Imiquimod (hydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.0594181
RPL3 ribosomal protein L3 0.0502531
EEF2 eukaryotic translation elongation factor 2 0.0457154
CEMIP cell migration inducing protein, hyaluronan binding 0.0433251
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0399266
WAC WW domain containing adaptor with coiled-coil 0.0377811
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0366471
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0352199
EREG epiregulin 0.0339917
ANKRD11 ankyrin repeat domain 11 0.0336945
RNF145 ring finger protein 145 0.0318255
ZFAND3 zinc finger, AN1-type domain 3 0.0313321
RBM39 RNA binding motif protein 39 0.0300345
FAM13A family with sequence similarity 13, member A 0.0295519
ESRP1 epithelial splicing regulatory protein 1 0.0281385
KDM6A lysine (K)-specific demethylase 6A 0.0266903
NCKAP1 NCK-associated protein 1 0.0259628
ZFC3H1 zinc finger, C3H1-type containing 0.0258202
AFDN afadin, adherens junction formation factor 0.0254822
PIGR polymeric immunoglobulin receptor 0.0250865
MYH9 myosin, heavy chain 9, non-muscle 0.0248627
KDM3A lysine (K)-specific demethylase 3A 0.0243433
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0239093
MACF1 microtubule-actin crosslinking factor 1 0.0236246
HDLBP high density lipoprotein binding protein 0.0232301
TFG TRK-fused gene 0.0230735
EWSR1 EWS RNA-binding protein 1 0.0223012
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0222475
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0214024
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0206075
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0205689
MED13L mediator complex subunit 13-like 0.0196903
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0196011
MARS1 methionyl-tRNA synthetase 1 0.019415
CD46 CD46 molecule, complement regulatory protein 0.0193384
LMO7 LIM domain 7 0.0192042
CTBP2 C-terminal binding protein 2 0.0191311
ANXA11 annexin A11 0.0189583
GRB10 growth factor receptor-bound protein 10 0.0189262
PICALM phosphatidylinositol binding clathrin assembly protein 0.0187971
PUM2 pumilio RNA-binding family member 2 0.0186897
DSCAM Down syndrome cell adhesion molecule 0.0186607
ZC3H11A zinc finger CCCH-type containing 11A 0.0184285
SRRM2 serine/arginine repetitive matrix 2 0.0182119
KDM7A lysine (K)-specific demethylase 7A 0.0181219
MARCHF6 membrane associated ring-CH-type finger 6 0.01812
NUP58 nucleoporin 58 0.0180813
PRELID2 PRELI domain containing 2 0.018034
FLNB filamin B, beta 0.0178386
MPRIP myosin phosphatase Rho interacting protein 0.0175781
AHNAK AHNAK nucleoprotein 0.0175398
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0172631
PUM1 pumilio RNA-binding family member 1 0.0169506
HELZ helicase with zinc finger 0.0168554
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0165067
IARS1 isoleucyl-tRNA synthetase 1 0.0164784
WDR43 WD repeat domain 43 0.0164554
MYO5B myosin VB 0.0164401
HSPA8 heat shock 70kDa protein 8 0.0162577
ITPRID2 ITPR interacting domain containing 2 0.0162124
H2AC6 H2A clustered histone 6 0.0160557
FUBP1 far upstream element (FUSE) binding protein 1 0.0159925
SENP6 SUMO1/sentrin specific peptidase 6 0.0157334
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0156076
TRIM2 tripartite motif containing 2 0.0156023
CSNK1A1 casein kinase 1, alpha 1 0.0155889
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0155624
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.015544
DERA deoxyribose-phosphate aldolase (putative) 0.015516
EPS8 epidermal growth factor receptor pathway substrate 8 0.0155011
PLEC plectin 0.015424
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0152004
GSK3B glycogen synthase kinase 3 beta 0.0150422
CCNL1 cyclin L1 0.0150183
EIF4B eukaryotic translation initiation factor 4B 0.0149768
ANTXR2 anthrax toxin receptor 2 0.0149588
SREBF1 sterol regulatory element binding transcription factor 1 0.0148925
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0147593
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0147139
PDZD8 PDZ domain containing 8 0.0146707
DHFR dihydrofolate reductase 0.0146436
IWS1 IWS1 homolog (S. cerevisiae) 0.0146411
NBAS neuroblastoma amplified sequence 0.0145756
MBNL2 muscleblind-like splicing regulator 2 0.014457
RNF43 ring finger protein 43 0.0144529
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0144326
RPL4 ribosomal protein L4 0.014405
TPM3 tropomyosin 3 0.0143173
STRN3 striatin, calmodulin binding protein 3 0.0141814
PARD3 par-3 family cell polarity regulator 0.0141753
ARHGAP26 Rho GTPase activating protein 26 0.0141665
COG5 component of oligomeric golgi complex 5 0.014107
CCNY cyclin Y 0.01405
VEGFA vascular endothelial growth factor A 0.0140461
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0139917
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0139356
YTHDC1 YTH domain containing 1 0.0139104
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0137994
NUMA1 nuclear mitotic apparatus protein 1 0.013723
USP9X ubiquitin specific peptidase 9, X-linked 0.013676

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291494
TMSB10 thymosin beta 10 -0.197581
PTMA prothymosin, alpha -0.182478
RPS6 ribosomal protein S6 -0.147052
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.117482
RPLP1 ribosomal protein, large, P1 -0.0993574
RPL35A ribosomal protein L35a -0.0906062
RPS8 ribosomal protein S8 -0.088772
RPS19 ribosomal protein S19 -0.0879638
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0878054
TPT1 tumor protein, translationally-controlled 1 -0.0844543
FTL ferritin, light polypeptide -0.0807995
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0713456
RPL36 ribosomal protein L36 -0.0704207
RPL12 ribosomal protein L12 -0.0680971
RPL9 ribosomal protein L9 -0.0648918
RPL34 ribosomal protein L34 -0.0636764
RPLP2 ribosomal protein, large, P2 -0.0605325
S100A6 S100 calcium binding protein A6 -0.0578807
RPL37A ribosomal protein L37a -0.0578305
MT2A metallothionein 2A -0.0559335
RPL19 ribosomal protein L19 -0.052401
NPSR1 neuropeptide S receptor 1 -0.0523283
ACTG1 actin gamma 1 -0.0518825
RPS12 ribosomal protein S12 -0.0517242
RPL23 ribosomal protein L23 -0.0507883
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0502525
RPL31 ribosomal protein L31 -0.049685
ENO1 enolase 1, (alpha) -0.0463242
RPLP0 ribosomal protein, large, P0 -0.0450388
RPS25 ribosomal protein S25 -0.044641
RPL26 ribosomal protein L26 -0.0442778
S100A10 S100 calcium binding protein A10 -0.0437246
RPS23 ribosomal protein S23 -0.0426081
RPS29 ribosomal protein S29 -0.0424916
S100A9 S100 calcium binding protein A9 -0.0414525
RPS3 ribosomal protein S3 -0.0404408
RPL28 ribosomal protein L28 -0.0395576
RPL5 ribosomal protein L5 -0.0391062
RPS24 ribosomal protein S24 -0.0390931
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0388572
LDHA lactate dehydrogenase A -0.0387856
RPL32 ribosomal protein L32 -0.0381834
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0380161
NALF1 NALCN channel auxiliary factor 1 -0.0379005
EZR ezrin -0.0376843
S100P S100 calcium binding protein P -0.0363344
RPS14 ribosomal protein S14 -0.0360388
RPS13 ribosomal protein S13 -0.0355725
RPS21 ribosomal protein S21 -0.0348851
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0347789
RPS11 ribosomal protein S11 -0.0347438
KRT18 keratin 18, type I -0.0347267
EIF1 eukaryotic translation initiation factor 1 -0.0336184
LOC102724023 ES1 protein homolog, mitochondrial -0.0330759
AGR2 anterior gradient 2 -0.0330704
RPS27 ribosomal protein S27 -0.0329331
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0326347
RPL11 ribosomal protein L11 -0.0324957
ANXA1 annexin A1 -0.0323467
RPL7A ribosomal protein L7a -0.0316471
RPL35 ribosomal protein L35 -0.0313946
KRT19 keratin 19, type I -0.0313686
RPS16 ribosomal protein S16 -0.0313045
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0311914
RPS27A ribosomal protein S27a -0.0305349
RPS17 ribosomal protein S17 -0.0302138
RPL18 ribosomal protein L18 -0.0300205
RPS5 ribosomal protein S5 -0.0298681
HMGB1 high mobility group box 1 -0.0297501
POTEF POTE ankyrin domain family, member F -0.0294968
ALCAM activated leukocyte cell adhesion molecule -0.0294025
RPL37 ribosomal protein L37 -0.0287732
PFN1 profilin 1 -0.0287717
HMGA1 high mobility group AT-hook 1 -0.028693
KTN1 kinectin 1 (kinesin receptor) -0.0286521
RPL27A ribosomal protein L27a -0.0286341
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0286326
GSTP1 glutathione S-transferase pi 1 -0.0285068
RPS20 ribosomal protein S20 -0.02819
LMNA lamin A/C -0.0279207
PDE4D phosphodiesterase 4D, cAMP-specific -0.027854
CADPS Ca++-dependent secretion activator -0.0273413
EIF5B eukaryotic translation initiation factor 5B -0.0273199
RPL36A ribosomal protein L36a -0.0269855
VDAC1 voltage-dependent anion channel 1 -0.0265919
RPL7 ribosomal protein L7 -0.0262102
TXNIP thioredoxin interacting protein -0.0257018
RPL8 ribosomal protein L8 -0.0256685
RBM25 RNA binding motif protein 25 -0.0254964
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0251462
RPS2 ribosomal protein S2 -0.0251124
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0249285
RPL27 ribosomal protein L27 -0.0247909
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0247511
TUBB4B tubulin, beta 4B class IVb -0.0245806
CCND1 cyclin D1 -0.0244064
SERBP1 SERPINE1 mRNA binding protein 1 -0.0242257
EMP1 epithelial membrane protein 1 -0.024183
CENPF centromere protein F, 350/400kDa -0.0241667