Imiquimod (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.157372
MYH9 myosin, heavy chain 9, non-muscle 0.0773235
EEF2 eukaryotic translation elongation factor 2 0.059983
FNDC3B fibronectin type III domain containing 3B 0.0542299
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0524448
PLEC plectin 0.0466438
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0454946
ARRDC3 arrestin domain containing 3 0.044073
RPL3 ribosomal protein L3 0.0399128
RPL4 ribosomal protein L4 0.034808
TPM3 tropomyosin 3 0.0318131
MSN moesin 0.0310007
CCNL1 cyclin L1 0.0307614
HSPA8 heat shock 70kDa protein 8 0.0302474
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0300761
FLNA filamin A, alpha 0.0287008
LAMC2 laminin, gamma 2 0.0284806
NCKAP1 NCK-associated protein 1 0.0273373
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0264876
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.026413
PAPOLA poly(A) polymerase alpha 0.0259142
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0255416
KDM6A lysine (K)-specific demethylase 6A 0.0253087
GRB10 growth factor receptor-bound protein 10 0.0252077
DUSP10 dual specificity phosphatase 10 0.0250268
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0248202
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.024561
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0243791
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0243709
NDRG1 N-myc downstream regulated 1 0.0242339
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0241629
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0240866
AFDN afadin, adherens junction formation factor 0.0238418
UBC ubiquitin C 0.0233978
PPARD peroxisome proliferator-activated receptor delta 0.0223192
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0222726
DSPP dentin sialophosphoprotein 0.0221634
RNF145 ring finger protein 145 0.021969
UBAP2L ubiquitin associated protein 2-like 0.0219482
FXR1 fragile X mental retardation, autosomal homolog 1 0.0215931
TRIO trio Rho guanine nucleotide exchange factor 0.0212234
CAPN2 calpain 2, (m/II) large subunit 0.0208337
CD46 CD46 molecule, complement regulatory protein 0.0207949
APLP2 amyloid beta (A4) precursor-like protein 2 0.0207112
DSCAM Down syndrome cell adhesion molecule 0.0205929
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0199937
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0197108
DHFR dihydrofolate reductase 0.019701
MSMO1 methylsterol monooxygenase 1 0.0194076
MYO5B myosin VB 0.0192154
AHNAK AHNAK nucleoprotein 0.0187463
TFG TRK-fused gene 0.0187307
CSDE1 cold shock domain containing E1, RNA-binding 0.0183135
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0182902
HMGB2 high mobility group box 2 0.0182505
NAV2 neuron navigator 2 0.017878
MKRN1 makorin ring finger protein 1 0.0177731
PCBP2 poly(rC) binding protein 2 0.0175348
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0175235
TNIP1 TNFAIP3 interacting protein 1 0.017013
MARCHF6 membrane associated ring-CH-type finger 6 0.0170102
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0166685
DIAPH1 diaphanous-related formin 1 0.0165757
EWSR1 EWS RNA-binding protein 1 0.0165356
MCL1 myeloid cell leukemia 1 0.0165275
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0164665
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0161978
SMAD3 SMAD family member 3 0.0161354
VMP1 vacuole membrane protein 1 0.0153428
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0152438
NAMPT nicotinamide phosphoribosyltransferase 0.0152331
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0151695
RASA2 RAS p21 protein activator 2 0.0151569
RAD23B RAD23 homolog B (S. cerevisiae) 0.0149366
IRF6 interferon regulatory factor 6 0.0149324
TACSTD2 tumor-associated calcium signal transducer 2 0.0147975
TSPAN15 tetraspanin 15 0.0147891
USP9X ubiquitin specific peptidase 9, X-linked 0.0145787
NUP58 nucleoporin 58 0.0145608
MYO6 myosin VI 0.0144735
RBM39 RNA binding motif protein 39 0.014471
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0144255
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0143267
TFRC transferrin receptor 0.0143046
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0142016
GLS2 glutaminase 2 (liver, mitochondrial) 0.0139901
CD24 CD24 molecule 0.0139781
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0139108
NUMA1 nuclear mitotic apparatus protein 1 0.0138794
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0138491
VIRMA vir like m6A methyltransferase associated 0.0137535
YTHDC1 YTH domain containing 1 0.0137208
CORO1C coronin, actin binding protein, 1C 0.0135391
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.013486
MKI67 marker of proliferation Ki-67 0.0134801
MBNL1 muscleblind-like splicing regulator 1 0.0134622
PTK2 protein tyrosine kinase 2 0.0134505
ECT2 epithelial cell transforming 2 0.0131449
CNN3 calponin 3, acidic 0.0130949
CASC3 cancer susceptibility candidate 3 0.0130861

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.23595
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196528
TMSB10 thymosin beta 10 -0.116693
S100A6 S100 calcium binding protein A6 -0.107687
ACTG1 actin gamma 1 -0.106781
PTMA prothymosin, alpha -0.0894168
RPL35A ribosomal protein L35a -0.0761016
RPLP1 ribosomal protein, large, P1 -0.0756477
TPT1 tumor protein, translationally-controlled 1 -0.0742354
S100A10 S100 calcium binding protein A10 -0.059666
RPL34 ribosomal protein L34 -0.0586777
RPS8 ribosomal protein S8 -0.0572434
IFI27 interferon, alpha-inducible protein 27 -0.0547893
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0498664
MT2A metallothionein 2A -0.0473342
RPS29 ribosomal protein S29 -0.0459023
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0450794
ISG15 ISG15 ubiquitin-like modifier -0.0449918
RPL19 ribosomal protein L19 -0.0447177
RPS19 ribosomal protein S19 -0.0439661
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0439237
RPS6 ribosomal protein S6 -0.0439127
EIF1 eukaryotic translation initiation factor 1 -0.0435748
IFITM3 interferon induced transmembrane protein 3 -0.0418014
GNAS GNAS complex locus -0.039652
CSTB cystatin B (stefin B) -0.0388448
VIM vimentin -0.037258
RPLP2 ribosomal protein, large, P2 -0.0371784
IFITM1 interferon induced transmembrane protein 1 -0.0353065
SQSTM1 sequestosome 1 -0.0346669
RPS14 ribosomal protein S14 -0.0346312
RPL37A ribosomal protein L37a -0.0332862
RPS3 ribosomal protein S3 -0.0328074
RPL12 ribosomal protein L12 -0.0325748
S100A9 S100 calcium binding protein A9 -0.0325118
RPL28 ribosomal protein L28 -0.0309297
RPLP0 ribosomal protein, large, P0 -0.0302091
RPL36 ribosomal protein L36 -0.030008
RPS23 ribosomal protein S23 -0.0295287
RPS27 ribosomal protein S27 -0.0293567
IGFBP3 insulin-like growth factor binding protein 3 -0.0289136
ENO1 enolase 1, (alpha) -0.0288198
IFI6 interferon, alpha-inducible protein 6 -0.0284367
LMNA lamin A/C -0.0275847
RPL32 ribosomal protein L32 -0.0268104
SLC38A1 solute carrier family 38, member 1 -0.0267478
RPS25 ribosomal protein S25 -0.0266961
RPS16 ribosomal protein S16 -0.0260312
RPS24 ribosomal protein S24 -0.0257393
TM4SF1 transmembrane 4 L six family member 1 -0.0254144
G0S2 G0/G1 switch 2 -0.025345
RPS13 ribosomal protein S13 -0.0245771
RPS21 ribosomal protein S21 -0.024262
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0240708
KRT19 keratin 19, type I -0.0239431
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0234011
RPL31 ribosomal protein L31 -0.0230597
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0228571
TSC22D2 TSC22 domain family, member 2 -0.0226756
MDK midkine (neurite growth-promoting factor 2) -0.0225505
RPL35 ribosomal protein L35 -0.0225214
RPL9 ribosomal protein L9 -0.0222398
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0221219
RPS10 ribosomal protein S10 -0.0220648
ANXA2 annexin A2 -0.0220433
UQCRB ubiquinol-cytochrome c reductase binding protein -0.021913
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0218898
HLA-B major histocompatibility complex, class I, B -0.0215698
SOX4 SRY (sex determining region Y)-box 4 -0.0214532
SAMD4A sterile alpha motif domain containing 4A -0.0212529
ACBD3 acyl-CoA binding domain containing 3 -0.0209726
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0209002
RPL8 ribosomal protein L8 -0.0208869
LAMB3 laminin, beta 3 -0.0208207
RPS20 ribosomal protein S20 -0.0205967
COX7C cytochrome c oxidase subunit VIIc -0.0204715
RPS5 ribosomal protein S5 -0.0203087
RPL37 ribosomal protein L37 -0.020188
CD2AP CD2-associated protein -0.0201822
IFI16 interferon, gamma-inducible protein 16 -0.0201531
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0200966
ATP5F1E ATP synthase F1 subunit epsilon -0.0196785
RPL27A ribosomal protein L27a -0.0196759
RPL30 ribosomal protein L30 -0.0196608
TMEM263 transmembrane protein 263 -0.0196568
RPL5 ribosomal protein L5 -0.0194955
HMGB1 high mobility group box 1 -0.0194915
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0194814
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0194775
HSPB1 heat shock 27kDa protein 1 -0.0193943
KRT7 keratin 7, type II -0.0193573
NPEPPS aminopeptidase puromycin sensitive -0.0193172
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0190814
LY6E lymphocyte antigen 6 complex, locus E -0.0190504
RPS17 ribosomal protein S17 -0.0189026
RPS15 ribosomal protein S15 -0.0188674
RPL15 ribosomal protein L15 -0.0185296
RPS27A ribosomal protein S27a -0.0184681
RPS11 ribosomal protein S11 -0.0184677
NPC2 Niemann-Pick disease, type C2 -0.0184549