Imiquimod (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0597165
SMOX spermine oxidase 0.0431279
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0382384
SMAD3 SMAD family member 3 0.0376995
EXT1 exostosin glycosyltransferase 1 0.0340213
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308469
MYH9 myosin, heavy chain 9, non-muscle 0.0306183
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0277859
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0271549
NAMPT nicotinamide phosphoribosyltransferase 0.0262773
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0253929
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0250507
MARCHF6 membrane associated ring-CH-type finger 6 0.0240987
CD109 CD109 molecule 0.0237524
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0231525
FLNA filamin A, alpha 0.0223333
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0220933
ELL2 elongation factor, RNA polymerase II, 2 0.0215993
ARRDC3 arrestin domain containing 3 0.0215941
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0213017
SUCO SUN domain containing ossification factor 0.0212069
CTNND1 catenin (cadherin-associated protein), delta 1 0.0207801
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0206405
DHFR dihydrofolate reductase 0.0206176
PELO pelota homolog (Drosophila) 0.0201649
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0200276
FAT1 FAT atypical cadherin 1 0.0198795
SEPTIN9 septin 9 0.0198494
KSR1 kinase suppressor of ras 1 0.019117
ETNK1 ethanolamine kinase 1 0.0188018
BIRC6 baculoviral IAP repeat containing 6 0.0186544
EPS8 epidermal growth factor receptor pathway substrate 8 0.0186029
TTC3 tetratricopeptide repeat domain 3 0.0185839
CTBP2 C-terminal binding protein 2 0.0177939
SOD2 superoxide dismutase 2, mitochondrial 0.0176897
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0176386
RPL3 ribosomal protein L3 0.0175196
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0174821
AHR aryl hydrocarbon receptor 0.0172089
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0171787
FOXO3 forkhead box O3 0.0171639
VCL vinculin 0.0171564
TPR translocated promoter region, nuclear basket protein 0.0171474
SEC23A Sec23 homolog A (S. cerevisiae) 0.0170386
SLTM SAFB-like, transcription modulator 0.0163548
CUL3 cullin 3 0.0162876
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0162343
KDM3A lysine (K)-specific demethylase 3A 0.0162251
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0160433
HMGB3 high mobility group box 3 0.0159674
HELZ helicase with zinc finger 0.0153732
ACADVL acyl-CoA dehydrogenase, very long chain 0.0151676
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0151158
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.015066
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0149828
RNF145 ring finger protein 145 0.0147558
CRLS1 cardiolipin synthase 1 0.0147185
PRPF39 pre-mRNA processing factor 39 0.0146814
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0146095
ADAM17 ADAM metallopeptidase domain 17 0.0144575
RAB8B RAB8B, member RAS oncogene family 0.0144366
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0143852
TENT2 terminal nucleotidyltransferase 2 0.0143178
IRAK3 interleukin-1 receptor-associated kinase 3 0.0142971
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0142694
AFDN afadin, adherens junction formation factor 0.0142561
OGA O-GlcNAcase 0.0141086
NUMA1 nuclear mitotic apparatus protein 1 0.0141058
HSPA8 heat shock 70kDa protein 8 0.0140224
FBXL5 F-box and leucine-rich repeat protein 5 0.0139639
CLOCK clock circadian regulator 0.0139461
ADD3 adducin 3 (gamma) 0.0138746
APLP2 amyloid beta (A4) precursor-like protein 2 0.0137985
TFG TRK-fused gene 0.0137819
NEK7 NIMA-related kinase 7 0.0135048
APP amyloid beta (A4) precursor protein 0.0134592
UBAP2L ubiquitin associated protein 2-like 0.0134295
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0132279
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0131796
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.013155
SERINC1 serine incorporator 1 0.0131405
ZFC3H1 zinc finger, C3H1-type containing 0.0131075
DOCK5 dedicator of cytokinesis 5 0.0130905
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.0129621
SHB Src homology 2 domain containing adaptor protein B 0.012915
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0128522
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0128206
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0126835
RAB18 RAB18, member RAS oncogene family 0.0126183
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0126065
SEC31A SEC31 homolog A (S. cerevisiae) 0.0125541
PICALM phosphatidylinositol binding clathrin assembly protein 0.0125528
RUNX2 runt-related transcription factor 2 0.0125423
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0124264
LCOR ligand dependent nuclear receptor corepressor 0.0123748
DENND4C DENN/MADD domain containing 4C 0.0123328
TMEM39A transmembrane protein 39A 0.0122833
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0122568
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0122198
TNIP1 TNFAIP3 interacting protein 1 0.0122138

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22963
NRG1 neuregulin 1 -0.193236
FN1 fibronectin 1 -0.147135
HMGA2 high mobility group AT-hook 2 -0.111027
MT2A metallothionein 2A -0.103293
ASPH aspartate beta-hydroxylase -0.0986153
PTMA prothymosin, alpha -0.0906947
TMSB10 thymosin beta 10 -0.0870323
VIM vimentin -0.0812932
FTL ferritin, light polypeptide -0.0808176
S100A6 S100 calcium binding protein A6 -0.0680533
HLA-B major histocompatibility complex, class I, B -0.0675625
RPS6 ribosomal protein S6 -0.0669479
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0664506
IFI27 interferon, alpha-inducible protein 27 -0.0569105
SYT1 synaptotagmin I -0.0539589
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0530439
RPL35A ribosomal protein L35a -0.0511582
TPT1 tumor protein, translationally-controlled 1 -0.0497517
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0493692
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.047769
RPL37A ribosomal protein L37a -0.0457656
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0443312
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0419376
RPLP1 ribosomal protein, large, P1 -0.0416585
RPL12 ribosomal protein L12 -0.0390774
RPS19 ribosomal protein S19 -0.0372168
ENO1 enolase 1, (alpha) -0.0363168
MAP1B microtubule-associated protein 1B -0.0361766
TMSB4X thymosin beta 4, X-linked -0.0354038
RPL9 ribosomal protein L9 -0.0352285
RPS12 ribosomal protein S12 -0.0349685
ACTG1 actin gamma 1 -0.0345277
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0337506
SOX4 SRY (sex determining region Y)-box 4 -0.0331234
RPS8 ribosomal protein S8 -0.0330564
S100A10 S100 calcium binding protein A10 -0.032952
RPL31 ribosomal protein L31 -0.032181
GLIS3 GLIS family zinc finger 3 -0.0319886
EFNA5 ephrin-A5 -0.0318427
RPL26 ribosomal protein L26 -0.0317961
RPL36 ribosomal protein L36 -0.0315466
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0308254
SQSTM1 sequestosome 1 -0.0305074
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0303936
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0293112
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0289264
LMNA lamin A/C -0.0288377
GNAS GNAS complex locus -0.0278791
RPL34 ribosomal protein L34 -0.0272884
RPS16 ribosomal protein S16 -0.0267815
GRB10 growth factor receptor-bound protein 10 -0.0265294
ETV1 ets variant 1 -0.0263443
RTN4 reticulon 4 -0.0262304
RPS27 ribosomal protein S27 -0.0261999
RPS21 ribosomal protein S21 -0.0261089
PDE4D phosphodiesterase 4D, cAMP-specific -0.0260982
PSD3 pleckstrin and Sec7 domain containing 3 -0.0257378
RPL23 ribosomal protein L23 -0.0255615
ZBTB20 zinc finger and BTB domain containing 20 -0.0254701
IER3 immediate early response 3 -0.02547
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0253753
IFI16 interferon, gamma-inducible protein 16 -0.0253371
POTEF POTE ankyrin domain family, member F -0.0252987
RPL37 ribosomal protein L37 -0.0250911
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0250078
ITGA1 integrin, alpha 1 -0.0247819
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0247701
B2M beta-2-microglobulin -0.0245774
RPL19 ribosomal protein L19 -0.0244679
SLC38A2 solute carrier family 38, member 2 -0.0244646
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0242445
LOC102724023 ES1 protein homolog, mitochondrial -0.0239409
TSC22D1 TSC22 domain family, member 1 -0.0237782
DNAH5 dynein, axonemal, heavy chain 5 -0.0237726
HMGA1 high mobility group AT-hook 1 -0.0237718
EIF5B eukaryotic translation initiation factor 5B -0.0237395
RPS24 ribosomal protein S24 -0.0236743
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0233179
S100A9 S100 calcium binding protein A9 -0.0231992
IFI6 interferon, alpha-inducible protein 6 -0.0226502
RPS27A ribosomal protein S27a -0.0217593
RNF213 ring finger protein 213 -0.0217266
RPLP0 ribosomal protein, large, P0 -0.0217173
HLA-A major histocompatibility complex, class I, A -0.0216743
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0215173
SLC35F3 solute carrier family 35, member F3 -0.0213683
RPS29 ribosomal protein S29 -0.0212633
DST dystonin -0.0211139
RPL28 ribosomal protein L28 -0.0210152
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0209787
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0208743
RPS20 ribosomal protein S20 -0.0206999
PFN1 profilin 1 -0.0206648
RANBP17 RAN binding protein 17 -0.0206637
KLHL5 kelch-like family member 5 -0.0204004
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0203472
NAP1L1 nucleosome assembly protein 1-like 1 -0.0199196
RPS5 ribosomal protein S5 -0.0198358
RPS3 ribosomal protein S3 -0.0196316