Imiquimod (maleate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0831322
NRIP1 nuclear receptor interacting protein 1 0.0826702
CSF1 colony stimulating factor 1 (macrophage) 0.075904
CXCL8 chemokine (C-X-C motif) ligand 8 0.0669266
GLS2 glutaminase 2 (liver, mitochondrial) 0.0615983
NRP2 neuropilin 2 0.054305
MYH9 myosin, heavy chain 9, non-muscle 0.0522132
FNDC3B fibronectin type III domain containing 3B 0.0513539
SMAD3 SMAD family member 3 0.0502952
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0486441
WAC WW domain containing adaptor with coiled-coil 0.0450896
ANKRD33B ankyrin repeat domain 33B 0.0443219
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0419309
RUNX1 runt-related transcription factor 1 0.0407574
SPTBN1 spectrin, beta, non-erythrocytic 1 0.040421
ATP13A3 ATPase type 13A3 0.0399669
DENND2B DENN domain containing 2B 0.0388534
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0384124
OSBPL3 oxysterol binding protein-like 3 0.0384046
CADM1 cell adhesion molecule 1 0.0383399
ZFAND3 zinc finger, AN1-type domain 3 0.0383088
ZFP36L1 ZFP36 ring finger protein-like 1 0.038231
UGCG UDP-glucose ceramide glucosyltransferase 0.0378507
SP3 Sp3 transcription factor 0.0372625
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0371452
EML4 echinoderm microtubule associated protein like 4 0.0368467
RIPK2 receptor-interacting serine-threonine kinase 2 0.0360669
NAMPT nicotinamide phosphoribosyltransferase 0.0356794
ANLN anillin, actin binding protein 0.0354619
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0352127
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0351818
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0346089
SBF2 SET binding factor 2 0.0342128
RTN4 reticulon 4 0.0341459
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0340501
ADAM17 ADAM metallopeptidase domain 17 0.0330642
TFG TRK-fused gene 0.0329753
TRIO trio Rho guanine nucleotide exchange factor 0.0322729
PTBP3 polypyrimidine tract binding protein 3 0.0317807
USP3 ubiquitin specific peptidase 3 0.031574
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0307535
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0306524
NAV2 neuron navigator 2 0.0304868
ADAM9 ADAM metallopeptidase domain 9 0.030207
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0292849
MSN moesin 0.0292791
EPS8 epidermal growth factor receptor pathway substrate 8 0.0287375
P3H2 prolyl 3-hydroxylase 2 0.0284728
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0283731
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0282947
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0282931
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0279464
RHEB Ras homolog enriched in brain 0.0278128
MARCHF6 membrane associated ring-CH-type finger 6 0.0277673
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0276261
ARHGAP26 Rho GTPase activating protein 26 0.0275522
SUCO SUN domain containing ossification factor 0.0272427
ANKRD10 ankyrin repeat domain 10 0.0272049
CKAP5 cytoskeleton associated protein 5 0.0268304
ITCH itchy E3 ubiquitin protein ligase 0.0268217
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0267975
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0266674
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0264075
XPO1 exportin 1 0.0263702
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0261503
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0259409
KDM6A lysine (K)-specific demethylase 6A 0.0256004
RAB8B RAB8B, member RAS oncogene family 0.0249464
ARRDC3 arrestin domain containing 3 0.0248276
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0246664
PTK2 protein tyrosine kinase 2 0.0245207
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0242313
AKAP13 A kinase (PRKA) anchor protein 13 0.0240993
NFE2L2 nuclear factor, erythroid 2-like 2 0.0240718
BHLHE40 basic helix-loop-helix family, member e40 0.0238109
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0236846
COG5 component of oligomeric golgi complex 5 0.0236819
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0236617
RNF145 ring finger protein 145 0.0236102
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0233364
USP12 ubiquitin specific peptidase 12 0.0233235
ACO1 aconitase 1, soluble 0.023
LYN LYN proto-oncogene, Src family tyrosine kinase 0.02286
NPEPPS aminopeptidase puromycin sensitive 0.0228036
UBA6 ubiquitin-like modifier activating enzyme 6 0.0227857
TNIP1 TNFAIP3 interacting protein 1 0.0227476
NCKAP1 NCK-associated protein 1 0.0225224
TPM3 tropomyosin 3 0.0224825
AVL9 AVL9 homolog (S. cerevisiase) 0.0224327
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0223999
ANKRD17 ankyrin repeat domain 17 0.0222763
MYO10 myosin X 0.0220673
MBNL1 muscleblind-like splicing regulator 1 0.022056
PLPP3 phospholipid phosphatase 3 0.0219679
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0217882
GRID1 glutamate receptor, ionotropic, delta 1 0.0217354
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.021731
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.021689
JAK1 Janus kinase 1 0.0215629
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0215227

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.205824
FRMD4A FERM domain containing 4A -0.194587
VIM vimentin -0.136387
TMSB10 thymosin beta 10 -0.12784
FTL ferritin, light polypeptide -0.115236
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0963101
ASPH aspartate beta-hydroxylase -0.0909233
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.085152
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0753807
HLA-B major histocompatibility complex, class I, B -0.0710138
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0605901
CP ceruloplasmin (ferroxidase) -0.0585228
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.058213
RPS6 ribosomal protein S6 -0.057148
RPS8 ribosomal protein S8 -0.0545547
RNF213 ring finger protein 213 -0.0504855
RIGI RNA sensor RIG-I -0.0464255
RPL35A ribosomal protein L35a -0.0461434
B2M beta-2-microglobulin -0.0455163
HSPB1 heat shock 27kDa protein 1 -0.0446386
CALR calreticulin -0.0431583
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0428752
TPT1 tumor protein, translationally-controlled 1 -0.0427947
GLIS3 GLIS family zinc finger 3 -0.0422957
NDRG1 N-myc downstream regulated 1 -0.0415007
RPL23 ribosomal protein L23 -0.0401869
RPLP2 ribosomal protein, large, P2 -0.0392582
INTS6 integrator complex subunit 6 -0.0382979
ZBTB20 zinc finger and BTB domain containing 20 -0.0382887
RPL26 ribosomal protein L26 -0.0370158
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0356761
EIF1 eukaryotic translation initiation factor 1 -0.0350856
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0345398
CTSD cathepsin D -0.0344379
RPL31 ribosomal protein L31 -0.0343101
RPS19 ribosomal protein S19 -0.0337991
RPL37A ribosomal protein L37a -0.0337985
SP100 SP100 nuclear antigen -0.0334508
HLA-C major histocompatibility complex, class I, C -0.03335
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0333443
TSHZ2 teashirt zinc finger homeobox 2 -0.0332191
ACTG1 actin gamma 1 -0.0328588
EHBP1 EH domain binding protein 1 -0.0325774
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0321786
LMNA lamin A/C -0.0317812
MT2A metallothionein 2A -0.0312719
POTEF POTE ankyrin domain family, member F -0.0311859
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0311696
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0311655
IFI44L interferon-induced protein 44-like -0.0310366
RRBP1 ribosome binding protein 1 -0.0306845
RPL28 ribosomal protein L28 -0.0306744
CA12 carbonic anhydrase XII -0.0303495
RPS27A ribosomal protein S27a -0.0302201
PFN1 profilin 1 -0.0299702
HM13 histocompatibility (minor) 13 -0.0294715
RPS13 ribosomal protein S13 -0.0289806
PDIA3 protein disulfide isomerase family A, member 3 -0.0281958
RPL34 ribosomal protein L34 -0.0281763
RPL8 ribosomal protein L8 -0.0281653
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0280559
APOL1 apolipoprotein L, 1 -0.0276939
CD44 CD44 molecule (Indian blood group) -0.0273663
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0273619
RPS24 ribosomal protein S24 -0.0273358
IFI16 interferon, gamma-inducible protein 16 -0.0273251
CUX1 cut-like homeobox 1 -0.0272616
RPS21 ribosomal protein S21 -0.0269828
TBCA tubulin folding cofactor A -0.0266923
S100A11 S100 calcium binding protein A11 -0.0266189
RPS17 ribosomal protein S17 -0.0265778
BICD1 bicaudal D homolog 1 (Drosophila) -0.0265124
RPL38 ribosomal protein L38 -0.026341
HLA-A major histocompatibility complex, class I, A -0.0263155
S100A6 S100 calcium binding protein A6 -0.0260501
ARL4C ADP-ribosylation factor-like 4C -0.0255377
RPL19 ribosomal protein L19 -0.0253285
MAP1B microtubule-associated protein 1B -0.0250524
EXOC4 exocyst complex component 4 -0.025014
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0245574
UBAP2 ubiquitin associated protein 2 -0.0245185
IFITM3 interferon induced transmembrane protein 3 -0.0244541
MRPS6 mitochondrial ribosomal protein S6 -0.0243219
RPL37 ribosomal protein L37 -0.0241413
IFIH1 interferon induced with helicase C domain 1 -0.0241192
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0239942
TIMP2 TIMP metallopeptidase inhibitor 2 -0.023994
PTH2R parathyroid hormone 2 receptor -0.0236626
RPLP1 ribosomal protein, large, P1 -0.0233262
MTDH metadherin -0.0230341
GOLGB1 golgin B1 -0.022907
CANX calnexin -0.0228874
IARS1 isoleucyl-tRNA synthetase 1 -0.0228729
DGKI diacylglycerol kinase, iota -0.0222887
KYNU kynureninase -0.0219094
RPL9 ribosomal protein L9 -0.0218731
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0218162
TPM1 tropomyosin 1 (alpha) -0.0217957
RPL7A ribosomal protein L7a -0.0217696
SPDYA speedy/RINGO cell cycle regulator family member A -0.021708