| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Imiquimod (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.145467 |
| ZNF292 | zinc finger protein 292 | 0.091126 |
| NCKAP1 | NCK-associated protein 1 | 0.0585709 |
| ITGAV | integrin, alpha V | 0.0583967 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0574123 |
| COL5A2 | collagen, type V, alpha 2 | 0.0555025 |
| SHROOM3 | shroom family member 3 | 0.053541 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0528161 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0523016 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0518065 |
| PEG10 | paternally expressed 10 | 0.0507651 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0497563 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0490923 |
| MTF2 | metal response element binding transcription factor 2 | 0.0490122 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0489427 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0476335 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0475085 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0463608 |
| HDAC9 | histone deacetylase 9 | 0.045791 |
| DST | dystonin | 0.0443494 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0433238 |
| TMEM64 | transmembrane protein 64 | 0.043083 |
| RPL3 | ribosomal protein L3 | 0.0427728 |
| MYO10 | myosin X | 0.0416945 |
| SPAG9 | sperm associated antigen 9 | 0.0409069 |
| QKI | QKI, KH domain containing, RNA binding | 0.0397524 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0392204 |
| CCN2 | cellular communication network factor 2 | 0.0390827 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.038979 |
| RHEB | Ras homolog enriched in brain | 0.0377522 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0374084 |
| CALU | calumenin | 0.0367029 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0364427 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.036401 |
| PCBP2 | poly(rC) binding protein 2 | 0.0360194 |
| H1-5 | H1.5 linker histone, cluster member | 0.0357562 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.035122 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.034844 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0336091 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0335804 |
| ENAH | enabled homolog (Drosophila) | 0.0335139 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0319989 |
| CCNL1 | cyclin L1 | 0.031544 |
| CFL2 | cofilin 2 (muscle) | 0.0313107 |
| APP | amyloid beta (A4) precursor protein | 0.0309833 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0309659 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0306609 |
| PDGFC | platelet derived growth factor C | 0.0305506 |
| SYT1 | synaptotagmin I | 0.0302744 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0301234 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0300878 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0296812 |
| PHIP | pleckstrin homology domain interacting protein | 0.0296454 |
| WDR43 | WD repeat domain 43 | 0.0293977 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0293778 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0290536 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0288396 |
| NONO | non-POU domain containing, octamer-binding | 0.0284936 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0284278 |
| CALCR | calcitonin receptor | 0.0283134 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0283103 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0283013 |
| CADM2 | cell adhesion molecule 2 | 0.0282602 |
| GASK1B | golgi associated kinase 1B | 0.0281955 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0280891 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0277132 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0275918 |
| SRP54 | signal recognition particle 54kDa | 0.0271589 |
| TMSB4X | thymosin beta 4, X-linked | 0.0270999 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0266428 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0259585 |
| RASAL2 | RAS protein activator like 2 | 0.0259079 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0258926 |
| PDS5B | PDS5 cohesin associated factor B | 0.0254619 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0254567 |
| UBC | ubiquitin C | 0.0254002 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0253804 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0247599 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0247207 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0243997 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0243858 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0243049 |
| PER1 | period circadian clock 1 | 0.0242914 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0242391 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.02419 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0234821 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0233613 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0232202 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0230108 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0228076 |
| YAP1 | Yes-associated protein 1 | 0.0225536 |
| MB21D2 | Mab-21 domain containing 2 | 0.0221885 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0220994 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0220232 |
| POTEF | POTE ankyrin domain family, member F | 0.0219991 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0218052 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0217942 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0217439 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0217091 |
| RPL4 | ribosomal protein L4 | 0.0215578 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.163017 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0950217 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0692795 |
| PTMA | prothymosin, alpha | -0.0631799 |
| RPLP1 | ribosomal protein, large, P1 | -0.0601459 |
| RPS8 | ribosomal protein S8 | -0.0576781 |
| RPS16 | ribosomal protein S16 | -0.0571321 |
| TMSB10 | thymosin beta 10 | -0.0556184 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0532309 |
| ACTG1 | actin gamma 1 | -0.0491902 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.048481 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0481724 |
| RPS6 | ribosomal protein S6 | -0.0459051 |
| GNAS | GNAS complex locus | -0.0439995 |
| RPS19 | ribosomal protein S19 | -0.0431058 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0414337 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0403278 |
| MKI67 | marker of proliferation Ki-67 | -0.0398617 |
| PCDH9 | protocadherin 9 | -0.0383192 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.035405 |
| RPL35A | ribosomal protein L35a | -0.0329621 |
| RPS21 | ribosomal protein S21 | -0.0314297 |
| RPS24 | ribosomal protein S24 | -0.0312758 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0309304 |
| RPL31 | ribosomal protein L31 | -0.0308513 |
| NPAS3 | neuronal PAS domain protein 3 | -0.030406 |
| RPL12 | ribosomal protein L12 | -0.0297748 |
| COL1A2 | collagen, type I, alpha 2 | -0.0297744 |
| ZFR | zinc finger RNA binding protein | -0.029218 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0291214 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0289649 |
| HMGB1 | high mobility group box 1 | -0.0286609 |
| RPS12 | ribosomal protein S12 | -0.0285472 |
| CENPF | centromere protein F, 350/400kDa | -0.0278399 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0275009 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0274036 |
| RPS2 | ribosomal protein S2 | -0.0272401 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0269029 |
| RPL38 | ribosomal protein L38 | -0.0268342 |
| RPL34 | ribosomal protein L34 | -0.026666 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0266019 |
| RPS25 | ribosomal protein S25 | -0.0262424 |
| RPLP0 | ribosomal protein, large, P0 | -0.0260691 |
| CALR | calreticulin | -0.026062 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0257409 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0255888 |
| RPL36 | ribosomal protein L36 | -0.0250654 |
| PHF3 | PHD finger protein 3 | -0.0250647 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0249027 |
| CDH19 | cadherin 19, type 2 | -0.0248846 |
| FN1 | fibronectin 1 | -0.0243623 |
| RPS3 | ribosomal protein S3 | -0.0239667 |
| NDRG1 | N-myc downstream regulated 1 | -0.0238131 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0236911 |
| RPL37A | ribosomal protein L37a | -0.0235878 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0233779 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0232031 |
| RPS27 | ribosomal protein S27 | -0.0229132 |
| S100A10 | S100 calcium binding protein A10 | -0.0226061 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0221542 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0219842 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0218897 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0213162 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0212696 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0212639 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0212224 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0211372 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0209127 |
| WDR45B | WD repeat domain 45B | -0.0207166 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0205706 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0205001 |
| RPS14 | ribosomal protein S14 | -0.02016 |
| OGA | O-GlcNAcase | -0.0201278 |
| KNL1 | kinetochore scaffold 1 | -0.0199676 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0198609 |
| EP400 | E1A binding protein p400 | -0.0194117 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0192667 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0191993 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.019196 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0191834 |
| RPS13 | ribosomal protein S13 | -0.0190707 |
| FOXP2 | forkhead box P2 | -0.0190233 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0188918 |
| ARF1 | ADP-ribosylation factor 1 | -0.018856 |
| PHF21A | PHD finger protein 21A | -0.0188424 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0188096 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0187066 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0186123 |
| SBF2 | SET binding factor 2 | -0.0185394 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0183884 |
| RPL32 | ribosomal protein L32 | -0.0183609 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.0182319 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0181152 |
| USP1 | ubiquitin specific peptidase 1 | -0.0181107 |
| NBEAL1 | neurobeachin-like 1 | -0.0180301 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0179888 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0179235 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0179068 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0178356 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.017825 |
