| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Imiquimod (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.201515 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0936437 |
| LOXL2 | lysyl oxidase-like 2 | 0.083505 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0766552 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0606759 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0547095 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0510095 |
| SMAD3 | SMAD family member 3 | 0.0474454 |
| ARRDC3 | arrestin domain containing 3 | 0.0449005 |
| CLIC4 | chloride intracellular channel 4 | 0.0426925 |
| ATP13A3 | ATPase type 13A3 | 0.037546 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0374536 |
| PLEC | plectin | 0.0359781 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0352163 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0342202 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0333002 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.030922 |
| RPL3 | ribosomal protein L3 | 0.0300113 |
| CD44 | CD44 molecule (Indian blood group) | 0.0296741 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0292952 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0270085 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0261494 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0254671 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0248797 |
| RASA2 | RAS p21 protein activator 2 | 0.0246336 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0240844 |
| FLNA | filamin A, alpha | 0.0225765 |
| TNS1 | tensin 1 | 0.0225641 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0221417 |
| ECE1 | endothelin converting enzyme 1 | 0.0216723 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0213798 |
| APP | amyloid beta (A4) precursor protein | 0.0213354 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0199525 |
| MTSS1 | metastasis suppressor 1 | 0.0198891 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0194129 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0193171 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0191317 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0188073 |
| NAV2 | neuron navigator 2 | 0.0187652 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0185399 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0184533 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0181437 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0180417 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0180109 |
| CALU | calumenin | 0.0177841 |
| VCL | vinculin | 0.0175222 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0172693 |
| LOX | lysyl oxidase | 0.0171486 |
| FAM20C | family with sequence similarity 20, member C | 0.0170132 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0169086 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0164725 |
| MSN | moesin | 0.0158727 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.015459 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0153133 |
| TAPBP | TAP binding protein (tapasin) | 0.0150892 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0150309 |
| TLN1 | talin 1 | 0.0149664 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0149306 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0149213 |
| SPAG9 | sperm associated antigen 9 | 0.0148129 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0146721 |
| ITGAV | integrin, alpha V | 0.0145854 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0145033 |
| VMP1 | vacuole membrane protein 1 | 0.0145007 |
| DHFR | dihydrofolate reductase | 0.0144697 |
| FMNL2 | formin-like 2 | 0.0143921 |
| STC1 | stanniocalcin 1 | 0.0143907 |
| SEPTIN9 | septin 9 | 0.0143719 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0141513 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.014102 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.014075 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0139791 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0138221 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.01374 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0135238 |
| POSTN | periostin, osteoblast specific factor | 0.0134568 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.013081 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0129203 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0128699 |
| NCKAP1 | NCK-associated protein 1 | 0.0127042 |
| TFG | TRK-fused gene | 0.0126697 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.012567 |
| COL4A2 | collagen, type IV, alpha 2 | 0.012536 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0123068 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0121587 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0120397 |
| VEGFA | vascular endothelial growth factor A | 0.0120374 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0118938 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0117769 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0117121 |
| BRD2 | bromodomain containing 2 | 0.0113213 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0111893 |
| TMEM39A | transmembrane protein 39A | 0.0111462 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0108779 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0108713 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.010728 |
| TBC1D10A | TBC1 domain family, member 10A | 0.0107114 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0106759 |
| FAM219A | family with sequence similarity 219, member A | 0.0106675 |
| IGSF9B | immunoglobulin superfamily, member 9B | 0.0103271 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.174331 |
| COL1A1 | collagen, type I, alpha 1 | -0.10418 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0891849 |
| TMSB10 | thymosin beta 10 | -0.0865385 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0780648 |
| CDH13 | cadherin 13 | -0.0742896 |
| COL1A2 | collagen, type I, alpha 2 | -0.0684908 |
| RPS8 | ribosomal protein S8 | -0.0479998 |
| ASPH | aspartate beta-hydroxylase | -0.0476313 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0475781 |
| RPS6 | ribosomal protein S6 | -0.0466311 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0464152 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0460112 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0450228 |
| MT2A | metallothionein 2A | -0.0442701 |
| RPL35A | ribosomal protein L35a | -0.0440238 |
| FTL | ferritin, light polypeptide | -0.0436795 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0432488 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0385818 |
| HMGA2 | high mobility group AT-hook 2 | -0.0353934 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0352131 |
| ACTG1 | actin gamma 1 | -0.0342473 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.034129 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0326276 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.031727 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0297342 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0290718 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0290593 |
| ENO1 | enolase 1, (alpha) | -0.0282749 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0280667 |
| PTMA | prothymosin, alpha | -0.0276143 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0275133 |
| RPS19 | ribosomal protein S19 | -0.0272495 |
| HLA-B | major histocompatibility complex, class I, B | -0.0265413 |
| SLC38A2 | solute carrier family 38, member 2 | -0.026209 |
| GLIS3 | GLIS family zinc finger 3 | -0.0260971 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0260074 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0257554 |
| FOXP1 | forkhead box P1 | -0.0257498 |
| IER3 | immediate early response 3 | -0.0254485 |
| S100A6 | S100 calcium binding protein A6 | -0.0252423 |
| RPLP1 | ribosomal protein, large, P1 | -0.0250311 |
| RPL19 | ribosomal protein L19 | -0.0245616 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0239481 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.023788 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0237474 |
| RPL37A | ribosomal protein L37a | -0.023572 |
| OXR1 | oxidation resistance 1 | -0.0227304 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0225585 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.022338 |
| MTDH | metadherin | -0.0222207 |
| PFN1 | profilin 1 | -0.0220185 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0218344 |
| RPL28 | ribosomal protein L28 | -0.021808 |
| RPL26 | ribosomal protein L26 | -0.0213878 |
| RPL36 | ribosomal protein L36 | -0.0213131 |
| S100A9 | S100 calcium binding protein A9 | -0.0205216 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0200123 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0199844 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0199767 |
| RPL9 | ribosomal protein L9 | -0.019944 |
| CLMP | CXADR-like membrane protein | -0.0193837 |
| RPS14 | ribosomal protein S14 | -0.0189098 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0188649 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0188277 |
| RPL12 | ribosomal protein L12 | -0.0187009 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0185746 |
| S100A10 | S100 calcium binding protein A10 | -0.0178403 |
| RPL34 | ribosomal protein L34 | -0.0177304 |
| RPS12 | ribosomal protein S12 | -0.0177221 |
| RPS20 | ribosomal protein S20 | -0.0176819 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0176541 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0175155 |
| RPL5 | ribosomal protein L5 | -0.0174294 |
| RPL18 | ribosomal protein L18 | -0.0173906 |
| RPLP2 | ribosomal protein, large, P2 | -0.0170556 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0168164 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0164182 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0162183 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0159539 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0158351 |
| MYADM | myeloid-associated differentiation marker | -0.0156529 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0155263 |
| BBX | bobby sox homolog (Drosophila) | -0.0155154 |
| JMJD1C | jumonji domain containing 1C | -0.0154357 |
| CALD1 | caldesmon 1 | -0.0154289 |
| VCAN | versican | -0.0151718 |
| HMCN1 | hemicentin 1 | -0.0151033 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0150403 |
| BNC2 | basonuclin 2 | -0.0148738 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0147648 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0146857 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0146052 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0145772 |
| CUX1 | cut-like homeobox 1 | -0.0145288 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0145174 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0144801 |
| SEPTIN7 | septin 7 | -0.0144437 |
| NAV1 | neuron navigator 1 | -0.0142894 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0142289 |
