Imiquimod (maleate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENM3 teneurin transmembrane protein 3 0.0848869
ZNF608 zinc finger protein 608 0.072492
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0687687
NEBL nebulette 0.0684584
DST dystonin 0.0596245
JMJD1C jumonji domain containing 1C 0.0510253
RAD51B RAD51 paralog B 0.0509744
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0444786
PTK2 protein tyrosine kinase 2 0.0404761
ARHGAP32 Rho GTPase activating protein 32 0.0399983
SMYD3 SET and MYND domain containing 3 0.0374908
SBF2 SET binding factor 2 0.0370082
TRIO trio Rho guanine nucleotide exchange factor 0.036227
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.032674
ATP11A ATPase, class VI, type 11A 0.0318313
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0311556
TAS2R14 taste receptor, type 2, member 14 0.0311352
SMAD2 SMAD family member 2 0.0307719
DIDO1 death inducer-obliterator 1 0.0303536
ZNF292 zinc finger protein 292 0.029421
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0290277
ARB2A ARB2 cotranscriptional regulator A 0.0288144
KDM6A lysine (K)-specific demethylase 6A 0.0287287
TOX thymocyte selection-associated high mobility group box 0.0279699
ARFGEF3 ARFGEF family member 3 0.0276877
OSBPL10 oxysterol binding protein-like 10 0.0273085
USP34 ubiquitin specific peptidase 34 0.025397
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0251866
AUTS2 autism susceptibility candidate 2 0.0250906
NGLY1 N-glycanase 1 0.0249323
EFNA5 ephrin-A5 0.0246108
EIF4B eukaryotic translation initiation factor 4B 0.0245315
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0244525
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0243522
YEATS2 YEATS domain containing 2 0.0239212
DENND5A DENN/MADD domain containing 5A 0.0235367
ZFAND3 zinc finger, AN1-type domain 3 0.0232765
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0229941
CCNY cyclin Y 0.0227351
TTC28 tetratricopeptide repeat domain 28 0.0222603
CHD1 chromodomain helicase DNA binding protein 1 0.0217046
ANKRD36 ankyrin repeat domain 36 0.0216391
WDR33 WD repeat domain 33 0.0215618
KMT2C lysine (K)-specific methyltransferase 2C 0.0213561
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0211699
DSCAM Down syndrome cell adhesion molecule 0.0211605
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0209941
RBM33 RNA binding motif protein 33 0.0208155
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0207531
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0206483
MEF2A myocyte enhancer factor 2A 0.0203553
ATG10 autophagy related 10 0.0200065
AGTPBP1 ATP/GTP binding protein 1 0.0199054
STAU1 staufen double-stranded RNA binding protein 1 0.0198268
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0197791
PIAS2 protein inhibitor of activated STAT, 2 0.0197356
FMNL2 formin-like 2 0.0196615
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0195429
CAMTA1 calmodulin binding transcription activator 1 0.0194584
AOPEP aminopeptidase O (putative) 0.0194292
KIAA1328 KIAA1328 0.0193763
NPAS3 neuronal PAS domain protein 3 0.0193636
PHF3 PHD finger protein 3 0.0193628
CEP95 centrosomal protein 95kDa 0.0193553
ABI2 abl-interactor 2 0.0189264
NF1 neurofibromin 1 0.0187272
AFDN afadin, adherens junction formation factor 0.0187116
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0185353
MBD5 methyl-CpG binding domain protein 5 0.0185326
PDE4D phosphodiesterase 4D, cAMP-specific 0.0184823
PDS5B PDS5 cohesin associated factor B 0.0184618
TCF12 transcription factor 12 0.0184094
PCNX1 pecanex 1 0.0182978
BRWD3 bromodomain and WD repeat domain containing 3 0.0180735
WAC WW domain containing adaptor with coiled-coil 0.0179569
VCL vinculin 0.0179258
STRN3 striatin, calmodulin binding protein 3 0.0179107
CDK19 cyclin-dependent kinase 19 0.0178691
PUM2 pumilio RNA-binding family member 2 0.0176595
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0176384
WDFY3 WD repeat and FYVE domain containing 3 0.0175578
DENND1A DENN/MADD domain containing 1A 0.0173302
ZFAND6 zinc finger, AN1-type domain 6 0.0173235
TET2 tet methylcytosine dioxygenase 2 0.0172056
KDM3A lysine (K)-specific demethylase 3A 0.0171267
SRSF1 serine/arginine-rich splicing factor 1 0.0171223
LARP4B La ribonucleoprotein domain family, member 4B 0.0170416
MAPK8 mitogen-activated protein kinase 8 0.0168187
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0167789
ARHGAP5 Rho GTPase activating protein 5 0.0167746
RTN4 reticulon 4 0.0167591
SMAP1 small ArfGAP 1 0.0166948
MARCHF6 membrane associated ring-CH-type finger 6 0.0166334
GSK3B glycogen synthase kinase 3 beta 0.0165664
BIRC6 baculoviral IAP repeat containing 6 0.01653
CARD16 caspase recruitment domain family, member 16 0.0163534
DOCK3 dedicator of cytokinesis 3 0.0163448
SMAD6 SMAD family member 6 0.0163304
EXT1 exostosin glycosyltransferase 1 0.0162931
TULP4 tubby like protein 4 0.0162425

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291728
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.168292
RPS6 ribosomal protein S6 -0.117669
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.116831
PTMA prothymosin, alpha -0.116796
RPL11 ribosomal protein L11 -0.102635
TMSB10 thymosin beta 10 -0.100595
RPS8 ribosomal protein S8 -0.0981129
RPLP1 ribosomal protein, large, P1 -0.0974522
IFI6 interferon, alpha-inducible protein 6 -0.0900687
RPL23 ribosomal protein L23 -0.0751893
RPL28 ribosomal protein L28 -0.0710623
ACTG1 actin gamma 1 -0.069113
RPS3 ribosomal protein S3 -0.0661674
RPS21 ribosomal protein S21 -0.0658017
RPS12 ribosomal protein S12 -0.0648663
RPL12 ribosomal protein L12 -0.06457
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0616083
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0611511
RPLP2 ribosomal protein, large, P2 -0.0608693
RPL34 ribosomal protein L34 -0.0604911
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0604709
RPL31 ribosomal protein L31 -0.0589017
RPS19 ribosomal protein S19 -0.0577472
RPS29 ribosomal protein S29 -0.0567767
B2M beta-2-microglobulin -0.0567056
PFN1 profilin 1 -0.0557645
RPL18 ribosomal protein L18 -0.0546848
RPL37A ribosomal protein L37a -0.0542528
SOX4 SRY (sex determining region Y)-box 4 -0.0538928
RPL26 ribosomal protein L26 -0.0533825
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0527288
S100A9 S100 calcium binding protein A9 -0.0520116
RPL36 ribosomal protein L36 -0.0516887
EEF2 eukaryotic translation elongation factor 2 -0.0499682
RPL8 ribosomal protein L8 -0.0497853
RPL32 ribosomal protein L32 -0.0489502
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.048527
RPS13 ribosomal protein S13 -0.0482196
RPL19 ribosomal protein L19 -0.0481145
HMGA1 high mobility group AT-hook 1 -0.0474923
RPLP0 ribosomal protein, large, P0 -0.0469048
RPS11 ribosomal protein S11 -0.0462481
LOC112694756 uncharaterized LOC112694756 -0.0462256
RPS15 ribosomal protein S15 -0.045963
KTN1 kinectin 1 (kinesin receptor) -0.0459072
RPS5 ribosomal protein S5 -0.0453588
RPS25 ribosomal protein S25 -0.0440633
VIM vimentin -0.0438926
RPS27 ribosomal protein S27 -0.0433649
RPS24 ribosomal protein S24 -0.043194
TPI1 triosephosphate isomerase 1 -0.0429017
RPS14 ribosomal protein S14 -0.0428598
LDHA lactate dehydrogenase A -0.0414518
DEK DEK proto-oncogene -0.041286
EIF5B eukaryotic translation initiation factor 5B -0.0411401
CENPF centromere protein F, 350/400kDa -0.0411262
RPL35 ribosomal protein L35 -0.0406451
GNAS GNAS complex locus -0.0404703
RPL35A ribosomal protein L35a -0.0402095
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0399744
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0399302
RPS17 ribosomal protein S17 -0.0397678
YBX1 Y box binding protein 1 -0.0394892
RPL9 ribosomal protein L9 -0.0394215
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.038991
EGR1 early growth response 1 -0.0385261
HMGB1 high mobility group box 1 -0.0384664
RACK1 receptor for activated C kinase 1 -0.0382636
FTL ferritin, light polypeptide -0.0382107
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0381064
RPS16 ribosomal protein S16 -0.037789
RPS20 ribosomal protein S20 -0.0376402
RPS4X ribosomal protein S4, X-linked -0.0369195
LDHB lactate dehydrogenase B -0.0368419
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0360202
RPL7A ribosomal protein L7a -0.0359132
ISG15 ISG15 ubiquitin-like modifier -0.0358813
RPL30 ribosomal protein L30 -0.0355402
RPL5 ribosomal protein L5 -0.035421
RPL7 ribosomal protein L7 -0.0352136
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0351035
CBX3 chromobox homolog 3 -0.0348737
RPS28 ribosomal protein S28 -0.0342083
ENO1 enolase 1, (alpha) -0.0340794
RPS23 ribosomal protein S23 -0.0339057
MYL12B myosin, light chain 12B, regulatory -0.0332899
RPS2 ribosomal protein S2 -0.0330444
RPL13A ribosomal protein L13a -0.0328222
SERBP1 SERPINE1 mRNA binding protein 1 -0.0325714
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0321928
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0320465
EIF1 eukaryotic translation initiation factor 1 -0.0318167
RPS27A ribosomal protein S27a -0.03026
VDAC1 voltage-dependent anion channel 1 -0.0299153
RPL27A ribosomal protein L27a -0.029701
PCBP2 poly(rC) binding protein 2 -0.029344
RPL10A ribosomal protein L10a -0.0292766
RPS10 ribosomal protein S10 -0.0291531
ATP5F1B ATP synthase F1 subunit beta -0.0283934