Imiquimod (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.126418
ERRFI1 ERBB receptor feedback inhibitor 1 0.120207
ACTN4 actinin, alpha 4 0.0637717
MYH9 myosin, heavy chain 9, non-muscle 0.0619472
SMAD3 SMAD family member 3 0.0549622
ZFP36 ZFP36 ring finger protein 0.0469394
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0388418
WWTR1 WW domain containing transcription regulator 1 0.037357
SEPTIN9 septin 9 0.0338057
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0334015
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0317675
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0306364
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0292852
MCL1 myeloid cell leukemia 1 0.0292231
ARRDC3 arrestin domain containing 3 0.0288906
AHNAK AHNAK nucleoprotein 0.0286801
SPRED2 sprouty-related, EVH1 domain containing 2 0.0284981
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0284728
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0279354
SAMD4B sterile alpha motif domain containing 4B 0.0270452
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0270191
BIRC2 baculoviral IAP repeat containing 2 0.0259779
VMP1 vacuole membrane protein 1 0.025763
CSNK1A1 casein kinase 1, alpha 1 0.0253203
ANLN anillin, actin binding protein 0.0245343
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0229104
UBC ubiquitin C 0.0224028
DGKD diacylglycerol kinase, delta 130kDa 0.0223705
EEF2 eukaryotic translation elongation factor 2 0.0223664
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0222208
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0222084
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0221256
ELL2 elongation factor, RNA polymerase II, 2 0.0213632
APP amyloid beta (A4) precursor protein 0.0212876
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0212589
RPL3 ribosomal protein L3 0.0210536
JMJD1C jumonji domain containing 1C 0.0206902
AHNAK2 AHNAK nucleoprotein 2 0.0203843
TMEM41B transmembrane protein 41B 0.0201794
PLEC plectin 0.0201421
TRIO trio Rho guanine nucleotide exchange factor 0.0200766
TXNRD1 thioredoxin reductase 1 0.0200661
AFDN afadin, adherens junction formation factor 0.0199658
DSCAM Down syndrome cell adhesion molecule 0.0197093
TM4SF1 transmembrane 4 L six family member 1 0.018986
RPL4 ribosomal protein L4 0.018802
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.018735
SPTBN1 spectrin, beta, non-erythrocytic 1 0.018708
NCEH1 neutral cholesterol ester hydrolase 1 0.0185279
ATP13A3 ATPase type 13A3 0.0182927
ADGRG6 adhesion G protein-coupled receptor G6 0.0178904
SPAG9 sperm associated antigen 9 0.0175364
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0174133
ITGAV integrin, alpha V 0.0172625
ASPH aspartate beta-hydroxylase 0.0167942
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0167117
ELOVL5 ELOVL fatty acid elongase 5 0.016622
OGA O-GlcNAcase 0.0166192
DHFR dihydrofolate reductase 0.016603
MACF1 microtubule-actin crosslinking factor 1 0.0165873
ANXA2 annexin A2 0.0162691
SMYD3 SET and MYND domain containing 3 0.0157909
MARCHF6 membrane associated ring-CH-type finger 6 0.0157822
MKI67 marker of proliferation Ki-67 0.0157817
CTNND1 catenin (cadherin-associated protein), delta 1 0.0156327
FLNA filamin A, alpha 0.0153417
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0153178
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0152214
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.015173
FOXO3 forkhead box O3 0.0150351
PRELID2 PRELI domain containing 2 0.0149615
MED13L mediator complex subunit 13-like 0.0146976
ECT2 epithelial cell transforming 2 0.0145908
CA8 carbonic anhydrase VIII 0.0142888
APLP2 amyloid beta (A4) precursor-like protein 2 0.0141037
CD59 CD59 molecule, complement regulatory protein 0.0140253
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0138818
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0136461
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0135052
BMP6 bone morphogenetic protein 6 0.0132658
SERINC1 serine incorporator 1 0.0132429
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0132256
TRIP12 thyroid hormone receptor interactor 12 0.0132201
KDM3A lysine (K)-specific demethylase 3A 0.0132079
NCKAP1 NCK-associated protein 1 0.0131687
MYOF myoferlin 0.0131192
ITPRID2 ITPR interacting domain containing 2 0.013083
SEPTIN10 septin 10 0.0130524
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0130159
ANO6 anoctamin 6 0.0130154
CD164 CD164 molecule, sialomucin 0.012993
PICALM phosphatidylinositol binding clathrin assembly protein 0.0127503
ZNF217 zinc finger protein 217 0.012616
BMAL2 basic helix-loop-helix ARNT like 2 0.0125321
NUP98 nucleoporin 98kDa 0.0125112
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0125005
ICAM1 intercellular adhesion molecule 1 0.0124209
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0123819
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0123238
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0123224

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.252951
VIM vimentin -0.189535
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101134
PTMA prothymosin, alpha -0.0872759
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0856964
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0836422
TMSB10 thymosin beta 10 -0.0791803
RPL35A ribosomal protein L35a -0.0780911
RPLP1 ribosomal protein, large, P1 -0.061433
RPLP2 ribosomal protein, large, P2 -0.0555787
FTL ferritin, light polypeptide -0.0552808
RPS12 ribosomal protein S12 -0.045905
RPS8 ribosomal protein S8 -0.0450239
RPL37A ribosomal protein L37a -0.0429762
MT2A metallothionein 2A -0.0427944
S100A6 S100 calcium binding protein A6 -0.0393686
RPS6 ribosomal protein S6 -0.0358107
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0354512
FBL fibrillarin -0.0350467
RPS3 ribosomal protein S3 -0.0348855
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0299044
RPLP0 ribosomal protein, large, P0 -0.0298471
AKAP12 A kinase (PRKA) anchor protein 12 -0.0291168
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0284046
PFN1 profilin 1 -0.0276448
RPS25 ribosomal protein S25 -0.0272373
RPS17 ribosomal protein S17 -0.027233
RPS24 ribosomal protein S24 -0.0268445
RPL26 ribosomal protein L26 -0.0264409
RPS19 ribosomal protein S19 -0.0264376
RPL12 ribosomal protein L12 -0.0262015
EIF1 eukaryotic translation initiation factor 1 -0.0261028
ACTG1 actin gamma 1 -0.0260611
TPT1 tumor protein, translationally-controlled 1 -0.0258642
RPL9 ribosomal protein L9 -0.0256948
RPS14 ribosomal protein S14 -0.0253217
RPL11 ribosomal protein L11 -0.0245165
RPS27A ribosomal protein S27a -0.0243311
RPL31 ribosomal protein L31 -0.0242343
RPL28 ribosomal protein L28 -0.0239995
RPL34 ribosomal protein L34 -0.0239724
HMGA1 high mobility group AT-hook 1 -0.023937
RPS13 ribosomal protein S13 -0.0237094
RPS5 ribosomal protein S5 -0.0234459
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0230212
GNAS GNAS complex locus -0.0226095
SEPTIN7 septin 7 -0.0219463
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0219247
RPL36A ribosomal protein L36a -0.0202749
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0202424
EIF5B eukaryotic translation initiation factor 5B -0.020149
RPL36 ribosomal protein L36 -0.020119
CTSD cathepsin D -0.0198058
PDIA3 protein disulfide isomerase family A, member 3 -0.0197853
GARS1 glycyl-tRNA synthetase 1 -0.0196949
RPS27 ribosomal protein S27 -0.0194491
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0186737
IFITM3 interferon induced transmembrane protein 3 -0.018664
KTN1 kinectin 1 (kinesin receptor) -0.0185723
WSB1 WD repeat and SOCS box containing 1 -0.0184413
RPS29 ribosomal protein S29 -0.0180019
HLA-B major histocompatibility complex, class I, B -0.0178121
RPL19 ribosomal protein L19 -0.0177507
HMGB1 high mobility group box 1 -0.0177322
RPL37 ribosomal protein L37 -0.0174338
RPS21 ribosomal protein S21 -0.017238
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0169306
HSPG2 heparan sulfate proteoglycan 2 -0.0169061
RPS23 ribosomal protein S23 -0.0168905
RPS20 ribosomal protein S20 -0.0168583
RPL30 ribosomal protein L30 -0.0168114
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0167148
RPL38 ribosomal protein L38 -0.0166493
KPNB1 karyopherin (importin) beta 1 -0.0165647
MAP1B microtubule-associated protein 1B -0.0165043
CBX3 chromobox homolog 3 -0.0160004
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0157506
RPS10 ribosomal protein S10 -0.0156214
RPL23 ribosomal protein L23 -0.0155989
VDAC1 voltage-dependent anion channel 1 -0.0155833
RPL35 ribosomal protein L35 -0.0154751
EGFR epidermal growth factor receptor -0.0152927
RPL27A ribosomal protein L27a -0.0152676
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0151017
S100A9 S100 calcium binding protein A9 -0.0150797
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0147175
ASTN2 astrotactin 2 -0.0146086
MYADM myeloid-associated differentiation marker -0.0144962
RPL5 ribosomal protein L5 -0.0141603
RPS2 ribosomal protein S2 -0.0140999
THOC2 THO complex 2 -0.0139965
SERBP1 SERPINE1 mRNA binding protein 1 -0.0139286
NAP1L1 nucleosome assembly protein 1-like 1 -0.0138287
GOLGA4 golgin A4 -0.0135287
ANKRD12 ankyrin repeat domain 12 -0.0132195
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0130336
RPS28 ribosomal protein S28 -0.0129968
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0129553
RPL39 ribosomal protein L39 -0.0125775
RPL32 ribosomal protein L32 -0.0124043