Imiquimod (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0771341
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0768685
MCL1 myeloid cell leukemia 1 0.0586845
ELL2 elongation factor, RNA polymerase II, 2 0.0553183
PM20D1 peptidase M20 domain containing 1 0.0524358
PDLIM5 PDZ and LIM domain 5 0.0480744
ERRFI1 ERBB receptor feedback inhibitor 1 0.0363165
KYNU kynureninase 0.0361325
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0330568
RPL3 ribosomal protein L3 0.0328945
SOD2 superoxide dismutase 2, mitochondrial 0.0315243
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0304157
NEK7 NIMA-related kinase 7 0.0292796
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0275182
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0269448
FNDC3B fibronectin type III domain containing 3B 0.0242677
SAMD4A sterile alpha motif domain containing 4A 0.0240433
ADGRD1 adhesion G protein-coupled receptor D1 0.023616
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0235435
GDA guanine deaminase 0.0228794
MYOF myoferlin 0.0227943
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0226694
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0224761
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0222455
DOCK4 dedicator of cytokinesis 4 0.0221399
CD109 CD109 molecule 0.0220278
CHD1 chromodomain helicase DNA binding protein 1 0.0215743
AGFG1 ArfGAP with FG repeats 1 0.0215067
CXCL8 chemokine (C-X-C motif) ligand 8 0.0213123
BMP6 bone morphogenetic protein 6 0.0212369
ZEB2 zinc finger E-box binding homeobox 2 0.0211767
NCKAP1 NCK-associated protein 1 0.0197322
NRCAM neuronal cell adhesion molecule 0.0192899
SMOC1 SPARC related modular calcium binding 1 0.0191591
VCL vinculin 0.0189417
KDM6A lysine (K)-specific demethylase 6A 0.0183901
HSPA8 heat shock 70kDa protein 8 0.017767
UBAP2L ubiquitin associated protein 2-like 0.0177339
BCAR3 breast cancer anti-estrogen resistance 3 0.0175884
STC1 stanniocalcin 1 0.0172533
FLNA filamin A, alpha 0.0170476
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0168214
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.016646
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0164869
DST dystonin 0.0162318
IGFBP3 insulin-like growth factor binding protein 3 0.0160334
ESYT2 extended synaptotagmin-like protein 2 0.0157251
NCOR2 nuclear receptor corepressor 2 0.0154401
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.01544
ITPRID2 ITPR interacting domain containing 2 0.0152839
TRIO trio Rho guanine nucleotide exchange factor 0.0152289
FMNL2 formin-like 2 0.0150467
NCAM1 neural cell adhesion molecule 1 0.0149656
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.01471
ARRDC3 arrestin domain containing 3 0.0144218
EFNA5 ephrin-A5 0.0143765
GPRIN3 GPRIN family member 3 0.0143055
TSC22D2 TSC22 domain family, member 2 0.0141438
DHFR dihydrofolate reductase 0.0140035
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0138568
SPAG9 sperm associated antigen 9 0.0136867
CASC3 cancer susceptibility candidate 3 0.0134924
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0133066
SAR1A secretion associated, Ras related GTPase 1A 0.0130118
PYGL phosphorylase, glycogen, liver 0.0129637
USP9X ubiquitin specific peptidase 9, X-linked 0.0127941
CD46 CD46 molecule, complement regulatory protein 0.0127551
TNIP1 TNFAIP3 interacting protein 1 0.0127495
ANXA5 annexin A5 0.0124742
NPAS2 neuronal PAS domain protein 2 0.0124701
CEP72 centrosomal protein 72kDa 0.0124364
RAB3B RAB3B, member RAS oncogene family 0.0123391
RNF145 ring finger protein 145 0.0121317
TGFBI transforming growth factor, beta-induced, 68kDa 0.0121158
NUP58 nucleoporin 58 0.0120278
CXCL5 chemokine (C-X-C motif) ligand 5 0.0119274
EIF4H eukaryotic translation initiation factor 4H 0.0118968
CDH13 cadherin 13 0.0116281
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0113626
EEF2 eukaryotic translation elongation factor 2 0.0112642
MARCHF6 membrane associated ring-CH-type finger 6 0.0112615
CORO1C coronin, actin binding protein, 1C 0.0110344
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0109389
COL4A6 collagen, type IV, alpha 6 0.0108137
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.0107739
ZFC3H1 zinc finger, C3H1-type containing 0.0107457
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.010549
CTIF CBP80/20-dependent translation initiation factor 0.0105295
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0105068
GRB10 growth factor receptor-bound protein 10 0.0104934
KDM5C lysine (K)-specific demethylase 5C 0.010366
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0103546
CTSL cathepsin L 0.0103323
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0102705
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0101644
MSN moesin 0.0101362
BDNF brain-derived neurotrophic factor 0.0101315
CHL1 cell adhesion molecule L1-like 0.0101064
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.0100548
AFDN afadin, adherens junction formation factor 0.00992977

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180216
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165749
VIM vimentin -0.158222
TMSB10 thymosin beta 10 -0.140942
PTMA prothymosin, alpha -0.0967885
RPS6 ribosomal protein S6 -0.0876011
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0815238
RPLP1 ribosomal protein, large, P1 -0.0796111
FTL ferritin, light polypeptide -0.072264
RPS8 ribosomal protein S8 -0.0679222
RPS27A ribosomal protein S27a -0.0657448
TPT1 tumor protein, translationally-controlled 1 -0.0636848
RPL37A ribosomal protein L37a -0.0635188
RPL26 ribosomal protein L26 -0.0598325
RPL12 ribosomal protein L12 -0.0597028
RPS12 ribosomal protein S12 -0.0580374
S100A6 S100 calcium binding protein A6 -0.0547118
RPL19 ribosomal protein L19 -0.0523636
RPL23 ribosomal protein L23 -0.0515454
RPL31 ribosomal protein L31 -0.0499852
CANX calnexin -0.0487342
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0474901
NAP1L1 nucleosome assembly protein 1-like 1 -0.0463386
RPS19 ribosomal protein S19 -0.0450834
RPL9 ribosomal protein L9 -0.0439875
NALF1 NALCN channel auxiliary factor 1 -0.0435631
ENO1 enolase 1, (alpha) -0.0432006
RPS3 ribosomal protein S3 -0.0428823
RPL35A ribosomal protein L35a -0.0414517
RPS24 ribosomal protein S24 -0.0408616
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0402299
RPL34 ribosomal protein L34 -0.0399063
S100A10 S100 calcium binding protein A10 -0.0398505
MT2A metallothionein 2A -0.0398162
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0396857
ASPH aspartate beta-hydroxylase -0.0396782
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0387536
RPLP2 ribosomal protein, large, P2 -0.038198
EIF1 eukaryotic translation initiation factor 1 -0.0379973
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0377358
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0373434
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0371599
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0369501
TM4SF1 transmembrane 4 L six family member 1 -0.0365447
PDE4D phosphodiesterase 4D, cAMP-specific -0.035911
SMYD3 SET and MYND domain containing 3 -0.0349929
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.034763
RPS23 ribosomal protein S23 -0.0347443
RPS27 ribosomal protein S27 -0.0344261
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0335869
TXNRD1 thioredoxin reductase 1 -0.0334965
B2M beta-2-microglobulin -0.0330118
RPL36 ribosomal protein L36 -0.0329178
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0326504
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0319598
RPS29 ribosomal protein S29 -0.0311541
RPS16 ribosomal protein S16 -0.0306691
UBC ubiquitin C -0.0306661
RPS14 ribosomal protein S14 -0.0306524
RPL37 ribosomal protein L37 -0.0306406
GNAS GNAS complex locus -0.0303314
ACTG1 actin gamma 1 -0.0303026
RPL36A ribosomal protein L36a -0.0297505
SLC38A2 solute carrier family 38, member 2 -0.0296496
RPL5 ribosomal protein L5 -0.0294578
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0293117
RPLP0 ribosomal protein, large, P0 -0.0281219
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0278759
RPS25 ribosomal protein S25 -0.0273326
RPS21 ribosomal protein S21 -0.0272929
PTGR1 prostaglandin reductase 1 -0.0270496
RPL7A ribosomal protein L7a -0.0268694
RPL35 ribosomal protein L35 -0.0265227
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0264253
PDIA3 protein disulfide isomerase family A, member 3 -0.0256059
LDHA lactate dehydrogenase A -0.0255801
PDIA4 protein disulfide isomerase family A, member 4 -0.02527
RPS17 ribosomal protein S17 -0.0247855
JMJD1C jumonji domain containing 1C -0.0240876
VDAC1 voltage-dependent anion channel 1 -0.0234229
RPS13 ribosomal protein S13 -0.0232075
PCBP2 poly(rC) binding protein 2 -0.0231859
CALR calreticulin -0.0229215
SET SET nuclear proto-oncogene -0.0225647
RPL28 ribosomal protein L28 -0.0225118
MAML3 mastermind-like 3 (Drosophila) -0.0224577
RPS4X ribosomal protein S4, X-linked -0.0223588
RPL13A ribosomal protein L13a -0.0222921
PDE10A phosphodiesterase 10A -0.0221251
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.021799
RPL32 ribosomal protein L32 -0.0217223
WSB1 WD repeat and SOCS box containing 1 -0.0214471
EIF5B eukaryotic translation initiation factor 5B -0.0212776
SRGN serglycin -0.0212411
HLA-B major histocompatibility complex, class I, B -0.0212087
MORF4L2 mortality factor 4 like 2 -0.0211173
RPL38 ribosomal protein L38 -0.0210902
RPL18 ribosomal protein L18 -0.0209891
ASTN2 astrotactin 2 -0.0209758
RPL11 ribosomal protein L11 -0.0209153