Imiquimod (maleate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.141447
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0988432
FNDC3B fibronectin type III domain containing 3B 0.0717186
FBF1 Fas (TNFRSF6) binding factor 1 0.0641036
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0587193
AFDN afadin, adherens junction formation factor 0.0582207
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.057933
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0569538
TRIO trio Rho guanine nucleotide exchange factor 0.0449753
PARD3 par-3 family cell polarity regulator 0.0449276
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0444616
SAMD4A sterile alpha motif domain containing 4A 0.0444573
ELL2 elongation factor, RNA polymerase II, 2 0.042889
TRIM26 tripartite motif containing 26 0.0423927
WDFY2 WD repeat and FYVE domain containing 2 0.0421611
GPC6 glypican 6 0.0406625
MACF1 microtubule-actin crosslinking factor 1 0.0405946
YAP1 Yes-associated protein 1 0.0377575
MAML2 mastermind-like 2 (Drosophila) 0.0368872
ZFAND3 zinc finger, AN1-type domain 3 0.0365555
DOCK4 dedicator of cytokinesis 4 0.0359888
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0341721
PICALM phosphatidylinositol binding clathrin assembly protein 0.0340197
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0339723
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0317256
FLNB filamin B, beta 0.0310165
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0305793
JMJD1C jumonji domain containing 1C 0.030347
KIF1B kinesin family member 1B 0.0303416
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0302747
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0300162
INSIG2 insulin induced gene 2 0.0298595
NRIP1 nuclear receptor interacting protein 1 0.0296708
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0288938
CCNY cyclin Y 0.028433
RPL3 ribosomal protein L3 0.0282086
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0272229
DST dystonin 0.0271655
NCKAP1 NCK-associated protein 1 0.0270942
SVIL supervillin 0.0270572
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0269087
FNIP1 folliculin interacting protein 1 0.0266444
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.026301
WWC2 WW and C2 domain containing 2 0.0262716
MRTFA myocardin related transcription factor A 0.0260281
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0259839
DIAPH1 diaphanous-related formin 1 0.0258324
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0256803
QKI QKI, KH domain containing, RNA binding 0.0255085
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0252194
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0247948
EIF4B eukaryotic translation initiation factor 4B 0.0246808
PEAK1 pseudopodium-enriched atypical kinase 1 0.0245874
EPS8 epidermal growth factor receptor pathway substrate 8 0.0245717
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0243535
DLC1 DLC1 Rho GTPase activating protein 0.0240799
GRB2 growth factor receptor-bound protein 2 0.0237503
ARFGEF3 ARFGEF family member 3 0.0237364
AHR aryl hydrocarbon receptor 0.0236925
TLK1 tousled-like kinase 1 0.0236777
TNS1 tensin 1 0.0235357
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0234424
PHF10 PHD finger protein 10 0.0234321
PUM2 pumilio RNA-binding family member 2 0.0233956
MYO1B myosin IB 0.0232038
ANKRD10 ankyrin repeat domain 10 0.0229816
MYH9 myosin, heavy chain 9, non-muscle 0.0229466
GMDS GDP-mannose 4,6-dehydratase 0.0226462
PTPRM protein tyrosine phosphatase, receptor type, M 0.0225824
TNIP1 TNFAIP3 interacting protein 1 0.0223172
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0219269
DTNA dystrobrevin, alpha 0.0218153
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.021808
ADAM9 ADAM metallopeptidase domain 9 0.0217385
TM9SF3 transmembrane 9 superfamily member 3 0.0216158
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0214711
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0212276
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0211283
LCOR ligand dependent nuclear receptor corepressor 0.0208349
WNK1 WNK lysine deficient protein kinase 1 0.0207398
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0206703
FAT1 FAT atypical cadherin 1 0.0206526
CEMIP2 cell migration inducing hyaluronidase 2 0.0206471
JAK1 Janus kinase 1 0.0205202
RPL4 ribosomal protein L4 0.0204928
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0204773
USP47 ubiquitin specific peptidase 47 0.0199457
FBXL17 F-box and leucine-rich repeat protein 17 0.0198738
RYBP RING1 and YY1 binding protein 0.0197706
FHIT fragile histidine triad 0.0197433
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0197315
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0195563
SCAF8 SR-related CTD-associated factor 8 0.0194664
CRY1 cryptochrome circadian clock 1 0.0193086
MAP2K1 mitogen-activated protein kinase kinase 1 0.0192279
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0190385
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0189569
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0188691
SORBS1 sorbin and SH3 domain containing 1 0.0188039
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0187552

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.366657
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.173775
TPT1 tumor protein, translationally-controlled 1 -0.120015
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.119796
APOA2 apolipoprotein A-II -0.111977
MT2A metallothionein 2A -0.110594
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.102232
RPS6 ribosomal protein S6 -0.0942986
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0940156
FTL ferritin, light polypeptide -0.085306
RPL35A ribosomal protein L35a -0.0679859
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0672597
ENO1 enolase 1, (alpha) -0.0667114
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0604918
RPL37A ribosomal protein L37a -0.0580365
RPL34 ribosomal protein L34 -0.0565038
RPS24 ribosomal protein S24 -0.0564902
RPS8 ribosomal protein S8 -0.0562639
RPLP1 ribosomal protein, large, P1 -0.0553987
FN1 fibronectin 1 -0.0527645
RPS19 ribosomal protein S19 -0.0522029
TMSB10 thymosin beta 10 -0.051394
RPL12 ribosomal protein L12 -0.0513
C3 complement component 3 -0.0500034
TM4SF1 transmembrane 4 L six family member 1 -0.0492808
RPLP2 ribosomal protein, large, P2 -0.0477016
RPL23 ribosomal protein L23 -0.0470107
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0469262
RPL11 ribosomal protein L11 -0.0454068
APOE apolipoprotein E -0.0437539
RPS21 ribosomal protein S21 -0.0412866
RPS29 ribosomal protein S29 -0.0401709
AHSG alpha-2-HS-glycoprotein -0.0397092
GPC3 glypican 3 -0.0375487
IGFBP1 insulin-like growth factor binding protein 1 -0.0372332
EIF1 eukaryotic translation initiation factor 1 -0.0360787
RPL31 ribosomal protein L31 -0.0352345
RPL26 ribosomal protein L26 -0.035018
RPS12 ribosomal protein S12 -0.0329538
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0329111
LOC112694756 uncharaterized LOC112694756 -0.0326459
CP ceruloplasmin (ferroxidase) -0.0325595
RPLP0 ribosomal protein, large, P0 -0.0315656
RPL5 ribosomal protein L5 -0.0314309
PEG3 paternally expressed 3 -0.0311309
GNAS GNAS complex locus -0.0311053
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0296628
RPS23 ribosomal protein S23 -0.0296493
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0296092
S100A9 S100 calcium binding protein A9 -0.0295368
APOC1 apolipoprotein C-I -0.0291862
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0288742
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0287179
APOA1 apolipoprotein A-I -0.0280896
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0279524
A2M alpha-2-macroglobulin -0.0276671
RPL36 ribosomal protein L36 -0.0272476
PDIA3 protein disulfide isomerase family A, member 3 -0.0270826
RNF213 ring finger protein 213 -0.0268954
EGR1 early growth response 1 -0.0266294
RPL19 ribosomal protein L19 -0.0265922
RPS3 ribosomal protein S3 -0.0261572
RPL9 ribosomal protein L9 -0.0255125
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0252803
IFI6 interferon, alpha-inducible protein 6 -0.0252162
LYZ lysozyme -0.0252004
HMGA1 high mobility group AT-hook 1 -0.0248737
RPS27 ribosomal protein S27 -0.0248365
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0247473
VIM vimentin -0.0244351
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0244174
CCDC146 coiled-coil domain containing 146 -0.0242875
RPL32 ribosomal protein L32 -0.0241458
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0241298
PERP PERP, TP53 apoptosis effector -0.0236522
RPS13 ribosomal protein S13 -0.0234941
IFITM3 interferon induced transmembrane protein 3 -0.0233829
H1-0 H1.0 linker histone -0.0225867
RPS11 ribosomal protein S11 -0.0224385
TPR translocated promoter region, nuclear basket protein -0.022429
CTSB cathepsin B -0.0223098
RPS14 ribosomal protein S14 -0.0221561
RPS27A ribosomal protein S27a -0.0216356
ZMYND8 zinc finger, MYND-type containing 8 -0.0210707
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0210629
IER3 immediate early response 3 -0.0210152
KDM3A lysine (K)-specific demethylase 3A -0.0209484
DDIT4 DNA-damage-inducible transcript 4 -0.0208853
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0207237
TPM4 tropomyosin 4 -0.0205541
RBM25 RNA binding motif protein 25 -0.0205344
CST3 cystatin C -0.020416
RPL8 ribosomal protein L8 -0.0203337
KRT18 keratin 18, type I -0.0201289
CALR calreticulin -0.0200514
FTH1 ferritin, heavy polypeptide 1 -0.0200508
NCOA7 nuclear receptor coactivator 7 -0.0198701
RPL38 ribosomal protein L38 -0.0197525
AMBP alpha-1-microglobulin/bikunin precursor -0.0196947
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0196786