Imiquimod (maleate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.163272
LAMB3 laminin, beta 3 0.141022
DST dystonin 0.120456
GPC6 glypican 6 0.111556
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.103507
KRT17 keratin 17, type I 0.0960213
CAMTA1 calmodulin binding transcription activator 1 0.0958644
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0916215
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0818455
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0796196
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0786679
ERRFI1 ERBB receptor feedback inhibitor 1 0.0785669
ACTN4 actinin, alpha 4 0.0764315
RUNX1 runt-related transcription factor 1 0.073365
C3 complement component 3 0.0731875
TPR translocated promoter region, nuclear basket protein 0.0716708
TOP1 topoisomerase (DNA) I 0.0715005
AGFG1 ArfGAP with FG repeats 1 0.0694113
RPL37A ribosomal protein L37a 0.0650344
LAMC2 laminin, gamma 2 0.0626353
ATP13A3 ATPase type 13A3 0.062387
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0603228
MACROD2 MACRO domain containing 2 0.0587688
DSCAM Down syndrome cell adhesion molecule 0.0579735
USP53 ubiquitin specific peptidase 53 0.0551601
RPS4X ribosomal protein S4, X-linked 0.0549821
CTNND1 catenin (cadherin-associated protein), delta 1 0.0547158
NAMPT nicotinamide phosphoribosyltransferase 0.0544284
DSTN destrin (actin depolymerizing factor) 0.053543
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0522281
PRELID2 PRELI domain containing 2 0.0521931
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0510019
ZFAND6 zinc finger, AN1-type domain 6 0.0504827
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0496803
RFC3 replication factor C (activator 1) 3, 38kDa 0.0494016
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0492526
IER3 immediate early response 3 0.0487391
PATJ PATJ crumbs cell polarity complex component 0.0487008
NDRG1 N-myc downstream regulated 1 0.0481336
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0476294
SAMD4A sterile alpha motif domain containing 4A 0.0475064
SYT1 synaptotagmin I 0.0468634
WDR26 WD repeat domain 26 0.0462196
MCL1 myeloid cell leukemia 1 0.0459338
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0453224
PRRC2C proline-rich coiled-coil 2C 0.0439812
TNPO1 transportin 1 0.0432616
RPS24 ribosomal protein S24 0.0430715
MAML2 mastermind-like 2 (Drosophila) 0.0429948
GNAS GNAS complex locus 0.0428968
BZW1 basic leucine zipper and W2 domains 1 0.0417603
PCBP2 poly(rC) binding protein 2 0.0403578
VMP1 vacuole membrane protein 1 0.0394219
RPLP2 ribosomal protein, large, P2 0.0393189
TRIO trio Rho guanine nucleotide exchange factor 0.0388547
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.038466
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0376372
SPAG9 sperm associated antigen 9 0.036873
RPS8 ribosomal protein S8 0.0366044
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0360713
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0349405
TIMP3 TIMP metallopeptidase inhibitor 3 0.0341154
ANKRD12 ankyrin repeat domain 12 0.0337723
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0336477
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0327925
RPL35A ribosomal protein L35a 0.0317164
PLAUR plasminogen activator, urokinase receptor 0.0302867
RPS21 ribosomal protein S21 0.0301536
PUM2 pumilio RNA-binding family member 2 0.029744
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.029556
UBC ubiquitin C 0.0293985
CEP95 centrosomal protein 95kDa 0.029109
ANXA1 annexin A1 0.0289406
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0286787
PGK1 phosphoglycerate kinase 1 0.0275092
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0271922
ITGB5 integrin, beta 5 0.0271157
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0265441
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.026364
LDHA lactate dehydrogenase A 0.0263443
RICTOR RPTOR independent companion of MTOR, complex 2 0.0259315
TSC22D2 TSC22 domain family, member 2 0.0253826
TBC1D5 TBC1 domain family, member 5 0.0231542
FNDC3B fibronectin type III domain containing 3B 0.0230205
GPHN gephyrin 0.0229233
ELL2 elongation factor, RNA polymerase II, 2 0.0226242
RPS23 ribosomal protein S23 0.0220903
MT2A metallothionein 2A 0.0218906
NUMB numb homolog (Drosophila) 0.0218825
GRB10 growth factor receptor-bound protein 10 0.0214009
FNDC3A fibronectin type III domain containing 3A 0.0211105
RAP1B RAP1B, member of RAS oncogene family 0.020917
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0208019
SPNS2 spinster homolog 2 (Drosophila) 0.0207808
SDC4 syndecan 4 0.0207793
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0202902
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0191992
IGF2 insulin-like growth factor 2 0.0178907
FMNL2 formin-like 2 0.0176684
ZNF451 zinc finger protein 451 0.0168857

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.152346
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.14038
FBXO11 F-box protein 11 -0.110996
EGFR epidermal growth factor receptor -0.110237
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0997846
MACF1 microtubule-actin crosslinking factor 1 -0.0983368
LMO7 LIM domain 7 -0.0950127
FBF1 Fas (TNFRSF6) binding factor 1 -0.0939153
LOXL2 lysyl oxidase-like 2 -0.0934648
BACE2 beta-site APP-cleaving enzyme 2 -0.0924897
FTL ferritin, light polypeptide -0.091433
SVIL supervillin -0.0912356
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.086516
NALF1 NALCN channel auxiliary factor 1 -0.0856908
RNF213 ring finger protein 213 -0.0856044
MYO1E myosin IE -0.0833483
EFNA5 ephrin-A5 -0.0806443
IGFBP3 insulin-like growth factor binding protein 3 -0.0805113
GOLGA4 golgin A4 -0.0774573
NAP1L1 nucleosome assembly protein 1-like 1 -0.0765077
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0750344
DLG1 discs, large homolog 1 (Drosophila) -0.0749092
MUC16 mucin 16, cell surface associated -0.0732638
EZR ezrin -0.0722213
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0721496
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0715132
NF1 neurofibromin 1 -0.0703814
PDE10A phosphodiesterase 10A -0.068894
SEC31A SEC31 homolog A (S. cerevisiae) -0.0688613
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0673758
RPS16 ribosomal protein S16 -0.066849
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0665508
ESYT2 extended synaptotagmin-like protein 2 -0.0664571
EXT1 exostosin glycosyltransferase 1 -0.0656158
ERBIN erbb2 interacting protein -0.0636612
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0617057
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0610703
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0610612
CEMIP cell migration inducing protein, hyaluronan binding -0.0592119
B2M beta-2-microglobulin -0.058757
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0535742
POTEF POTE ankyrin domain family, member F -0.0497239
PDE4D phosphodiesterase 4D, cAMP-specific -0.0481495
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0465505
SMOC1 SPARC related modular calcium binding 1 -0.045938
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0454074
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0436889
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0429845
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0424385
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0420061
FLNB filamin B, beta -0.0413466
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0411477
JMJD1C jumonji domain containing 1C -0.0407873
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0384043
ZBTB20 zinc finger and BTB domain containing 20 -0.0360449
SMAD3 SMAD family member 3 -0.0356181
PTMA prothymosin, alpha -0.0353057
AKAP9 A kinase (PRKA) anchor protein 9 -0.0337899
KMT2C lysine (K)-specific methyltransferase 2C -0.0335595
ANXA2 annexin A2 -0.0330512
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0316387
STC1 stanniocalcin 1 -0.0303103
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0298969
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0293606
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0290443
IFIH1 interferon induced with helicase C domain 1 -0.028823
ZMYND8 zinc finger, MYND-type containing 8 -0.0282594
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0250845
RPL31 ribosomal protein L31 -0.0237885
IGF1R insulin-like growth factor 1 receptor -0.0233727
NIPBL Nipped-B homolog (Drosophila) -0.0229245
RPL11 ribosomal protein L11 -0.0218474
PARD3 par-3 family cell polarity regulator -0.0205514
MEF2A myocyte enhancer factor 2A -0.0204499
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.019631
SLTM SAFB-like, transcription modulator -0.0195292
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0180765
LIMCH1 LIM and calponin homology domains 1 -0.0173185
AKAP12 A kinase (PRKA) anchor protein 12 -0.0170455
RPS12 ribosomal protein S12 -0.0165665
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0162841
TMEM87A transmembrane protein 87A -0.0155701
AHNAK AHNAK nucleoprotein -0.015554
HLA-B major histocompatibility complex, class I, B -0.0142474
HMGA2 high mobility group AT-hook 2 -0.0137005
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0130102
TJP1 tight junction protein 1 -0.0126139
RPS19 ribosomal protein S19 -0.011161
DOCK4 dedicator of cytokinesis 4 -0.0111315
FN1 fibronectin 1 -0.0111239
RSAD2 radical S-adenosyl methionine domain containing 2 -0.010969
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0108861
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0108503
IGF2R insulin-like growth factor 2 receptor -0.010575
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0102266
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.00996766
RPS6 ribosomal protein S6 -0.00964542
ARHGAP21 Rho GTPase activating protein 21 -0.00893013
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.00844801
IQGAP1 IQ motif containing GTPase activating protein 1 -0.00804968