Imiquimod (maleate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD109 CD109 molecule 0.0539168
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0489701
FNDC3B fibronectin type III domain containing 3B 0.0470641
GPC6 glypican 6 0.0469382
ZNF292 zinc finger protein 292 0.0411852
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0384508
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0370193
MSN moesin 0.0363932
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0360315
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0344205
PDE4D phosphodiesterase 4D, cAMP-specific 0.0340867
HELZ helicase with zinc finger 0.0336139
RPL21 ribosomal protein L21 0.0280491
GLS2 glutaminase 2 (liver, mitochondrial) 0.0275947
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0275357
NUP58 nucleoporin 58 0.0267973
ADAM9 ADAM metallopeptidase domain 9 0.0267185
RPL3 ribosomal protein L3 0.0266078
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.025733
NCKAP1 NCK-associated protein 1 0.024433
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0236667
ATP13A3 ATPase type 13A3 0.0227758
QKI QKI, KH domain containing, RNA binding 0.022729
CDK19 cyclin-dependent kinase 19 0.0226228
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0215335
RNF145 ring finger protein 145 0.0210617
CDC73 cell division cycle 73 0.0205341
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0201033
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0200801
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0197167
TSC22D2 TSC22 domain family, member 2 0.0196889
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0195774
TPM3 tropomyosin 3 0.0195442
UBA6 ubiquitin-like modifier activating enzyme 6 0.0191491
NLGN1 neuroligin 1 0.0190563
TFG TRK-fused gene 0.0188416
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.018062
SETD5 SET domain containing 5 0.0178742
FRMD6 FERM domain containing 6 0.0170202
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0168771
WAC WW domain containing adaptor with coiled-coil 0.0168457
PICALM phosphatidylinositol binding clathrin assembly protein 0.0163094
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0161698
MYOF myoferlin 0.0161624
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0159818
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0158623
PBX3 pre-B-cell leukemia homeobox 3 0.0158497
YAP1 Yes-associated protein 1 0.0157925
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.015455
KMT2E lysine (K)-specific methyltransferase 2E 0.01533
RARB retinoic acid receptor, beta 0.0152534
CORO1C coronin, actin binding protein, 1C 0.0151052
SMAD3 SMAD family member 3 0.0148634
PLK2 polo-like kinase 2 0.0147704
RAB8B RAB8B, member RAS oncogene family 0.0145546
MYO1B myosin IB 0.0144684
HILPDA hypoxia inducible lipid droplet-associated 0.0143976
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0140089
KDM6A lysine (K)-specific demethylase 6A 0.0140054
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0139562
MALT1 MALT1 paracaspase 0.0138312
SCAF4 SR-related CTD-associated factor 4 0.0137739
H1-0 H1.0 linker histone 0.013597
CUL3 cullin 3 0.0135676
MXI1 MAX interactor 1, dimerization protein 0.0135434
CASC3 cancer susceptibility candidate 3 0.0134974
CCNL1 cyclin L1 0.0134119
APLP2 amyloid beta (A4) precursor-like protein 2 0.0131757
PUM2 pumilio RNA-binding family member 2 0.013113
USP12 ubiquitin specific peptidase 12 0.0129191
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0128572
CHD1L chromodomain helicase DNA binding protein 1-like 0.012777
PEAK1 pseudopodium-enriched atypical kinase 1 0.0126891
PDS5B PDS5 cohesin associated factor B 0.0125285
MIER1 mesoderm induction early response 1, transcriptional regulator 0.012496
SSBP2 single-stranded DNA binding protein 2 0.0124939
TSC22D1 TSC22 domain family, member 1 0.0124478
SBF2 SET binding factor 2 0.0123701
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0120793
RYK receptor-like tyrosine kinase 0.0120604
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0118593
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0118316
CKAP5 cytoskeleton associated protein 5 0.0117206
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0117053
ETNK1 ethanolamine kinase 1 0.0116793
DDIT4 DNA-damage-inducible transcript 4 0.0116173
NOCT nocturnin 0.01151
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0114982
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.011498
INTS6 integrator complex subunit 6 0.0114947
COPA coatomer protein complex, subunit alpha 0.0113786
TENT4A terminal nucleotidyltransferase 4A 0.0113768
LOXL2 lysyl oxidase-like 2 0.011348
LPP LIM domain containing preferred translocation partner in lipoma 0.0112692
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0111838
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0111801
INSIG2 insulin induced gene 2 0.0110726
SUCO SUN domain containing ossification factor 0.0110348
MIDEAS mitotic deacetylase associated SANT domain protein 0.0109859
MMP12 matrix metallopeptidase 12 0.0108848

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.363233
RPS6 ribosomal protein S6 -0.17817
EXT1 exostosin glycosyltransferase 1 -0.174783
TMSB10 thymosin beta 10 -0.141423
AKAP12 A kinase (PRKA) anchor protein 12 -0.141226
TPT1 tumor protein, translationally-controlled 1 -0.134156
ACTG1 actin gamma 1 -0.112548
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111128
RPL35A ribosomal protein L35a -0.108711
RPLP1 ribosomal protein, large, P1 -0.0992491
MT2A metallothionein 2A -0.0973995
RPL23 ribosomal protein L23 -0.0914346
NAP1L1 nucleosome assembly protein 1-like 1 -0.0769823
PTMA prothymosin, alpha -0.0733699
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0686447
CAVIN1 caveolae associated protein 1 -0.0660842
PRKG1 protein kinase, cGMP-dependent, type I -0.0657213
RPL12 ribosomal protein L12 -0.0607924
FTL ferritin, light polypeptide -0.0606553
RPS19 ribosomal protein S19 -0.0602875
SAMD3 sterile alpha motif domain containing 3 -0.0564981
RPS8 ribosomal protein S8 -0.0564251
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0542736
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0533022
KPNB1 karyopherin (importin) beta 1 -0.0530925
ENKUR enkurin, TRPC channel interacting protein -0.0524333
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0518869
SDCCAG8 serologically defined colon cancer antigen 8 -0.0516067
AHNAK AHNAK nucleoprotein -0.0513089
EIF1 eukaryotic translation initiation factor 1 -0.0508789
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0506897
RPL37A ribosomal protein L37a -0.0504084
KIAA1549L KIAA1549-like -0.0500186
TPM4 tropomyosin 4 -0.0497398
LSAMP limbic system-associated membrane protein -0.0496666
RPL38 ribosomal protein L38 -0.0493896
RPS24 ribosomal protein S24 -0.048239
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0480958
CALD1 caldesmon 1 -0.0478041
RPL34 ribosomal protein L34 -0.0472991
TXNRD1 thioredoxin reductase 1 -0.0472129
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0470777
RPLP2 ribosomal protein, large, P2 -0.0470206
DSCAM Down syndrome cell adhesion molecule -0.0461171
WSB1 WD repeat and SOCS box containing 1 -0.0458163
RPL31 ribosomal protein L31 -0.0451805
RPS27A ribosomal protein S27a -0.0446768
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0443551
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0438272
RPL8 ribosomal protein L8 -0.0436654
NTM neurotrimin -0.0432653
ASPH aspartate beta-hydroxylase -0.0431981
RPL11 ribosomal protein L11 -0.042802
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0425417
C2CD2 C2 calcium-dependent domain containing 2 -0.0420656
RPL36 ribosomal protein L36 -0.0419982
RPS20 ribosomal protein S20 -0.0411606
RPS13 ribosomal protein S13 -0.0410663
PHACTR1 phosphatase and actin regulator 1 -0.0410051
RPS12 ribosomal protein S12 -0.0408924
PTPRG protein tyrosine phosphatase, receptor type, G -0.0406832
PGK1 phosphoglycerate kinase 1 -0.0403266
RPLP0 ribosomal protein, large, P0 -0.0402733
CFAP251 cilia and flagella associated protein 251 -0.0388858
KIAA1217 KIAA1217 -0.0383514
ALCAM activated leukocyte cell adhesion molecule -0.0374746
ESM1 endothelial cell-specific molecule 1 -0.0369258
VDAC1 voltage-dependent anion channel 1 -0.0369183
CD44 CD44 molecule (Indian blood group) -0.036916
GNAS GNAS complex locus -0.036707
RPL26 ribosomal protein L26 -0.0362513
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0362462
IFI16 interferon, gamma-inducible protein 16 -0.0359351
RPL36A ribosomal protein L36a -0.0354926
DOCK4 dedicator of cytokinesis 4 -0.0350611
RPS29 ribosomal protein S29 -0.0349417
RPL19 ribosomal protein L19 -0.0349131
LIMCH1 LIM and calponin homology domains 1 -0.0346754
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0346493
LOC112694756 uncharaterized LOC112694756 -0.0345497
RPL30 ribosomal protein L30 -0.0345392
BMAL2 basic helix-loop-helix ARNT like 2 -0.034453
LIMA1 LIM domain and actin binding 1 -0.0339218
PRRC2C proline-rich coiled-coil 2C -0.0335923
RPS21 ribosomal protein S21 -0.0331924
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0328408
RPS3 ribosomal protein S3 -0.0326054
RPS4X ribosomal protein S4, X-linked -0.0325757
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0323479
ANTXR2 anthrax toxin receptor 2 -0.0322548
ANXA2 annexin A2 -0.0320843
RPS14 ribosomal protein S14 -0.0320829
EEF2 eukaryotic translation elongation factor 2 -0.0319221
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0319109
BTG1 B-cell translocation gene 1, anti-proliferative -0.0316077
CDH13 cadherin 13 -0.0314016
BZW1 basic leucine zipper and W2 domains 1 -0.0310657
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0309082
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0306528
EIF5B eukaryotic translation initiation factor 5B -0.0303113