Imiquimod (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.132574
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0792138
EEF2 eukaryotic translation elongation factor 2 0.077947
ERRFI1 ERBB receptor feedback inhibitor 1 0.0734961
TFPI2 tissue factor pathway inhibitor 2 0.0667034
TRIO trio Rho guanine nucleotide exchange factor 0.0633783
GRAMD1B GRAM domain containing 1B 0.0503188
XPO1 exportin 1 0.0438276
TPM3 tropomyosin 3 0.0414632
MARCHF4 membrane associated ring-CH-type finger 4 0.0400226
RPL3 ribosomal protein L3 0.039329
CSDE1 cold shock domain containing E1, RNA-binding 0.0377962
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0362943
RTN4 reticulon 4 0.032771
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0327421
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0327054
KDM3A lysine (K)-specific demethylase 3A 0.0316722
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0313286
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0311391
OGA O-GlcNAcase 0.0301949
MYH9 myosin, heavy chain 9, non-muscle 0.029876
ANKRD36 ankyrin repeat domain 36 0.0294095
CSNK1A1 casein kinase 1, alpha 1 0.0286907
NCAPD2 non-SMC condensin I complex, subunit D2 0.0280106
SMAD3 SMAD family member 3 0.0279653
UBAP2L ubiquitin associated protein 2-like 0.0272021
CTTNBP2NL CTTNBP2 N-terminal like 0.0268182
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0253939
NCKAP1 NCK-associated protein 1 0.0253008
ANO6 anoctamin 6 0.0249317
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0245889
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0245017
ZFC3H1 zinc finger, C3H1-type containing 0.0240048
PGK1 phosphoglycerate kinase 1 0.0235424
NIPBL Nipped-B homolog (Drosophila) 0.0235282
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0234109
ELL2 elongation factor, RNA polymerase II, 2 0.0234047
RAD51B RAD51 paralog B 0.0229479
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0226913
PLEC plectin 0.0226116
ATP11A ATPase, class VI, type 11A 0.0225935
NUP153 nucleoporin 153kDa 0.0220796
PHIP pleckstrin homology domain interacting protein 0.0218485
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0218079
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0214661
CLTC clathrin, heavy chain (Hc) 0.0214199
SYNE2 spectrin repeat containing, nuclear envelope 2 0.021384
AHNAK AHNAK nucleoprotein 0.0212449
HSPA8 heat shock 70kDa protein 8 0.021082
EPN2 epsin 2 0.0210642
RRM2 ribonucleotide reductase M2 0.0209021
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0206599
PPME1 protein phosphatase methylesterase 1 0.0203374
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.020251
RUSC2 RUN and SH3 domain containing 2 0.0199388
RBM33 RNA binding motif protein 33 0.0196172
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0196114
PLCB4 phospholipase C, beta 4 0.0195759
ZFAND3 zinc finger, AN1-type domain 3 0.0194978
MYPN myopalladin 0.0193135
NAMPT nicotinamide phosphoribosyltransferase 0.019313
UBC ubiquitin C 0.0192594
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0191987
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0191695
PFKP phosphofructokinase, platelet 0.0191624
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0190384
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0184577
USP22 ubiquitin specific peptidase 22 0.0184261
EIF4B eukaryotic translation initiation factor 4B 0.0183362
MKI67 marker of proliferation Ki-67 0.0182062
FXR1 fragile X mental retardation, autosomal homolog 1 0.0181545
PRRC2A proline-rich coiled-coil 2A 0.018048
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0179655
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0179332
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0178499
MARCHF6 membrane associated ring-CH-type finger 6 0.0177341
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0175715
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0175562
DGKD diacylglycerol kinase, delta 130kDa 0.017511
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0174144
CEP250 centrosomal protein 250kDa 0.0173072
H1-0 H1.0 linker histone 0.017307
KDM7A lysine (K)-specific demethylase 7A 0.0172093
ARID1A AT rich interactive domain 1A (SWI-like) 0.0171616
CKAP5 cytoskeleton associated protein 5 0.0170806
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0169492
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.016873
SINHCAF SIN3-HDAC complex associated factor 0.0168174
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0167824
PUM1 pumilio RNA-binding family member 1 0.0167771
RNF145 ring finger protein 145 0.0167567
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0167086
ANKRD36B ankyrin repeat domain 36B 0.016396
RASA2 RAS p21 protein activator 2 0.0162448
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0160566
WNK1 WNK lysine deficient protein kinase 1 0.0159348
TOP2B topoisomerase (DNA) II beta 180kDa 0.0158934
ETNK1 ethanolamine kinase 1 0.01585
CCNL1 cyclin L1 0.0157784
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0156835

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.262479
TMSB10 thymosin beta 10 -0.114455
VIM vimentin -0.0919944
PTMA prothymosin, alpha -0.0799611
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0757174
RPL35A ribosomal protein L35a -0.0683417
RPS8 ribosomal protein S8 -0.065052
RPL37A ribosomal protein L37a -0.0624277
HLA-B major histocompatibility complex, class I, B -0.0619156
RPS3 ribosomal protein S3 -0.051478
RPLP1 ribosomal protein, large, P1 -0.0503953
RPS19 ribosomal protein S19 -0.0495892
TPT1 tumor protein, translationally-controlled 1 -0.04923
RPS21 ribosomal protein S21 -0.0484922
RPL37 ribosomal protein L37 -0.0470988
RPS27 ribosomal protein S27 -0.0458754
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.043759
RPL31 ribosomal protein L31 -0.0431774
RPS29 ribosomal protein S29 -0.0424451
IFI6 interferon, alpha-inducible protein 6 -0.0417115
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0414756
MT2A metallothionein 2A -0.0411211
RPS12 ribosomal protein S12 -0.0405931
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0396438
FTL ferritin, light polypeptide -0.0393829
RPS6 ribosomal protein S6 -0.0385361
ACTG1 actin gamma 1 -0.0379724
RPL23 ribosomal protein L23 -0.0365714
HMGA2 high mobility group AT-hook 2 -0.0363488
RPS15 ribosomal protein S15 -0.0361259
RPS10 ribosomal protein S10 -0.0355714
RPL36 ribosomal protein L36 -0.0349318
RPLP2 ribosomal protein, large, P2 -0.0343965
RPL26 ribosomal protein L26 -0.0343567
AFF3 AF4/FMR2 family, member 3 -0.0339553
EGR1 early growth response 1 -0.0335338
PFN1 profilin 1 -0.032954
RPL38 ribosomal protein L38 -0.0309606
RPL34 ribosomal protein L34 -0.0307365
EIF5B eukaryotic translation initiation factor 5B -0.0306225
PRH1 proline-rich protein HaeIII subfamily 1 -0.0302702
RPS27A ribosomal protein S27a -0.0299876
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0294697
S100A10 S100 calcium binding protein A10 -0.0294685
RPL9 ribosomal protein L9 -0.0285375
RPL19 ribosomal protein L19 -0.0273882
RPS25 ribosomal protein S25 -0.0259987
RYR3 ryanodine receptor 3 -0.0258561
RPS17 ribosomal protein S17 -0.0256928
AKAP12 A kinase (PRKA) anchor protein 12 -0.0256007
RPL11 ribosomal protein L11 -0.0254444
RPS14 ribosomal protein S14 -0.0245451
GNAS GNAS complex locus -0.0244844
RPL28 ribosomal protein L28 -0.0237515
IER3 immediate early response 3 -0.0236433
RPS23 ribosomal protein S23 -0.0236158
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0235822
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0233872
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0233822
POTEF POTE ankyrin domain family, member F -0.0233416
RPS13 ribosomal protein S13 -0.0229386
INTS6 integrator complex subunit 6 -0.0228931
TPM2 tropomyosin 2 (beta) -0.0228068
LOC102724023 ES1 protein homolog, mitochondrial -0.022781
RPL36A ribosomal protein L36a -0.0222666
RPL12 ribosomal protein L12 -0.0222574
RPS24 ribosomal protein S24 -0.0220609
EIF1 eukaryotic translation initiation factor 1 -0.0215951
RPL35 ribosomal protein L35 -0.0209597
RPS20 ribosomal protein S20 -0.0204641
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0204173
RAB7A RAB7A, member RAS oncogene family -0.0203874
RPL5 ribosomal protein L5 -0.020052
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0200376
RPL27 ribosomal protein L27 -0.0196879
RPLP0 ribosomal protein, large, P0 -0.0193961
CALR calreticulin -0.0191385
FNDC3B fibronectin type III domain containing 3B -0.0190233
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0187045
RPL32 ribosomal protein L32 -0.0186607
RIMS2 regulating synaptic membrane exocytosis 2 -0.0186055
ATXN1 ataxin 1 -0.0181709
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0181195
RPS16 ribosomal protein S16 -0.0181185
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.018112
THSD4 thrombospondin, type I, domain containing 4 -0.0179167
AEBP2 AE binding protein 2 -0.0178973
RPL8 ribosomal protein L8 -0.0178281
CUX1 cut-like homeobox 1 -0.0178028
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0176268
WNT2B wingless-type MMTV integration site family, member 2B -0.0175165
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.017326
NLGN1 neuroligin 1 -0.0172918
S100A6 S100 calcium binding protein A6 -0.0169532
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0168387
RSF1 remodeling and spacing factor 1 -0.0167798
MCL1 myeloid cell leukemia 1 -0.0166789
BPTF bromodomain PHD finger transcription factor -0.0161585
TAS2R14 taste receptor, type 2, member 14 -0.0158007
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0157951