Imiquimod (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.27387
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.109739
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0701242
NAV2 neuron navigator 2 0.0679784
EEF2 eukaryotic translation elongation factor 2 0.0529407
PLEC plectin 0.0492122
DST dystonin 0.0490496
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0474272
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0424792
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0423245
AHNAK AHNAK nucleoprotein 0.0421725
HDAC4 histone deacetylase 4 0.0418102
PROX1 prospero homeobox 1 0.0391914
TNS3 tensin 3 0.038452
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0374192
SPATA13 spermatogenesis associated 13 0.0366669
MAML2 mastermind-like 2 (Drosophila) 0.0364361
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0345964
AOPEP aminopeptidase O (putative) 0.0337982
ITPRID2 ITPR interacting domain containing 2 0.0332135
RPL3 ribosomal protein L3 0.0326958
BCL2L1 BCL2-like 1 0.0326895
PDE4D phosphodiesterase 4D, cAMP-specific 0.0326598
ATXN1 ataxin 1 0.0319016
CDK6 cyclin-dependent kinase 6 0.030592
DSPP dentin sialophosphoprotein 0.0303406
MYH9 myosin, heavy chain 9, non-muscle 0.0301785
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0301056
RBM26 RNA binding motif protein 26 0.0289856
KRT18 keratin 18, type I 0.0284851
NCEH1 neutral cholesterol ester hydrolase 1 0.0282909
YAP1 Yes-associated protein 1 0.0282279
CEMIP cell migration inducing protein, hyaluronan binding 0.0279086
CDH13 cadherin 13 0.0270512
CD46 CD46 molecule, complement regulatory protein 0.026873
SMAD3 SMAD family member 3 0.0267271
MACF1 microtubule-actin crosslinking factor 1 0.0260648
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0259457
SYT1 synaptotagmin I 0.0251189
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0246095
JAG1 jagged 1 0.0245861
ACTN4 actinin, alpha 4 0.0239432
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0238826
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0237609
SEPTIN9 septin 9 0.0237268
ETNK1 ethanolamine kinase 1 0.0230184
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0228169
TMEM163 transmembrane protein 163 0.0225298
RPL4 ribosomal protein L4 0.0224762
AFDN afadin, adherens junction formation factor 0.0224737
ARHGAP9 Rho GTPase activating protein 9 0.02228
CAPRIN1 cell cycle associated protein 1 0.0220227
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0218666
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0215907
VCL vinculin 0.0215748
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0213253
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0209899
OSBPL3 oxysterol binding protein-like 3 0.0209744
USP9X ubiquitin specific peptidase 9, X-linked 0.0208707
ITGA6 integrin, alpha 6 0.0205254
TRIP12 thyroid hormone receptor interactor 12 0.0200878
NPAS2 neuronal PAS domain protein 2 0.0198429
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0197481
SFPQ splicing factor proline/glutamine-rich 0.019729
FRMD5 FERM domain containing 5 0.0193559
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0192139
MED13 mediator complex subunit 13 0.0190505
ACTN1 actinin, alpha 1 0.0189786
FNDC3A fibronectin type III domain containing 3A 0.0186909
SRRM2 serine/arginine repetitive matrix 2 0.0186783
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0184809
FLNA filamin A, alpha 0.0184678
NCKAP1 NCK-associated protein 1 0.018323
KDM7A lysine (K)-specific demethylase 7A 0.0183132
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.018221
LMO7 LIM domain 7 0.0181705
ABHD2 abhydrolase domain containing 2 0.0181082
MSI2 musashi RNA-binding protein 2 0.0180496
LPP LIM domain containing preferred translocation partner in lipoma 0.0178578
CTNND1 catenin (cadherin-associated protein), delta 1 0.0176697
MARCHF6 membrane associated ring-CH-type finger 6 0.0173682
ANKRD10 ankyrin repeat domain 10 0.0173312
AFAP1L2 actin filament associated protein 1-like 2 0.0173274
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0172853
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0171816
NONO non-POU domain containing, octamer-binding 0.017164
HDAC8 histone deacetylase 8 0.0171239
ZMYM2 zinc finger, MYM-type 2 0.017078
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0166937
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.016608
WNK1 WNK lysine deficient protein kinase 1 0.0165065
APP amyloid beta (A4) precursor protein 0.0163946
STK24 serine/threonine kinase 24 0.016366
HSPA8 heat shock 70kDa protein 8 0.0162029
TMEM123 transmembrane protein 123 0.0161
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0160524
ASPH aspartate beta-hydroxylase 0.0159584
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.0158557
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0158194
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0157872

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.108057
EZR ezrin -0.0683791
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0606272
RPS6 ribosomal protein S6 -0.0560912
TPT1 tumor protein, translationally-controlled 1 -0.0535749
TMSB10 thymosin beta 10 -0.0514213
RPL35A ribosomal protein L35a -0.0502266
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0458998
RPLP1 ribosomal protein, large, P1 -0.0451036
EMP1 epithelial membrane protein 1 -0.0414699
RPS8 ribosomal protein S8 -0.0412996
RPS19 ribosomal protein S19 -0.041236
PTMA prothymosin, alpha -0.0380267
RPL37A ribosomal protein L37a -0.0376398
GOLGA4 golgin A4 -0.0360977
VIM vimentin -0.0347635
ANXA2 annexin A2 -0.0342137
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0338781
RPS12 ribosomal protein S12 -0.0321242
RPS3 ribosomal protein S3 -0.0318359
RPL26 ribosomal protein L26 -0.0309927
MORF4L2 mortality factor 4 like 2 -0.0305777
SMC4 structural maintenance of chromosomes 4 -0.0300755
FTL ferritin, light polypeptide -0.0293237
RPL28 ribosomal protein L28 -0.0285936
MT2A metallothionein 2A -0.0279096
ACTG1 actin gamma 1 -0.0272827
DDIT4 DNA-damage-inducible transcript 4 -0.0268471
NDRG1 N-myc downstream regulated 1 -0.0266301
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0264335
RPL31 ribosomal protein L31 -0.025775
RPL23 ribosomal protein L23 -0.0255318
AKAP9 A kinase (PRKA) anchor protein 9 -0.0250931
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0249147
KMT2E lysine (K)-specific methyltransferase 2E -0.0245502
RPS25 ribosomal protein S25 -0.0241918
RPLP2 ribosomal protein, large, P2 -0.0241443
RPL5 ribosomal protein L5 -0.0239606
RPS16 ribosomal protein S16 -0.0233953
RPL12 ribosomal protein L12 -0.0231551
ARF4 ADP-ribosylation factor 4 -0.0230097
GNAS GNAS complex locus -0.0229991
S100A10 S100 calcium binding protein A10 -0.0229285
RPL9 ribosomal protein L9 -0.02274
RPL34 ribosomal protein L34 -0.0217866
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0216262
RPS17 ribosomal protein S17 -0.0208689
HMGB1 high mobility group box 1 -0.0208059
RPL19 ribosomal protein L19 -0.0201859
RPL36 ribosomal protein L36 -0.0198327
RPS29 ribosomal protein S29 -0.0196912
RPS21 ribosomal protein S21 -0.0196084
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0194055
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0186729
PFN1 profilin 1 -0.0184925
EIF1 eukaryotic translation initiation factor 1 -0.0182886
JUN jun proto-oncogene -0.0181695
RPS20 ribosomal protein S20 -0.0178313
RPLP0 ribosomal protein, large, P0 -0.017693
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0176658
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0175418
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0172175
RPL35 ribosomal protein L35 -0.0171844
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0168848
MYADM myeloid-associated differentiation marker -0.016694
RPS14 ribosomal protein S14 -0.0158586
RPL27A ribosomal protein L27a -0.0157617
BLZF1 basic leucine zipper nuclear factor 1 -0.0155959
DDIT3 DNA-damage-inducible transcript 3 -0.015592
SVIL supervillin -0.0155378
RAB1A RAB1A, member RAS oncogene family -0.0155164
RPS13 ribosomal protein S13 -0.0155066
RPS23 ribosomal protein S23 -0.0154337
SEC31A SEC31 homolog A (S. cerevisiae) -0.0154196
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.015247
EIF5B eukaryotic translation initiation factor 5B -0.015176
IER3 immediate early response 3 -0.0151681
RPS10 ribosomal protein S10 -0.0149725
SQSTM1 sequestosome 1 -0.0149416
RPS5 ribosomal protein S5 -0.014743
DLG1 discs, large homolog 1 (Drosophila) -0.0146122
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0146002
LMNA lamin A/C -0.0145757
KPNB1 karyopherin (importin) beta 1 -0.0143517
IGBP1 immunoglobulin (CD79A) binding protein 1 -0.0141666
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0140932
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.0140359
RPL7A ribosomal protein L7a -0.0140269
FOSL1 FOS-like antigen 1 -0.0140226
NAP1L1 nucleosome assembly protein 1-like 1 -0.0140077
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0138826
RAB7A RAB7A, member RAS oncogene family -0.0135956
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0135158
HMGA1 high mobility group AT-hook 1 -0.0132293
TRA2A transformer 2 alpha homolog (Drosophila) -0.0132124
UGCG UDP-glucose ceramide glucosyltransferase -0.0131824
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.01307
SRP54 signal recognition particle 54kDa -0.0129252
ZNF207 zinc finger protein 207 -0.0127345
ACBD3 acyl-CoA binding domain containing 3 -0.0127025