Imiquimod (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.208374
AKAP12 A kinase (PRKA) anchor protein 12 0.113332
LSAMP limbic system-associated membrane protein 0.111144
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106633
FNDC3B fibronectin type III domain containing 3B 0.0938237
FMNL2 formin-like 2 0.09077
EEF2 eukaryotic translation elongation factor 2 0.0840557
MSI2 musashi RNA-binding protein 2 0.0823973
RPL3 ribosomal protein L3 0.0667942
FLNA filamin A, alpha 0.0664108
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0647827
SREBF2 sterol regulatory element binding transcription factor 2 0.0616974
CADM1 cell adhesion molecule 1 0.0562055
CSDE1 cold shock domain containing E1, RNA-binding 0.0518176
RACK1 receptor for activated C kinase 1 0.0481667
SLC39A11 solute carrier family 39, member 11 0.0474889
SEPTIN9 septin 9 0.0459835
IGFBP3 insulin-like growth factor binding protein 3 0.0457634
VIM vimentin 0.0454854
BACE2 beta-site APP-cleaving enzyme 2 0.0450997
EHBP1 EH domain binding protein 1 0.0423599
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0420408
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0419246
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0407061
FHIT fragile histidine triad 0.0405924
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0393294
LDHA lactate dehydrogenase A 0.0392939
INPP5F inositol polyphosphate-5-phosphatase F 0.0375725
LOC112694756 uncharaterized LOC112694756 0.0373071
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0369413
DENND1A DENN/MADD domain containing 1A 0.036266
SFTPA2 surfactant protein A2 0.0350994
CXCL8 chemokine (C-X-C motif) ligand 8 0.0336079
DHFR dihydrofolate reductase 0.0331914
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.032849
LRMDA leucine rich melanocyte differentiation associated 0.0325226
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.032513
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0322685
CTBP2 C-terminal binding protein 2 0.0318546
ZMIZ1 zinc finger, MIZ-type containing 1 0.0317851
PRRC2B proline-rich coiled-coil 2B 0.0314954
SBF2 SET binding factor 2 0.0308995
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0308459
NOTCH2 notch 2 0.0308121
TNNC1 troponin C type 1 (slow) 0.0307586
UBE2O ubiquitin-conjugating enzyme E2O 0.0307561
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0306457
RAB7A RAB7A, member RAS oncogene family 0.0305868
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0305304
CDK6 cyclin-dependent kinase 6 0.0300561
PLEC plectin 0.0296108
MAML3 mastermind-like 3 (Drosophila) 0.029446
CA8 carbonic anhydrase VIII 0.0293795
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0288995
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0286324
HPCAL1 hippocalcin-like 1 0.0283867
HELZ helicase with zinc finger 0.0283828
SOD2 superoxide dismutase 2, mitochondrial 0.0283647
PRELID2 PRELI domain containing 2 0.0282036
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0281778
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0277856
PUM1 pumilio RNA-binding family member 1 0.027773
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276931
TRIM33 tripartite motif containing 33 0.0276536
TPI1 triosephosphate isomerase 1 0.0272018
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0270665
ENO2 enolase 2 (gamma, neuronal) 0.0268034
RAD51B RAD51 paralog B 0.0265632
DST dystonin 0.0260431
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0259919
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0259481
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.0258265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0256554
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0253121
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0252823
TPM3 tropomyosin 3 0.0248489
KDM5B lysine (K)-specific demethylase 5B 0.0244172
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0240892
NLGN1 neuroligin 1 0.0240596
RPL4 ribosomal protein L4 0.0238929
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0235075
ZCCHC7 zinc finger, CCHC domain containing 7 0.0232406
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0232178
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0231205
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0231098
NRG3 neuregulin 3 0.0228484
FAM13A family with sequence similarity 13, member A 0.0226962
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0226145
MKRN1 makorin ring finger protein 1 0.0226074
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0224746
VAT1 vesicle amine transport 1 0.0224711
NFE2L1 nuclear factor, erythroid 2-like 1 0.0224094
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0220586
ARHGAP5 Rho GTPase activating protein 5 0.0219826
TCF20 transcription factor 20 (AR1) 0.0219102
IL1RAP interleukin 1 receptor accessory protein 0.0218422
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0215751
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0214549
LPP LIM domain containing preferred translocation partner in lipoma 0.0213798
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0213697

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0921846
MT2A metallothionein 2A -0.0884683
RPS6 ribosomal protein S6 -0.0571332
TXNRD1 thioredoxin reductase 1 -0.0544935
CENPF centromere protein F, 350/400kDa -0.0540651
CD44 CD44 molecule (Indian blood group) -0.0528871
RPLP1 ribosomal protein, large, P1 -0.0489266
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0484118
SQSTM1 sequestosome 1 -0.040595
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0401366
FMN1 formin 1 -0.0394766
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0382344
ANKRD28 ankyrin repeat domain 28 -0.0364338
TM4SF1 transmembrane 4 L six family member 1 -0.0361833
RUNX1 runt-related transcription factor 1 -0.0361816
STAT1 signal transducer and activator of transcription 1, 91kDa -0.036093
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0355684
ALCAM activated leukocyte cell adhesion molecule -0.0346952
SPAG9 sperm associated antigen 9 -0.0346706
TENM1 teneurin transmembrane protein 1 -0.034606
TFPI2 tissue factor pathway inhibitor 2 -0.0342024
ICAM1 intercellular adhesion molecule 1 -0.0327622
RPL38 ribosomal protein L38 -0.0323174
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0318605
TPT1 tumor protein, translationally-controlled 1 -0.0307608
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0279721
RPLP2 ribosomal protein, large, P2 -0.0278568
RPS2 ribosomal protein S2 -0.0276673
MTPN myotrophin -0.0265796
CCND1 cyclin D1 -0.0263349
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0263317
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0248804
EXT1 exostosin glycosyltransferase 1 -0.0242776
KIF4A kinesin family member 4A -0.0228705
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0228224
YBX3 Y box binding protein 3 -0.0227764
WSB1 WD repeat and SOCS box containing 1 -0.022641
RPS8 ribosomal protein S8 -0.0224706
MAP4 microtubule-associated protein 4 -0.0220992
RPL32 ribosomal protein L32 -0.0215839
CENPE centromere protein E, 312kDa -0.0213407
ERBIN erbb2 interacting protein -0.0212409
ACTG1 actin gamma 1 -0.0212044
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0211525
IL6ST interleukin 6 signal transducer -0.020902
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0205834
RPL28 ribosomal protein L28 -0.0205451
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0200074
RPL9 ribosomal protein L9 -0.0199794
EXOC6B exocyst complex component 6B -0.0197257
TP63 tumor protein p63 -0.0193108
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0192988
B2M beta-2-microglobulin -0.0192956
ELL2 elongation factor, RNA polymerase II, 2 -0.0192747
ASPH aspartate beta-hydroxylase -0.0189568
ANXA2 annexin A2 -0.0187619
FRMD5 FERM domain containing 5 -0.0187229
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0180948
SMC4 structural maintenance of chromosomes 4 -0.0180815
PCNX4 pecanex 4 -0.0177585
RPS23 ribosomal protein S23 -0.0175974
MSN moesin -0.0175547
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0174337
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0173277
PLAUR plasminogen activator, urokinase receptor -0.0172611
SEPTIN7 septin 7 -0.0172344
TMSB10 thymosin beta 10 -0.0171481
CEP128 centrosomal protein 128kDa -0.0169739
MT1X metallothionein 1X -0.016912
GSTO1 glutathione S-transferase omega 1 -0.0169045
RPS15 ribosomal protein S15 -0.0168349
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0167014
RPS21 ribosomal protein S21 -0.0166458
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0163768
MKI67 marker of proliferation Ki-67 -0.01629
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.016288
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0162574
RPS5 ribosomal protein S5 -0.0161676
TUBB6 tubulin, beta 6 class V -0.0160771
SNX24 sorting nexin 24 -0.0159074
FBXL17 F-box and leucine-rich repeat protein 17 -0.0158422
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0157365
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0157242
FRMD4A FERM domain containing 4A -0.015673
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0156388
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0155439
SCAF11 SR-related CTD-associated factor 11 -0.0154616
FBXO32 F-box protein 32 -0.0153308
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0153196
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0152214
ANLN anillin, actin binding protein -0.0152206
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0149498
RPS16 ribosomal protein S16 -0.0149042
NKTR natural killer cell triggering receptor -0.0148389
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0147901
SAMD9 sterile alpha motif domain containing 9 -0.0147161
SCLT1 sodium channel and clathrin linker 1 -0.0147139
TPX2 TPX2, microtubule-associated -0.0146834
CELF1 CUGBP, Elav-like family member 1 -0.0146362
MED13 mediator complex subunit 13 -0.0146232