Imiquimod (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

89 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.164765
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.132322
ZC3H3 zinc finger CCCH-type containing 3 0.121813
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0961125
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0925432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0921248
SYT1 synaptotagmin I 0.0883484
RBM39 RNA binding motif protein 39 0.0878752
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0826576
RUNX1 runt-related transcription factor 1 0.0818704
NAMPT nicotinamide phosphoribosyltransferase 0.0793376
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0790739
DST dystonin 0.0734434
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0726449
AKAP12 A kinase (PRKA) anchor protein 12 0.0686693
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0663815
DSCAM Down syndrome cell adhesion molecule 0.0651756
PDGFA platelet-derived growth factor alpha polypeptide 0.0606489
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0601131
ARHGAP26 Rho GTPase activating protein 26 0.0566459
RAP1B RAP1B, member of RAS oncogene family 0.054946
FN1 fibronectin 1 0.0545828
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0528083
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0508373
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0419883
RORA RAR-related orphan receptor A 0.0382247
NDRG1 N-myc downstream regulated 1 0.037165
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0353921
NRG1 neuregulin 1 0.0340809
USP34 ubiquitin specific peptidase 34 0.0334589
GPR75-ASB3 GPR75-ASB3 readthrough 0.0331697
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0298479
BCL2L1 BCL2-like 1 0.0289426
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0272663
ASPH aspartate beta-hydroxylase 0.0237685
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0234066
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0206918
PTMA prothymosin, alpha 0.0174018
FNDC3B fibronectin type III domain containing 3B 0.0147836
NKD1 naked cuticle homolog 1 (Drosophila) 0.0107602
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00926901
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0089433
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00526143
TRIO trio Rho guanine nucleotide exchange factor 5.47347E-4

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.142118
MACF1 microtubule-actin crosslinking factor 1 -0.103275
RPS16 ribosomal protein S16 -0.0888959
PDE10A phosphodiesterase 10A -0.0835726
SNX9 sorting nexin 9 -0.0800807
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0731117
CARD16 caspase recruitment domain family, member 16 -0.0705438
ZBTB20 zinc finger and BTB domain containing 20 -0.0692319
NALF1 NALCN channel auxiliary factor 1 -0.0688598
LMO7 LIM domain 7 -0.0682389
RPLP2 ribosomal protein, large, P2 -0.0615995
TMSB10 thymosin beta 10 -0.0593003
LIMS1 LIM and senescent cell antigen-like domains 1 -0.056681
JMJD1C jumonji domain containing 1C -0.0553126
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0531187
WSB1 WD repeat and SOCS box containing 1 -0.0518861
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0507606
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0471255
BIRC6 baculoviral IAP repeat containing 6 -0.0442834
SMYD3 SET and MYND domain containing 3 -0.0422157
PSD3 pleckstrin and Sec7 domain containing 3 -0.0419636
RPLP1 ribosomal protein, large, P1 -0.0409111
COL6A3 collagen, type VI, alpha 3 -0.0385716
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0360386
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0360378
NIPBL Nipped-B homolog (Drosophila) -0.0334021
MYOF myoferlin -0.0328648
STAG2 stromal antigen 2 -0.03136
INHBA inhibin, beta A -0.0301712
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0281586
MAML2 mastermind-like 2 (Drosophila) -0.0270143
VIM vimentin -0.0230321
RPS6 ribosomal protein S6 -0.0199403
MAML3 mastermind-like 3 (Drosophila) -0.0184271
CD44 CD44 molecule (Indian blood group) -0.0172992
RBM25 RNA binding motif protein 25 -0.0156433
EFNA5 ephrin-A5 -0.0143047
ITGA6 integrin, alpha 6 -0.0138894
SAMD4A sterile alpha motif domain containing 4A -0.012294
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0117978
RPS8 ribosomal protein S8 -0.0111582
EEF2 eukaryotic translation elongation factor 2 -0.0102269
NAV2 neuron navigator 2 -0.00334776
CDH13 cadherin 13 -0.00217012
ANKRD11 ankyrin repeat domain 11 -0.00122366