| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.211961 |
| MCL1 | myeloid cell leukemia 1 | 0.12376 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.108127 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0955013 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.093804 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0917636 |
| RPL11 | ribosomal protein L11 | 0.0901727 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0872472 |
| RPS24 | ribosomal protein S24 | 0.0870527 |
| EGFR | epidermal growth factor receptor | 0.0841687 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0832742 |
| FAT1 | FAT atypical cadherin 1 | 0.0766033 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0727493 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0693044 |
| LAMB3 | laminin, beta 3 | 0.0691116 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0683851 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0668671 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.066319 |
| TPI1 | triosephosphate isomerase 1 | 0.0652731 |
| H1-0 | H1.0 linker histone | 0.0648711 |
| PHF3 | PHD finger protein 3 | 0.0636419 |
| HLA-A | major histocompatibility complex, class I, A | 0.0633944 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0630559 |
| SLMAP | sarcolemma associated protein | 0.060517 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0602957 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0599543 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0593206 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0587068 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0582771 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.057036 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0570202 |
| FOXO3 | forkhead box O3 | 0.0565686 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.055519 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0553036 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0540527 |
| SLTM | SAFB-like, transcription modulator | 0.053995 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0537322 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0533299 |
| SEC24A | SEC24 family member A | 0.05317 |
| SMAD3 | SMAD family member 3 | 0.0528669 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0527706 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0523397 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0518385 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0515834 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0513103 |
| CTBP2 | C-terminal binding protein 2 | 0.0508196 |
| RAB10 | RAB10, member RAS oncogene family | 0.0506788 |
| COG5 | component of oligomeric golgi complex 5 | 0.0505738 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0504637 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0499201 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | 0.0487276 |
| GPHN | gephyrin | 0.0483383 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0480228 |
| EZR | ezrin | 0.0471432 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0467256 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0465593 |
| STAG2 | stromal antigen 2 | 0.0462115 |
| TXNRD1 | thioredoxin reductase 1 | 0.0457554 |
| PCBP2 | poly(rC) binding protein 2 | 0.04568 |
| NEBL | nebulette | 0.0444412 |
| USP34 | ubiquitin specific peptidase 34 | 0.044159 |
| BBX | bobby sox homolog (Drosophila) | 0.0435721 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0430703 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0426841 |
| RIOK3 | RIO kinase 3 | 0.0423589 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0421664 |
| DSTN | destrin (actin depolymerizing factor) | 0.0420931 |
| RNF145 | ring finger protein 145 | 0.0417973 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.041767 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0414149 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0405469 |
| CCNL1 | cyclin L1 | 0.0404851 |
| GOLGA4 | golgin A4 | 0.0403116 |
| RSF1 | remodeling and spacing factor 1 | 0.0401059 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0393301 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0392851 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0391923 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0377515 |
| RBM25 | RNA binding motif protein 25 | 0.0377261 |
| SQSTM1 | sequestosome 1 | 0.0373705 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0372457 |
| KYNU | kynureninase | 0.0367536 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0362599 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0361528 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0361091 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0357904 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0354712 |
| RPL23 | ribosomal protein L23 | 0.0345215 |
| PRELID2 | PRELI domain containing 2 | 0.0340277 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0336999 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0329621 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0327467 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0326411 |
| RTN4 | reticulon 4 | 0.0325695 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0323458 |
| POTEF | POTE ankyrin domain family, member F | 0.0322974 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0321689 |
| RAD51B | RAD51 paralog B | 0.0320067 |
| KRT17 | keratin 17, type I | 0.0318637 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0317726 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.257075 |
| FN1 | fibronectin 1 | -0.17021 |
| MYO1E | myosin IE | -0.148513 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.137538 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.132821 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.102697 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.102033 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0933428 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0917319 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0838274 |
| VIM | vimentin | -0.0837477 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0826712 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0824994 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0817356 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0800134 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0774578 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0723621 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0713111 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0705815 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0697358 |
| PLAUR | plasminogen activator, urokinase receptor | -0.068437 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0675817 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0662047 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0661728 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0646146 |
| EFNA5 | ephrin-A5 | -0.0643305 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0615887 |
| MXD1 | MAX dimerization protein 1 | -0.0609963 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0606601 |
| RBM47 | RNA binding motif protein 47 | -0.0601068 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0599919 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0586804 |
| PARD3 | par-3 family cell polarity regulator | -0.0586604 |
| MYO10 | myosin X | -0.0585684 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0583149 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0579342 |
| ABHD17C | abhydrolase domain containing 17C | -0.0576024 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0569608 |
| MMP1 | matrix metallopeptidase 1 | -0.0562156 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0528527 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0526143 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0523913 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0521504 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.050307 |
| RBM39 | RNA binding motif protein 39 | -0.04962 |
| DST | dystonin | -0.0494481 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0487535 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0478756 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0477516 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0473176 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0470138 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0464896 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0454363 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0451271 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0449174 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0447848 |
| FAM13A | family with sequence similarity 13, member A | -0.0442956 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0431602 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0425077 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0423365 |
| CD44 | CD44 molecule (Indian blood group) | -0.0420983 |
| ERBIN | erbb2 interacting protein | -0.0418633 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0417123 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0412469 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0400881 |
| GPC6 | glypican 6 | -0.0399035 |
| CLTC | clathrin, heavy chain (Hc) | -0.0398249 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0397781 |
| ATP13A3 | ATPase type 13A3 | -0.0396794 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0393129 |
| RORA | RAR-related orphan receptor A | -0.0389564 |
| NBEAL1 | neurobeachin-like 1 | -0.0385778 |
| RASA2 | RAS p21 protein activator 2 | -0.0384337 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0380994 |
| ASPH | aspartate beta-hydroxylase | -0.0377624 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0373945 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0372064 |
| AHNAK | AHNAK nucleoprotein | -0.0371749 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0370452 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0369503 |
| ATOSA | atos homolog A | -0.0369017 |
| FRMD5 | FERM domain containing 5 | -0.0367196 |
| VMP1 | vacuole membrane protein 1 | -0.0358867 |
| WASF2 | WAS protein family, member 2 | -0.0355641 |
| JMJD1C | jumonji domain containing 1C | -0.0351708 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0351198 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0350233 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0349975 |
| FTL | ferritin, light polypeptide | -0.0341976 |
| PTK2 | protein tyrosine kinase 2 | -0.0340409 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0330879 |
| TJP1 | tight junction protein 1 | -0.0328856 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0324117 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0323248 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0312458 |
| PKM | pyruvate kinase, muscle | -0.0308061 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0299951 |
| HMGA2 | high mobility group AT-hook 2 | -0.0295496 |
| NABP1 | nucleic acid binding protein 1 | -0.0291453 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0290325 |
