Imiquimod (maleate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 0.204796
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.177307
FAT1 FAT atypical cadherin 1 0.105903
GOLGA4 golgin A4 0.0975444
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0754643
PRELID2 PRELI domain containing 2 0.0716316
DSCAM Down syndrome cell adhesion molecule 0.0650814
BTBD9 BTB (POZ) domain containing 9 0.0618697
RPL3 ribosomal protein L3 0.0605463
RNF145 ring finger protein 145 0.0584277
KMT2C lysine (K)-specific methyltransferase 2C 0.0575147
AKAP9 A kinase (PRKA) anchor protein 9 0.0559785
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0551088
RPL4 ribosomal protein L4 0.0538563
COG5 component of oligomeric golgi complex 5 0.0538024
SHROOM3 shroom family member 3 0.0533416
ZFAND3 zinc finger, AN1-type domain 3 0.0530907
TRIM2 tripartite motif containing 2 0.0527136
MON2 MON2 homolog (S. cerevisiae) 0.0516263
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0515558
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0514264
FOXO1 forkhead box O1 0.0509957
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0509128
ITGA6 integrin, alpha 6 0.0507326
TXNRD1 thioredoxin reductase 1 0.050233
MED13L mediator complex subunit 13-like 0.0497541
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0492721
PDE4D phosphodiesterase 4D, cAMP-specific 0.0486217
AKAP13 A kinase (PRKA) anchor protein 13 0.0485224
ETNK1 ethanolamine kinase 1 0.047393
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.04688
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.045856
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0458118
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0452954
CCPG1 cell cycle progression 1 0.0449778
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0447615
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0446417
SETD5 SET domain containing 5 0.0443702
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0442512
PTEN phosphatase and tensin homolog 0.0439529
PTPRR protein tyrosine phosphatase, receptor type, R 0.0438855
NKTR natural killer cell triggering receptor 0.0438081
BIRC6 baculoviral IAP repeat containing 6 0.0423834
PKP2 plakophilin 2 0.0418975
ARHGAP29 Rho GTPase activating protein 29 0.0411343
ARHGAP26 Rho GTPase activating protein 26 0.0402285
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0400713
GARS1 glycyl-tRNA synthetase 1 0.0400483
ZFC3H1 zinc finger, C3H1-type containing 0.0400216
EXT1 exostosin glycosyltransferase 1 0.0398891
SOS1 son of sevenless homolog 1 (Drosophila) 0.039775
ZNF292 zinc finger protein 292 0.0397733
SEC31A SEC31 homolog A (S. cerevisiae) 0.0397656
ABHD17C abhydrolase domain containing 17C 0.0396137
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0392891
FLNB filamin B, beta 0.0390198
MYO6 myosin VI 0.0389505
EREG epiregulin 0.0388999
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0387705
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0385487
ATXN1 ataxin 1 0.038149
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0379931
EEF2 eukaryotic translation elongation factor 2 0.0375834
TTC3 tetratricopeptide repeat domain 3 0.0373809
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0371459
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0371313
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0370359
COPA coatomer protein complex, subunit alpha 0.0368712
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0367019
EIF4B eukaryotic translation initiation factor 4B 0.0362743
SBF2 SET binding factor 2 0.035881
ANKRD11 ankyrin repeat domain 11 0.0355409
FNDC3B fibronectin type III domain containing 3B 0.0355406
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0354728
TAS2R14 taste receptor, type 2, member 14 0.0351909
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0351896
ANKRD17 ankyrin repeat domain 17 0.0349167
RAD51B RAD51 paralog B 0.0347241
EXOC4 exocyst complex component 4 0.034679
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0346347
NF1 neurofibromin 1 0.034523
TCF12 transcription factor 12 0.0343956
PTPRK protein tyrosine phosphatase, receptor type, K 0.0343693
USP3 ubiquitin specific peptidase 3 0.0341541
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.033877
USP34 ubiquitin specific peptidase 34 0.0338513
UBA6 ubiquitin-like modifier activating enzyme 6 0.0335771
CDK19 cyclin-dependent kinase 19 0.0334072
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0333582
CTNND1 catenin (cadherin-associated protein), delta 1 0.0331237
SEC24D SEC24 family member D 0.0330571
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0328652
NBAS neuroblastoma amplified sequence 0.0326286
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0324467
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0323303
SND1 staphylococcal nuclease and tudor domain containing 1 0.031974
RAP1B RAP1B, member of RAS oncogene family 0.0319603
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0319287
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0313151
WWC1 WW and C2 domain containing 1 0.0312969

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.156203
RPLP1 ribosomal protein, large, P1 -0.118692
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.113963
RPS6 ribosomal protein S6 -0.0908252
RPL35A ribosomal protein L35a -0.0623189
F3 coagulation factor III (thromboplastin, tissue factor) -0.055786
RPS19 ribosomal protein S19 -0.0544872
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0544001
RPS8 ribosomal protein S8 -0.0540884
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0534117
RPL34 ribosomal protein L34 -0.0529102
TMSB10 thymosin beta 10 -0.050607
RPL31 ribosomal protein L31 -0.0459249
EZR ezrin -0.0444968
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0435778
PKM pyruvate kinase, muscle -0.04131
HLA-B major histocompatibility complex, class I, B -0.0401062
IFI6 interferon, alpha-inducible protein 6 -0.0399187
ACTG1 actin gamma 1 -0.0396514
RPL36 ribosomal protein L36 -0.038161
RPL38 ribosomal protein L38 -0.038027
NPSR1 neuropeptide S receptor 1 -0.0357804
RPLP2 ribosomal protein, large, P2 -0.0348388
RPS25 ribosomal protein S25 -0.0347342
RPL12 ribosomal protein L12 -0.0342053
LOC112694756 uncharaterized LOC112694756 -0.0339721
RPS29 ribosomal protein S29 -0.033216
PTMA prothymosin, alpha -0.0330525
RPL23 ribosomal protein L23 -0.0315921
RPL9 ribosomal protein L9 -0.0298781
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0293917
KLF5 Kruppel-like factor 5 (intestinal) -0.0293915
RIGI RNA sensor RIG-I -0.0290509
RPS27 ribosomal protein S27 -0.0283888
RPS24 ribosomal protein S24 -0.028191
RPL37A ribosomal protein L37a -0.0281557
RPL26 ribosomal protein L26 -0.0281384
MX1 MX dynamin-like GTPase 1 -0.0273645
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0272059
RPS14 ribosomal protein S14 -0.0270371
S100A10 S100 calcium binding protein A10 -0.0270287
RPLP0 ribosomal protein, large, P0 -0.0270214
KRT18 keratin 18, type I -0.0268876
RPL8 ribosomal protein L8 -0.0268431
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0261101
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0255069
RPS23 ribosomal protein S23 -0.0253443
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0247376
KRT19 keratin 19, type I -0.0245827
RPL37 ribosomal protein L37 -0.0244128
ITGB4 integrin, beta 4 -0.0240553
IFITM3 interferon induced transmembrane protein 3 -0.0238549
JUN jun proto-oncogene -0.0234788
TPM4 tropomyosin 4 -0.0234644
RPS11 ribosomal protein S11 -0.0232143
RPL19 ribosomal protein L19 -0.0224456
SP100 SP100 nuclear antigen -0.0221408
FERMT1 fermitin family member 1 -0.0220143
ISG15 ISG15 ubiquitin-like modifier -0.0217216
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0214694
RPS13 ribosomal protein S13 -0.021268
RPL32 ribosomal protein L32 -0.0211025
RACK1 receptor for activated C kinase 1 -0.0209625
DSG2 desmoglein 2 -0.0208914
IFI27 interferon, alpha-inducible protein 27 -0.0208317
XAF1 XIAP associated factor 1 -0.0206901
RPS20 ribosomal protein S20 -0.0206083
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0206029
RPS27A ribosomal protein S27a -0.0205593
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0205391
RPS12 ribosomal protein S12 -0.020536
FRMD5 FERM domain containing 5 -0.0205337
VDAC1 voltage-dependent anion channel 1 -0.0199229
RPL35 ribosomal protein L35 -0.0196736
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0196024
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.019525
RPL36A ribosomal protein L36a -0.0194591
EIF5B eukaryotic translation initiation factor 5B -0.0191873
CCND1 cyclin D1 -0.0190596
RNF213 ring finger protein 213 -0.0190219
S100A6 S100 calcium binding protein A6 -0.0186654
FUS FUS RNA binding protein -0.0185308
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0182943
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0181434
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0181285
EGR1 early growth response 1 -0.0179594
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.017935
MYH14 myosin, heavy chain 14, non-muscle -0.0179262
CLDN4 claudin 4 -0.0179244
RPS3 ribosomal protein S3 -0.0179174
HLA-A major histocompatibility complex, class I, A -0.0177627
RPL28 ribosomal protein L28 -0.0176079
S100A9 S100 calcium binding protein A9 -0.0175407
S100A11 S100 calcium binding protein A11 -0.01754
INHBA inhibin, beta A -0.017232
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0171026
IFIH1 interferon induced with helicase C domain 1 -0.0170628
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0169239
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0166
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0164379