Imiquimod (maleate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.0761212
ARHGAP26 Rho GTPase activating protein 26 0.0715555
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0657493
NRIP1 nuclear receptor interacting protein 1 0.05727
DGKD diacylglycerol kinase, delta 130kDa 0.0509783
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0505709
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0501022
FNDC3B fibronectin type III domain containing 3B 0.0470925
NAMPT nicotinamide phosphoribosyltransferase 0.0461048
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0429714
TRIO trio Rho guanine nucleotide exchange factor 0.0411782
HELZ helicase with zinc finger 0.0395199
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0372707
FGD6 FYVE, RhoGEF and PH domain containing 6 0.036299
RPL4 ribosomal protein L4 0.035453
ECT2 epithelial cell transforming 2 0.0326996
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0322509
AGFG1 ArfGAP with FG repeats 1 0.0320145
KYNU kynureninase 0.0315168
STAT1 signal transducer and activator of transcription 1, 91kDa 0.031455
NAV2 neuron navigator 2 0.0314253
SPAG9 sperm associated antigen 9 0.0305
RASA2 RAS p21 protein activator 2 0.0304607
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0304041
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.027448
ARL5B ADP-ribosylation factor-like 5B 0.0270935
DSCAM Down syndrome cell adhesion molecule 0.0269907
TXNRD1 thioredoxin reductase 1 0.0257087
SBF2 SET binding factor 2 0.0254337
RB1CC1 RB1-inducible coiled-coil 1 0.0250008
CA8 carbonic anhydrase VIII 0.0245018
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0244931
RNF145 ring finger protein 145 0.0241523
VEZT vezatin, adherens junctions transmembrane protein 0.0239233
ADAM17 ADAM metallopeptidase domain 17 0.0238746
USP3 ubiquitin specific peptidase 3 0.0236505
TNIP1 TNFAIP3 interacting protein 1 0.0235075
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0234498
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0230427
BIRC2 baculoviral IAP repeat containing 2 0.0229622
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0226428
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0217373
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0216969
TFG TRK-fused gene 0.02158
OGA O-GlcNAcase 0.021408
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0209616
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0208842
JAK1 Janus kinase 1 0.0207937
EREG epiregulin 0.0207708
BIRC6 baculoviral IAP repeat containing 6 0.0207209
NUP58 nucleoporin 58 0.0202249
PGK1 phosphoglycerate kinase 1 0.0190983
HSPA8 heat shock 70kDa protein 8 0.0189067
DMXL2 Dmx-like 2 0.0188993
NCKAP1 NCK-associated protein 1 0.0188495
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.018815
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0188149
ZNF292 zinc finger protein 292 0.0185681
SP3 Sp3 transcription factor 0.0184995
MYH9 myosin, heavy chain 9, non-muscle 0.018368
GLS2 glutaminase 2 (liver, mitochondrial) 0.0179632
OLA1 Obg-like ATPase 1 0.0179265
PRELID2 PRELI domain containing 2 0.0175929
GPRIN3 GPRIN family member 3 0.0174185
USP9X ubiquitin specific peptidase 9, X-linked 0.0173356
TENT4A terminal nucleotidyltransferase 4A 0.0171453
PUM2 pumilio RNA-binding family member 2 0.0170627
BMAL2 basic helix-loop-helix ARNT like 2 0.0169284
FAR1 fatty acyl CoA reductase 1 0.016847
ARHGAP5 Rho GTPase activating protein 5 0.0167766
GPC6 glypican 6 0.0165908
ANLN anillin, actin binding protein 0.0164673
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0164564
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0164075
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0163345
RTN4 reticulon 4 0.0162389
ZFAND6 zinc finger, AN1-type domain 6 0.0159318
ATP13A3 ATPase type 13A3 0.0159298
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0158959
CKAP5 cytoskeleton associated protein 5 0.0158468
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0156112
ADAM9 ADAM metallopeptidase domain 9 0.0155208
RUNX1 runt-related transcription factor 1 0.0154431
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.015383
UBA6 ubiquitin-like modifier activating enzyme 6 0.0152471
RARB retinoic acid receptor, beta 0.0149049
ZMYM2 zinc finger, MYM-type 2 0.014746
PDE8A phosphodiesterase 8A 0.0146633
TDRD7 tudor domain containing 7 0.0145733
CEP95 centrosomal protein 95kDa 0.0145024
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0144623
AFDN afadin, adherens junction formation factor 0.0142974
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.014207
CDC27 cell division cycle 27 0.0142034
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0141561
EML4 echinoderm microtubule associated protein like 4 0.0139979
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0139167
TOP2B topoisomerase (DNA) II beta 180kDa 0.0139038
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0138334
ANKRD33B ankyrin repeat domain 33B 0.0138267

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.283936
TMSB10 thymosin beta 10 -0.257777
VIM vimentin -0.196733
NDRG1 N-myc downstream regulated 1 -0.192892
AKAP12 A kinase (PRKA) anchor protein 12 -0.154301
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144324
PDE4D phosphodiesterase 4D, cAMP-specific -0.120635
FTH1 ferritin, heavy polypeptide 1 -0.111499
RPS6 ribosomal protein S6 -0.109248
ACTG1 actin gamma 1 -0.107754
IGFBP4 insulin-like growth factor binding protein 4 -0.102315
RPS19 ribosomal protein S19 -0.100872
CA12 carbonic anhydrase XII -0.081167
EFNA5 ephrin-A5 -0.0753504
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0745488
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0737684
S100A6 S100 calcium binding protein A6 -0.0712164
POTEF POTE ankyrin domain family, member F -0.068809
EGFR epidermal growth factor receptor -0.0666564
BASP1 brain abundant, membrane attached signal protein 1 -0.0640436
RPLP1 ribosomal protein, large, P1 -0.0616523
EIF1 eukaryotic translation initiation factor 1 -0.0600551
MT2A metallothionein 2A -0.0597381
FTL ferritin, light polypeptide -0.0572741
PKM pyruvate kinase, muscle -0.0539742
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0534312
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0512188
THSD4 thrombospondin, type I, domain containing 4 -0.0511644
GRB10 growth factor receptor-bound protein 10 -0.0490863
PFN1 profilin 1 -0.0476094
RPS16 ribosomal protein S16 -0.0475659
DOCK5 dedicator of cytokinesis 5 -0.0464013
TPM4 tropomyosin 4 -0.0456078
KRT81 keratin 81, type II -0.0454281
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0453922
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0439647
RPL23 ribosomal protein L23 -0.0439481
RNF213 ring finger protein 213 -0.0435271
EGR1 early growth response 1 -0.0433071
CCDC88A coiled-coil domain containing 88A -0.0417149
MYO1E myosin IE -0.040841
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0408086
ANXA2 annexin A2 -0.0406082
ANXA4 annexin A4 -0.0405824
RPL35A ribosomal protein L35a -0.0405435
TPT1 tumor protein, translationally-controlled 1 -0.0404333
MYADM myeloid-associated differentiation marker -0.0403139
S100A10 S100 calcium binding protein A10 -0.0402691
ALCAM activated leukocyte cell adhesion molecule -0.0401441
HMGA1 high mobility group AT-hook 1 -0.0401189
PRKCA protein kinase C, alpha -0.0399458
BTG1 B-cell translocation gene 1, anti-proliferative -0.0397991
IGFBP1 insulin-like growth factor binding protein 1 -0.0393816
ZBTB20 zinc finger and BTB domain containing 20 -0.0389556
PTMA prothymosin, alpha -0.0372781
EHBP1 EH domain binding protein 1 -0.0372454
RPS13 ribosomal protein S13 -0.0372285
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0365932
MCL1 myeloid cell leukemia 1 -0.0354892
MT1X metallothionein 1X -0.035369
RPS8 ribosomal protein S8 -0.0351584
HMGA2 high mobility group AT-hook 2 -0.0344705
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0343341
LMNA lamin A/C -0.0343335
LIMCH1 LIM and calponin homology domains 1 -0.0336651
MAML3 mastermind-like 3 (Drosophila) -0.0336258
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0333976
FLNB filamin B, beta -0.0333551
IFI6 interferon, alpha-inducible protein 6 -0.0328726
RPS11 ribosomal protein S11 -0.0328534
LDHA lactate dehydrogenase A -0.0325227
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0316099
RPL31 ribosomal protein L31 -0.0313752
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0310955
RPL12 ribosomal protein L12 -0.0308424
RPL28 ribosomal protein L28 -0.0307906
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.030296
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0300432
HLA-B major histocompatibility complex, class I, B -0.0298159
IGF1R insulin-like growth factor 1 receptor -0.0297775
ADM adrenomedullin -0.0296636
FBXO11 F-box protein 11 -0.029426
RPS14 ribosomal protein S14 -0.0293626
RPL26 ribosomal protein L26 -0.0285276
B2M beta-2-microglobulin -0.0283796
RPL8 ribosomal protein L8 -0.0283222
ZMYND8 zinc finger, MYND-type containing 8 -0.0280961
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0279551
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0278307
RPL37A ribosomal protein L37a -0.0274149
RPLP2 ribosomal protein, large, P2 -0.0273948
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0272608
RPL19 ribosomal protein L19 -0.0264804
TNS3 tensin 3 -0.0263112
PYGL phosphorylase, glycogen, liver -0.0258592
LAMA5 laminin, alpha 5 -0.025785
RPS3 ribosomal protein S3 -0.0256896
CNRIP1 cannabinoid receptor interacting protein 1 -0.025312
SLC38A1 solute carrier family 38, member 1 -0.0253027
ZFHX3 zinc finger homeobox 3 -0.0252602