Imiquimod (maleate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in HOP62 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Imiquimod (maleate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.134627
EXT1 exostosin glycosyltransferase 1 0.0997585
PCBP3 poly(rC) binding protein 3 0.0590376
CDH13 cadherin 13 0.0572815
TPT1 tumor protein, translationally-controlled 1 0.0553469
NAV2 neuron navigator 2 0.0550513
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.052779
VCL vinculin 0.0522587
HMGA2 high mobility group AT-hook 2 0.0512638
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0497013
NALF1 NALCN channel auxiliary factor 1 0.0450491
RAI14 retinoic acid induced 14 0.0447186
INHBA inhibin, beta A 0.0385833
NAV1 neuron navigator 1 0.038234
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0373874
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0367502
TAS2R14 taste receptor, type 2, member 14 0.0363262
INTS6 integrator complex subunit 6 0.034394
CLIC4 chloride intracellular channel 4 0.0343896
CLMP CXADR-like membrane protein 0.0340065
AFF3 AF4/FMR2 family, member 3 0.0326709
CXCL8 chemokine (C-X-C motif) ligand 8 0.0320244
ANKRD11 ankyrin repeat domain 11 0.0316602
JARID2 jumonji, AT rich interactive domain 2 0.0311393
COL5A1 collagen, type V, alpha 1 0.0310946
HM13 histocompatibility (minor) 13 0.0301778
LPP LIM domain containing preferred translocation partner in lipoma 0.0289347
ACTG1 actin gamma 1 0.0285712
RPL37A ribosomal protein L37a 0.0281131
RPL35A ribosomal protein L35a 0.0275182
SAMD4A sterile alpha motif domain containing 4A 0.0274422
PDE10A phosphodiesterase 10A 0.027195
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0271864
COL6A3 collagen, type VI, alpha 3 0.0269932
MYO10 myosin X 0.0269868
TUBB6 tubulin, beta 6 class V 0.0268463
CLIP2 CAP-GLY domain containing linker protein 2 0.0260822
ENO1 enolase 1, (alpha) 0.0260151
MAML3 mastermind-like 3 (Drosophila) 0.0258801
AKAP12 A kinase (PRKA) anchor protein 12 0.0254987
ZSWIM6 zinc finger, SWIM-type containing 6 0.0252864
RPL31 ribosomal protein L31 0.0249398
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.024889
FAF1 Fas (TNFRSF6) associated factor 1 0.0247642
MACF1 microtubule-actin crosslinking factor 1 0.0245715
RPS8 ribosomal protein S8 0.0237276
CUX1 cut-like homeobox 1 0.0236996
DOCK5 dedicator of cytokinesis 5 0.0234485
EHBP1 EH domain binding protein 1 0.0233491
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0233474
ZBTB20 zinc finger and BTB domain containing 20 0.0232004
ATXN1 ataxin 1 0.0229185
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.022885
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0228749
SHISA5 shisa family member 5 0.0227454
HIPK2 homeodomain interacting protein kinase 2 0.0225593
ZNF638 zinc finger protein 638 0.0225151
RRBP1 ribosome binding protein 1 0.0224844
PCNX4 pecanex 4 0.0222643
SDK1 sidekick cell adhesion molecule 1 0.022244
CALD1 caldesmon 1 0.0221393
NSD2 nuclear receptor binding SET domain protein 2 0.022132
RPL37 ribosomal protein L37 0.0219489
ETV6 ets variant 6 0.0218733
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0218033
FRMD4A FERM domain containing 4A 0.0217024
RPS23 ribosomal protein S23 0.0211292
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.021062
BACE2 beta-site APP-cleaving enzyme 2 0.0207433
COL7A1 collagen, type VII, alpha 1 0.0205178
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0203334
RRM2 ribonucleotide reductase M2 0.0203222
MAP4 microtubule-associated protein 4 0.0201334
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.020127
CMIP c-Maf inducing protein 0.0200928
LAMB3 laminin, beta 3 0.0200565
NECTIN2 nectin cell adhesion molecule 2 0.0198858
RPLP1 ribosomal protein, large, P1 0.0197691
PDE4D phosphodiesterase 4D, cAMP-specific 0.0193155
KIAA1328 KIAA1328 0.0191406
AAK1 AP2 associated kinase 1 0.0191359
LOXL2 lysyl oxidase-like 2 0.0190305
AUTS2 autism susceptibility candidate 2 0.0188305
RPL9 ribosomal protein L9 0.0187159
TBCA tubulin folding cofactor A 0.0186281
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0185917
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0183934
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0183355
COL6A1 collagen, type VI, alpha 1 0.0183316
AFF1 AF4/FMR2 family, member 1 0.0182774
LMO7 LIM domain 7 0.0179754
IL1B interleukin 1, beta 0.0177398
MT1E metallothionein 1E 0.0175619
ASPH aspartate beta-hydroxylase 0.017549
EXOC4 exocyst complex component 4 0.0175243
SEPTIN9 septin 9 0.0174311
NFE2L2 nuclear factor, erythroid 2-like 2 0.017317
ZCCHC7 zinc finger, CCHC domain containing 7 0.017275
MYH9 myosin, heavy chain 9, non-muscle 0.0171826
VMP1 vacuole membrane protein 1 0.0171457

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.422964
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.229312
FN1 fibronectin 1 -0.191597
NDRG1 N-myc downstream regulated 1 -0.167112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.131678
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.110713
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0882488
TMSB10 thymosin beta 10 -0.0774181
ELL2 elongation factor, RNA polymerase II, 2 -0.0762264
FAM13A family with sequence similarity 13, member A -0.0691019
VIM vimentin -0.0690653
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.065832
IGFBP3 insulin-like growth factor binding protein 3 -0.0626948
PTMA prothymosin, alpha -0.0543636
EGR1 early growth response 1 -0.0517157
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0514022
CD44 CD44 molecule (Indian blood group) -0.0510406
MT2A metallothionein 2A -0.0499377
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0496235
LOX lysyl oxidase -0.0484715
LOC112694756 uncharaterized LOC112694756 -0.0476379
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0470523
MAP1B microtubule-associated protein 1B -0.0457462
LDHA lactate dehydrogenase A -0.0426146
RNF24 ring finger protein 24 -0.0417689
CDCP1 CUB domain containing protein 1 -0.0411261
STC1 stanniocalcin 1 -0.0379594
ANXA2 annexin A2 -0.0379119
MT1X metallothionein 1X -0.0376206
JUN jun proto-oncogene -0.0364047
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0358509
TXNIP thioredoxin interacting protein -0.0353802
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.035178
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0332105
USP3 ubiquitin specific peptidase 3 -0.0327249
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0324769
HILPDA hypoxia inducible lipid droplet-associated -0.0323873
DEPP1 DEPP autophagy regulator 1 -0.0314792
TGFBI transforming growth factor, beta-induced, 68kDa -0.0310312
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0304417
PDIA3 protein disulfide isomerase family A, member 3 -0.0304326
PLAUR plasminogen activator, urokinase receptor -0.0298669
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0296006
RNMT RNA (guanine-7-) methyltransferase -0.0286064
TRIO trio Rho guanine nucleotide exchange factor -0.028135
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0280582
P4HB prolyl 4-hydroxylase, beta polypeptide -0.027665
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0273277
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0271888
PGK1 phosphoglycerate kinase 1 -0.0266118
FOSL1 FOS-like antigen 1 -0.0264386
LMNA lamin A/C -0.0264023
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0261055
DST dystonin -0.0255081
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0245248
PKM pyruvate kinase, muscle -0.0244679
TENM2 teneurin transmembrane protein 2 -0.024384
KMT2E lysine (K)-specific methyltransferase 2E -0.0239259
DUSP6 dual specificity phosphatase 6 -0.0238428
SPAG9 sperm associated antigen 9 -0.0235067
MORF4L2 mortality factor 4 like 2 -0.0231677
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0229202
UGCG UDP-glucose ceramide glucosyltransferase -0.0227459
VEGFA vascular endothelial growth factor A -0.0225668
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.022454
S100A6 S100 calcium binding protein A6 -0.0222604
WSB1 WD repeat and SOCS box containing 1 -0.0221794
TAC4 tachykinin 4 (hemokinin) -0.0221509
RAI1 retinoic acid induced 1 -0.022088
DDIT4 DNA-damage-inducible transcript 4 -0.0220096
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0219573
BHLHE40 basic helix-loop-helix family, member e40 -0.0214747
HELZ helicase with zinc finger -0.0212175
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0208889
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0205055
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0204374
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0204037
PFN1 profilin 1 -0.0196758
LMAN1 lectin, mannose-binding, 1 -0.0190396
RLF rearranged L-myc fusion -0.0188983
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0184002
CHSY1 chondroitin sulfate synthase 1 -0.0183955
CAV1 caveolin 1, caveolae protein, 22kDa -0.0182842
WDR45B WD repeat domain 45B -0.017977
RICTOR RPTOR independent companion of MTOR, complex 2 -0.017682
SSBP2 single-stranded DNA binding protein 2 -0.0175319
THBS1 thrombospondin 1 -0.0174156
RBM39 RNA binding motif protein 39 -0.017401
ADAM9 ADAM metallopeptidase domain 9 -0.0171782
CEP192 centrosomal protein 192kDa -0.0171388
ANXA1 annexin A1 -0.017076
MLXIP MLX interacting protein -0.0170468
COL6A2 collagen, type VI, alpha 2 -0.0170225
KCTD9 potassium channel tetramerization domain containing 9 -0.0169385
SEC24A SEC24 family member A -0.0169189
YBX1 Y box binding protein 1 -0.0168021
CD109 CD109 molecule -0.0167251
FAM162A family with sequence similarity 162, member A -0.0166359
EIF1 eukaryotic translation initiation factor 1 -0.0165439
ZNF292 zinc finger protein 292 -0.0165381