Imiquimod (maleate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.127215
UBA6 ubiquitin-like modifier activating enzyme 6 0.112319
ERRFI1 ERBB receptor feedback inhibitor 1 0.0959657
FAM107B family with sequence similarity 107, member B 0.0831511
FAM13A family with sequence similarity 13, member A 0.080065
RICTOR RPTOR independent companion of MTOR, complex 2 0.0780009
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0776416
GRB10 growth factor receptor-bound protein 10 0.0749341
BAIAP2L1 BAI1-associated protein 2-like 1 0.0713349
ESYT2 extended synaptotagmin-like protein 2 0.0705437
FLNB filamin B, beta 0.0660403
SLMAP sarcolemma associated protein 0.0657344
ADAM9 ADAM metallopeptidase domain 9 0.0649671
ZNF292 zinc finger protein 292 0.0647486
TSC22D2 TSC22 domain family, member 2 0.0602213
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0532675
USP3 ubiquitin specific peptidase 3 0.0503263
HSPA8 heat shock 70kDa protein 8 0.048649
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0482277
FMNL2 formin-like 2 0.0467825
PSD3 pleckstrin and Sec7 domain containing 3 0.0457404
APLP2 amyloid beta (A4) precursor-like protein 2 0.0438611
STK39 serine threonine kinase 39 0.0437878
NCKAP1 NCK-associated protein 1 0.0434709
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0419038
PARD3 par-3 family cell polarity regulator 0.041416
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0413407
NDRG1 N-myc downstream regulated 1 0.0405088
RNF145 ring finger protein 145 0.0400061
WAC WW domain containing adaptor with coiled-coil 0.039967
PGK1 phosphoglycerate kinase 1 0.0395818
DPY19L1 dpy-19-like 1 (C. elegans) 0.0391627
BRWD3 bromodomain and WD repeat domain containing 3 0.0389839
ATP13A3 ATPase type 13A3 0.0386687
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0385418
AKAP12 A kinase (PRKA) anchor protein 12 0.0382451
SBF2 SET binding factor 2 0.0379904
ITGA6 integrin, alpha 6 0.0375344
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0374633
NAMPT nicotinamide phosphoribosyltransferase 0.0374
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0369771
ASPH aspartate beta-hydroxylase 0.0362127
MXD1 MAX dimerization protein 1 0.0359689
RIOK3 RIO kinase 3 0.0341248
ADAM17 ADAM metallopeptidase domain 17 0.0335498
VEZT vezatin, adherens junctions transmembrane protein 0.03287
OSBPL9 oxysterol binding protein-like 9 0.0324204
CAPRIN2 caprin family member 2 0.0323508
PTK2 protein tyrosine kinase 2 0.032018
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0319762
SLK STE20-like kinase 0.0315632
FXR1 fragile X mental retardation, autosomal homolog 1 0.031251
HSPH1 heat shock 105kDa/110kDa protein 1 0.0311391
ENO1 enolase 1, (alpha) 0.0306811
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0306348
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0303143
MXI1 MAX interactor 1, dimerization protein 0.0303066
PTPRJ protein tyrosine phosphatase, receptor type, J 0.03012
OSBPL3 oxysterol binding protein-like 3 0.0301144
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0296243
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0295133
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0289446
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0288543
SESTD1 SEC14 and spectrin domains 1 0.0287431
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0287088
TOP1 topoisomerase (DNA) I 0.0280965
PELI1 pellino E3 ubiquitin protein ligase 1 0.0278768
NPTN neuroplastin 0.0277739
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0273445
PUM2 pumilio RNA-binding family member 2 0.027327
ZEB1 zinc finger E-box binding homeobox 1 0.0273232
RREB1 ras responsive element binding protein 1 0.0272832
TPM3 tropomyosin 3 0.0271189
DDIT4 DNA-damage-inducible transcript 4 0.0270587
WDFY2 WD repeat and FYVE domain containing 2 0.0269628
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0268556
FAM3C family with sequence similarity 3, member C 0.0262775
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0258351
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0257751
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0256781
NUP58 nucleoporin 58 0.0256436
XPO1 exportin 1 0.0256179
OGA O-GlcNAcase 0.0254005
EPS8 epidermal growth factor receptor pathway substrate 8 0.0253461
ZMYM2 zinc finger, MYM-type 2 0.0252556
WSB1 WD repeat and SOCS box containing 1 0.024671
KDM6A lysine (K)-specific demethylase 6A 0.0246609
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.024561
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0245449
INSIG2 insulin induced gene 2 0.0243645
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0242124
ZDHHC20 zinc finger, DHHC-type containing 20 0.0239235
CDK17 cyclin-dependent kinase 17 0.0237501
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0235652
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.0234944
PPARD peroxisome proliferator-activated receptor delta 0.0232717
CCDC88A coiled-coil domain containing 88A 0.0232569
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0232172
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0230421
UPP1 uridine phosphorylase 1 0.0229727

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.204787
IGFBP3 insulin-like growth factor binding protein 3 -0.142935
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.120889
EGFR epidermal growth factor receptor -0.111362
LAMA4 laminin, alpha 4 -0.106444
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0962539
LMO7 LIM domain 7 -0.0910732
MUC17 mucin 17, cell surface associated -0.0848497
VIM vimentin -0.0776165
MYOF myoferlin -0.0748975
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0738255
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0723689
TXNRD1 thioredoxin reductase 1 -0.0721281
VCL vinculin -0.0712367
GREB1L growth regulation by estrogen in breast cancer-like -0.0680026
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0675406
FBXO11 F-box protein 11 -0.0673793
LAMB3 laminin, beta 3 -0.0652223
SLC38A2 solute carrier family 38, member 2 -0.0642663
DOCK5 dedicator of cytokinesis 5 -0.0598061
HMGA1 high mobility group AT-hook 1 -0.0588116
LOC112694756 uncharaterized LOC112694756 -0.0587429
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.057898
ACTN4 actinin, alpha 4 -0.057421
KLF6 Kruppel-like factor 6 -0.0569468
RASAL2 RAS protein activator like 2 -0.0564961
FTH1 ferritin, heavy polypeptide 1 -0.0560408
PDLIM5 PDZ and LIM domain 5 -0.0560071
TJP1 tight junction protein 1 -0.0539151
EGR1 early growth response 1 -0.0521739
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0519116
AKAP9 A kinase (PRKA) anchor protein 9 -0.0510621
NPSR1 neuropeptide S receptor 1 -0.0508125
MYO1E myosin IE -0.0477063
LAMC2 laminin, gamma 2 -0.0472197
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.045513
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.044643
CDK13 cyclin-dependent kinase 13 -0.0446114
S100A10 S100 calcium binding protein A10 -0.0441719
SAMD4A sterile alpha motif domain containing 4A -0.0440941
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0437788
WWC1 WW and C2 domain containing 1 -0.0432478
MPRIP myosin phosphatase Rho interacting protein -0.0429527
EMP1 epithelial membrane protein 1 -0.0427382
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0418663
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0413262
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0408201
PTPRB protein tyrosine phosphatase, receptor type, B -0.0407919
HMGA2 high mobility group AT-hook 2 -0.0407835
NCEH1 neutral cholesterol ester hydrolase 1 -0.0405505
RPL12 ribosomal protein L12 -0.0397958
SEPTIN9 septin 9 -0.0391341
NABP1 nucleic acid binding protein 1 -0.0384009
SACK1A scaffolding CK1 anchoring protein A -0.0375748
HDLBP high density lipoprotein binding protein -0.0374932
SP100 SP100 nuclear antigen -0.0374012
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0373172
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0368906
PLEC plectin -0.0368839
PMM2 phosphomannomutase 2 -0.0362716
PTPRR protein tyrosine phosphatase, receptor type, R -0.0353094
RPL37A ribosomal protein L37a -0.0352599
PRELID2 PRELI domain containing 2 -0.0351974
EXT1 exostosin glycosyltransferase 1 -0.0349234
OXSR1 oxidative stress responsive 1 -0.034764
S100A4 S100 calcium binding protein A4 -0.0347488
RRBP1 ribosome binding protein 1 -0.0343494
RPL34 ribosomal protein L34 -0.0342535
RBM39 RNA binding motif protein 39 -0.0341891
REEP3 receptor accessory protein 3 -0.0340746
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0339518
KLK10 kallikrein-related peptidase 10 -0.0336652
GDI2 GDP dissociation inhibitor 2 -0.0333277
RPL35A ribosomal protein L35a -0.0330731
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0330515
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0328351
COL17A1 collagen, type XVII, alpha 1 -0.0325932
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0325669
EIF1 eukaryotic translation initiation factor 1 -0.03253
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0323467
LARP4B La ribonucleoprotein domain family, member 4B -0.0321935
ANXA2 annexin A2 -0.032154
RHOA ras homolog family member A -0.0320697
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0319577
NUP98 nucleoporin 98kDa -0.0317217
RPLP2 ribosomal protein, large, P2 -0.0313997
GOLGB1 golgin B1 -0.0312159
PERP PERP, TP53 apoptosis effector -0.0311036
IFI6 interferon, alpha-inducible protein 6 -0.0310906
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0310606
RPL23 ribosomal protein L23 -0.0310075
F3 coagulation factor III (thromboplastin, tissue factor) -0.030976
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0303669
GCC2 GRIP and coiled-coil domain containing 2 -0.0302328
BCL2L1 BCL2-like 1 -0.0302213
DPYSL2 dihydropyrimidinase-like 2 -0.0302133
ITGB4 integrin, beta 4 -0.0301886
ACTG1 actin gamma 1 -0.0301664
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0301467
SGMS2 sphingomyelin synthase 2 -0.0300356