Imiquimod (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.0813975
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0756965
RPL3 ribosomal protein L3 0.0688666
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0601971
ITPRID2 ITPR interacting domain containing 2 0.059145
FAT1 FAT atypical cadherin 1 0.0587523
LMO7 LIM domain 7 0.0558621
LAMC2 laminin, gamma 2 0.0533414
PDE4B phosphodiesterase 4B, cAMP-specific 0.047565
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0461082
KMT2C lysine (K)-specific methyltransferase 2C 0.0387212
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0378705
NUP58 nucleoporin 58 0.0372622
HSPA8 heat shock 70kDa protein 8 0.0370133
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0358133
RNF43 ring finger protein 43 0.0356519
HILPDA hypoxia inducible lipid droplet-associated 0.035536
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0354352
TOP1 topoisomerase (DNA) I 0.0337009
AREG amphiregulin 0.0334883
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0322912
RUNX2 runt-related transcription factor 2 0.0315429
NCEH1 neutral cholesterol ester hydrolase 1 0.0314345
NDRG1 N-myc downstream regulated 1 0.0297165
KDM6A lysine (K)-specific demethylase 6A 0.0287393
DSCAM Down syndrome cell adhesion molecule 0.0286316
TSC22D2 TSC22 domain family, member 2 0.0281102
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0276002
FAR1 fatty acyl CoA reductase 1 0.0275632
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0270543
ANXA11 annexin A11 0.0263712
EPHA2 EPH receptor A2 0.0260831
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0258322
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0256475
EIF4A2 eukaryotic translation initiation factor 4A2 0.0255206
EREG epiregulin 0.0254303
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0246486
NCKAP1 NCK-associated protein 1 0.023299
WAC WW domain containing adaptor with coiled-coil 0.0231596
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.022194
TFG TRK-fused gene 0.0217675
EWSR1 EWS RNA-binding protein 1 0.0216031
ESRP1 epithelial splicing regulatory protein 1 0.021598
RANBP9 RAN binding protein 9 0.0215397
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0206417
DIAPH1 diaphanous-related formin 1 0.0204717
PFKP phosphofructokinase, platelet 0.0203052
PUM1 pumilio RNA-binding family member 1 0.0202471
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0201848
TM9SF3 transmembrane 9 superfamily member 3 0.0198017
SLMAP sarcolemma associated protein 0.0196505
SLTM SAFB-like, transcription modulator 0.0195946
RAB6A RAB6A, member RAS oncogene family 0.0195505
TXNIP thioredoxin interacting protein 0.0194683
BIRC3 baculoviral IAP repeat containing 3 0.0194258
ZMYM2 zinc finger, MYM-type 2 0.0193082
CCNL1 cyclin L1 0.0191567
FLNA filamin A, alpha 0.0189645
YTHDC1 YTH domain containing 1 0.0189336
EZR ezrin 0.0189
DSPP dentin sialophosphoprotein 0.0186616
COPA coatomer protein complex, subunit alpha 0.0186556
SPAG9 sperm associated antigen 9 0.0186518
LDHA lactate dehydrogenase A 0.0184554
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0183998
UBA6 ubiquitin-like modifier activating enzyme 6 0.0183882
RBM39 RNA binding motif protein 39 0.0182438
RNF145 ring finger protein 145 0.0182098
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0179383
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.017791
UBC ubiquitin C 0.0177895
MPZL3 myelin protein zero-like 3 0.0177777
RAB18 RAB18, member RAS oncogene family 0.01755
ZFAND3 zinc finger, AN1-type domain 3 0.0173972
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0173894
USP9X ubiquitin specific peptidase 9, X-linked 0.0172995
CLTC clathrin, heavy chain (Hc) 0.0171484
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0170724
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.016996
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0169944
GSK3B glycogen synthase kinase 3 beta 0.0169684
FXR1 fragile X mental retardation, autosomal homolog 1 0.0168472
EIF4B eukaryotic translation initiation factor 4B 0.0168336
CHD1 chromodomain helicase DNA binding protein 1 0.0165383
TFRC transferrin receptor 0.0164324
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0163985
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0162792
ANLN anillin, actin binding protein 0.0162094
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0161945
DDIT4 DNA-damage-inducible transcript 4 0.0161761
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0161626
CORO1C coronin, actin binding protein, 1C 0.0159086
ARRDC3 arrestin domain containing 3 0.015832
MATR3 matrin 3 0.0158171
CPOX coproporphyrinogen oxidase 0.0155967
ECT2 epithelial cell transforming 2 0.0155376
NPEPPS aminopeptidase puromycin sensitive 0.0154991
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0154716
INSIG2 insulin induced gene 2 0.0154543
AXIN2 axin 2 0.0153981

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0908137
RPS6 ribosomal protein S6 -0.0903166
TPT1 tumor protein, translationally-controlled 1 -0.0881699
HMGA2 high mobility group AT-hook 2 -0.0861017
TMSB10 thymosin beta 10 -0.0826113
RPL35A ribosomal protein L35a -0.0799759
ACTG1 actin gamma 1 -0.0756764
IER3 immediate early response 3 -0.0715189
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0677575
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0670649
RPLP1 ribosomal protein, large, P1 -0.0610222
RPS8 ribosomal protein S8 -0.0564555
RPL34 ribosomal protein L34 -0.050767
FHIT fragile histidine triad -0.0501305
RPS19 ribosomal protein S19 -0.0390629
CUX1 cut-like homeobox 1 -0.0384221
RPS24 ribosomal protein S24 -0.0382732
RAD51B RAD51 paralog B -0.0381015
RPL36 ribosomal protein L36 -0.0379494
RPS29 ribosomal protein S29 -0.0369706
RPL19 ribosomal protein L19 -0.036496
RPL5 ribosomal protein L5 -0.0355343
RPL26 ribosomal protein L26 -0.0350433
RPS25 ribosomal protein S25 -0.0349973
S100A6 S100 calcium binding protein A6 -0.0331807
EXOC4 exocyst complex component 4 -0.0328437
RPL12 ribosomal protein L12 -0.0308721
RPLP0 ribosomal protein, large, P0 -0.0307915
RPS3 ribosomal protein S3 -0.0307136
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.030481
EMP1 epithelial membrane protein 1 -0.0303285
RPL31 ribosomal protein L31 -0.0299267
RPL23 ribosomal protein L23 -0.0296677
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0293611
RPLP2 ribosomal protein, large, P2 -0.0292401
CCSER1 coiled-coil serine-rich protein 1 -0.0289435
S100A10 S100 calcium binding protein A10 -0.0284163
RPL35 ribosomal protein L35 -0.0278471
LAMA4 laminin, alpha 4 -0.0274856
GPHN gephyrin -0.027138
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0266833
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0263588
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.025315
RPS17 ribosomal protein S17 -0.0248548
RPS27A ribosomal protein S27a -0.0246227
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0242781
RCOR1 REST corepressor 1 -0.0242613
GPC5 glypican 5 -0.0241121
RPL37A ribosomal protein L37a -0.0240185
CDK13 cyclin-dependent kinase 13 -0.0239745
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0235904
RPL9 ribosomal protein L9 -0.0235023
RPS14 ribosomal protein S14 -0.0234121
EHBP1 EH domain binding protein 1 -0.023066
RPS15 ribosomal protein S15 -0.0228503
RPS16 ribosomal protein S16 -0.0227381
TAS2R14 taste receptor, type 2, member 14 -0.0221274
CMIP c-Maf inducing protein -0.021545
PHF14 PHD finger protein 14 -0.021332
RSL1D1 ribosomal L1 domain containing 1 -0.0210898
RPS28 ribosomal protein S28 -0.0208465
SKAP1 src kinase associated phosphoprotein 1 -0.0207636
SMYD3 SET and MYND domain containing 3 -0.0207306
RPL18 ribosomal protein L18 -0.0203285
RPS4X ribosomal protein S4, X-linked -0.0203056
RPS12 ribosomal protein S12 -0.0202929
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0202285
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0201921
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0200391
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0200387
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0200145
RPL11 ribosomal protein L11 -0.0197233
RPS21 ribosomal protein S21 -0.0197049
ANXA2 annexin A2 -0.0196649
RPL13A ribosomal protein L13a -0.0194574
TENM3 teneurin transmembrane protein 3 -0.0193711
RPS13 ribosomal protein S13 -0.0193701
HDAC2 histone deacetylase 2 -0.0192065
DIAPH2 diaphanous-related formin 2 -0.0191353
SERINC5 serine incorporator 5 -0.0190351
RPL28 ribosomal protein L28 -0.0185584
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0178738
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0178553
RPS23 ribosomal protein S23 -0.0178209
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0178185
EGR1 early growth response 1 -0.0177833
RPL38 ribosomal protein L38 -0.0176655
BPTF bromodomain PHD finger transcription factor -0.0176628
EIF5B eukaryotic translation initiation factor 5B -0.0175543
RPL7A ribosomal protein L7a -0.0175129
RPL32 ribosomal protein L32 -0.0173879
FAF1 Fas (TNFRSF6) associated factor 1 -0.0172182
RTN3 reticulon 3 -0.017033
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0168907
MAML3 mastermind-like 3 (Drosophila) -0.0167836
RABGAP1L RAB GTPase activating protein 1-like -0.0165211
BICD1 bicaudal D homolog 1 (Drosophila) -0.0163205
RPS5 ribosomal protein S5 -0.0162076
TBC1D5 TBC1 domain family, member 5 -0.0162033
FTL ferritin, light polypeptide -0.0160212