| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Imiquimod (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.155447 |
| FN1 | fibronectin 1 | 0.129854 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0912227 |
| APOB | apolipoprotein B | 0.0816484 |
| C3 | complement component 3 | 0.0807611 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0751296 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0716621 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0696248 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0667789 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0653438 |
| DSPP | dentin sialophosphoprotein | 0.0592647 |
| RPL3 | ribosomal protein L3 | 0.0570974 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0545075 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.045315 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0434163 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0419414 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0409938 |
| SMAD3 | SMAD family member 3 | 0.040886 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0405333 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0398966 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0395187 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0390703 |
| AFDN | afadin, adherens junction formation factor | 0.0385392 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0372268 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0364866 |
| FAT1 | FAT atypical cadherin 1 | 0.0346558 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0336515 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.033357 |
| VCL | vinculin | 0.0330978 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0326927 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0320969 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0303073 |
| MALT1 | MALT1 paracaspase | 0.0301038 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0291632 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0290873 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0283329 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0280157 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0276734 |
| DOCK4 | dedicator of cytokinesis 4 | 0.027433 |
| VMP1 | vacuole membrane protein 1 | 0.0272236 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0265953 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0254467 |
| PLEC | plectin | 0.0253032 |
| TNS1 | tensin 1 | 0.0251637 |
| KIF1B | kinesin family member 1B | 0.0247619 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0247086 |
| NCKAP1 | NCK-associated protein 1 | 0.0238682 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0234474 |
| RPL4 | ribosomal protein L4 | 0.0234456 |
| ANO6 | anoctamin 6 | 0.023384 |
| JAG1 | jagged 1 | 0.0230739 |
| DHFR | dihydrofolate reductase | 0.0230275 |
| CORO1C | coronin, actin binding protein, 1C | 0.0229366 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0227221 |
| PDZD8 | PDZ domain containing 8 | 0.0226617 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0226092 |
| CFB | complement factor B | 0.02253 |
| PEG3 | paternally expressed 3 | 0.0225188 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0222166 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0221423 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0217186 |
| FOXO1 | forkhead box O1 | 0.021566 |
| CUL3 | cullin 3 | 0.0214419 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0211531 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0210533 |
| FAM107B | family with sequence similarity 107, member B | 0.0210066 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0209616 |
| ABAT | 4-aminobutyrate aminotransferase | 0.0207841 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0207105 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.0198744 |
| SIK3 | SIK family kinase 3 | 0.0198072 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0197884 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0197747 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.019659 |
| ATXN1 | ataxin 1 | 0.0195996 |
| TOP1 | topoisomerase (DNA) I | 0.0193171 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0193027 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0191713 |
| ITGB5 | integrin, beta 5 | 0.0190231 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.018814 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0186449 |
| PCBP2 | poly(rC) binding protein 2 | 0.018493 |
| DIAPH1 | diaphanous-related formin 1 | 0.0183499 |
| MRTFA | myocardin related transcription factor A | 0.0182672 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0182302 |
| HLF | hepatic leukemia factor | 0.0182203 |
| ANXA5 | annexin A5 | 0.0181 |
| FOXO3 | forkhead box O3 | 0.0179283 |
| JAK1 | Janus kinase 1 | 0.0178428 |
| KIF5B | kinesin family member 5B | 0.0178077 |
| SVIL | supervillin | 0.0176473 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.01764 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0176183 |
| SKIL | SKI-like proto-oncogene | 0.0175326 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0175256 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0173718 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.017355 |
| HDLBP | high density lipoprotein binding protein | 0.0173085 |
| FERMT2 | fermitin family member 2 | 0.0171547 |
| NCOA4 | nuclear receptor coactivator 4 | 0.0170949 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.333479 |
| MT2A | metallothionein 2A | -0.0979624 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0786234 |
| RPS6 | ribosomal protein S6 | -0.0700634 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0662899 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.065757 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0596257 |
| RPL37A | ribosomal protein L37a | -0.049532 |
| APOA2 | apolipoprotein A-II | -0.0480782 |
| RPLP1 | ribosomal protein, large, P1 | -0.0475072 |
| RPS8 | ribosomal protein S8 | -0.0473793 |
| TMSB10 | thymosin beta 10 | -0.046156 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0428247 |
| RPL35A | ribosomal protein L35a | -0.0404128 |
| RPL31 | ribosomal protein L31 | -0.0403034 |
| RPL34 | ribosomal protein L34 | -0.0393064 |
| RPL26 | ribosomal protein L26 | -0.0392158 |
| CP | ceruloplasmin (ferroxidase) | -0.0387289 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.037145 |
| FTL | ferritin, light polypeptide | -0.036441 |
| GPC6 | glypican 6 | -0.0349069 |
| RPS19 | ribosomal protein S19 | -0.0336411 |
| GNAS | GNAS complex locus | -0.0324056 |
| AHSG | alpha-2-HS-glycoprotein | -0.0315611 |
| APOA1 | apolipoprotein A-I | -0.0306361 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0306056 |
| RPL9 | ribosomal protein L9 | -0.0304553 |
| RPL12 | ribosomal protein L12 | -0.0303884 |
| RPS24 | ribosomal protein S24 | -0.0283634 |
| RPLP0 | ribosomal protein, large, P0 | -0.0283034 |
| RPS12 | ribosomal protein S12 | -0.0278441 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0275285 |
| APOE | apolipoprotein E | -0.0269031 |
| RPLP2 | ribosomal protein, large, P2 | -0.0264385 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0258589 |
| RPS14 | ribosomal protein S14 | -0.0257359 |
| RPL36 | ribosomal protein L36 | -0.0255428 |
| EHBP1 | EH domain binding protein 1 | -0.0248661 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0242566 |
| RPS21 | ribosomal protein S21 | -0.0238481 |
| RPS27A | ribosomal protein S27a | -0.0229301 |
| IER3 | immediate early response 3 | -0.0225127 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0218659 |
| RPS29 | ribosomal protein S29 | -0.0213783 |
| PLIN2 | perilipin 2 | -0.0209522 |
| RPL11 | ribosomal protein L11 | -0.0208961 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.02059 |
| RPS3 | ribosomal protein S3 | -0.0204752 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0192902 |
| FRMD5 | FERM domain containing 5 | -0.0192198 |
| RPL32 | ribosomal protein L32 | -0.0191679 |
| S100A9 | S100 calcium binding protein A9 | -0.0189065 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0187702 |
| NDRG1 | N-myc downstream regulated 1 | -0.0187052 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0185139 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.018491 |
| RPS16 | ribosomal protein S16 | -0.018418 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.018383 |
| CST3 | cystatin C | -0.0181118 |
| RPS25 | ribosomal protein S25 | -0.0180386 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0177713 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0175579 |
| HMGA1 | high mobility group AT-hook 1 | -0.0172425 |
| PFN1 | profilin 1 | -0.0170441 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.017023 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.01702 |
| RPL23 | ribosomal protein L23 | -0.0169588 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0165008 |
| RPS5 | ribosomal protein S5 | -0.0163573 |
| GPC3 | glypican 3 | -0.0162057 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0161839 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0160198 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0158356 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0156886 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0156659 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.0156439 |
| RPS10 | ribosomal protein S10 | -0.0155818 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0155143 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0150157 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0149354 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.014853 |
| RPS27 | ribosomal protein S27 | -0.0147667 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0146827 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0145094 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0144153 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0144051 |
| ITGA1 | integrin, alpha 1 | -0.0144003 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0143939 |
| AGXT | alanine-glyoxylate aminotransferase | -0.0143682 |
| ACTG1 | actin gamma 1 | -0.0142923 |
| RPL35 | ribosomal protein L35 | -0.0141218 |
| FAM162A | family with sequence similarity 162, member A | -0.0140847 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0140191 |
| RPS23 | ribosomal protein S23 | -0.0139646 |
| RPL27 | ribosomal protein L27 | -0.0138396 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0138286 |
| PTMA | prothymosin, alpha | -0.013791 |
| HMGA2 | high mobility group AT-hook 2 | -0.013712 |
| RPS17 | ribosomal protein S17 | -0.0136778 |
| NHSL1 | NHS-like 1 | -0.0135607 |
