Imiquimod (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.139027
FLNB filamin B, beta 0.0987299
FAT1 FAT atypical cadherin 1 0.0910498
EEF2 eukaryotic translation elongation factor 2 0.0890919
THSD4 thrombospondin, type I, domain containing 4 0.07829
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0771177
RPL3 ribosomal protein L3 0.0637817
ITPRID2 ITPR interacting domain containing 2 0.0622599
DSPP dentin sialophosphoprotein 0.05653
VCL vinculin 0.055392
ITGA6 integrin, alpha 6 0.0553818
MYO1E myosin IE 0.0543266
PTPRB protein tyrosine phosphatase, receptor type, B 0.0531765
PTPRR protein tyrosine phosphatase, receptor type, R 0.050055
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.049654
MPRIP myosin phosphatase Rho interacting protein 0.0490467
F3 coagulation factor III (thromboplastin, tissue factor) 0.0479425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0469179
CALB1 calbindin 1, 28kDa 0.0460294
CEMIP cell migration inducing protein, hyaluronan binding 0.0458745
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0450494
MYOF myoferlin 0.042239
PDLIM5 PDZ and LIM domain 5 0.0413188
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0410063
SRRM2 serine/arginine repetitive matrix 2 0.0404961
BACE2 beta-site APP-cleaving enzyme 2 0.0402581
PTPRK protein tyrosine phosphatase, receptor type, K 0.0390241
AKAP13 A kinase (PRKA) anchor protein 13 0.0389132
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0384933
NCOR2 nuclear receptor corepressor 2 0.0360138
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0359821
MYO5B myosin VB 0.0354547
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.035395
MYH9 myosin, heavy chain 9, non-muscle 0.0340764
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0317909
SHROOM3 shroom family member 3 0.0309898
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.029945
ACTN4 actinin, alpha 4 0.029779
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0292145
EGFR epidermal growth factor receptor 0.0291309
AOPEP aminopeptidase O (putative) 0.028554
TJP1 tight junction protein 1 0.0279201
GOLGA3 golgin A3 0.0273133
LAMA4 laminin, alpha 4 0.0271263
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0262278
LAMB3 laminin, beta 3 0.0256655
PICALM phosphatidylinositol binding clathrin assembly protein 0.0256598
EPHA2 EPH receptor A2 0.0254589
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0250564
ZFC3H1 zinc finger, C3H1-type containing 0.0247983
MYH14 myosin, heavy chain 14, non-muscle 0.0247396
MSI2 musashi RNA-binding protein 2 0.0246514
UBC ubiquitin C 0.0243952
RACK1 receptor for activated C kinase 1 0.0242295
SLTM SAFB-like, transcription modulator 0.0240042
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0239529
MUC13 mucin 13, cell surface associated 0.0233843
P3H2 prolyl 3-hydroxylase 2 0.0231651
MACF1 microtubule-actin crosslinking factor 1 0.023085
MX1 MX dynamin-like GTPase 1 0.0230499
MAML2 mastermind-like 2 (Drosophila) 0.0227886
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0227487
SPON1 spondin 1, extracellular matrix protein 0.0227248
UBE2H ubiquitin-conjugating enzyme E2H 0.0223058
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0222867
CTNND1 catenin (cadherin-associated protein), delta 1 0.021984
MCL1 myeloid cell leukemia 1 0.0219073
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0218459
RNF213 ring finger protein 213 0.0214465
CDK13 cyclin-dependent kinase 13 0.0211998
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0209761
ANKRD17 ankyrin repeat domain 17 0.0203384
GMDS GDP-mannose 4,6-dehydratase 0.0201274
CLOCK clock circadian regulator 0.019816
CSNK1A1 casein kinase 1, alpha 1 0.0197291
SND1 staphylococcal nuclease and tudor domain containing 1 0.0196176
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0195769
EZR ezrin 0.0193991
KLF3 Kruppel-like factor 3 (basic) 0.0193966
ETNK1 ethanolamine kinase 1 0.019359
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0193234
RAB7A RAB7A, member RAS oncogene family 0.0192505
USO1 USO1 vesicle transport factor 0.0192404
AFDN afadin, adherens junction formation factor 0.0187097
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0186563
HDLBP high density lipoprotein binding protein 0.0185357
UBE3C ubiquitin protein ligase E3C 0.0182077
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0180862
RIGI RNA sensor RIG-I 0.0180674
RNF217 ring finger protein 217 0.0179437
SMAD3 SMAD family member 3 0.0179435
ZNF638 zinc finger protein 638 0.0179303
RIMKLB ribosomal modification protein rimK-like family member B 0.0178868
CATSPERB catsper channel auxiliary subunit beta 0.0177824
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0177769
RCOR1 REST corepressor 1 0.0177445
DHFR dihydrofolate reductase 0.0176537
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0174843
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0174596
CLIC5 chloride intracellular channel 5 0.0172219

decreased expression

Symbol Name Standardized Value
RPLP1 ribosomal protein, large, P1 -0.17134
RPS6 ribosomal protein S6 -0.138933
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.125635
TPT1 tumor protein, translationally-controlled 1 -0.121084
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0970989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0911515
PTMA prothymosin, alpha -0.0816936
RPS8 ribosomal protein S8 -0.076638
RPS19 ribosomal protein S19 -0.0743003
RPL34 ribosomal protein L34 -0.0653413
RPLP0 ribosomal protein, large, P0 -0.0628058
RPL35A ribosomal protein L35a -0.0608785
TMSB10 thymosin beta 10 -0.0581686
RPL37A ribosomal protein L37a -0.052644
RPL12 ribosomal protein L12 -0.0525665
RPS12 ribosomal protein S12 -0.0505709
RPS25 ribosomal protein S25 -0.0488923
RPL19 ribosomal protein L19 -0.0481504
RPLP2 ribosomal protein, large, P2 -0.0466474
RPS24 ribosomal protein S24 -0.0459962
RPS23 ribosomal protein S23 -0.044097
RPL23 ribosomal protein L23 -0.0430176
RPS20 ribosomal protein S20 -0.0428984
RPS17 ribosomal protein S17 -0.0397637
RPL13A ribosomal protein L13a -0.0394167
RPL9 ribosomal protein L9 -0.0384087
RPS16 ribosomal protein S16 -0.0374482
PDE4D phosphodiesterase 4D, cAMP-specific -0.0373291
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0372931
RPS3 ribosomal protein S3 -0.0362159
RPL5 ribosomal protein L5 -0.0346841
RPS27A ribosomal protein S27a -0.0340996
NAP1L1 nucleosome assembly protein 1-like 1 -0.0337617
RPS21 ribosomal protein S21 -0.0330426
RPL28 ribosomal protein L28 -0.0329464
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0326966
RPS29 ribosomal protein S29 -0.0321296
RPL26 ribosomal protein L26 -0.0314488
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0311755
RPL36 ribosomal protein L36 -0.0310156
RPL27A ribosomal protein L27a -0.0308674
RPS14 ribosomal protein S14 -0.0302087
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0291628
RPL31 ribosomal protein L31 -0.0289197
RPS27 ribosomal protein S27 -0.0270482
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0264845
TXNRD1 thioredoxin reductase 1 -0.0261004
EIF1 eukaryotic translation initiation factor 1 -0.0256242
RPS5 ribosomal protein S5 -0.0255887
HMGB2 high mobility group box 2 -0.0255858
RPL35 ribosomal protein L35 -0.0255006
RPS2 ribosomal protein S2 -0.0250636
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0242302
ACTG1 actin gamma 1 -0.0231343
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0227817
RPL37 ribosomal protein L37 -0.0225281
USP3 ubiquitin specific peptidase 3 -0.0220251
RPS11 ribosomal protein S11 -0.0218089
SMC4 structural maintenance of chromosomes 4 -0.0215897
RPL11 ribosomal protein L11 -0.0211981
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0210271
RPS15 ribosomal protein S15 -0.020823
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0207597
RPL32 ribosomal protein L32 -0.0202821
S100A10 S100 calcium binding protein A10 -0.0198311
CENPF centromere protein F, 350/400kDa -0.019687
FBXO32 F-box protein 32 -0.0194987
SEPTIN7 septin 7 -0.0193846
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0191115
NFIA nuclear factor I/A -0.0190745
HMGB1 high mobility group box 1 -0.0188654
ZNF292 zinc finger protein 292 -0.0188527
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0187873
COG5 component of oligomeric golgi complex 5 -0.0184244
ATXN1 ataxin 1 -0.0181961
DLG1 discs, large homolog 1 (Drosophila) -0.0181069
RPL18 ribosomal protein L18 -0.0180927
SEC61G Sec61 gamma subunit -0.0180463
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.018027
RPL23A ribosomal protein L23a -0.0179745
RPL8 ribosomal protein L8 -0.0175107
EREG epiregulin -0.0172975
PDIA3 protein disulfide isomerase family A, member 3 -0.0172909
PHIP pleckstrin homology domain interacting protein -0.017213
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.017111
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.017013
RPL7A ribosomal protein L7a -0.0163983
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0163246
RPL38 ribosomal protein L38 -0.016174
RAD21 RAD21 homolog (S. pombe) -0.0161504
RPS13 ribosomal protein S13 -0.0161323
CD2AP CD2-associated protein -0.0161252
FTL ferritin, light polypeptide -0.0160754
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.015933
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0158006
S100A9 S100 calcium binding protein A9 -0.0154906
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0152889
RPS10 ribosomal protein S10 -0.0152384
BZW2 basic leucine zipper and W2 domains 2 -0.0152135
BBX bobby sox homolog (Drosophila) -0.0149018