Imiquimod (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPM3 tropomyosin 3 0.126732
EEF2 eukaryotic translation elongation factor 2 0.108097
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0990227
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0944036
RPL3 ribosomal protein L3 0.0919755
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0797828
MCL1 myeloid cell leukemia 1 0.0772557
AKAP12 A kinase (PRKA) anchor protein 12 0.075487
POTEF POTE ankyrin domain family, member F 0.068871
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0677685
ERRFI1 ERBB receptor feedback inhibitor 1 0.06752
SAMD4A sterile alpha motif domain containing 4A 0.0650527
UBASH3B ubiquitin associated and SH3 domain containing B 0.0610788
KTN1 kinectin 1 (kinesin receptor) 0.0584969
PKM pyruvate kinase, muscle 0.0574852
ACTN1 actinin, alpha 1 0.0533762
EGFR epidermal growth factor receptor 0.0515784
FLNA filamin A, alpha 0.0511142
HSPA8 heat shock 70kDa protein 8 0.0496487
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0496372
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0488769
PYGL phosphorylase, glycogen, liver 0.0470069
MYH9 myosin, heavy chain 9, non-muscle 0.046162
FMNL2 formin-like 2 0.0460392
MSN moesin 0.0454174
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0452292
PCBP2 poly(rC) binding protein 2 0.0449112
CALR calreticulin 0.0441965
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0436821
PDIA3 protein disulfide isomerase family A, member 3 0.0431591
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0430633
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0428126
TPM4 tropomyosin 4 0.0427942
BASP1 brain abundant, membrane attached signal protein 1 0.0426941
SRRM2 serine/arginine repetitive matrix 2 0.0417031
IGFBP3 insulin-like growth factor binding protein 3 0.0414207
APLP2 amyloid beta (A4) precursor-like protein 2 0.0412096
RPL4 ribosomal protein L4 0.0409762
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.040934
HYOU1 hypoxia up-regulated 1 0.0403659
CMIP c-Maf inducing protein 0.0401076
PFKP phosphofructokinase, platelet 0.0400418
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0394667
CALU calumenin 0.039455
VCL vinculin 0.0393512
PLS3 plastin 3 0.0378669
SFTPA2 surfactant protein A2 0.0369473
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0365539
HDGF hepatoma-derived growth factor 0.036104
ENO1 enolase 1, (alpha) 0.0359162
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0356139
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0353484
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.03445
UBAP2L ubiquitin associated protein 2-like 0.0338119
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0328928
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0327531
APP amyloid beta (A4) precursor protein 0.0322885
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0314189
SMAD3 SMAD family member 3 0.0312996
FLNB filamin B, beta 0.0312715
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0308005
IL6 interleukin 6 0.0306485
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0304359
IQGAP1 IQ motif containing GTPase activating protein 1 0.0302075
NCEH1 neutral cholesterol ester hydrolase 1 0.0302009
CSDE1 cold shock domain containing E1, RNA-binding 0.0289861
CASC3 cancer susceptibility candidate 3 0.028949
PDIA6 protein disulfide isomerase family A, member 6 0.028815
FNDC3B fibronectin type III domain containing 3B 0.0286426
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.028402
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0283538
NUMA1 nuclear mitotic apparatus protein 1 0.0281921
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0281438
ITCH itchy E3 ubiquitin protein ligase 0.0280198
STC1 stanniocalcin 1 0.0280055
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0277885
DOCK5 dedicator of cytokinesis 5 0.0277621
NEBL nebulette 0.0277373
FTH1 ferritin, heavy polypeptide 1 0.0274436
LDHA lactate dehydrogenase A 0.0270555
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0268121
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.026697
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.026123
TAGLN2 transgelin 2 0.0260984
SOD2 superoxide dismutase 2, mitochondrial 0.0259199
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0258017
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0256527
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0256237
GOLGA4 golgin A4 0.025606
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0255366
NPC1 Niemann-Pick disease, type C1 0.0254676
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0252943
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0252692
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0249357
COPA coatomer protein complex, subunit alpha 0.0248032
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0247221
IQGAP3 IQ motif containing GTPase activating protein 3 0.0246037
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.024525
LPP LIM domain containing preferred translocation partner in lipoma 0.024451
HMGA1 high mobility group AT-hook 1 0.0243776

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.119173
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103458
TFPI2 tissue factor pathway inhibitor 2 -0.0888595
FTL ferritin, light polypeptide -0.0690686
RPL19 ribosomal protein L19 -0.0624943
RPLP1 ribosomal protein, large, P1 -0.0621891
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0591159
GRAMD1B GRAM domain containing 1B -0.0538176
ACTG1 actin gamma 1 -0.0524875
SLC38A2 solute carrier family 38, member 2 -0.051544
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0476675
RPS8 ribosomal protein S8 -0.04338
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0428769
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0426709
BHLHE40 basic helix-loop-helix family, member e40 -0.0409152
RPL36 ribosomal protein L36 -0.0401054
MT2A metallothionein 2A -0.0399724
TPT1 tumor protein, translationally-controlled 1 -0.0368897
RPL35A ribosomal protein L35a -0.035846
NRG1 neuregulin 1 -0.0358373
RASAL2 RAS protein activator like 2 -0.0340923
IER3 immediate early response 3 -0.0338286
HDAC9 histone deacetylase 9 -0.033592
EIF1 eukaryotic translation initiation factor 1 -0.0330533
THSD4 thrombospondin, type I, domain containing 4 -0.0322428
NEGR1 neuronal growth regulator 1 -0.0322405
RPS12 ribosomal protein S12 -0.0322368
HMGB1 high mobility group box 1 -0.0317899
SPIDR scaffolding protein involved in DNA repair -0.0315262
ZNF804A zinc finger protein 804A -0.0309366
RPS19 ribosomal protein S19 -0.0306177
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0302005
USP3 ubiquitin specific peptidase 3 -0.0295944
OSMR oncostatin M receptor -0.0294558
RPLP2 ribosomal protein, large, P2 -0.0285198
BICC1 BicC family RNA binding protein 1 -0.0285029
RPS21 ribosomal protein S21 -0.0279641
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0277159
AK1 adenylate kinase 1 -0.0275484
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.026981
S100A6 S100 calcium binding protein A6 -0.0264403
MIPOL1 mirror-image polydactyly 1 -0.0262297
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.0256298
ATP5F1E ATP synthase F1 subunit epsilon -0.0255292
RPL31 ribosomal protein L31 -0.0248041
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0247072
KLF6 Kruppel-like factor 6 -0.0246458
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0246138
MAML3 mastermind-like 3 (Drosophila) -0.0236792
RPS20 ribosomal protein S20 -0.0236249
PHF3 PHD finger protein 3 -0.0230877
SLC38A1 solute carrier family 38, member 1 -0.0229955
AGO2 argonaute RISC catalytic component 2 -0.022483
NPR2 natriuretic peptide receptor 2 -0.0224774
YBX3 Y box binding protein 3 -0.0223829
SVIL supervillin -0.0223508
RPS29 ribosomal protein S29 -0.0223231
ANKRD28 ankyrin repeat domain 28 -0.022136
GPHN gephyrin -0.0219053
RIMS2 regulating synaptic membrane exocytosis 2 -0.021865
EFNA5 ephrin-A5 -0.0214104
RPS16 ribosomal protein S16 -0.0212788
SMAD2 SMAD family member 2 -0.0212766
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0212751
RPS6 ribosomal protein S6 -0.0209406
PRKN parkin RBR E3 ubiquitin protein ligase -0.0208836
RPLP0 ribosomal protein, large, P0 -0.0208447
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0201781
DSCAM Down syndrome cell adhesion molecule -0.0201631
DTNB dystrobrevin, beta -0.0197721
RAD21 RAD21 homolog (S. pombe) -0.0195334
RSPO3 R-spondin 3 -0.0192355
PTK2 protein tyrosine kinase 2 -0.0192275
RPL9 ribosomal protein L9 -0.0191956
DENND4A DENN/MADD domain containing 4A -0.0190548
RPL26 ribosomal protein L26 -0.0190489
WTAP Wilms tumor 1 associated protein -0.0189198
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0188953
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.018846
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0188421
FBXO11 F-box protein 11 -0.0187689
NAP1L1 nucleosome assembly protein 1-like 1 -0.0187382
RAB7A RAB7A, member RAS oncogene family -0.0185007
RTN4 reticulon 4 -0.0184239
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0183455
CHN1 chimerin 1 -0.0181783
NABP1 nucleic acid binding protein 1 -0.0181366
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0180086
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0179815
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0177794
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.0173209
RPL37A ribosomal protein L37a -0.0172377
RPL34 ribosomal protein L34 -0.0172045
PDE4D phosphodiesterase 4D, cAMP-specific -0.0171705
ZFAND6 zinc finger, AN1-type domain 6 -0.017134
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0170036
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0169902
RPS23 ribosomal protein S23 -0.0169289
ZFAND3 zinc finger, AN1-type domain 3 -0.0169051
DOCK3 dedicator of cytokinesis 3 -0.0168902