Imiquimod (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.0531046
LYZ lysozyme 0.0346636
SLC45A4 solute carrier family 45, member 4 0.0325434
RAD21 RAD21 homolog (S. pombe) 0.0298822
LMO7 LIM domain 7 0.0291144
RPL3 ribosomal protein L3 0.0266544
RPL4 ribosomal protein L4 0.0246551
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0234197
NCKAP1 NCK-associated protein 1 0.0219064
MMP7 matrix metallopeptidase 7 0.0212413
KRT18 keratin 18, type I 0.0204795
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0184116
TXNRD1 thioredoxin reductase 1 0.0184077
EPS8L1 EPS8-like 1 0.0174344
HSPA8 heat shock 70kDa protein 8 0.0173965
H1-0 H1.0 linker histone 0.0172322
PLEC plectin 0.01701
KDM6A lysine (K)-specific demethylase 6A 0.0169336
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0167035
LAMB3 laminin, beta 3 0.0166069
DHFR dihydrofolate reductase 0.0164921
CD2AP CD2-associated protein 0.0163612
PDZD8 PDZ domain containing 8 0.0161523
SLMAP sarcolemma associated protein 0.01589
CAPRIN1 cell cycle associated protein 1 0.0154022
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0153723
STK24 serine/threonine kinase 24 0.0153687
CD164 CD164 molecule, sialomucin 0.0152221
DST dystonin 0.0150019
ARHGAP23 Rho GTPase activating protein 23 0.0149059
AHNAK AHNAK nucleoprotein 0.0146477
NUMA1 nuclear mitotic apparatus protein 1 0.0143441
PICALM phosphatidylinositol binding clathrin assembly protein 0.0142403
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0142293
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.0141622
EPCAM epithelial cell adhesion molecule 0.0140396
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0139607
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.0139294
KIAA0232 KIAA0232 0.0135654
MKI67 marker of proliferation Ki-67 0.013524
AFDN afadin, adherens junction formation factor 0.0133933
SRSF6 serine/arginine-rich splicing factor 6 0.0128922
ARCN1 archain 1 0.0127045
HLA-E major histocompatibility complex, class I, E 0.0126815
PTPRH protein tyrosine phosphatase, receptor type, H 0.0125988
FOXO1 forkhead box O1 0.0124202
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0123
MGLL monoglyceride lipase 0.0122849
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 0.0121627
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.0119972
PPARG peroxisome proliferator-activated receptor gamma 0.0118681
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0118358
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0117185
STX3 syntaxin 3 0.0116827
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0116593
NIBAN2 niban apoptosis regulator 2 0.011427
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0114185
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0113329
GCLC glutamate-cysteine ligase, catalytic subunit 0.0112403
CD46 CD46 molecule, complement regulatory protein 0.0111174
SEPTIN9 septin 9 0.0111021
STIP1 stress-induced phosphoprotein 1 0.0107949
IGF2R insulin-like growth factor 2 receptor 0.0107754
KLF13 Kruppel-like factor 13 0.0106967
RPL41 ribosomal protein L41 0.010384
DSPP dentin sialophosphoprotein 0.010248
KLF10 Kruppel-like factor 10 0.0102194
RESF1 retroelement silencing factor 1 0.0101921
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.010115
NTSR1 neurotensin receptor 1 (high affinity) 0.0100528
WWC1 WW and C2 domain containing 1 0.0100461
ZFAND5 zinc finger, AN1-type domain 5 0.0100333
TET3 tet methylcytosine dioxygenase 3 0.00991423
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.00986769
TC2N tandem C2 domains, nuclear 0.0096951
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.00964836
FLNA filamin A, alpha 0.00959529
CNOT12 CCR4-NOT transcription complex subunit 12 0.00956847
H1-4 H1.4 linker histone, cluster member 0.00952599
CORO1C coronin, actin binding protein, 1C 0.00942546
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.00941609
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.00939433
RAB1B RAB1B, member RAS oncogene family 0.0093346
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.00915743
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.00909564
GPAT3 glycerol-3-phosphate acyltransferase 3 0.00908691
IQGAP1 IQ motif containing GTPase activating protein 1 0.00901326
IFNGR1 interferon gamma receptor 1 0.00880697
LAPTM4A lysosomal protein transmembrane 4 alpha 0.00879034
HSPH1 heat shock 105kDa/110kDa protein 1 0.00872497
BRWD3 bromodomain and WD repeat domain containing 3 0.00872025
BZW1 basic leucine zipper and W2 domains 1 0.00871252
PYGB phosphorylase, glycogen; brain 0.00870515
TJP2 tight junction protein 2 0.0086882
ERRFI1 ERBB receptor feedback inhibitor 1 0.0086621
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00860627
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.00859888
ARHGAP29 Rho GTPase activating protein 29 0.00851246
SERINC1 serine incorporator 1 0.00851195
TGFA transforming growth factor, alpha 0.00850596

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180833
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.161439
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.123933
RPS6 ribosomal protein S6 -0.120619
TMSB10 thymosin beta 10 -0.0896408
EZR ezrin -0.088069
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0816091
FTL ferritin, light polypeptide -0.0801521
UBC ubiquitin C -0.0758311
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0714262
PTMA prothymosin, alpha -0.0692657
TPT1 tumor protein, translationally-controlled 1 -0.0689774
FNDC3B fibronectin type III domain containing 3B -0.0675264
RPL23 ribosomal protein L23 -0.0659079
ANXA2 annexin A2 -0.0611906
RPS3 ribosomal protein S3 -0.0598416
RPLP1 ribosomal protein, large, P1 -0.0595968
ACTG1 actin gamma 1 -0.0587415
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0586071
PDIA4 protein disulfide isomerase family A, member 4 -0.0580259
RPS19 ribosomal protein S19 -0.0577745
PDIA3 protein disulfide isomerase family A, member 3 -0.0573101
FBXO32 F-box protein 32 -0.0551783
EXT1 exostosin glycosyltransferase 1 -0.0542459
EGR1 early growth response 1 -0.052532
GOLGA4 golgin A4 -0.0520575
JUN jun proto-oncogene -0.052005
GMDS GDP-mannose 4,6-dehydratase -0.0511182
VMP1 vacuole membrane protein 1 -0.0503694
NDRG1 N-myc downstream regulated 1 -0.0502583
B2M beta-2-microglobulin -0.0500217
RPS16 ribosomal protein S16 -0.0498275
RPS8 ribosomal protein S8 -0.049714
PCBP2 poly(rC) binding protein 2 -0.049284
S100A10 S100 calcium binding protein A10 -0.0483162
RPS27A ribosomal protein S27a -0.0480609
FTH1 ferritin, heavy polypeptide 1 -0.047678
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0476671
ITPKC inositol-trisphosphate 3-kinase C -0.0472912
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.047212
SAMD12 sterile alpha motif domain containing 12 -0.0465675
CALR calreticulin -0.0458882
ENO1 enolase 1, (alpha) -0.0453395
EMP1 epithelial membrane protein 1 -0.0451276
RPL28 ribosomal protein L28 -0.0449708
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0445742
SEC31A SEC31 homolog A (S. cerevisiae) -0.0445434
AREG amphiregulin -0.0443531
RPS25 ribosomal protein S25 -0.0427718
ANKRD11 ankyrin repeat domain 11 -0.0425066
RPLP2 ribosomal protein, large, P2 -0.0423362
RPS11 ribosomal protein S11 -0.042333
POTEF POTE ankyrin domain family, member F -0.0418327
PKM pyruvate kinase, muscle -0.0409792
FRY furry homolog (Drosophila) -0.0408063
RPS13 ribosomal protein S13 -0.0403751
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0401222
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0397369
MORF4L2 mortality factor 4 like 2 -0.0395135
TJP1 tight junction protein 1 -0.0394243
AKAP9 A kinase (PRKA) anchor protein 9 -0.0392814
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0387836
PTK2 protein tyrosine kinase 2 -0.0386285
RPS5 ribosomal protein S5 -0.0379163
RPL19 ribosomal protein L19 -0.0371456
KRT19 keratin 19, type I -0.0364644
RPL9 ribosomal protein L9 -0.0362604
LDHA lactate dehydrogenase A -0.0358577
RPS21 ribosomal protein S21 -0.0356423
BPTF bromodomain PHD finger transcription factor -0.0354381
RPS12 ribosomal protein S12 -0.0351746
VEGFA vascular endothelial growth factor A -0.0347708
HM13 histocompatibility (minor) 13 -0.0344955
RPS17 ribosomal protein S17 -0.0344902
RPL37A ribosomal protein L37a -0.0337149
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0337001
MYO1E myosin IE -0.0335636
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0333015
RPL31 ribosomal protein L31 -0.0330003
KMT2C lysine (K)-specific methyltransferase 2C -0.032908
ZNF207 zinc finger protein 207 -0.032523
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0318679
GARS1 glycyl-tRNA synthetase 1 -0.0317663
ZNF292 zinc finger protein 292 -0.0316294
CANX calnexin -0.0315619
LOC102724023 ES1 protein homolog, mitochondrial -0.031379
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0312938
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0309345
ZBTB20 zinc finger and BTB domain containing 20 -0.0308148
KRT8 keratin 8, type II -0.0304577
KRT20 keratin 20, type I -0.0303392
SQSTM1 sequestosome 1 -0.0303249
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0303113
CEMIP2 cell migration inducing hyaluronidase 2 -0.030197
AKAP13 A kinase (PRKA) anchor protein 13 -0.0301584
ARF4 ADP-ribosylation factor 4 -0.0297809
RPL5 ribosomal protein L5 -0.0296363
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0295535
WASF2 WAS protein family, member 2 -0.0293101
AGR2 anterior gradient 2 -0.0292155