Imiquimod (hydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNA filamin A, alpha 0.037828
HSPA8 heat shock 70kDa protein 8 0.0360132
EFNA5 ephrin-A5 0.0320593
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0310584
RPL3 ribosomal protein L3 0.0295677
FRMD6 FERM domain containing 6 0.0284801
SAMD4A sterile alpha motif domain containing 4A 0.0280664
MYH9 myosin, heavy chain 9, non-muscle 0.0270022
EEF2 eukaryotic translation elongation factor 2 0.02695
ADAM19 ADAM metallopeptidase domain 19 0.0266966
ERRFI1 ERBB receptor feedback inhibitor 1 0.0266004
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0258465
VCL vinculin 0.0247292
KDM3A lysine (K)-specific demethylase 3A 0.0234351
AHNAK AHNAK nucleoprotein 0.0226751
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.021788
CALD1 caldesmon 1 0.0212605
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0192885
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0188033
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0187356
EXT1 exostosin glycosyltransferase 1 0.0181633
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.017546
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0175219
PRKCE protein kinase C, epsilon 0.0167655
RPL4 ribosomal protein L4 0.016639
NCKAP1 NCK-associated protein 1 0.0165639
MAML2 mastermind-like 2 (Drosophila) 0.0164723
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.016279
CFAP251 cilia and flagella associated protein 251 0.0161213
NPC1 Niemann-Pick disease, type C1 0.0160072
MARCHF4 membrane associated ring-CH-type finger 4 0.0157305
NUP58 nucleoporin 58 0.0153755
DTNA dystrobrevin, alpha 0.0151433
CORO1C coronin, actin binding protein, 1C 0.015109
ELL2 elongation factor, RNA polymerase II, 2 0.0150714
DHFR dihydrofolate reductase 0.0148277
PLEC plectin 0.0142889
PICALM phosphatidylinositol binding clathrin assembly protein 0.0138263
BCAR3 breast cancer anti-estrogen resistance 3 0.0135863
ENKUR enkurin, TRPC channel interacting protein 0.0127574
SERINC1 serine incorporator 1 0.0122479
SRRM2 serine/arginine repetitive matrix 2 0.0121519
SPRED1 sprouty-related, EVH1 domain containing 1 0.0120767
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0120719
ANO6 anoctamin 6 0.0120605
CASC3 cancer susceptibility candidate 3 0.0119359
OSMR oncostatin M receptor 0.0117305
BDNF brain-derived neurotrophic factor 0.0116449
RUNX1 runt-related transcription factor 1 0.011627
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0113448
APP amyloid beta (A4) precursor protein 0.0112111
TPM3 tropomyosin 3 0.0106638
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0105996
EIF4A2 eukaryotic translation initiation factor 4A2 0.0105995
PRRC2A proline-rich coiled-coil 2A 0.0105851
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0105157
MARCHF6 membrane associated ring-CH-type finger 6 0.0104674
ALPK2 alpha-kinase 2 0.0104345
EIF4B eukaryotic translation initiation factor 4B 0.00989886
ECT2 epithelial cell transforming 2 0.00971435
ATP13A3 ATPase type 13A3 0.00961702
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.00956976
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.00944212
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.00938636
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.00924315
FNIP1 folliculin interacting protein 1 0.00923749
PRELID2 PRELI domain containing 2 0.00911755
PAX3 paired box 3 0.00903436
IL6ST interleukin 6 signal transducer 0.00903327
ARFGEF3 ARFGEF family member 3 0.00890975
AFDN afadin, adherens junction formation factor 0.00890823
HAPSTR1 HUWE1 associated protein modifying stress responses 0.00887981
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.00885444
LOXL2 lysyl oxidase-like 2 0.00878931
CD109 CD109 molecule 0.00873491
DGKD diacylglycerol kinase, delta 130kDa 0.00868357
RBM33 RNA binding motif protein 33 0.00855068
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00854304
ZFC3H1 zinc finger, C3H1-type containing 0.00845079
PRRC2B proline-rich coiled-coil 2B 0.00839414
KYNU kynureninase 0.00837925
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00826848
ATL2 atlastin GTPase 2 0.00822259
CLIC4 chloride intracellular channel 4 0.00814461
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.00806654
DENR density-regulated protein 0.00805392
RAD21 RAD21 homolog (S. pombe) 0.00802235
CLTC clathrin, heavy chain (Hc) 0.00797942
CAPRIN1 cell cycle associated protein 1 0.00796529
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00793775
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00789153
PARVA parvin, alpha 0.00788893
UBAP2L ubiquitin associated protein 2-like 0.00785793
SP3 Sp3 transcription factor 0.00785675
MYSM1 Myb-like, SWIRM and MPN domains 1 0.00784101
ELOVL5 ELOVL fatty acid elongase 5 0.00776728
RARB retinoic acid receptor, beta 0.00770124
WDR26 WD repeat domain 26 0.00764484
NRP2 neuropilin 2 0.00763025
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00748463

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.350967
VIM vimentin -0.333002
RPS6 ribosomal protein S6 -0.176274
TMSB10 thymosin beta 10 -0.165915
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0943879
PTMA prothymosin, alpha -0.0903999
FTL ferritin, light polypeptide -0.0865008
RPL35A ribosomal protein L35a -0.0772446
ACTG1 actin gamma 1 -0.0752188
TPT1 tumor protein, translationally-controlled 1 -0.0730797
RPLP1 ribosomal protein, large, P1 -0.0726492
RPL23 ribosomal protein L23 -0.0696666
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0690495
MT2A metallothionein 2A -0.0680236
RPS8 ribosomal protein S8 -0.0651014
RPS19 ribosomal protein S19 -0.0606541
NAP1L1 nucleosome assembly protein 1-like 1 -0.0536576
RPLP2 ribosomal protein, large, P2 -0.0518097
RPS12 ribosomal protein S12 -0.0516017
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.051499
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0504608
RPL37A ribosomal protein L37a -0.049854
RPL12 ribosomal protein L12 -0.0496331
RPS3 ribosomal protein S3 -0.0470119
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0469789
RPL5 ribosomal protein L5 -0.0450912
AKAP12 A kinase (PRKA) anchor protein 12 -0.0442879
EGR1 early growth response 1 -0.0442244
RPS25 ribosomal protein S25 -0.0406957
RPS13 ribosomal protein S13 -0.0402096
RPL19 ribosomal protein L19 -0.040092
RPLP0 ribosomal protein, large, P0 -0.039924
RPL36 ribosomal protein L36 -0.0390281
LSAMP limbic system-associated membrane protein -0.0377556
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0367094
NDRG1 N-myc downstream regulated 1 -0.0363371
EIF1 eukaryotic translation initiation factor 1 -0.0357776
RPS23 ribosomal protein S23 -0.0357487
RPL34 ribosomal protein L34 -0.0339641
RPL31 ribosomal protein L31 -0.0332568
RPS17 ribosomal protein S17 -0.0324939
YBX3 Y box binding protein 3 -0.0316585
RPL35 ribosomal protein L35 -0.0313369
RPL8 ribosomal protein L8 -0.0312105
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0310299
RPS14 ribosomal protein S14 -0.0310295
RPL26 ribosomal protein L26 -0.0305496
RPS20 ribosomal protein S20 -0.0305482
RPL28 ribosomal protein L28 -0.0305449
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0302938
GNAS GNAS complex locus -0.0299587
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0295449
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0295391
RPS29 ribosomal protein S29 -0.0293604
RPL32 ribosomal protein L32 -0.0291736
RPS27A ribosomal protein S27a -0.0291602
RPS21 ribosomal protein S21 -0.0287266
PFN1 profilin 1 -0.0286882
HMGA1 high mobility group AT-hook 1 -0.0277834
RPL36A ribosomal protein L36a -0.0273868
RPS24 ribosomal protein S24 -0.0272134
LOC102724023 ES1 protein homolog, mitochondrial -0.0270293
WSB1 WD repeat and SOCS box containing 1 -0.0268037
RPS16 ribosomal protein S16 -0.0267782
RPL9 ribosomal protein L9 -0.0264763
LDHA lactate dehydrogenase A -0.0261386
UGCG UDP-glucose ceramide glucosyltransferase -0.026026
PHACTR1 phosphatase and actin regulator 1 -0.0257942
RPL11 ribosomal protein L11 -0.0252399
SEPTIN7 septin 7 -0.0249379
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0247715
GPC6 glypican 6 -0.0244036
NALF1 NALCN channel auxiliary factor 1 -0.0241624
KPNB1 karyopherin (importin) beta 1 -0.0239475
B2M beta-2-microglobulin -0.0238738
RPS27 ribosomal protein S27 -0.0238594
PTK2 protein tyrosine kinase 2 -0.0234176
TXNIP thioredoxin interacting protein -0.0231093
ASTN2 astrotactin 2 -0.0228545
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.022576
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0225543
ENO1 enolase 1, (alpha) -0.0225337
RPL38 ribosomal protein L38 -0.02253
PRRC2C proline-rich coiled-coil 2C -0.0223043
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0223006
GOLGA4 golgin A4 -0.022294
CSTB cystatin B (stefin B) -0.022281
RPL7A ribosomal protein L7a -0.0221915
ALCAM activated leukocyte cell adhesion molecule -0.0221511
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0221491
ANXA2 annexin A2 -0.0218826
BTG1 B-cell translocation gene 1, anti-proliferative -0.0218751
RPS10 ribosomal protein S10 -0.0218023
RPS11 ribosomal protein S11 -0.0217189
RPL27A ribosomal protein L27a -0.0216607
KTN1 kinectin 1 (kinesin receptor) -0.0211916
RPL37 ribosomal protein L37 -0.0210836
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0207102
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0205518
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0203144