| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (maleate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Imiquimod (maleate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.118433 |
| TXNRD1 | thioredoxin reductase 1 | 0.10228 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0905264 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0832103 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0607301 |
| TPM3 | tropomyosin 3 | 0.0543577 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0514883 |
| RRM2 | ribonucleotide reductase M2 | 0.0504252 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0496304 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0489431 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0478816 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0461552 |
| RTN4 | reticulon 4 | 0.0443144 |
| PHIP | pleckstrin homology domain interacting protein | 0.0428845 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0427521 |
| MKI67 | marker of proliferation Ki-67 | 0.0426922 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0407528 |
| XPO1 | exportin 1 | 0.0396577 |
| MED13L | mediator complex subunit 13-like | 0.0396537 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0385892 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0375494 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0369136 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0360772 |
| ETNK1 | ethanolamine kinase 1 | 0.0350196 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.034976 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0349014 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0346674 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0346662 |
| COG5 | component of oligomeric golgi complex 5 | 0.0344379 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0342742 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0341632 |
| PLCB4 | phospholipase C, beta 4 | 0.0327999 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0316976 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0316776 |
| PNN | pinin, desmosome associated protein | 0.0312838 |
| ADAR | adenosine deaminase, RNA-specific | 0.0311573 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0309758 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0298273 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0297571 |
| SBF2 | SET binding factor 2 | 0.0296823 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0293722 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0291123 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0290978 |
| SP3 | Sp3 transcription factor | 0.0290428 |
| RPL3 | ribosomal protein L3 | 0.028775 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0286721 |
| SRPK1 | SRSF protein kinase 1 | 0.0285054 |
| ZNF292 | zinc finger protein 292 | 0.0283237 |
| RNF145 | ring finger protein 145 | 0.0282862 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0279617 |
| EXOC4 | exocyst complex component 4 | 0.0274687 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0274591 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0272544 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0271669 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0269159 |
| RLIM | ring finger protein, LIM domain interacting | 0.0267683 |
| DIAPH3 | diaphanous-related formin 3 | 0.026667 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0266516 |
| CENPF | centromere protein F, 350/400kDa | 0.0266407 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0266005 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0265805 |
| JMJD1C | jumonji domain containing 1C | 0.0265071 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0264571 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0258604 |
| PCBP2 | poly(rC) binding protein 2 | 0.0256193 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0255357 |
| TFG | TRK-fused gene | 0.0255346 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 0.0255014 |
| WDR43 | WD repeat domain 43 | 0.0254156 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0253851 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0251566 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.02514 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0250448 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0248788 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0246338 |
| GPHN | gephyrin | 0.0246286 |
| NUP153 | nucleoporin 153kDa | 0.0245455 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0244851 |
| RBM33 | RNA binding motif protein 33 | 0.0243756 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0243629 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0241175 |
| CEP192 | centrosomal protein 192kDa | 0.0240141 |
| RNF38 | ring finger protein 38 | 0.0240083 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.023623 |
| ANLN | anillin, actin binding protein | 0.0233182 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0232967 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0232411 |
| OGA | O-GlcNAcase | 0.0231867 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0230294 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0230151 |
| TPX2 | TPX2, microtubule-associated | 0.0229833 |
| H1-0 | H1.0 linker histone | 0.0227993 |
| NCKAP1 | NCK-associated protein 1 | 0.0225955 |
| BBX | bobby sox homolog (Drosophila) | 0.0225826 |
| IPO7 | importin 7 | 0.0222815 |
| MELK | maternal embryonic leucine zipper kinase | 0.0222045 |
| YAP1 | Yes-associated protein 1 | 0.0221385 |
| SET | SET nuclear proto-oncogene | 0.0220914 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0220764 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0220606 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.446898 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.178091 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.133979 |
| TMSB10 | thymosin beta 10 | -0.114884 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0925942 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0757254 |
| YBX3 | Y box binding protein 3 | -0.0740465 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0722701 |
| OSMR | oncostatin M receptor | -0.0717881 |
| RPL35A | ribosomal protein L35a | -0.0689527 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0674373 |
| VIM | vimentin | -0.0655516 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0627985 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0625749 |
| ACTG1 | actin gamma 1 | -0.0623722 |
| HLA-B | major histocompatibility complex, class I, B | -0.0600615 |
| HMGA2 | high mobility group AT-hook 2 | -0.059848 |
| IER3 | immediate early response 3 | -0.0572231 |
| CAVIN1 | caveolae associated protein 1 | -0.0532888 |
| RPL37 | ribosomal protein L37 | -0.0505488 |
| TPM4 | tropomyosin 4 | -0.0503532 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0496423 |
| EGR1 | early growth response 1 | -0.049382 |
| RPS8 | ribosomal protein S8 | -0.0460027 |
| RNF213 | ring finger protein 213 | -0.0452394 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0446496 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0444856 |
| GNAS | GNAS complex locus | -0.0443625 |
| MT2A | metallothionein 2A | -0.0432489 |
| PTMA | prothymosin, alpha | -0.0425824 |
| STC1 | stanniocalcin 1 | -0.0421385 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0419173 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0406451 |
| RPL31 | ribosomal protein L31 | -0.0405465 |
| RPL26 | ribosomal protein L26 | -0.0402156 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0401188 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0397206 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.039717 |
| PDE10A | phosphodiesterase 10A | -0.039687 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0395461 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0393817 |
| RPS3 | ribosomal protein S3 | -0.0389022 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0385641 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0381257 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0372281 |
| FTL | ferritin, light polypeptide | -0.0366436 |
| RPL34 | ribosomal protein L34 | -0.036253 |
| RPL38 | ribosomal protein L38 | -0.0353007 |
| S100A10 | S100 calcium binding protein A10 | -0.035105 |
| RPS27 | ribosomal protein S27 | -0.0337325 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0335875 |
| RPL37A | ribosomal protein L37a | -0.0334413 |
| FBXO11 | F-box protein 11 | -0.0332082 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0331344 |
| RPL9 | ribosomal protein L9 | -0.0326926 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0322505 |
| RPL11 | ribosomal protein L11 | -0.0316996 |
| ATG7 | autophagy related 7 | -0.0316351 |
| FMNL2 | formin-like 2 | -0.031522 |
| IGF2 | insulin-like growth factor 2 | -0.0313158 |
| RPLP1 | ribosomal protein, large, P1 | -0.0312292 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0312008 |
| RPS6 | ribosomal protein S6 | -0.0311598 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0309654 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0307168 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0305345 |
| PRKCE | protein kinase C, epsilon | -0.0302789 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0294415 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0291131 |
| RPL23 | ribosomal protein L23 | -0.0289524 |
| S100A11 | S100 calcium binding protein A11 | -0.0285232 |
| RPS24 | ribosomal protein S24 | -0.0284548 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0283728 |
| RYR3 | ryanodine receptor 3 | -0.0281727 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0279784 |
| RPL36A | ribosomal protein L36a | -0.027797 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0276043 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0273304 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0272417 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0267074 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0266783 |
| EGFR | epidermal growth factor receptor | -0.0265303 |
| MCL1 | myeloid cell leukemia 1 | -0.0264487 |
| GOLGB1 | golgin B1 | -0.0263065 |
| PYGL | phosphorylase, glycogen, liver | -0.026148 |
| HLA-C | major histocompatibility complex, class I, C | -0.0258368 |
| ETV6 | ets variant 6 | -0.0252546 |
| RPL8 | ribosomal protein L8 | -0.0247295 |
| CANX | calnexin | -0.0245803 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0243799 |
| TPM2 | tropomyosin 2 (beta) | -0.0243321 |
| RPS19 | ribosomal protein S19 | -0.0242618 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.024175 |
| NDRG1 | N-myc downstream regulated 1 | -0.0240145 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0239157 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.023899 |
| ENOSF1 | enolase superfamily member 1 | -0.0236761 |
| EPAS1 | endothelial PAS domain protein 1 | -0.023664 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.023545 |
| KLF6 | Kruppel-like factor 6 | -0.0234397 |
