Imiquimod (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0991772
NAMPT nicotinamide phosphoribosyltransferase 0.093692
SMAD3 SMAD family member 3 0.0912778
FNDC3B fibronectin type III domain containing 3B 0.0825658
SOD2 superoxide dismutase 2, mitochondrial 0.0714466
NAV2 neuron navigator 2 0.0614976
GRB10 growth factor receptor-bound protein 10 0.058604
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.058159
PCBP2 poly(rC) binding protein 2 0.0520621
ELL2 elongation factor, RNA polymerase II, 2 0.0519457
TGM2 transglutaminase 2 0.0478914
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.045536
EFNA5 ephrin-A5 0.0429848
PRELID2 PRELI domain containing 2 0.0418449
FAM20C family with sequence similarity 20, member C 0.0416905
DOCK5 dedicator of cytokinesis 5 0.0410244
TRIO trio Rho guanine nucleotide exchange factor 0.0403737
NPC1 Niemann-Pick disease, type C1 0.040113
EEF2 eukaryotic translation elongation factor 2 0.0400474
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0399706
FAM13A family with sequence similarity 13, member A 0.0384438
ATP13A3 ATPase type 13A3 0.0376434
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0367044
MYH9 myosin, heavy chain 9, non-muscle 0.0365246
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0359174
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0357826
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0348171
RBM39 RNA binding motif protein 39 0.0334659
RPL3 ribosomal protein L3 0.0333246
CTNND1 catenin (cadherin-associated protein), delta 1 0.0331442
KMT2C lysine (K)-specific methyltransferase 2C 0.0323752
PFKP phosphofructokinase, platelet 0.0317541
NGLY1 N-glycanase 1 0.0315312
ZEB2 zinc finger E-box binding homeobox 2 0.0313888
PDE4D phosphodiesterase 4D, cAMP-specific 0.029675
RAB8B RAB8B, member RAS oncogene family 0.0294256
ZFC3H1 zinc finger, C3H1-type containing 0.0289286
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0285655
KDM2A lysine (K)-specific demethylase 2A 0.0285264
VMP1 vacuole membrane protein 1 0.0282941
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.028029
DSCAM Down syndrome cell adhesion molecule 0.0279111
ARRDC3 arrestin domain containing 3 0.0272716
SS18 synovial sarcoma translocation, chromosome 18 0.0272667
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0262062
EGFR epidermal growth factor receptor 0.0258784
SLTM SAFB-like, transcription modulator 0.0256454
ANKRD36 ankyrin repeat domain 36 0.0254118
USP34 ubiquitin specific peptidase 34 0.0252277
PICALM phosphatidylinositol binding clathrin assembly protein 0.0247706
TNIP1 TNFAIP3 interacting protein 1 0.0246663
ATXN1 ataxin 1 0.0245943
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0244406
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0243759
STK38L serine/threonine kinase 38 like 0.0243603
UBA6 ubiquitin-like modifier activating enzyme 6 0.0241585
HELZ helicase with zinc finger 0.0241011
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0239525
AGFG1 ArfGAP with FG repeats 1 0.0238243
KDM6A lysine (K)-specific demethylase 6A 0.0231868
MSN moesin 0.0227744
AHR aryl hydrocarbon receptor 0.0224831
SAMD4A sterile alpha motif domain containing 4A 0.0220547
NBAS neuroblastoma amplified sequence 0.0219298
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.021748
RUNX2 runt-related transcription factor 2 0.0212796
ABI1 abl-interactor 1 0.0211333
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0209367
SRRM2 serine/arginine repetitive matrix 2 0.0207775
ESYT2 extended synaptotagmin-like protein 2 0.0207212
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0203698
WAC WW domain containing adaptor with coiled-coil 0.0201595
CEP250 centrosomal protein 250kDa 0.0200541
APLP2 amyloid beta (A4) precursor-like protein 2 0.0199273
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0198701
PELI1 pellino E3 ubiquitin protein ligase 1 0.0198228
CXCL5 chemokine (C-X-C motif) ligand 5 0.0197613
RUNX1 runt-related transcription factor 1 0.0196478
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0195012
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0194638
SPRED2 sprouty-related, EVH1 domain containing 2 0.0193313
UBAP2L ubiquitin associated protein 2-like 0.0192653
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0191865
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0191567
WWTR1 WW domain containing transcription regulator 1 0.0191241
FLNB filamin B, beta 0.019105
SIK3 SIK family kinase 3 0.0189963
CHD1 chromodomain helicase DNA binding protein 1 0.0189351
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0188429
RANBP2 RAN binding protein 2 0.0188201
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0186519
RBM33 RNA binding motif protein 33 0.0186355
YEATS2 YEATS domain containing 2 0.018601
ECPAS Ecm29 proteasome adaptor and scaffold 0.018584
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0185262
BACE2 beta-site APP-cleaving enzyme 2 0.0184636
STRN3 striatin, calmodulin binding protein 3 0.0184578
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0183948
SEC23A Sec23 homolog A (S. cerevisiae) 0.0183672
ANO6 anoctamin 6 0.0180649

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.251376
VIM vimentin -0.251334
TMSB10 thymosin beta 10 -0.212447
FTL ferritin, light polypeptide -0.126471
RPLP1 ribosomal protein, large, P1 -0.106692
PTMA prothymosin, alpha -0.0846085
RPL35A ribosomal protein L35a -0.0756399
RPS19 ribosomal protein S19 -0.0723762
S100A6 S100 calcium binding protein A6 -0.0714638
TPT1 tumor protein, translationally-controlled 1 -0.0676494
MT2A metallothionein 2A -0.0650019
RPS8 ribosomal protein S8 -0.0633903
IER3 immediate early response 3 -0.0630971
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0629467
EIF1 eukaryotic translation initiation factor 1 -0.0621806
RPS6 ribosomal protein S6 -0.0614431
RPL34 ribosomal protein L34 -0.0562084
RPS21 ribosomal protein S21 -0.0531911
TFPI2 tissue factor pathway inhibitor 2 -0.0529826
FN1 fibronectin 1 -0.0529417
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0512167
NAP1L1 nucleosome assembly protein 1-like 1 -0.0475234
RPS12 ribosomal protein S12 -0.0467664
RPS29 ribosomal protein S29 -0.0464849
RPL31 ribosomal protein L31 -0.0461554
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.046072
RPLP2 ribosomal protein, large, P2 -0.0454697
RPLP0 ribosomal protein, large, P0 -0.0451073
RPL36 ribosomal protein L36 -0.0447016
S100A10 S100 calcium binding protein A10 -0.0443883
RPS24 ribosomal protein S24 -0.0431179
RPL32 ribosomal protein L32 -0.0422837
GLCCI1 glucocorticoid induced 1 -0.0416309
NRG1 neuregulin 1 -0.0415295
RPL23 ribosomal protein L23 -0.0412213
RPL19 ribosomal protein L19 -0.0410481
RPL37A ribosomal protein L37a -0.0408732
B2M beta-2-microglobulin -0.0408217
RPL12 ribosomal protein L12 -0.0407779
RPL28 ribosomal protein L28 -0.039436
ANKRD28 ankyrin repeat domain 28 -0.0393516
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0386542
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0384852
HMGA2 high mobility group AT-hook 2 -0.0381049
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0372541
RPS25 ribosomal protein S25 -0.0364978
GNAS GNAS complex locus -0.036024
CDH13 cadherin 13 -0.0358486
RPL5 ribosomal protein L5 -0.0356033
RPS3 ribosomal protein S3 -0.0349034
RPL37 ribosomal protein L37 -0.034704
DPYD dihydropyrimidine dehydrogenase -0.034616
LOC102724023 ES1 protein homolog, mitochondrial -0.0341788
C15ORF48 chromosome 15 open reading frame 48 -0.0341192
TMSB4X thymosin beta 4, X-linked -0.0339641
RPL11 ribosomal protein L11 -0.0339281
RPS16 ribosomal protein S16 -0.0337034
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0332712
RPL9 ribosomal protein L9 -0.0322854
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0320005
WSB1 WD repeat and SOCS box containing 1 -0.0318905
BTG1 B-cell translocation gene 1, anti-proliferative -0.0317448
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0315658
RPS27 ribosomal protein S27 -0.0306418
RPS5 ribosomal protein S5 -0.0301833
RPS13 ribosomal protein S13 -0.0301495
EGR1 early growth response 1 -0.0299957
SLC38A1 solute carrier family 38, member 1 -0.0298243
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0297006
S100A9 S100 calcium binding protein A9 -0.0295035
ENO1 enolase 1, (alpha) -0.0294775
RPS11 ribosomal protein S11 -0.0292768
VDAC1 voltage-dependent anion channel 1 -0.0292559
HLA-B major histocompatibility complex, class I, B -0.0283674
SOS1 son of sevenless homolog 1 (Drosophila) -0.0280839
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0275441
KPNB1 karyopherin (importin) beta 1 -0.0270312
DDIT3 DNA-damage-inducible transcript 3 -0.0268972
SEC61G Sec61 gamma subunit -0.0268585
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0268222
RPL7A ribosomal protein L7a -0.0266934
RPS14 ribosomal protein S14 -0.0266656
FTH1 ferritin, heavy polypeptide 1 -0.0265724
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0263364
RPL38 ribosomal protein L38 -0.0260947
RPS23 ribosomal protein S23 -0.0260179
SYT1 synaptotagmin I -0.0259924
ANXA2 annexin A2 -0.0257701
STC1 stanniocalcin 1 -0.0257113
RPS17 ribosomal protein S17 -0.0254347
IFI6 interferon, alpha-inducible protein 6 -0.0253595
HMGA1 high mobility group AT-hook 1 -0.0249027
RPL26 ribosomal protein L26 -0.0248247
RAB1A RAB1A, member RAS oncogene family -0.0243028
ACTG1 actin gamma 1 -0.0241306
CCNI cyclin I -0.0238046
TMEM263 transmembrane protein 263 -0.0237486
TM4SF1 transmembrane 4 L six family member 1 -0.0232199
PFN1 profilin 1 -0.0231743
LMNA lamin A/C -0.0229231