Imiquimod (maleate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.155029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.149426
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.140605
ERRFI1 ERBB receptor feedback inhibitor 1 0.0867748
DSCAM Down syndrome cell adhesion molecule 0.0726107
ZNF292 zinc finger protein 292 0.070414
PRELID2 PRELI domain containing 2 0.0700794
GOLGA4 golgin A4 0.0662749
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0638288
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0570103
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0557976
OGA O-GlcNAcase 0.0503706
HELZ helicase with zinc finger 0.0486731
TBC1D22A TBC1 domain family, member 22A 0.0486562
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0469886
ZNF638 zinc finger protein 638 0.042963
NBAS neuroblastoma amplified sequence 0.0422512
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0421562
UBA6 ubiquitin-like modifier activating enzyme 6 0.0420773
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0417178
TXNRD1 thioredoxin reductase 1 0.0411944
AHNAK AHNAK nucleoprotein 0.0409923
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0407484
YEATS2 YEATS domain containing 2 0.0406957
SUCO SUN domain containing ossification factor 0.0400745
RNMT RNA (guanine-7-) methyltransferase 0.03989
NUP58 nucleoporin 58 0.039622
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0395316
PDIA4 protein disulfide isomerase family A, member 4 0.0394382
COPB1 coatomer protein complex, subunit beta 1 0.039375
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0390183
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0383632
MYH9 myosin, heavy chain 9, non-muscle 0.0376845
KMT2C lysine (K)-specific methyltransferase 2C 0.036918
KDM4C lysine (K)-specific demethylase 4C 0.0360987
SRP54 signal recognition particle 54kDa 0.0357074
TM9SF3 transmembrane 9 superfamily member 3 0.0354322
ZC3H11A zinc finger CCCH-type containing 11A 0.0352676
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0350248
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0350009
YME1L1 YME1-like 1 ATPase 0.0349285
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0345249
CANX calnexin 0.0340355
RUNX1 runt-related transcription factor 1 0.0336032
SEC31A SEC31 homolog A (S. cerevisiae) 0.0334131
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0330016
SEC24D SEC24 family member D 0.0329283
GARS1 glycyl-tRNA synthetase 1 0.0326713
ZNF654 zinc finger protein 654 0.0324632
RAB1A RAB1A, member RAS oncogene family 0.0324328
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0324046
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0319345
AFF4 AF4/FMR2 family, member 4 0.0317749
ZFAND3 zinc finger, AN1-type domain 3 0.031747
RLF rearranged L-myc fusion 0.0314608
TAS2R14 taste receptor, type 2, member 14 0.0310111
CLTC clathrin, heavy chain (Hc) 0.0308588
RBM39 RNA binding motif protein 39 0.0308461
KMT2E lysine (K)-specific methyltransferase 2E 0.0307751
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0307235
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0304405
FAM117B family with sequence similarity 117, member B 0.0304201
WDR26 WD repeat domain 26 0.0300877
LCORL ligand dependent nuclear receptor corepressor-like 0.02991
SFXN1 sideroflexin 1 0.0293334
BRWD3 bromodomain and WD repeat domain containing 3 0.0293218
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0288907
SBF2 SET binding factor 2 0.0285569
INSIG2 insulin induced gene 2 0.0283186
BTBD9 BTB (POZ) domain containing 9 0.0282376
ANKRD12 ankyrin repeat domain 12 0.0282375
PAPOLA poly(A) polymerase alpha 0.0280302
TRA2A transformer 2 alpha homolog (Drosophila) 0.0278622
TMEM39A transmembrane protein 39A 0.027574
ZFC3H1 zinc finger, C3H1-type containing 0.0273484
WAC WW domain containing adaptor with coiled-coil 0.027272
ARL5B ADP-ribosylation factor-like 5B 0.0272666
STRN3 striatin, calmodulin binding protein 3 0.0270596
SMC5 structural maintenance of chromosomes 5 0.0270144
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0267506
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0266065
CDK19 cyclin-dependent kinase 19 0.0265227
BIRC6 baculoviral IAP repeat containing 6 0.0264439
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0262137
RARS1 arginyl-tRNA synthetase 1 0.0260791
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0260763
NF1 neurofibromin 1 0.0260467
SPAG9 sperm associated antigen 9 0.0260266
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026026
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.02571
YTHDC1 YTH domain containing 1 0.0256251
SEC24A SEC24 family member A 0.0252927
TPR translocated promoter region, nuclear basket protein 0.0251874
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0250144
COPA coatomer protein complex, subunit alpha 0.025005
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0249673
LCOR ligand dependent nuclear receptor corepressor 0.0247439
RIC1 RAB6A GEF complex partner 1 0.0247043
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0246755
MATR3 matrin 3 0.0246073

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.189639
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152783
TMSB10 thymosin beta 10 -0.139038
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.127617
RPS6 ribosomal protein S6 -0.11146
TPT1 tumor protein, translationally-controlled 1 -0.10991
RPL35A ribosomal protein L35a -0.0957963
RPS8 ribosomal protein S8 -0.0699827
FTL ferritin, light polypeptide -0.0697968
FAT1 FAT atypical cadherin 1 -0.0673122
EGR1 early growth response 1 -0.0645889
RPLP1 ribosomal protein, large, P1 -0.0585415
POTEF POTE ankyrin domain family, member F -0.0559825
RPS13 ribosomal protein S13 -0.05315
RPL34 ribosomal protein L34 -0.0530284
RPLP2 ribosomal protein, large, P2 -0.0508434
RPS19 ribosomal protein S19 -0.0508134
ACTG1 actin gamma 1 -0.0491711
RPL31 ribosomal protein L31 -0.0487093
RPL11 ribosomal protein L11 -0.0477054
RPL37A ribosomal protein L37a -0.0463276
RPL26 ribosomal protein L26 -0.0449248
MT2A metallothionein 2A -0.0448176
RPS25 ribosomal protein S25 -0.0445397
PKM pyruvate kinase, muscle -0.0443142
RPS29 ribosomal protein S29 -0.0405646
NDRG1 N-myc downstream regulated 1 -0.0400794
RPL12 ribosomal protein L12 -0.0384528
RPS24 ribosomal protein S24 -0.0381336
RPL19 ribosomal protein L19 -0.0380208
HMGA1 high mobility group AT-hook 1 -0.0372616
HLA-B major histocompatibility complex, class I, B -0.0364171
RPL37 ribosomal protein L37 -0.0362408
RPL23 ribosomal protein L23 -0.036035
RPS14 ribosomal protein S14 -0.0350209
TUBA1B tubulin, alpha 1b -0.0344446
LOC112694756 uncharaterized LOC112694756 -0.0342435
HLA-A major histocompatibility complex, class I, A -0.0341339
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0339212
RPS23 ribosomal protein S23 -0.0338542
S100A10 S100 calcium binding protein A10 -0.0336927
RPS3 ribosomal protein S3 -0.0336839
RPS10 ribosomal protein S10 -0.0336072
RPS27A ribosomal protein S27a -0.0334445
RPL30 ribosomal protein L30 -0.0333268
RPL38 ribosomal protein L38 -0.0330387
RPL5 ribosomal protein L5 -0.0327689
INTS6 integrator complex subunit 6 -0.0326896
KRT19 keratin 19, type I -0.0320215
S100A9 S100 calcium binding protein A9 -0.031823
RPS15 ribosomal protein S15 -0.0314209
RPL8 ribosomal protein L8 -0.0310528
RPS27 ribosomal protein S27 -0.0294137
RPS17 ribosomal protein S17 -0.0292325
RPL7 ribosomal protein L7 -0.0292087
RPS11 ribosomal protein S11 -0.0287207
RPL36 ribosomal protein L36 -0.0279433
RPL28 ribosomal protein L28 -0.0267752
RPS12 ribosomal protein S12 -0.0264806
VDAC1 voltage-dependent anion channel 1 -0.0256561
PFN1 profilin 1 -0.0254192
RPS20 ribosomal protein S20 -0.0252458
IFITM3 interferon induced transmembrane protein 3 -0.0240339
TUBB4B tubulin, beta 4B class IVb -0.0236274
S100A6 S100 calcium binding protein A6 -0.0236119
RPL9 ribosomal protein L9 -0.023369
RPL36A ribosomal protein L36a -0.023081
RPL15 ribosomal protein L15 -0.0230637
PA2G4 proliferation-associated 2G4, 38kDa -0.0229722
LDHB lactate dehydrogenase B -0.0222667
EEF2 eukaryotic translation elongation factor 2 -0.0220964
TPI1 triosephosphate isomerase 1 -0.0220889
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0220414
RPS5 ribosomal protein S5 -0.0219501
CCND1 cyclin D1 -0.0218951
ENO2 enolase 2 (gamma, neuronal) -0.021847
RPL7A ribosomal protein L7a -0.021816
RPS16 ribosomal protein S16 -0.0218068
RPL27 ribosomal protein L27 -0.0217841
RPLP0 ribosomal protein, large, P0 -0.0217081
PRDX2 peroxiredoxin 2 -0.0215315
SLC38A2 solute carrier family 38, member 2 -0.021361
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0213353
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0213137
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0212842
RPL32 ribosomal protein L32 -0.0212187
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0211559
FUS FUS RNA binding protein -0.0210524
RACK1 receptor for activated C kinase 1 -0.0209807
LOC102724023 ES1 protein homolog, mitochondrial -0.0208756
HMGA2 high mobility group AT-hook 2 -0.0207863
RPS21 ribosomal protein S21 -0.0205361
LMNA lamin A/C -0.0205057
MCL1 myeloid cell leukemia 1 -0.0203505
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0203244
HMGB1 high mobility group box 1 -0.0201364
CADPS Ca++-dependent secretion activator -0.0201225
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0197314
TPM4 tropomyosin 4 -0.0195909
EIF5B eukaryotic translation initiation factor 5B -0.0195506