Imiquimod (maleate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.154669
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0860857
COL6A3 collagen, type VI, alpha 3 0.0823378
FNDC3B fibronectin type III domain containing 3B 0.0717596
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0582304
TRIO trio Rho guanine nucleotide exchange factor 0.0550811
DGKD diacylglycerol kinase, delta 130kDa 0.0498469
RAB1A RAB1A, member RAS oncogene family 0.0497331
CXCL8 chemokine (C-X-C motif) ligand 8 0.048705
FAM13A family with sequence similarity 13, member A 0.0467414
ATP13A3 ATPase type 13A3 0.0453941
CADM1 cell adhesion molecule 1 0.0442866
RTN4 reticulon 4 0.0441911
NAMPT nicotinamide phosphoribosyltransferase 0.0440684
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0432319
ERRFI1 ERBB receptor feedback inhibitor 1 0.0427146
SBF2 SET binding factor 2 0.042712
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0407599
LPP LIM domain containing preferred translocation partner in lipoma 0.0404134
SEC24D SEC24 family member D 0.0393025
ANKRD11 ankyrin repeat domain 11 0.0391474
MACF1 microtubule-actin crosslinking factor 1 0.0390787
ZFAND3 zinc finger, AN1-type domain 3 0.0389611
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0377954
EGFR epidermal growth factor receptor 0.0374785
USP34 ubiquitin specific peptidase 34 0.0373178
ASPH aspartate beta-hydroxylase 0.0371811
DSCAM Down syndrome cell adhesion molecule 0.0359333
ADAM17 ADAM metallopeptidase domain 17 0.0343055
KDM3A lysine (K)-specific demethylase 3A 0.0329185
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0328691
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0321946
ELL2 elongation factor, RNA polymerase II, 2 0.0319816
TTC3 tetratricopeptide repeat domain 3 0.03182
AVL9 AVL9 homolog (S. cerevisiase) 0.0314016
OGA O-GlcNAcase 0.031321
COPA coatomer protein complex, subunit alpha 0.0313177
GOLGA4 golgin A4 0.0308462
NAP1L1 nucleosome assembly protein 1-like 1 0.0308398
CALU calumenin 0.029901
STK17A serine/threonine kinase 17a 0.0288373
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0285534
SPAG9 sperm associated antigen 9 0.028402
CDK13 cyclin-dependent kinase 13 0.0282509
ZFC3H1 zinc finger, C3H1-type containing 0.0281094
GOLGB1 golgin B1 0.0280523
GLIS3 GLIS family zinc finger 3 0.0275269
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0274032
TFG TRK-fused gene 0.0271571
ZNF292 zinc finger protein 292 0.027025
SMAD3 SMAD family member 3 0.0269644
PHF3 PHD finger protein 3 0.0267756
HELZ helicase with zinc finger 0.0267068
JARID2 jumonji, AT rich interactive domain 2 0.0266254
AHNAK AHNAK nucleoprotein 0.0266241
SAMD4A sterile alpha motif domain containing 4A 0.026422
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.026367
USP36 ubiquitin specific peptidase 36 0.0263626
SEC23A Sec23 homolog A (S. cerevisiae) 0.0260973
MARCHF6 membrane associated ring-CH-type finger 6 0.0260933
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0260359
ZCCHC7 zinc finger, CCHC domain containing 7 0.0259677
PCBP3 poly(rC) binding protein 3 0.02586
SUCO SUN domain containing ossification factor 0.0256539
CAMTA1 calmodulin binding transcription activator 1 0.025534
PTPRM protein tyrosine phosphatase, receptor type, M 0.0250468
ZNF841 zinc finger protein 841 0.024875
XPO1 exportin 1 0.0248401
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0247976
MXI1 MAX interactor 1, dimerization protein 0.0247004
GARS1 glycyl-tRNA synthetase 1 0.0242919
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0241459
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.024076
CSNK1A1 casein kinase 1, alpha 1 0.0240207
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0239928
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0237481
TMEM39A transmembrane protein 39A 0.0236946
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0236602
DOCK5 dedicator of cytokinesis 5 0.0235631
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0234007
TENT2 terminal nucleotidyltransferase 2 0.0233004
ANO6 anoctamin 6 0.0231937
HIPK2 homeodomain interacting protein kinase 2 0.0231603
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0231492
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0231331
ANKRD17 ankyrin repeat domain 17 0.0229779
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0229734
TNIP1 TNFAIP3 interacting protein 1 0.0229247
INSIG2 insulin induced gene 2 0.0228815
RLF rearranged L-myc fusion 0.0226962
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0223054
COG5 component of oligomeric golgi complex 5 0.0222825
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0222493
ANTXR2 anthrax toxin receptor 2 0.0222374
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0220696
MYH9 myosin, heavy chain 9, non-muscle 0.0219427
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0218886
ERBIN erbb2 interacting protein 0.0217585
LTN1 listerin E3 ubiquitin protein ligase 1 0.0216532
ARHGAP21 Rho GTPase activating protein 21 0.0215491

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.269407
FTL ferritin, light polypeptide -0.16571
TMSB10 thymosin beta 10 -0.16507
IGFBP3 insulin-like growth factor binding protein 3 -0.123071
MT2A metallothionein 2A -0.121089
VIM vimentin -0.0998979
RPS6 ribosomal protein S6 -0.0564892
TGFBI transforming growth factor, beta-induced, 68kDa -0.0529226
B2M beta-2-microglobulin -0.0510839
NDRG1 N-myc downstream regulated 1 -0.0509189
PKM pyruvate kinase, muscle -0.0503807
EGR1 early growth response 1 -0.0499964
POTEF POTE ankyrin domain family, member F -0.0484495
RPLP1 ribosomal protein, large, P1 -0.0477856
RPS8 ribosomal protein S8 -0.0477336
FN1 fibronectin 1 -0.0450301
RPL35A ribosomal protein L35a -0.043188
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0429291
NALF1 NALCN channel auxiliary factor 1 -0.0426643
IGFBP5 insulin-like growth factor binding protein 5 -0.0412156
RPS19 ribosomal protein S19 -0.0402536
NLGN1 neuroligin 1 -0.0394098
HLA-B major histocompatibility complex, class I, B -0.0392339
TPM4 tropomyosin 4 -0.0371047
RPL23 ribosomal protein L23 -0.0361306
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.03475
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0338003
TPI1 triosephosphate isomerase 1 -0.0335324
RPL12 ribosomal protein L12 -0.0334951
PTMA prothymosin, alpha -0.0332747
RPLP2 ribosomal protein, large, P2 -0.033003
MT1X metallothionein 1X -0.0314064
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0313983
RPL28 ribosomal protein L28 -0.0313507
PDIA3 protein disulfide isomerase family A, member 3 -0.0308422
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0306102
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0301688
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0300673
CENPF centromere protein F, 350/400kDa -0.0275954
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0268123
S100A10 S100 calcium binding protein A10 -0.0267949
HMGA1 high mobility group AT-hook 1 -0.0267094
RPS13 ribosomal protein S13 -0.0266476
RPS23 ribosomal protein S23 -0.0262522
RPL11 ribosomal protein L11 -0.0259888
LOC112694756 uncharaterized LOC112694756 -0.0257664
RPL37A ribosomal protein L37a -0.0254454
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0251643
FTH1 ferritin, heavy polypeptide 1 -0.0251312
LMNA lamin A/C -0.0242542
RPL32 ribosomal protein L32 -0.0239809
GANAB glucosidase, alpha; neutral AB -0.0239328
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0237731
HLA-C major histocompatibility complex, class I, C -0.0233727
RPS24 ribosomal protein S24 -0.0233589
LOX lysyl oxidase -0.0229049
RPL19 ribosomal protein L19 -0.0225375
ACTG1 actin gamma 1 -0.0224279
ENO1 enolase 1, (alpha) -0.0220624
GNAS GNAS complex locus -0.0219811
RPL36 ribosomal protein L36 -0.0219713
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0219401
CENPE centromere protein E, 312kDa -0.0218817
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0209683
S100A6 S100 calcium binding protein A6 -0.0208639
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0207157
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0206865
TUBA1B tubulin, alpha 1b -0.0206457
S100A9 S100 calcium binding protein A9 -0.0205906
EEF1G eukaryotic translation elongation factor 1 gamma -0.0205281
RPL31 ribosomal protein L31 -0.0205092
HLA-A major histocompatibility complex, class I, A -0.0204616
PFN1 profilin 1 -0.0204492
SMC4 structural maintenance of chromosomes 4 -0.0203673
JUN jun proto-oncogene -0.0203585
RPS3 ribosomal protein S3 -0.0202729
RPS5 ribosomal protein S5 -0.0201184
CBX3 chromobox homolog 3 -0.0199386
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0197723
RPS27A ribosomal protein S27a -0.0195769
RPL34 ribosomal protein L34 -0.0195558
KTN1 kinectin 1 (kinesin receptor) -0.0191698
RPL9 ribosomal protein L9 -0.0191421
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0189944
ATF4 activating transcription factor 4 -0.0189603
ITGA6 integrin, alpha 6 -0.0189525
RPL8 ribosomal protein L8 -0.0188515
RPLP0 ribosomal protein, large, P0 -0.0186658
TUBB4B tubulin, beta 4B class IVb -0.0185399
TAPBP TAP binding protein (tapasin) -0.0184879
PRSS23 protease, serine, 23 -0.0182945
RPS12 ribosomal protein S12 -0.0181294
FOSL1 FOS-like antigen 1 -0.0180451
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0179613
IGF2 insulin-like growth factor 2 -0.0179439
CLMP CXADR-like membrane protein -0.0178959
RPS17 ribosomal protein S17 -0.0174883
RPS21 ribosomal protein S21 -0.0168568
CA9 carbonic anhydrase IX -0.0166963
RPS29 ribosomal protein S29 -0.0166547