Imiquimod (maleate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
QKI QKI, KH domain containing, RNA binding 0.0750413
ZFAND3 zinc finger, AN1-type domain 3 0.0681361
ZNF292 zinc finger protein 292 0.0559618
ZEB1 zinc finger E-box binding homeobox 1 0.055329
USP3 ubiquitin specific peptidase 3 0.0539747
RLF rearranged L-myc fusion 0.0513857
SBF2 SET binding factor 2 0.0482376
MED13L mediator complex subunit 13-like 0.0468645
NAMPT nicotinamide phosphoribosyltransferase 0.0458452
KDM6A lysine (K)-specific demethylase 6A 0.0438804
PICALM phosphatidylinositol binding clathrin assembly protein 0.0418611
KMT2E lysine (K)-specific methyltransferase 2E 0.041088
TSC22D2 TSC22 domain family, member 2 0.039887
ANKRD11 ankyrin repeat domain 11 0.0392744
PELI1 pellino E3 ubiquitin protein ligase 1 0.0387763
ZMYM2 zinc finger, MYM-type 2 0.0365638
PIAS1 protein inhibitor of activated STAT, 1 0.0354081
MARCHF6 membrane associated ring-CH-type finger 6 0.0348124
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0346737
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0345825
GLS2 glutaminase 2 (liver, mitochondrial) 0.0342006
CSNK1G3 casein kinase 1, gamma 3 0.0325527
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0324991
KMT2C lysine (K)-specific methyltransferase 2C 0.0323479
ZNF148 zinc finger protein 148 0.0314596
RFX7 regulatory factor X, 7 0.031004
RB1CC1 RB1-inducible coiled-coil 1 0.0308783
OGA O-GlcNAcase 0.0305114
RNF145 ring finger protein 145 0.030192
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0298985
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0298208
RPL3 ribosomal protein L3 0.0295817
PIAS2 protein inhibitor of activated STAT, 2 0.0293506
ANKRD12 ankyrin repeat domain 12 0.0291441
MEF2A myocyte enhancer factor 2A 0.0291221
JMJD1C jumonji domain containing 1C 0.0289422
FER fer (fps/fes related) tyrosine kinase 0.0288108
HBS1L HBS1-like translational GTPase 0.0287504
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0286643
ZNF451 zinc finger protein 451 0.0278559
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0273036
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0272981
GSK3B glycogen synthase kinase 3 beta 0.026959
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0269098
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0268375
RBM33 RNA binding motif protein 33 0.0267599
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0260427
ZFAND6 zinc finger, AN1-type domain 6 0.0258998
CDC73 cell division cycle 73 0.0256232
CKAP5 cytoskeleton associated protein 5 0.0255712
RNMT RNA (guanine-7-) methyltransferase 0.0253614
TM9SF3 transmembrane 9 superfamily member 3 0.0253086
KDM2A lysine (K)-specific demethylase 2A 0.0252199
YME1L1 YME1-like 1 ATPase 0.025176
KDM4C lysine (K)-specific demethylase 4C 0.0250709
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0249792
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.02476
WDFY3 WD repeat and FYVE domain containing 3 0.024409
NBAS neuroblastoma amplified sequence 0.024403
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0243016
NPTN neuroplastin 0.0242124
SPPL3 signal peptide peptidase like 3 0.0241787
SIK3 SIK family kinase 3 0.0239938
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0238084
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0237857
ASPH aspartate beta-hydroxylase 0.0237679
DCAF6 DDB1 and CUL4 associated factor 6 0.023709
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.023665
APP amyloid beta (A4) precursor protein 0.0235937
PNISR PNN-interacting serine/arginine-rich protein 0.0235854
DENND4C DENN/MADD domain containing 4C 0.0234281
PDS5B PDS5 cohesin associated factor B 0.023244
IFRD1 interferon-related developmental regulator 1 0.0232003
SUCO SUN domain containing ossification factor 0.0231881
XRN2 5'-3' exoribonuclease 2 0.0230595
SNX9 sorting nexin 9 0.0229299
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0229278
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0228272
MCU mitochondrial calcium uniporter 0.0227194
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0226828
ITCH itchy E3 ubiquitin protein ligase 0.022681
RAB1A RAB1A, member RAS oncogene family 0.0226193
FN1 fibronectin 1 0.022583
MTF2 metal response element binding transcription factor 2 0.0225115
WTAP Wilms tumor 1 associated protein 0.0224949
RSRC2 arginine/serine-rich coiled-coil 2 0.0224729
BCLAF1 BCL2-associated transcription factor 1 0.0222093
FAM168A family with sequence similarity 168, member A 0.022135
NFYA nuclear transcription factor Y, alpha 0.0221291
LINGO2 leucine rich repeat and Ig domain containing 2 0.0220918
ARFIP1 ADP-ribosylation factor interacting protein 1 0.0220906
AHNAK AHNAK nucleoprotein 0.0220663
DENND5A DENN/MADD domain containing 5A 0.0220536
ARHGAP11A Rho GTPase activating protein 11A 0.0219209
RUNX1 runt-related transcription factor 1 0.0217465
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0215494
UVRAG UV radiation resistance associated 0.0215404
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0214969
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0214666
MB21D2 Mab-21 domain containing 2 0.0213075

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.283725
PRKG1 protein kinase, cGMP-dependent, type I -0.101214
PTMA prothymosin, alpha -0.0899888
PEG10 paternally expressed 10 -0.0843048
SOX4 SRY (sex determining region Y)-box 4 -0.080997
TSHZ2 teashirt zinc finger homeobox 2 -0.0797756
RPS6 ribosomal protein S6 -0.0797525
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.07286
FGFR1 fibroblast growth factor receptor 1 -0.0708709
MGP matrix Gla protein -0.0681874
TMSB10 thymosin beta 10 -0.0667855
ACTG1 actin gamma 1 -0.0654607
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0652969
RPLP1 ribosomal protein, large, P1 -0.0640053
RPLP2 ribosomal protein, large, P2 -0.0601247
RPS8 ribosomal protein S8 -0.0582867
RPS19 ribosomal protein S19 -0.0559567
CADM2 cell adhesion molecule 2 -0.0557177
HMGA2 high mobility group AT-hook 2 -0.0552304
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0549053
CANX calnexin -0.0536612
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0517499
EEF2 eukaryotic translation elongation factor 2 -0.0508497
RPL35A ribosomal protein L35a -0.0492434
TPM4 tropomyosin 4 -0.0486406
RPS23 ribosomal protein S23 -0.0482162
MT2A metallothionein 2A -0.0479726
IER3 immediate early response 3 -0.0464478
RPL23 ribosomal protein L23 -0.045545
RPS13 ribosomal protein S13 -0.0429817
TUBB tubulin, beta class I -0.0428187
RPS4X ribosomal protein S4, X-linked -0.0421739
ZFHX3 zinc finger homeobox 3 -0.0408799
RACK1 receptor for activated C kinase 1 -0.0404841
IGF2 insulin-like growth factor 2 -0.0402669
RPL34 ribosomal protein L34 -0.0397301
KAZN kazrin, periplakin interacting protein -0.0388977
RPL19 ribosomal protein L19 -0.0387634
RPL11 ribosomal protein L11 -0.0380183
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0375219
COL1A2 collagen, type I, alpha 2 -0.0374357
RPL37A ribosomal protein L37a -0.0372347
TMSB4X thymosin beta 4, X-linked -0.0368632
LOC112694756 uncharaterized LOC112694756 -0.0367694
RPL26 ribosomal protein L26 -0.0364921
RPS2 ribosomal protein S2 -0.0356316
TPT1 tumor protein, translationally-controlled 1 -0.0351808
RPS27A ribosomal protein S27a -0.0349309
HMGA1 high mobility group AT-hook 1 -0.0348674
FTL ferritin, light polypeptide -0.0347756
RPS3 ribosomal protein S3 -0.034654
RPL31 ribosomal protein L31 -0.0335217
RPS14 ribosomal protein S14 -0.0333388
PHF14 PHD finger protein 14 -0.032276
SLC38A2 solute carrier family 38, member 2 -0.0313997
RPL36 ribosomal protein L36 -0.0311699
RPS11 ribosomal protein S11 -0.0308048
MAML2 mastermind-like 2 (Drosophila) -0.0304666
RPL12 ribosomal protein L12 -0.0303101
SMC3 structural maintenance of chromosomes 3 -0.0302679
TBCA tubulin folding cofactor A -0.0300433
RPL7A ribosomal protein L7a -0.0298356
PCM1 pericentriolar material 1 -0.0293401
ATP5F1B ATP synthase F1 subunit beta -0.0288105
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0284484
POTEF POTE ankyrin domain family, member F -0.028255
LDHA lactate dehydrogenase A -0.0279301
RPS17 ribosomal protein S17 -0.0278476
CBX3 chromobox homolog 3 -0.0276003
MEST mesoderm specific transcript -0.0273746
RPLP0 ribosomal protein, large, P0 -0.0271601
RPL32 ribosomal protein L32 -0.0271415
EGR1 early growth response 1 -0.0270927
NBEA neurobeachin -0.0267489
RPL30 ribosomal protein L30 -0.0262467
TPI1 triosephosphate isomerase 1 -0.0261759
SMC4 structural maintenance of chromosomes 4 -0.026161
RPS21 ribosomal protein S21 -0.0259979
YBX1 Y box binding protein 1 -0.0257013
RPS24 ribosomal protein S24 -0.025486
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0254321
RPL35 ribosomal protein L35 -0.0253271
KIF26B kinesin family member 26B -0.025295
ITGAV integrin, alpha V -0.0251868
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0251611
TUBA1B tubulin, alpha 1b -0.0250376
ZMYND8 zinc finger, MYND-type containing 8 -0.0250327
S100A10 S100 calcium binding protein A10 -0.0249046
HMGB1 high mobility group box 1 -0.0248994
RPS20 ribosomal protein S20 -0.0247979
RPL9 ribosomal protein L9 -0.0245637
RPL7 ribosomal protein L7 -0.024153
ATP11A ATPase, class VI, type 11A -0.0240526
NACA nascent polypeptide-associated complex alpha subunit -0.0239473
RPS29 ribosomal protein S29 -0.0238597
RPL38 ribosomal protein L38 -0.0236973
RPS12 ribosomal protein S12 -0.0236011
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0234972
EIF1 eukaryotic translation initiation factor 1 -0.0234959
FOXO3 forkhead box O3 -0.0233106