Imiquimod (maleate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.112424
FNDC3B fibronectin type III domain containing 3B 0.106714
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.100741
GRB10 growth factor receptor-bound protein 10 0.0994262
RICTOR RPTOR independent companion of MTOR, complex 2 0.0913801
PDE4D phosphodiesterase 4D, cAMP-specific 0.0784233
UBA6 ubiquitin-like modifier activating enzyme 6 0.0766214
TRIO trio Rho guanine nucleotide exchange factor 0.0717655
MEF2A myocyte enhancer factor 2A 0.0701587
SDK1 sidekick cell adhesion molecule 1 0.06995
GOLGA4 golgin A4 0.0681899
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0672515
KDM2A lysine (K)-specific demethylase 2A 0.067091
HELZ helicase with zinc finger 0.066704
SETD5 SET domain containing 5 0.0584931
PCBP2 poly(rC) binding protein 2 0.0579963
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0566315
USP34 ubiquitin specific peptidase 34 0.0564683
ATP13A3 ATPase type 13A3 0.0553613
PIAS2 protein inhibitor of activated STAT, 2 0.0551722
ITCH itchy E3 ubiquitin protein ligase 0.0536932
NAMPT nicotinamide phosphoribosyltransferase 0.0535107
DLG1 discs, large homolog 1 (Drosophila) 0.0518041
NGLY1 N-glycanase 1 0.0512754
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0505727
WAC WW domain containing adaptor with coiled-coil 0.0495352
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0493635
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0473071
KMT2C lysine (K)-specific methyltransferase 2C 0.0460916
COPA coatomer protein complex, subunit alpha 0.0453358
ZNF292 zinc finger protein 292 0.0444643
SPAG9 sperm associated antigen 9 0.0435253
USP3 ubiquitin specific peptidase 3 0.0429575
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.042465
RAB1A RAB1A, member RAS oncogene family 0.0419784
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0409065
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0404319
SIK3 SIK family kinase 3 0.0390466
RIOK3 RIO kinase 3 0.0386929
ZFAND3 zinc finger, AN1-type domain 3 0.0385179
RAB8B RAB8B, member RAS oncogene family 0.0383186
RUNX2 runt-related transcription factor 2 0.0382067
KDM3A lysine (K)-specific demethylase 3A 0.0375137
RNF145 ring finger protein 145 0.0372031
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0369369
ANKRD11 ankyrin repeat domain 11 0.036929
SUCO SUN domain containing ossification factor 0.0366368
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0363777
NBAS neuroblastoma amplified sequence 0.0361304
SOD2 superoxide dismutase 2, mitochondrial 0.0360194
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0359131
ESYT2 extended synaptotagmin-like protein 2 0.0349113
NPEPPS aminopeptidase puromycin sensitive 0.0346303
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0341944
LCOR ligand dependent nuclear receptor corepressor 0.033453
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0334129
MYO1B myosin IB 0.0333481
QKI QKI, KH domain containing, RNA binding 0.0331189
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0330817
COG5 component of oligomeric golgi complex 5 0.0328074
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0327636
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.032414
GPC6 glypican 6 0.032385
CDC73 cell division cycle 73 0.0321466
IGFBP3 insulin-like growth factor binding protein 3 0.0320916
SMAD3 SMAD family member 3 0.0314468
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.031309
PHF21A PHD finger protein 21A 0.031207
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.030592
KDM6A lysine (K)-specific demethylase 6A 0.0303391
SBF2 SET binding factor 2 0.0302537
STRN3 striatin, calmodulin binding protein 3 0.0300723
FLNB filamin B, beta 0.0300686
JMJD1C jumonji domain containing 1C 0.029852
RAB6A RAB6A, member RAS oncogene family 0.0293084
PICALM phosphatidylinositol binding clathrin assembly protein 0.0291934
SEC23A Sec23 homolog A (S. cerevisiae) 0.0291862
ARHGAP12 Rho GTPase activating protein 12 0.0289718
ADD3 adducin 3 (gamma) 0.0284004
CHD1 chromodomain helicase DNA binding protein 1 0.0284004
KCMF1 potassium channel modulatory factor 1 0.028051
OGA O-GlcNAcase 0.0278118
MARCHF6 membrane associated ring-CH-type finger 6 0.0275909
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.027402
CD109 CD109 molecule 0.0270589
PTBP2 polypyrimidine tract binding protein 2 0.02696
HILPDA hypoxia inducible lipid droplet-associated 0.0269226
ELL2 elongation factor, RNA polymerase II, 2 0.026852
SSBP2 single-stranded DNA binding protein 2 0.0267968
SLTM SAFB-like, transcription modulator 0.0267931
PTK2 protein tyrosine kinase 2 0.026744
AKAP13 A kinase (PRKA) anchor protein 13 0.0265959
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0264494
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0263228
PSD3 pleckstrin and Sec7 domain containing 3 0.0262875
NUP58 nucleoporin 58 0.0262737
RPL3 ribosomal protein L3 0.0260564
PRELID2 PRELI domain containing 2 0.025969
ARHGAP32 Rho GTPase activating protein 32 0.0258557
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0253695

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196435
VIM vimentin -0.194225
TMSB10 thymosin beta 10 -0.160024
MT2A metallothionein 2A -0.150023
RPLP1 ribosomal protein, large, P1 -0.0980683
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0883059
RPL35A ribosomal protein L35a -0.0875681
FTL ferritin, light polypeptide -0.0780376
CD44 CD44 molecule (Indian blood group) -0.0778764
CXCL8 chemokine (C-X-C motif) ligand 8 -0.074708
PTMA prothymosin, alpha -0.0653173
RPS19 ribosomal protein S19 -0.0606755
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0596818
RPL23 ribosomal protein L23 -0.0537942
EIF1 eukaryotic translation initiation factor 1 -0.0513745
RPL34 ribosomal protein L34 -0.0511086
RPS24 ribosomal protein S24 -0.0502457
GLCCI1 glucocorticoid induced 1 -0.0493033
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.047606
RPS6 ribosomal protein S6 -0.0454226
RPS29 ribosomal protein S29 -0.0451008
C15ORF48 chromosome 15 open reading frame 48 -0.0449509
RPL31 ribosomal protein L31 -0.0437351
RPLP2 ribosomal protein, large, P2 -0.0433092
RPL36 ribosomal protein L36 -0.0424502
RPL32 ribosomal protein L32 -0.0422658
RPL12 ribosomal protein L12 -0.0422527
S100A10 S100 calcium binding protein A10 -0.0414097
B2M beta-2-microglobulin -0.0409635
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0408515
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.04015
RPS21 ribosomal protein S21 -0.0400986
LOX lysyl oxidase -0.0386274
IFI16 interferon, gamma-inducible protein 16 -0.0385527
NCOA7 nuclear receptor coactivator 7 -0.038157
HLA-B major histocompatibility complex, class I, B -0.0381529
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0379176
EGR1 early growth response 1 -0.0378331
IER3 immediate early response 3 -0.0378123
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0376674
TFPI2 tissue factor pathway inhibitor 2 -0.0376312
TPT1 tumor protein, translationally-controlled 1 -0.0375716
ZBTB20 zinc finger and BTB domain containing 20 -0.0367145
FN1 fibronectin 1 -0.0366209
SLC38A1 solute carrier family 38, member 1 -0.0352077
RPL38 ribosomal protein L38 -0.0346856
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.034642
RPS8 ribosomal protein S8 -0.0334767
TM4SF1 transmembrane 4 L six family member 1 -0.0327943
IFI6 interferon, alpha-inducible protein 6 -0.0327164
RPS13 ribosomal protein S13 -0.0322631
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0321821
STC1 stanniocalcin 1 -0.0321098
KLF6 Kruppel-like factor 6 -0.0316448
SAMD9 sterile alpha motif domain containing 9 -0.0309337
RPL11 ribosomal protein L11 -0.0301279
S100A6 S100 calcium binding protein A6 -0.0297767
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0293065
TIMP1 TIMP metallopeptidase inhibitor 1 -0.028641
ACTG1 actin gamma 1 -0.0285971
RPL28 ribosomal protein L28 -0.0285387
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0284781
EXT1 exostosin glycosyltransferase 1 -0.0275215
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0274488
IFITM3 interferon induced transmembrane protein 3 -0.0273066
IFIH1 interferon induced with helicase C domain 1 -0.0270799
RPL37A ribosomal protein L37a -0.0266709
HMGA2 high mobility group AT-hook 2 -0.0260784
AHNAK AHNAK nucleoprotein -0.0258483
RPL19 ribosomal protein L19 -0.0255453
BASP1 brain abundant, membrane attached signal protein 1 -0.0252
OSMR oncostatin M receptor -0.0248436
RPS11 ribosomal protein S11 -0.0247768
SEC61G Sec61 gamma subunit -0.0247533
VDAC1 voltage-dependent anion channel 1 -0.0247358
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0245498
HMGA1 high mobility group AT-hook 1 -0.0243339
ANTXR2 anthrax toxin receptor 2 -0.0241825
LMNA lamin A/C -0.0240872
RPL9 ribosomal protein L9 -0.0240567
TMSB4X thymosin beta 4, X-linked -0.0235847
EMP1 epithelial membrane protein 1 -0.0233892
RPS27 ribosomal protein S27 -0.0232158
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0230794
RNF213 ring finger protein 213 -0.023029
RACK1 receptor for activated C kinase 1 -0.0228188
HLA-A major histocompatibility complex, class I, A -0.0227182
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0226036
RPL5 ribosomal protein L5 -0.0225336
BTG1 B-cell translocation gene 1, anti-proliferative -0.0224054
VCL vinculin -0.0223527
RPL30 ribosomal protein L30 -0.0219317
RPL26 ribosomal protein L26 -0.0217306
RAB13 RAB13, member RAS oncogene family -0.0215525
EFNA5 ephrin-A5 -0.0213045
RPS25 ribosomal protein S25 -0.0211852
HLA-C major histocompatibility complex, class I, C -0.021053
HAS2 hyaluronan synthase 2 -0.0209796
RPS20 ribosomal protein S20 -0.0208931
RPL8 ribosomal protein L8 -0.0208781