Imiquimod (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.155744
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.129294
RPL3 ribosomal protein L3 0.0860716
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0800797
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0751577
SSBP2 single-stranded DNA binding protein 2 0.0738081
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0710559
ECT2 epithelial cell transforming 2 0.0681601
PDE4B phosphodiesterase 4B, cAMP-specific 0.0673357
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0647056
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0612909
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0606537
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0545154
KMT2E lysine (K)-specific methyltransferase 2E 0.0496586
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0489606
ELOVL5 ELOVL fatty acid elongase 5 0.0482836
ENO2 enolase 2 (gamma, neuronal) 0.0472791
VCL vinculin 0.0471023
LPP LIM domain containing preferred translocation partner in lipoma 0.0462144
KDM3A lysine (K)-specific demethylase 3A 0.0451775
TXNIP thioredoxin interacting protein 0.0434175
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0433373
NUP58 nucleoporin 58 0.0429331
CALR calreticulin 0.0424928
HELZ helicase with zinc finger 0.0424606
ZNF292 zinc finger protein 292 0.0406038
TFG TRK-fused gene 0.0400367
NFIA nuclear factor I/A 0.0395486
PCBP2 poly(rC) binding protein 2 0.0389191
KIF5B kinesin family member 5B 0.0386292
RNF145 ring finger protein 145 0.0382537
EZR ezrin 0.0381554
DHFR dihydrofolate reductase 0.0381473
RBM39 RNA binding motif protein 39 0.0379017
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.03665
SMC3 structural maintenance of chromosomes 3 0.0358064
CPED1 cadherin-like and PC-esterase domain containing 1 0.0354098
SRRM2 serine/arginine repetitive matrix 2 0.0349459
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0347148
PER1 period circadian clock 1 0.034043
ZFC3H1 zinc finger, C3H1-type containing 0.0335225
DSCAM Down syndrome cell adhesion molecule 0.0324467
CDC73 cell division cycle 73 0.0319743
TPR translocated promoter region, nuclear basket protein 0.0319664
NAMPT nicotinamide phosphoribosyltransferase 0.0317172
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0310383
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0302582
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0297838
INSIG2 insulin induced gene 2 0.0293868
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0291083
CENPF centromere protein F, 350/400kDa 0.0288804
FAT1 FAT atypical cadherin 1 0.0288446
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0287969
UBA6 ubiquitin-like modifier activating enzyme 6 0.0286816
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0284831
FXR1 fragile X mental retardation, autosomal homolog 1 0.0284669
CD47 CD47 molecule 0.0283979
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0281921
WAC WW domain containing adaptor with coiled-coil 0.0281085
CTBP2 C-terminal binding protein 2 0.0278551
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0277829
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0275132
TPM4 tropomyosin 4 0.0275038
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0272897
QKI QKI, KH domain containing, RNA binding 0.0270245
PDIA6 protein disulfide isomerase family A, member 6 0.0269828
CASC3 cancer susceptibility candidate 3 0.0266452
GOLGA4 golgin A4 0.0265584
XPO1 exportin 1 0.0265073
FAM168A family with sequence similarity 168, member A 0.0265044
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0264789
TOP1 topoisomerase (DNA) I 0.0253107
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0249742
VMP1 vacuole membrane protein 1 0.0249093
MKI67 marker of proliferation Ki-67 0.0246442
KPNB1 karyopherin (importin) beta 1 0.0246069
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.024576
DDIT4 DNA-damage-inducible transcript 4 0.0245459
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0245304
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0244575
TGFBR3 transforming growth factor, beta receptor III 0.0240808
EVI5 ecotropic viral integration site 5 0.0237844
NCKAP1 NCK-associated protein 1 0.0235381
ATOSA atos homolog A 0.023388
ADAM9 ADAM metallopeptidase domain 9 0.0233699
ASXL1 additional sex combs like transcriptional regulator 1 0.023353
LOC112694756 uncharaterized LOC112694756 0.0233196
RBM25 RNA binding motif protein 25 0.0232409
PDIA3 protein disulfide isomerase family A, member 3 0.0231642
FAM13A family with sequence similarity 13, member A 0.0230992
PUM1 pumilio RNA-binding family member 1 0.0230916
CSNK1A1 casein kinase 1, alpha 1 0.0229502
NBAS neuroblastoma amplified sequence 0.0228804
HILPDA hypoxia inducible lipid droplet-associated 0.022824
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0228219
KMT2C lysine (K)-specific methyltransferase 2C 0.0225733
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0222699
DSTN destrin (actin depolymerizing factor) 0.0220363
CRY1 cryptochrome circadian clock 1 0.0219554
GLS2 glutaminase 2 (liver, mitochondrial) 0.0218388

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.181929
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162946
TPT1 tumor protein, translationally-controlled 1 -0.103619
RPS8 ribosomal protein S8 -0.0945213
RPS6 ribosomal protein S6 -0.0893676
TXNRD1 thioredoxin reductase 1 -0.0608131
RPL35A ribosomal protein L35a -0.0597332
RPL34 ribosomal protein L34 -0.0572671
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0566475
RPS2 ribosomal protein S2 -0.0549231
RPS12 ribosomal protein S12 -0.0529389
RPL26 ribosomal protein L26 -0.0527473
RPL9 ribosomal protein L9 -0.0513605
ACTG1 actin gamma 1 -0.050811
SLC38A2 solute carrier family 38, member 2 -0.0482845
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0464541
RPL12 ribosomal protein L12 -0.0457539
SQSTM1 sequestosome 1 -0.0449552
RPLP1 ribosomal protein, large, P1 -0.0448822
RPL19 ribosomal protein L19 -0.0409608
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0401983
TAS2R14 taste receptor, type 2, member 14 -0.0395682
RPS23 ribosomal protein S23 -0.0377214
RPL32 ribosomal protein L32 -0.03489
RPLP2 ribosomal protein, large, P2 -0.0336772
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0335774
RPL36 ribosomal protein L36 -0.0335097
RPS19 ribosomal protein S19 -0.033435
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0328914
S100A4 S100 calcium binding protein A4 -0.0315733
RPL31 ribosomal protein L31 -0.0307136
RPS16 ribosomal protein S16 -0.0306564
S100A6 S100 calcium binding protein A6 -0.0306519
BBS9 Bardet-Biedl syndrome 9 -0.0298599
S100A10 S100 calcium binding protein A10 -0.0297956
ARL4C ADP-ribosylation factor-like 4C -0.029283
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0289347
SMYD3 SET and MYND domain containing 3 -0.0288334
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0273908
TASOR2 transcription activation suppressor family member 2 -0.0267986
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0267548
RPS13 ribosomal protein S13 -0.0265463
RPL38 ribosomal protein L38 -0.0264673
RPL23 ribosomal protein L23 -0.0255789
RPS17 ribosomal protein S17 -0.0251665
TM4SF1 transmembrane 4 L six family member 1 -0.0251138
RPS29 ribosomal protein S29 -0.0249077
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0239314
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0237043
EGFR epidermal growth factor receptor -0.0230732
RPS27A ribosomal protein S27a -0.0227965
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0226625
GCLM glutamate-cysteine ligase, modifier subunit -0.0226293
B2M beta-2-microglobulin -0.0220643
JMJD1C jumonji domain containing 1C -0.0219543
EXT1 exostosin glycosyltransferase 1 -0.0215293
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0213969
TBC1D5 TBC1 domain family, member 5 -0.0212809
RPS3 ribosomal protein S3 -0.0211684
RAB27B RAB27B, member RAS oncogene family -0.0207994
MACROD2 MACRO domain containing 2 -0.0205135
RPS11 ribosomal protein S11 -0.0201554
OSMR oncostatin M receptor -0.0198562
RPS5 ribosomal protein S5 -0.0198061
RPS10 ribosomal protein S10 -0.0197747
HEG1 heart development protein with EGF-like domains 1 -0.0197255
FTL ferritin, light polypeptide -0.0196022
RPL11 ribosomal protein L11 -0.0194996
FER fer (fps/fes related) tyrosine kinase -0.0193957
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0193352
STXBP5 syntaxin binding protein 5 (tomosyn) -0.019187
RPS14 ribosomal protein S14 -0.0191407
ATP9B ATPase, class II, type 9B -0.0188798
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0188352
RPL36A ribosomal protein L36a -0.0185748
RPL28 ribosomal protein L28 -0.0185046
IFITM3 interferon induced transmembrane protein 3 -0.0182343
PYGB phosphorylase, glycogen; brain -0.018173
EIF1 eukaryotic translation initiation factor 1 -0.0181554
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.018009
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0179927
MIPOL1 mirror-image polydactyly 1 -0.0178988
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0178363
RPS27 ribosomal protein S27 -0.0177856
RTN4 reticulon 4 -0.0176321
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0174926
PTMA prothymosin, alpha -0.01747
AHI1 Abelson helper integration site 1 -0.0173893
RPS24 ribosomal protein S24 -0.0173739
RPL37A ribosomal protein L37a -0.0173111
RPLP0 ribosomal protein, large, P0 -0.0172316
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0171754
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0170451
FBXL17 F-box and leucine-rich repeat protein 17 -0.016733
SPIDR scaffolding protein involved in DNA repair -0.0167034
PARD3B par-3 family cell polarity regulator beta -0.0166311
CCND1 cyclin D1 -0.0164408
SPIRE1 spire-type actin nucleation factor 1 -0.0164081
ARB2A ARB2 cotranscriptional regulator A -0.0162716
LRRC7 leucine rich repeat containing 7 -0.0161924