Imiquimod (maleate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Imiquimod (maleate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0709487
APP amyloid beta (A4) precursor protein 0.0654895
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0639461
RNF145 ring finger protein 145 0.0533976
MATR3 matrin 3 0.050613
KDM3A lysine (K)-specific demethylase 3A 0.050257
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0447409
UGCG UDP-glucose ceramide glucosyltransferase 0.0447141
NCKAP1 NCK-associated protein 1 0.0437354
WAC WW domain containing adaptor with coiled-coil 0.0434896
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0428152
NPEPPS aminopeptidase puromycin sensitive 0.0420786
ANKRD10 ankyrin repeat domain 10 0.0400692
RLF rearranged L-myc fusion 0.0390936
KMT2E lysine (K)-specific methyltransferase 2E 0.0372334
PGK1 phosphoglycerate kinase 1 0.0346949
TMSB4X thymosin beta 4, X-linked 0.0334063
TFG TRK-fused gene 0.0328682
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0327897
USP9X ubiquitin specific peptidase 9, X-linked 0.0325349
FXR1 fragile X mental retardation, autosomal homolog 1 0.0325047
OGA O-GlcNAcase 0.0322377
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0321325
TOP2B topoisomerase (DNA) II beta 180kDa 0.0310193
FNBP1L formin binding protein 1-like 0.0310009
USP3 ubiquitin specific peptidase 3 0.0301791
CDC73 cell division cycle 73 0.029989
NAMPT nicotinamide phosphoribosyltransferase 0.0295918
ANKRD28 ankyrin repeat domain 28 0.0295575
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0293624
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0284168
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0282132
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0276544
HELZ helicase with zinc finger 0.027545
CLINT1 clathrin interactor 1 0.0274649
PUM1 pumilio RNA-binding family member 1 0.0272576
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0271479
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0271156
PUM2 pumilio RNA-binding family member 2 0.0265159
TRA2A transformer 2 alpha homolog (Drosophila) 0.0261646
MARCHF6 membrane associated ring-CH-type finger 6 0.0261466
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0259176
SNX4 sorting nexin 4 0.0257669
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0256921
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0253635
RAD21 RAD21 homolog (S. pombe) 0.0251688
QKI QKI, KH domain containing, RNA binding 0.0249549
TM9SF3 transmembrane 9 superfamily member 3 0.0245989
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0245313
PDS5B PDS5 cohesin associated factor B 0.0244183
PARD3 par-3 family cell polarity regulator 0.0244169
ERRFI1 ERBB receptor feedback inhibitor 1 0.0241302
SLMAP sarcolemma associated protein 0.0240824
PNISR PNN-interacting serine/arginine-rich protein 0.0237589
KDM6A lysine (K)-specific demethylase 6A 0.0237094
PRRC2C proline-rich coiled-coil 2C 0.0232686
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0232284
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0228898
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0227382
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0226403
RPL4 ribosomal protein L4 0.022587
SPOPL speckle-type POZ protein-like 0.0221656
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0220961
WDFY3 WD repeat and FYVE domain containing 3 0.0218255
CCNL1 cyclin L1 0.0217524
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0215306
RBM27 RNA binding motif protein 27 0.021332
ARID4B AT rich interactive domain 4B (RBP1-like) 0.02114
NDFIP1 Nedd4 family interacting protein 1 0.0208682
KPNB1 karyopherin (importin) beta 1 0.0205744
CCNT2 cyclin T2 0.0204398
RSRC2 arginine/serine-rich coiled-coil 2 0.0203901
RAB1A RAB1A, member RAS oncogene family 0.0201767
SINHCAF SIN3-HDAC complex associated factor 0.0200648
CAMTA1 calmodulin binding transcription activator 1 0.0198594
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0196942
WDR45B WD repeat domain 45B 0.019678
MEF2A myocyte enhancer factor 2A 0.0194866
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0194028
RAD23B RAD23 homolog B (S. cerevisiae) 0.0192991
OSBPL9 oxysterol binding protein-like 9 0.0192306
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0192
KMT2C lysine (K)-specific methyltransferase 2C 0.0191975
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0191425
RIOK3 RIO kinase 3 0.0190916
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0189762
AFDN afadin, adherens junction formation factor 0.0189631
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0189255
SNX9 sorting nexin 9 0.0188866
KDM1A lysine (K)-specific demethylase 1A 0.0188726
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0186128
H1-0 H1.0 linker histone 0.0185865
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0183807
COPS2 COP9 signalosome subunit 2 0.0183664
RYK receptor-like tyrosine kinase 0.0182734
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0180427
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0180099
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0179992
FAM168B family with sequence similarity 168, member B 0.0179563
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0179304

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.135372
MT2A metallothionein 2A -0.121028
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119966
ASPH aspartate beta-hydroxylase -0.112053
RAD51B RAD51 paralog B -0.0826651
FTL ferritin, light polypeptide -0.0764405
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0732739
PRELID2 PRELI domain containing 2 -0.0721226
PAX8 paired box 8 -0.0705623
ACTG1 actin gamma 1 -0.0653717
NDRG1 N-myc downstream regulated 1 -0.0641131
POTEF POTE ankyrin domain family, member F -0.0600046
HMGA2 high mobility group AT-hook 2 -0.0588547
EGFR epidermal growth factor receptor -0.0574328
HMGA1 high mobility group AT-hook 1 -0.0565525
RPL35A ribosomal protein L35a -0.0547499
SVIL supervillin -0.0542477
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0531603
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0514641
FHIT fragile histidine triad -0.0514293
FLNA filamin A, alpha -0.0503614
PSD3 pleckstrin and Sec7 domain containing 3 -0.0503158
CD44 CD44 molecule (Indian blood group) -0.0501394
PKM pyruvate kinase, muscle -0.0492455
ALCAM activated leukocyte cell adhesion molecule -0.048802
RPS19 ribosomal protein S19 -0.0475581
CREB5 cAMP responsive element binding protein 5 -0.0475552
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0441906
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0438362
RPL31 ribosomal protein L31 -0.0434744
RPL23 ribosomal protein L23 -0.0421053
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.041196
FLNB filamin B, beta -0.0409608
DLC1 DLC1 Rho GTPase activating protein -0.0405977
RPS6 ribosomal protein S6 -0.0405908
ZBTB20 zinc finger and BTB domain containing 20 -0.0402275
RPS8 ribosomal protein S8 -0.0400277
BPTF bromodomain PHD finger transcription factor -0.0386942
SEPTIN9 septin 9 -0.0384105
IGFBP3 insulin-like growth factor binding protein 3 -0.0382843
DIAPH3 diaphanous-related formin 3 -0.0382668
ATXN1 ataxin 1 -0.0382465
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0381608
LPP LIM domain containing preferred translocation partner in lipoma -0.0376634
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0362497
RPL28 ribosomal protein L28 -0.036203
RPL9 ribosomal protein L9 -0.0354194
RPL37A ribosomal protein L37a -0.0350082
INTS6 integrator complex subunit 6 -0.0345785
RUNX1 runt-related transcription factor 1 -0.0344738
TTC3 tetratricopeptide repeat domain 3 -0.0344209
ITGA6 integrin, alpha 6 -0.0342199
GPR39 G protein-coupled receptor 39 -0.0342045
LAMC2 laminin, gamma 2 -0.0335556
RNF213 ring finger protein 213 -0.032982
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0321005
MYO1E myosin IE -0.0320875
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0316508
MACROD2 MACRO domain containing 2 -0.0316482
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0315756
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0312631
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0312387
RPS12 ribosomal protein S12 -0.0310782
ATG7 autophagy related 7 -0.0302114
BICD1 bicaudal D homolog 1 (Drosophila) -0.0301357
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0300325
FNIP1 folliculin interacting protein 1 -0.0298639
PATJ PATJ crumbs cell polarity complex component -0.029504
SMC4 structural maintenance of chromosomes 4 -0.029322
PCED1B PC-esterase domain containing 1B -0.029276
TPM4 tropomyosin 4 -0.0290733
OSBPL10 oxysterol binding protein-like 10 -0.0290371
RPL19 ribosomal protein L19 -0.0288506
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.02877
TBC1D5 TBC1 domain family, member 5 -0.0284525
KRT7 keratin 7, type II -0.0282834
TBC1D22A TBC1 domain family, member 22A -0.0280262
DOCK1 dedicator of cytokinesis 1 -0.0279739
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0279319
IARS1 isoleucyl-tRNA synthetase 1 -0.027751
PFN1 profilin 1 -0.0274367
EXOC4 exocyst complex component 4 -0.0272079
ZNF638 zinc finger protein 638 -0.0271429
LAMA4 laminin, alpha 4 -0.0267792
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.026502
RPLP2 ribosomal protein, large, P2 -0.0263611
EHBP1 EH domain binding protein 1 -0.0262456
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0261706
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.026169
LIMCH1 LIM and calponin homology domains 1 -0.0261688
RPS14 ribosomal protein S14 -0.0260898
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.026062
CDK13 cyclin-dependent kinase 13 -0.0260079
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0259043
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0258874
RPLP1 ribosomal protein, large, P1 -0.02585
ERBIN erbb2 interacting protein -0.0255782
SMYD3 SET and MYND domain containing 3 -0.0254649
RPL32 ribosomal protein L32 -0.0253353
TNIK TRAF2 and NCK interacting kinase -0.0252706