| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Imiquimod (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.189524 |
| RPL3 | ribosomal protein L3 | 0.119602 |
| FRMD6 | FERM domain containing 6 | 0.104951 |
| FLNB | filamin B, beta | 0.0960212 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0942324 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0903681 |
| CALD1 | caldesmon 1 | 0.0741368 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.073317 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0726427 |
| MCL1 | myeloid cell leukemia 1 | 0.0700827 |
| NAV2 | neuron navigator 2 | 0.0684843 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0658273 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0647276 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.062828 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0626869 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0598292 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0586847 |
| NCKAP1 | NCK-associated protein 1 | 0.0570797 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0569137 |
| STC1 | stanniocalcin 1 | 0.0545711 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0542223 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0541003 |
| CORO1C | coronin, actin binding protein, 1C | 0.0537443 |
| TTR | transthyretin | 0.0527689 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0521313 |
| PTK2 | protein tyrosine kinase 2 | 0.0520961 |
| RACK1 | receptor for activated C kinase 1 | 0.0520535 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0501909 |
| TPM4 | tropomyosin 4 | 0.0496357 |
| RPL4 | ribosomal protein L4 | 0.047454 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0455454 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0455425 |
| HMGA2 | high mobility group AT-hook 2 | 0.0450253 |
| ERBIN | erbb2 interacting protein | 0.0449296 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0442963 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0441235 |
| APP | amyloid beta (A4) precursor protein | 0.0439327 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0437146 |
| ZNF438 | zinc finger protein 438 | 0.0435395 |
| LAMB3 | laminin, beta 3 | 0.0425096 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0424356 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0423075 |
| SLC38A2 | solute carrier family 38, member 2 | 0.041199 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0410987 |
| FRMD4A | FERM domain containing 4A | 0.0404827 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0402394 |
| HDAC9 | histone deacetylase 9 | 0.039981 |
| DENND1A | DENN/MADD domain containing 1A | 0.0385588 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0379215 |
| RPL7 | ribosomal protein L7 | 0.0379177 |
| FAM120A | family with sequence similarity 120A | 0.037017 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0369887 |
| CAPRIN2 | caprin family member 2 | 0.0352313 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0339253 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0339027 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0338492 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.0337664 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0335815 |
| PGK1 | phosphoglycerate kinase 1 | 0.0332682 |
| ATP13A3 | ATPase type 13A3 | 0.0332399 |
| FLNA | filamin A, alpha | 0.0332029 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0331592 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0313889 |
| POTEF | POTE ankyrin domain family, member F | 0.0312247 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0310508 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0310494 |
| BRD4 | bromodomain containing 4 | 0.0309337 |
| GSE1 | Gse1 coiled-coil protein | 0.0306881 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.030659 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0305683 |
| PCBP2 | poly(rC) binding protein 2 | 0.0302941 |
| UBC | ubiquitin C | 0.0297441 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0297283 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0293696 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0292571 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0291254 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0288358 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0285936 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0285602 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0285322 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0284484 |
| ENO1 | enolase 1, (alpha) | 0.0282826 |
| RPS3 | ribosomal protein S3 | 0.0281356 |
| PKM | pyruvate kinase, muscle | 0.0277017 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0275428 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0274161 |
| WDR43 | WD repeat domain 43 | 0.0273647 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0271348 |
| DHFR | dihydrofolate reductase | 0.027119 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0270798 |
| NUP58 | nucleoporin 58 | 0.0270761 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0269976 |
| TPM3 | tropomyosin 3 | 0.026749 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0266759 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0266734 |
| CLTC | clathrin, heavy chain (Hc) | 0.0265646 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0264995 |
| CEP250 | centrosomal protein 250kDa | 0.0264279 |
| CDK6 | cyclin-dependent kinase 6 | 0.0261627 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0261018 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0930317 |
| ACTG1 | actin gamma 1 | -0.0915953 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0897747 |
| RPLP1 | ribosomal protein, large, P1 | -0.0723758 |
| MT2A | metallothionein 2A | -0.0659231 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0647725 |
| RPL35 | ribosomal protein L35 | -0.0579284 |
| RPL35A | ribosomal protein L35a | -0.0528191 |
| RPS21 | ribosomal protein S21 | -0.0479174 |
| RPLP2 | ribosomal protein, large, P2 | -0.0469731 |
| RPS24 | ribosomal protein S24 | -0.0448355 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0423388 |
| RPS8 | ribosomal protein S8 | -0.0394581 |
| PTMA | prothymosin, alpha | -0.0376038 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0362082 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0358633 |
| RPS6 | ribosomal protein S6 | -0.0351259 |
| DIAPH3 | diaphanous-related formin 3 | -0.0350793 |
| RPS20 | ribosomal protein S20 | -0.0342471 |
| RPL38 | ribosomal protein L38 | -0.0331897 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0320689 |
| RPL9 | ribosomal protein L9 | -0.0312023 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0299684 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0298678 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0297599 |
| RPL34 | ribosomal protein L34 | -0.0290529 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0287947 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0286582 |
| RRBP1 | ribosome binding protein 1 | -0.0285967 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0283717 |
| COG5 | component of oligomeric golgi complex 5 | -0.0275952 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0265531 |
| RPS15 | ribosomal protein S15 | -0.0264261 |
| S100A6 | S100 calcium binding protein A6 | -0.0261988 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0259343 |
| RPS19 | ribosomal protein S19 | -0.0245286 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0244518 |
| RPL36 | ribosomal protein L36 | -0.0243248 |
| RPL5 | ribosomal protein L5 | -0.0240837 |
| RPS10 | ribosomal protein S10 | -0.0239136 |
| HMGB1 | high mobility group box 1 | -0.0235906 |
| DEK | DEK proto-oncogene | -0.0233064 |
| ZFR | zinc finger RNA binding protein | -0.0231264 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0230477 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0229018 |
| RPL28 | ribosomal protein L28 | -0.0228972 |
| RPS29 | ribosomal protein S29 | -0.0225341 |
| MORF4L2 | mortality factor 4 like 2 | -0.022491 |
| GPHN | gephyrin | -0.0221787 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | -0.0221699 |
| TXNRD1 | thioredoxin reductase 1 | -0.0214566 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0209195 |
| SCFD1 | sec1 family domain containing 1 | -0.0197944 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0196057 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.019401 |
| MTPN | myotrophin | -0.0193409 |
| RPLP0 | ribosomal protein, large, P0 | -0.01914 |
| RPS27A | ribosomal protein S27a | -0.0189446 |
| ATAD5 | ATPase family, AAA domain containing 5 | -0.0189315 |
| S100A2 | S100 calcium binding protein A2 | -0.018889 |
| FUS | FUS RNA binding protein | -0.0187674 |
| SGMS2 | sphingomyelin synthase 2 | -0.0187311 |
| RPL37A | ribosomal protein L37a | -0.0187065 |
| CENPF | centromere protein F, 350/400kDa | -0.0185276 |
| WDR45B | WD repeat domain 45B | -0.0184594 |
| ZNF267 | zinc finger protein 267 | -0.0184159 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0183065 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.018207 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.018146 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0180884 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0180293 |
| TMSB10 | thymosin beta 10 | -0.0179111 |
| RPL36A | ribosomal protein L36a | -0.0177862 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0177828 |
| RPS12 | ribosomal protein S12 | -0.0177622 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0177536 |
| RPL27 | ribosomal protein L27 | -0.0177296 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0176727 |
| SMYD3 | SET and MYND domain containing 3 | -0.0176596 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0175696 |
| GTF2B | general transcription factor IIB | -0.0175375 |
| RPS11 | ribosomal protein S11 | -0.017263 |
| SDCBP | syndecan binding protein (syntenin) | -0.0171855 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0170601 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.017059 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0168774 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0168676 |
| CDCP1 | CUB domain containing protein 1 | -0.0167815 |
| EZR | ezrin | -0.0166968 |
| S100A10 | S100 calcium binding protein A10 | -0.0166027 |
| NOP58 | NOP58 ribonucleoprotein | -0.0165469 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0165195 |
| ARF4 | ADP-ribosylation factor 4 | -0.0164918 |
| MT1X | metallothionein 1X | -0.016308 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0162649 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0162418 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0161132 |
| ATF4 | activating transcription factor 4 | -0.0160109 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -0.0159569 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.015905 |
