomal protein L12 -0.0568761
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0555111
LDHA lactate dehydrogenase A -0.0538634
RPS8 ribosomal protein S8 -0.0524037
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0523887
RPL23 ribosomal protein L23 -0.0518898
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0504051
UBC ubiquitin C -0.0494194
FTL ferritin, light polypeptide -0.048006
ACTG1 actin gamma 1 -0.0451731
RPS19 ribosomal protein S19 -0.0451474
RPL9 ribosomal protein L9 -0.0419482
RPLP2 ribosomal protein, large, P2 -0.0408438
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0402133
CANX calnexin -0.039821
EIF1 eukaryotic translation initiation factor 1 -0.0396863
RPL35A ribosomal protein L35a -0.039598
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0395655
RPL37A ribosomal protein L37a -0.0395378
ANKRD12 ankyrin repeat domain 12 -0.0395073
RPL19 ribosomal protein L19 -0.0380081
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0373148
RPS12 ribosomal protein S12 -0.0360673
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0356774
AHNAK AHNAK nucleoprotein -0.0354543
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0334526
IER3 immediate early response 3 -0.0334423
TM4SF1 transmembrane 4 L six family member 1 -0.0321769
RPS3 ribosomal protein S3 -0.0321164
RPL31 ribosomal protein L31 -0.0320675
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.031955
RPL34 ribosomal protein L34 -0.0317991
RPL26 ribosomal protein L26 -0.0317368
RPS16 ribosomal protein S16 -0.0311583
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0308259
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0306568
NAP1L1 nucleosome assembly protein 1-like 1 -0.0304888
S100A10 S100 calcium binding protein A10 -0.0304166
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0304058
PKM pyruvate kinase, muscle -0.0303146
P4HB prolyl 4-hydroxylase, beta polypeptide -0.029752
RPL32 ribosomal protein L32 -0.0295542
ANKRD28 ankyrin repeat domain 28 -0.0295515
CALR calreticulin -0.0283962
S100A6 S100 calcium binding protein A6 -0.0283104
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0281523
GNAS GNAS complex locus -0.0278403
PDIA3 protein disulfide isomerase family A, member 3 -0.0273933
RPLP0 ribosomal protein, large, P0 -0.0273192
LOC112694756 uncharaterized LOC112694756 -0.0269301
RPS24 ribosomal protein S24 -0.0261397
RPL28 ribosomal protein L28 -0.0258544
RPL11 ribosomal protein L11 -0.0248047
RPS17 ribosomal protein S17 -0.0247598
GOLGA4 golgin A4 -0.0242295
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0240206
RPS14 ribosomal protein S14 -0.0237994
PDIA4 protein disulfide isomerase family A, member 4 -0.0236725
RPS20 ribosomal protein S20 -0.0235595
RPS13 ribosomal protein S13 -0.0234162
S100A9 S100 calcium binding protein A9 -0.0233827
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0233739
RPL5 ribosomal protein L5 -0.0231952
DST dystonin -0.0230022
RPL8 ribosomal protein L8 -0.0223154
ANXA2 annexin A2 -0.0221511
YBX1 Y box binding protein 1 -0.0220603
B2M beta-2-microglobulin -0.0219909
RPL37 ribosomal protein L37 -0.0218191
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0216769
RPS23 ribosomal protein S23 -0.0212068
RPL15 ribosomal protein L15 -0.0211657
LMNA lamin A/C -0.0211338
RPL36A ribosomal protein L36a -0.0211086
RPS27 ribosomal protein S27 -0.0206055
JUN jun proto-oncogene -0.0197502
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0195787
ACTN4 actinin, alpha 4 -0.0195375
PRRC2C proline-rich coiled-coil 2C -0.0194776
RPS25 ribosomal protein S25 -0.019318
RPS4X ribosomal protein S4, X-linked -0.0192999
KPNB1 karyopherin (importin) beta 1 -0.0192099
ASTN2 astrotactin 2 -0.0188737
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0188575
RPL35 ribosomal protein L35 -0.0187475