Imiquimod (maleate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Imiquimod (maleate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0568129
PTPRM protein tyrosine phosphatase, receptor type, M 0.0524979
ASPH aspartate beta-hydroxylase 0.0497236
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0402863
FNIP1 folliculin interacting protein 1 0.0400504
CAMTA1 calmodulin binding transcription activator 1 0.0387941
THSD4 thrombospondin, type I, domain containing 4 0.0332459
CEMIP cell migration inducing protein, hyaluronan binding 0.0299451
TTC3 tetratricopeptide repeat domain 3 0.0271243
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0269566
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0266778
PDLIM5 PDZ and LIM domain 5 0.0264047
SAMD4A sterile alpha motif domain containing 4A 0.0261865
FNDC3B fibronectin type III domain containing 3B 0.0257335
INTS6 integrator complex subunit 6 0.0243415
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0240885
PUM2 pumilio RNA-binding family member 2 0.02371
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0233726
DSCAM Down syndrome cell adhesion molecule 0.0231515
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0230315
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0229764
USP34 ubiquitin specific peptidase 34 0.0224212
SEC31A SEC31 homolog A (S. cerevisiae) 0.0215391
KDM6A lysine (K)-specific demethylase 6A 0.0214758
SUMF1 sulfatase modifying factor 1 0.0207255
TBC1D22A TBC1 domain family, member 22A 0.0206463
DTNA dystrobrevin, alpha 0.0204126
SLTM SAFB-like, transcription modulator 0.0202516
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0200758
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0200376
PTK2 protein tyrosine kinase 2 0.0197131
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0194852
GLS2 glutaminase 2 (liver, mitochondrial) 0.0193746
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0192695
ZNF638 zinc finger protein 638 0.0190865
ZC3H11A zinc finger CCCH-type containing 11A 0.0190831
ZFC3H1 zinc finger, C3H1-type containing 0.0188851
TAS2R14 taste receptor, type 2, member 14 0.0185166
HELZ helicase with zinc finger 0.0184884
YEATS2 YEATS domain containing 2 0.0184669
HYOU1 hypoxia up-regulated 1 0.0181398
HOMER1 homer scaffolding protein 1 0.0180552
NBAS neuroblastoma amplified sequence 0.0177683
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0174954
CTBP2 C-terminal binding protein 2 0.0174846
HDLBP high density lipoprotein binding protein 0.0173767
SUCO SUN domain containing ossification factor 0.0169424
ANKRD11 ankyrin repeat domain 11 0.0168352
ANKRD10 ankyrin repeat domain 10 0.0165354
SPIRE1 spire-type actin nucleation factor 1 0.0157624
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0156209
NPAS2 neuronal PAS domain protein 2 0.0153878
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0151739
OGA O-GlcNAcase 0.015169
SEC24D SEC24 family member D 0.0151053
MYH9 myosin, heavy chain 9, non-muscle 0.0150277
SCEL sciellin 0.0150067
MACF1 microtubule-actin crosslinking factor 1 0.0149165
TMEM39A transmembrane protein 39A 0.0147905
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0147103
AFDN afadin, adherens junction formation factor 0.0146441
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0145886
COG5 component of oligomeric golgi complex 5 0.0143676
PMM2 phosphomannomutase 2 0.0141573
DENND4A DENN/MADD domain containing 4A 0.0140673
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0139573
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.013627
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0136262
BIRC6 baculoviral IAP repeat containing 6 0.0135993
GIGYF2 GRB10 interacting GYF protein 2 0.0133892
XRRA1 X-ray radiation resistance associated 1 0.0132828
EWSR1 EWS RNA-binding protein 1 0.0131828
CLTC clathrin, heavy chain (Hc) 0.0129964
LRP12 low density lipoprotein receptor-related protein 12 0.0129935
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.0128514
AEBP2 AE binding protein 2 0.012653
TM9SF2 transmembrane 9 superfamily member 2 0.0126395
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0125552
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0124276
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0124184
UVRAG UV radiation resistance associated 0.0123739
CATSPERB catsper channel auxiliary subunit beta 0.0123616
TENT2 terminal nucleotidyltransferase 2 0.0123588
NGLY1 N-glycanase 1 0.0123369
SEPTIN2 septin 2 0.0123353
RPL4 ribosomal protein L4 0.0122629
PDIA5 protein disulfide isomerase family A, member 5 0.0122453
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0122067
TFG TRK-fused gene 0.0121607
MCU mitochondrial calcium uniporter 0.0121009
RCOR1 REST corepressor 1 0.0120612
GRB10 growth factor receptor-bound protein 10 0.0118976
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0117329
MYO5C myosin VC 0.0117152
FAM13A family with sequence similarity 13, member A 0.011569
PGM3 phosphoglucomutase 3 0.0115471
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0114185
USP53 ubiquitin specific peptidase 53 0.0113953
EP300 E1A binding protein p300 0.0111941
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0110848

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.490361
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.187431
TMSB10 thymosin beta 10 -0.148344
FTH1 ferritin, heavy polypeptide 1 -0.129594
MT2A metallothionein 2A -0.121792
NDRG1 N-myc downstream regulated 1 -0.121141
TXNRD1 thioredoxin reductase 1 -0.100786
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.100745
FTL ferritin, light polypeptide -0.0854314
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0783135
LOC112694756 uncharaterized LOC112694756 -0.0744604
S100A10 S100 calcium binding protein A10 -0.0679322
LDHA lactate dehydrogenase A -0.0676043
RPS3 ribosomal protein S3 -0.0675005
PKM pyruvate kinase, muscle -0.0652153
EGR1 early growth response 1 -0.0620775
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0584561
AKR1C1 aldo-keto reductase family 1, member C1 -0.0568921
SEC61G Sec61 gamma subunit -0.0564865
RPLP1 ribosomal protein, large, P1 -0.055706
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0555831
TPT1 tumor protein, translationally-controlled 1 -0.0554057
CAV1 caveolin 1, caveolae protein, 22kDa -0.0523248
NAMPT nicotinamide phosphoribosyltransferase -0.0466055
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0462914
RPL35A ribosomal protein L35a -0.0460428
ACTG1 actin gamma 1 -0.0452592
RPS8 ribosomal protein S8 -0.0451143
OSMR oncostatin M receptor -0.0448736
PTMA prothymosin, alpha -0.0448248
B2M beta-2-microglobulin -0.0445769
SLC38A1 solute carrier family 38, member 1 -0.0433191
RPS25 ribosomal protein S25 -0.0427658
ANXA2 annexin A2 -0.0423878
RPS6 ribosomal protein S6 -0.0414565
CES1 carboxylesterase 1 -0.0414044
CST3 cystatin C -0.0412055
RPL37A ribosomal protein L37a -0.040849
LAMA4 laminin, alpha 4 -0.0404125
RPL31 ribosomal protein L31 -0.039465
RPS12 ribosomal protein S12 -0.0391098
ENO1 enolase 1, (alpha) -0.038354
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.03778
CPE carboxypeptidase E -0.0372993
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0366736
RPS24 ribosomal protein S24 -0.0351246
STC1 stanniocalcin 1 -0.0351175
BTG1 B-cell translocation gene 1, anti-proliferative -0.0346442
RPL34 ribosomal protein L34 -0.0344127
IGFBP3 insulin-like growth factor binding protein 3 -0.0339038
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0337037
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0335342
PDE4D phosphodiesterase 4D, cAMP-specific -0.0327227
EIF1 eukaryotic translation initiation factor 1 -0.0326294
IFI6 interferon, alpha-inducible protein 6 -0.0316911
MT1X metallothionein 1X -0.0308095
RPL12 ribosomal protein L12 -0.0302665
AREG amphiregulin -0.0302107
RPS27A ribosomal protein S27a -0.0299417
RPLP0 ribosomal protein, large, P0 -0.0297077
RPL19 ribosomal protein L19 -0.0294947
HLA-B major histocompatibility complex, class I, B -0.0294911
RPS27 ribosomal protein S27 -0.0291015
LRP1B low density lipoprotein receptor-related protein 1B -0.0290412
S100P S100 calcium binding protein P -0.0284262
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0283203
RPS29 ribosomal protein S29 -0.0282001
S100A11 S100 calcium binding protein A11 -0.0279938
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.027871
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0276715
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0270509
RPS19 ribosomal protein S19 -0.0268977
RPL30 ribosomal protein L30 -0.0268298
RPL11 ribosomal protein L11 -0.026696
RNF213 ring finger protein 213 -0.0266797
RPLP2 ribosomal protein, large, P2 -0.0263703
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0262539
RPS23 ribosomal protein S23 -0.0258926
RPS17 ribosomal protein S17 -0.0254533
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0253497
RPL37 ribosomal protein L37 -0.0252992
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0252777
RPS14 ribosomal protein S14 -0.0248679
RPL26 ribosomal protein L26 -0.0247653
S100A6 S100 calcium binding protein A6 -0.0247569
CIB1 calcium and integrin binding 1 (calmyrin) -0.0246195
S100A9 S100 calcium binding protein A9 -0.0241531
RPL8 ribosomal protein L8 -0.0235311
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0231306
GRAMD1B GRAM domain containing 1B -0.0229868
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0226565
RPL36 ribosomal protein L36 -0.0219944
HMGA1 high mobility group AT-hook 1 -0.0219651
IER3 immediate early response 3 -0.0219631
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0218312
RACK1 receptor for activated C kinase 1 -0.0217433
MCL1 myeloid cell leukemia 1 -0.0214169
KRT18 keratin 18, type I -0.0213975
RPL23 ribosomal protein L23 -0.0213764
BIRC3 baculoviral IAP repeat containing 3 -0.0213224