Imiquimod (maleate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL4 ribosomal protein L4 0.0447972
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0436082
TPM3 tropomyosin 3 0.0337533
ERRFI1 ERBB receptor feedback inhibitor 1 0.0335188
HSPA8 heat shock 70kDa protein 8 0.031003
TM4SF1 transmembrane 4 L six family member 1 0.0289454
USP3 ubiquitin specific peptidase 3 0.0257005
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0246931
APP amyloid beta (A4) precursor protein 0.0235085
NAMPT nicotinamide phosphoribosyltransferase 0.0232629
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0229822
KDM3A lysine (K)-specific demethylase 3A 0.02179
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0213729
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0213072
DSCAM Down syndrome cell adhesion molecule 0.0210879
ZNF292 zinc finger protein 292 0.0204325
PTK2 protein tyrosine kinase 2 0.0195138
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.019369
TRIO trio Rho guanine nucleotide exchange factor 0.0188714
PUM2 pumilio RNA-binding family member 2 0.0186792
WDR43 WD repeat domain 43 0.0184189
RRM2 ribonucleotide reductase M2 0.0180094
ZFAND3 zinc finger, AN1-type domain 3 0.0178515
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.017717
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0175485
GLS2 glutaminase 2 (liver, mitochondrial) 0.0172781
NCKAP1 NCK-associated protein 1 0.0172759
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0171961
TPD52 tumor protein D52 0.0169641
YAP1 Yes-associated protein 1 0.0167128
ADAM17 ADAM metallopeptidase domain 17 0.0164866
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0164454
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0161336
ECT2 epithelial cell transforming 2 0.0159297
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0158971
JAK1 Janus kinase 1 0.0156992
DENND4A DENN/MADD domain containing 4A 0.0156606
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0155895
ARHGAP29 Rho GTPase activating protein 29 0.0152767
NUP153 nucleoporin 153kDa 0.015182
RAD21 RAD21 homolog (S. pombe) 0.0150881
BCLAF1 BCL2-associated transcription factor 1 0.0145718
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.014396
ADGRG6 adhesion G protein-coupled receptor G6 0.0143006
EWSR1 EWS RNA-binding protein 1 0.0142072
ADAM9 ADAM metallopeptidase domain 9 0.0141743
MKI67 marker of proliferation Ki-67 0.0140678
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0139639
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0139564
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0139301
MACF1 microtubule-actin crosslinking factor 1 0.0138779
GOLT1B golgi transport 1B 0.0137938
XPO1 exportin 1 0.0136436
ELOVL5 ELOVL fatty acid elongase 5 0.0134928
RPL3 ribosomal protein L3 0.0133982
COG5 component of oligomeric golgi complex 5 0.0133149
YME1L1 YME1-like 1 ATPase 0.0132643
SBF2 SET binding factor 2 0.013205
CHN1 chimerin 1 0.013117
NCOR1 nuclear receptor corepressor 1 0.01297
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0128337
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0127364
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0127023
CASC3 cancer susceptibility candidate 3 0.0126602
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0126327
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0126212
CAMTA1 calmodulin binding transcription activator 1 0.0124718
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0124322
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.012246
USP15 ubiquitin specific peptidase 15 0.0120874
CLTC clathrin, heavy chain (Hc) 0.0120731
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.011943
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0118777
SAMD4A sterile alpha motif domain containing 4A 0.0117677
RBM33 RNA binding motif protein 33 0.0116847
EIF4B eukaryotic translation initiation factor 4B 0.011681
RNF145 ring finger protein 145 0.0114529
NEK7 NIMA-related kinase 7 0.011428
ABI1 abl-interactor 1 0.0114268
WDR20 WD repeat domain 20 0.0113082
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.011291
SETD5 SET domain containing 5 0.0112228
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0110371
PICALM phosphatidylinositol binding clathrin assembly protein 0.011023
FOXJ3 forkhead box J3 0.0110121
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0109815
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0109645
MTMR3 myotubularin related protein 3 0.0109461
BMPR1B bone morphogenetic protein receptor, type IB 0.0109174
IST1 increased sodium tolerance 1 homolog (yeast) 0.0109128
PUM1 pumilio RNA-binding family member 1 0.0108684
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0108612
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0108461
YBX1 Y box binding protein 1 0.0108443
WAC WW domain containing adaptor with coiled-coil 0.0108435
ZNF512 zinc finger protein 512 0.0106893
TPR translocated promoter region, nuclear basket protein 0.0106858
OSBPL9 oxysterol binding protein-like 9 0.0106181
FAM168A family with sequence similarity 168, member A 0.0104468
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.010415

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.319698
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.219297
FTL ferritin, light polypeptide -0.167202
TMSB10 thymosin beta 10 -0.155078
VIM vimentin -0.148657
ACTG1 actin gamma 1 -0.0723476
FTH1 ferritin, heavy polypeptide 1 -0.0702301
POTEF POTE ankyrin domain family, member F -0.0666075
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0626612
IGF2 insulin-like growth factor 2 -0.0622579
THSD4 thrombospondin, type I, domain containing 4 -0.0620789
PDE4D phosphodiesterase 4D, cAMP-specific -0.0597998
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0589921
RPL23 ribosomal protein L23 -0.0583965
IGFBP3 insulin-like growth factor binding protein 3 -0.0522265
GRAMD1B GRAM domain containing 1B -0.0503132
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0500626
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0439986
RPLP1 ribosomal protein, large, P1 -0.0435954
EGR1 early growth response 1 -0.0431995
RPL35A ribosomal protein L35a -0.040819
EIF1 eukaryotic translation initiation factor 1 -0.0399
RPL19 ribosomal protein L19 -0.0396857
PFN1 profilin 1 -0.0362568
RPS19 ribosomal protein S19 -0.0340406
PYGL phosphorylase, glycogen, liver -0.0337792
STC1 stanniocalcin 1 -0.0337295
RPL36 ribosomal protein L36 -0.032842
PKM pyruvate kinase, muscle -0.0327295
RPS29 ribosomal protein S29 -0.0320729
RPS6 ribosomal protein S6 -0.0318634
S100A6 S100 calcium binding protein A6 -0.0312426
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.030728
BASP1 brain abundant, membrane attached signal protein 1 -0.0305143
TFPI2 tissue factor pathway inhibitor 2 -0.0295036
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0292308
PTMA prothymosin, alpha -0.0290051
MCL1 myeloid cell leukemia 1 -0.0277873
RPS8 ribosomal protein S8 -0.0274588
RPS21 ribosomal protein S21 -0.0270724
CMIP c-Maf inducing protein -0.0270311
HLA-B major histocompatibility complex, class I, B -0.0266687
S100A10 S100 calcium binding protein A10 -0.0257277
VDAC1 voltage-dependent anion channel 1 -0.0254977
RPLP0 ribosomal protein, large, P0 -0.0247561
RPL31 ribosomal protein L31 -0.0244367
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0241939
HMGA1 high mobility group AT-hook 1 -0.0240824
C15ORF48 chromosome 15 open reading frame 48 -0.0238987
RPS20 ribosomal protein S20 -0.0237392
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0233478
EEF2 eukaryotic translation elongation factor 2 -0.022653
PM20D1 peptidase M20 domain containing 1 -0.0224052
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0223868
IL6 interleukin 6 -0.022119
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0220263
TPM4 tropomyosin 4 -0.0220106
AKAP12 A kinase (PRKA) anchor protein 12 -0.0210305
PDIA3 protein disulfide isomerase family A, member 3 -0.020944
LOC102724023 ES1 protein homolog, mitochondrial -0.0207953
LOC112694756 uncharaterized LOC112694756 -0.0206155
RPL8 ribosomal protein L8 -0.0204396
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0203601
OSMR oncostatin M receptor -0.0200894
FGB fibrinogen beta chain -0.0200312
RPS27 ribosomal protein S27 -0.0197904
S100A11 S100 calcium binding protein A11 -0.0197537
ATP5F1E ATP synthase F1 subunit epsilon -0.0192582
ASTN2 astrotactin 2 -0.0190594
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.018852
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0187301
ARHGAP26 Rho GTPase activating protein 26 -0.0186848
ATP5F1B ATP synthase F1 subunit beta -0.0183464
RPS23 ribosomal protein S23 -0.0183281
CAVIN1 caveolae associated protein 1 -0.0182766
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0179583
BICC1 BicC family RNA binding protein 1 -0.0177496
IGFBP4 insulin-like growth factor binding protein 4 -0.0175052
MT1X metallothionein 1X -0.0174258
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0171366
TPI1 triosephosphate isomerase 1 -0.0170734
RPL9 ribosomal protein L9 -0.0169822
RPS5 ribosomal protein S5 -0.0169402
RPS11 ribosomal protein S11 -0.0168496
LDHA lactate dehydrogenase A -0.0168018
EGFR epidermal growth factor receptor -0.0167935
PRDX1 peroxiredoxin 1 -0.0167295
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.016725
S100A9 S100 calcium binding protein A9 -0.0166341
MAML3 mastermind-like 3 (Drosophila) -0.0165878
RPS14 ribosomal protein S14 -0.0164867
RPS16 ribosomal protein S16 -0.0163386
FLNB filamin B, beta -0.0161076
NNMT nicotinamide N-methyltransferase -0.0161073
RPL28 ribosomal protein L28 -0.0160859
WWOX WW domain containing oxidoreductase -0.0159031
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0158081
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0156998
RPL37A ribosomal protein L37a -0.0154765
RPS25 ribosomal protein S25 -0.0154533