Imiquimod (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMC2 laminin, gamma 2 0.0755966
MCL1 myeloid cell leukemia 1 0.0727782
SLTM SAFB-like, transcription modulator 0.06264
ARRDC3 arrestin domain containing 3 0.0570106
PLEC plectin 0.0519482
SOD2 superoxide dismutase 2, mitochondrial 0.0514547
CES1 carboxylesterase 1 0.0422373
EEF2 eukaryotic translation elongation factor 2 0.040605
MYH9 myosin, heavy chain 9, non-muscle 0.037452
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0362452
ELL2 elongation factor, RNA polymerase II, 2 0.0356387
RPL3 ribosomal protein L3 0.0353264
EGFR epidermal growth factor receptor 0.0347337
NDRG1 N-myc downstream regulated 1 0.0316328
SRRM2 serine/arginine repetitive matrix 2 0.0314004
LAMB3 laminin, beta 3 0.0292301
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0288019
GRB10 growth factor receptor-bound protein 10 0.0287652
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0276424
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0273561
SPAG9 sperm associated antigen 9 0.0265228
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026519
CAMTA1 calmodulin binding transcription activator 1 0.0260485
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.025756
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0257035
LAMA4 laminin, alpha 4 0.0256231
NCKAP1 NCK-associated protein 1 0.0256014
DSCAM Down syndrome cell adhesion molecule 0.0255909
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0253588
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0248892
UBC ubiquitin C 0.0248036
ANKRD10 ankyrin repeat domain 10 0.0247575
CSNK1A1 casein kinase 1, alpha 1 0.0241862
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0241678
DHFR dihydrofolate reductase 0.0237348
GLS2 glutaminase 2 (liver, mitochondrial) 0.0232865
VMP1 vacuole membrane protein 1 0.0231918
GSK3B glycogen synthase kinase 3 beta 0.0228632
TBC1D22A TBC1 domain family, member 22A 0.0225616
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0225606
ZFC3H1 zinc finger, C3H1-type containing 0.0225304
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0218474
AGO2 argonaute RISC catalytic component 2 0.0218224
NPTN neuroplastin 0.0217059
PCBP2 poly(rC) binding protein 2 0.0212064
ANO6 anoctamin 6 0.0207249
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0207019
SMAD3 SMAD family member 3 0.0202371
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0202034
CCNL1 cyclin L1 0.0196326
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0195502
KDM6A lysine (K)-specific demethylase 6A 0.0195388
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0194533
USP9X ubiquitin specific peptidase 9, X-linked 0.0194424
RPL4 ribosomal protein L4 0.0192464
ERRFI1 ERBB receptor feedback inhibitor 1 0.0191961
TOP1 topoisomerase (DNA) I 0.0191615
NAMPT nicotinamide phosphoribosyltransferase 0.0187474
FNIP1 folliculin interacting protein 1 0.0187187
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0186868
SAMD4A sterile alpha motif domain containing 4A 0.0184161
GCLC glutamate-cysteine ligase, catalytic subunit 0.0180279
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0180008
HYOU1 hypoxia up-regulated 1 0.0179918
TNIP1 TNFAIP3 interacting protein 1 0.0176326
ADAM17 ADAM metallopeptidase domain 17 0.0173838
ATP11A ATPase, class VI, type 11A 0.0172762
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0172641
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0170148
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0168719
ZNF638 zinc finger protein 638 0.0168013
PAPOLA poly(A) polymerase alpha 0.0166037
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0165721
JMJD1C jumonji domain containing 1C 0.0165081
MYO5B myosin VB 0.0164973
FAT1 FAT atypical cadherin 1 0.0164089
ATP13A3 ATPase type 13A3 0.0161739
USP34 ubiquitin specific peptidase 34 0.0160855
FRY furry homolog (Drosophila) 0.0160732
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0156513
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0156319
BCAR3 breast cancer anti-estrogen resistance 3 0.0152648
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0152128
ANXA5 annexin A5 0.0150194
HDLBP high density lipoprotein binding protein 0.014985
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0149069
ZC3H11A zinc finger CCCH-type containing 11A 0.0149027
CASC3 cancer susceptibility candidate 3 0.0148686
PTEN phosphatase and tensin homolog 0.0147421
MACF1 microtubule-actin crosslinking factor 1 0.0147414
YEATS2 YEATS domain containing 2 0.0146298
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0146201
RUNX1 runt-related transcription factor 1 0.0145221
EIF4B eukaryotic translation initiation factor 4B 0.0145193
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0145096
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0144244
HOOK2 hook microtubule-tethering protein 2 0.0144148
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0141122
NSUN6 NOP2/Sun domain family, member 6 0.0139511
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0139254

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.320151
TMSB10 thymosin beta 10 -0.147744
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108234
MT2A metallothionein 2A -0.101726
TPT1 tumor protein, translationally-controlled 1 -0.0909081
PTMA prothymosin, alpha -0.089683
ASPH aspartate beta-hydroxylase -0.0860492
FTL ferritin, light polypeptide -0.0737292
RPLP1 ribosomal protein, large, P1 -0.0648246
S100A10 S100 calcium binding protein A10 -0.0631889
RPL35A ribosomal protein L35a -0.05761
ACTG1 actin gamma 1 -0.0506361
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0505474
CAV1 caveolin 1, caveolae protein, 22kDa -0.0503638
RPS6 ribosomal protein S6 -0.0480101
THSD4 thrombospondin, type I, domain containing 4 -0.0444123
RPL34 ribosomal protein L34 -0.0427001
RPS8 ribosomal protein S8 -0.0418412
RPS25 ribosomal protein S25 -0.041361
ANKRD12 ankyrin repeat domain 12 -0.0411474
SEC61G Sec61 gamma subunit -0.0404868
RPS24 ribosomal protein S24 -0.038129
RPL12 ribosomal protein L12 -0.0376959
AKR1C1 aldo-keto reductase family 1, member C1 -0.0367689
RPL37A ribosomal protein L37a -0.0350473
IER3 immediate early response 3 -0.0347295
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0339114
RPLP0 ribosomal protein, large, P0 -0.0330785
S100P S100 calcium binding protein P -0.0329176
RPL19 ribosomal protein L19 -0.032538
PTPRM protein tyrosine phosphatase, receptor type, M -0.0323945
RPL31 ribosomal protein L31 -0.0320964
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0314651
BTG1 B-cell translocation gene 1, anti-proliferative -0.0311763
RPS3 ribosomal protein S3 -0.0306276
CST3 cystatin C -0.0304996
RPS12 ribosomal protein S12 -0.0297765
RPS27 ribosomal protein S27 -0.0297655
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0292151
RPS19 ribosomal protein S19 -0.029114
S100A6 S100 calcium binding protein A6 -0.0289119
MT1X metallothionein 1X -0.0280687
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0273831
RPS27A ribosomal protein S27a -0.0273348
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0269573
H1-0 H1.0 linker histone -0.0260927
S100A9 S100 calcium binding protein A9 -0.0260597
RPS29 ribosomal protein S29 -0.0252111
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0252011
GNAS GNAS complex locus -0.0246173
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0245254
RPS23 ribosomal protein S23 -0.02417
RPS21 ribosomal protein S21 -0.0241326
CSTB cystatin B (stefin B) -0.0230494
KRT7 keratin 7, type II -0.0222056
RPL36A ribosomal protein L36a -0.0221572
GRAMD1B GRAM domain containing 1B -0.0220288
CCND1 cyclin D1 -0.0219631
EIF1 eukaryotic translation initiation factor 1 -0.0214344
KRT18 keratin 18, type I -0.0211252
RPL36 ribosomal protein L36 -0.0208545
RPLP2 ribosomal protein, large, P2 -0.0205988
C15ORF48 chromosome 15 open reading frame 48 -0.0204088
MORF4L2 mortality factor 4 like 2 -0.0203815
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0200182
RPL26 ribosomal protein L26 -0.0199687
HLA-B major histocompatibility complex, class I, B -0.0198268
RPS17 ribosomal protein S17 -0.0197592
RPS14 ribosomal protein S14 -0.0192661
ZMYND8 zinc finger, MYND-type containing 8 -0.0192516
SLC38A1 solute carrier family 38, member 1 -0.0192235
RPL30 ribosomal protein L30 -0.0186271
PDIA3 protein disulfide isomerase family A, member 3 -0.018571
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0185709
RPL5 ribosomal protein L5 -0.0183315
SLC38A2 solute carrier family 38, member 2 -0.0181806
RPL9 ribosomal protein L9 -0.0181165
IFI6 interferon, alpha-inducible protein 6 -0.0180276
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0178641
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0177085
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0175896
WSB1 WD repeat and SOCS box containing 1 -0.0171001
ENO1 enolase 1, (alpha) -0.0170248
RPS16 ribosomal protein S16 -0.016729
RPL37 ribosomal protein L37 -0.0166901
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0166459
SPTSSA serine palmitoyltransferase, small subunit A -0.0164144
RNF213 ring finger protein 213 -0.0164053
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0164005
RPL28 ribosomal protein L28 -0.0163326
ATP5F1E ATP synthase F1 subunit epsilon -0.0161754
TRIM56 tripartite motif containing 56 -0.0161508
HMGA1 high mobility group AT-hook 1 -0.0160021
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0158515
TXNRD1 thioredoxin reductase 1 -0.0158403
KPNB1 karyopherin (importin) beta 1 -0.0156191
CANX calnexin -0.0155271
RPL35 ribosomal protein L35 -0.0154852
CUX1 cut-like homeobox 1 -0.0154079
MAML3 mastermind-like 3 (Drosophila) -0.01533