| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (maleate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Imiquimod (maleate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.211656 |
| CADM1 | cell adhesion molecule 1 | 0.126854 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.124535 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.113117 |
| FNDC3B | fibronectin type III domain containing 3B | 0.108001 |
| ATP13A3 | ATPase type 13A3 | 0.0837682 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0825418 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0776387 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0747493 |
| ZNF292 | zinc finger protein 292 | 0.0735599 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0689523 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0605328 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0594692 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0550347 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0533779 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.05162 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0499212 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0486351 |
| GOLGA4 | golgin A4 | 0.0474801 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0471042 |
| RUNX1 | runt-related transcription factor 1 | 0.0467537 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0459509 |
| PTK2 | protein tyrosine kinase 2 | 0.0456994 |
| VEGFA | vascular endothelial growth factor A | 0.0445614 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0429474 |
| IER3 | immediate early response 3 | 0.0421603 |
| PRELID2 | PRELI domain containing 2 | 0.0418046 |
| MRTFA | myocardin related transcription factor A | 0.0409074 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0400825 |
| SETD5 | SET domain containing 5 | 0.0383672 |
| PDE10A | phosphodiesterase 10A | 0.0383264 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0378347 |
| BBX | bobby sox homolog (Drosophila) | 0.0362698 |
| RLF | rearranged L-myc fusion | 0.035896 |
| USP3 | ubiquitin specific peptidase 3 | 0.035404 |
| CD109 | CD109 molecule | 0.0353116 |
| NDRG1 | N-myc downstream regulated 1 | 0.0351867 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0350192 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0337518 |
| SMAD3 | SMAD family member 3 | 0.03333 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0329908 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0327312 |
| FMNL2 | formin-like 2 | 0.0326751 |
| NAV2 | neuron navigator 2 | 0.0325735 |
| EFNA5 | ephrin-A5 | 0.031486 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0314483 |
| RNF145 | ring finger protein 145 | 0.0309583 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0308893 |
| LOXL2 | lysyl oxidase-like 2 | 0.0308512 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0305757 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0304023 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0302817 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0298184 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0296139 |
| COPA | coatomer protein complex, subunit alpha | 0.0292599 |
| MYO10 | myosin X | 0.0290275 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0289756 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0289587 |
| MSN | moesin | 0.0289312 |
| CLIC4 | chloride intracellular channel 4 | 0.0287312 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0286223 |
| QKI | QKI, KH domain containing, RNA binding | 0.0281322 |
| NGLY1 | N-glycanase 1 | 0.0280119 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280009 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.02792 |
| RYBP | RING1 and YY1 binding protein | 0.0277956 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0275096 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0272328 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0271826 |
| ENO1 | enolase 1, (alpha) | 0.0271821 |
| TFG | TRK-fused gene | 0.0268054 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0267922 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0261532 |
| MEF2A | myocyte enhancer factor 2A | 0.0260949 |
| RTN4 | reticulon 4 | 0.0260784 |
| MTSS1 | metastasis suppressor 1 | 0.0260302 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0257519 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0257358 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0257056 |
| HELZ | helicase with zinc finger | 0.0255667 |
| EGFR | epidermal growth factor receptor | 0.0253771 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0253597 |
| RASA2 | RAS p21 protein activator 2 | 0.0252833 |
| ATXN1 | ataxin 1 | 0.0252589 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0250341 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.024929 |
| FAM13A | family with sequence similarity 13, member A | 0.0248543 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0247297 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0246556 |
| PARD3 | par-3 family cell polarity regulator | 0.0242501 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0240194 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0240069 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0237884 |
| ANXA1 | annexin A1 | 0.023731 |
| NAV1 | neuron navigator 1 | 0.023702 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0236374 |
| HIP1 | huntingtin interacting protein 1 | 0.0231528 |
| SRP54 | signal recognition particle 54kDa | 0.0231519 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.023144 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0229601 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.398122 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.373041 |
| COL1A1 | collagen, type I, alpha 1 | -0.195274 |
| VIM | vimentin | -0.146867 |
| FBN1 | fibrillin 1 | -0.0656246 |
| COL1A2 | collagen, type I, alpha 2 | -0.0616203 |
| GLIS3 | GLIS family zinc finger 3 | -0.060687 |
| HMGA2 | high mobility group AT-hook 2 | -0.0573788 |
| LOX | lysyl oxidase | -0.0515173 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0486816 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.04668 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0465689 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0425485 |
| TMSB10 | thymosin beta 10 | -0.0413279 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0408977 |
| CD44 | CD44 molecule (Indian blood group) | -0.0383113 |
| VCL | vinculin | -0.0353044 |
| PALLD | palladin, cytoskeletal associated protein | -0.0344191 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0344094 |
| EGR1 | early growth response 1 | -0.0341609 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0341337 |
| RIGI | RNA sensor RIG-I | -0.034131 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0340732 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0327688 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.032348 |
| HLA-B | major histocompatibility complex, class I, B | -0.0320091 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0313805 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0296218 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0293962 |
| LDHA | lactate dehydrogenase A | -0.0285457 |
| OSMR | oncostatin M receptor | -0.0265923 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0258087 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0258055 |
| SVIL | supervillin | -0.0255349 |
| CAVIN1 | caveolae associated protein 1 | -0.0243298 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0242235 |
| COL3A1 | collagen, type III, alpha 1 | -0.0233735 |
| CANX | calnexin | -0.0233329 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0228281 |
| NREP | neuronal regeneration related protein | -0.0224861 |
| CALR | calreticulin | -0.0223844 |
| ASPH | aspartate beta-hydroxylase | -0.0217326 |
| MT1X | metallothionein 1X | -0.0215498 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.020997 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0209086 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0208573 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0202834 |
| COL5A1 | collagen, type V, alpha 1 | -0.0202321 |
| HDLBP | high density lipoprotein binding protein | -0.0198271 |
| AHNAK | AHNAK nucleoprotein | -0.0198231 |
| NABP1 | nucleic acid binding protein 1 | -0.0198167 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0197938 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0196008 |
| ARF1 | ADP-ribosylation factor 1 | -0.0194088 |
| PLEC | plectin | -0.0191223 |
| ACTG1 | actin gamma 1 | -0.0188347 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0188204 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0188066 |
| RPL23 | ribosomal protein L23 | -0.0187245 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0187095 |
| ANKRD28 | ankyrin repeat domain 28 | -0.018346 |
| RSU1 | Ras suppressor protein 1 | -0.0182091 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0180653 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0178968 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0176354 |
| ATM | ATM serine/threonine kinase | -0.0175861 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0175778 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0174607 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0172531 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0166631 |
| CFAP44 | cilia and flagella associated protein 44 | -0.0166003 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0164911 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0163204 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0161773 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0158682 |
| DGKI | diacylglycerol kinase, iota | -0.0157088 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0156559 |
| RPL35A | ribosomal protein L35a | -0.0154778 |
| HLA-C | major histocompatibility complex, class I, C | -0.0154469 |
| SP100 | SP100 nuclear antigen | -0.0154203 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0153459 |
| NRP1 | neuropilin 1 | -0.0152918 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0152287 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.0151801 |
| PLSCR1 | phospholipid scramblase 1 | -0.0151595 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0150057 |
| PRSS23 | protease, serine, 23 | -0.0149924 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0147236 |
| POSTN | periostin, osteoblast specific factor | -0.0146635 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0144342 |
| JUN | jun proto-oncogene | -0.0144151 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0142898 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0141795 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0141612 |
| VEGFC | vascular endothelial growth factor C | -0.0140884 |
| KLF6 | Kruppel-like factor 6 | -0.0140599 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | -0.0140406 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.013954 |
| GOLGA3 | golgin A3 | -0.0138688 |
| RRBP1 | ribosome binding protein 1 | -0.0138122 |
