| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (maleate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Imiquimod (maleate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.241724 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.184761 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0983156 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0932807 |
| ASPH | aspartate beta-hydroxylase | 0.0914535 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0739229 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0635558 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0602195 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0572242 |
| FN1 | fibronectin 1 | 0.0544152 |
| TFG | TRK-fused gene | 0.0531223 |
| RPL4 | ribosomal protein L4 | 0.0479339 |
| LAMC2 | laminin, gamma 2 | 0.0471473 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0460057 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0447024 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0443907 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0436736 |
| FAM13A | family with sequence similarity 13, member A | 0.04355 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0434729 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0430439 |
| ZNF292 | zinc finger protein 292 | 0.0411531 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0403626 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0396568 |
| HMGB2 | high mobility group box 2 | 0.0384913 |
| RYBP | RING1 and YY1 binding protein | 0.0382694 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.038036 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0377621 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0372948 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0360348 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0356195 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0356155 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0354962 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0352389 |
| RNF145 | ring finger protein 145 | 0.034484 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0340754 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0336632 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0328482 |
| USP3 | ubiquitin specific peptidase 3 | 0.0327762 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0321437 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0318936 |
| SQSTM1 | sequestosome 1 | 0.0318431 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.030025 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0297212 |
| YBX1 | Y box binding protein 1 | 0.0296375 |
| G0S2 | G0/G1 switch 2 | 0.0296343 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0295908 |
| CDC73 | cell division cycle 73 | 0.0292435 |
| NCKAP1 | NCK-associated protein 1 | 0.0288427 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0288256 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.028755 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0287441 |
| NUP58 | nucleoporin 58 | 0.0271888 |
| ANXA5 | annexin A5 | 0.0271886 |
| PAPOLA | poly(A) polymerase alpha | 0.0269094 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0269055 |
| QKI | QKI, KH domain containing, RNA binding | 0.0268038 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0265107 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0264039 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0259534 |
| ANXA1 | annexin A1 | 0.0258097 |
| RLF | rearranged L-myc fusion | 0.025407 |
| ANXA2 | annexin A2 | 0.0254039 |
| PEG10 | paternally expressed 10 | 0.0252231 |
| MATR3 | matrin 3 | 0.0249726 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0245246 |
| PLAU | plasminogen activator, urokinase | 0.0240443 |
| PGK1 | phosphoglycerate kinase 1 | 0.0238562 |
| YTHDC1 | YTH domain containing 1 | 0.0234694 |
| RHEB | Ras homolog enriched in brain | 0.0233456 |
| RPS3 | ribosomal protein S3 | 0.0229326 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0226399 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0224319 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.022401 |
| SUCO | SUN domain containing ossification factor | 0.0222832 |
| IRF6 | interferon regulatory factor 6 | 0.0221618 |
| UBC | ubiquitin C | 0.022097 |
| RPLP0 | ribosomal protein, large, P0 | 0.0218487 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0217931 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0217318 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0216628 |
| RACK1 | receptor for activated C kinase 1 | 0.0214 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0210857 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0210673 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0209479 |
| TPM3 | tropomyosin 3 | 0.0208393 |
| TFRC | transferrin receptor | 0.0207037 |
| LAMB3 | laminin, beta 3 | 0.0206339 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0205148 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0204365 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0201196 |
| NPTN | neuroplastin | 0.0196017 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0191396 |
| MEF2A | myocyte enhancer factor 2A | 0.0189202 |
| CCNL1 | cyclin L1 | 0.01885 |
| ECT2 | epithelial cell transforming 2 | 0.0186824 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.018553 |
| TXNRD1 | thioredoxin reductase 1 | 0.0185484 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0184711 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0181875 |
| RPL3 | ribosomal protein L3 | 0.0181037 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | -0.167097 |
| FTL | ferritin, light polypeptide | -0.162154 |
| TMSB10 | thymosin beta 10 | -0.147613 |
| PTMA | prothymosin, alpha | -0.139223 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.125283 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.12379 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.117363 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.112515 |
| FBXO32 | F-box protein 32 | -0.110348 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.108809 |
| ACTG1 | actin gamma 1 | -0.106005 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0992278 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0979903 |
| RPL35A | ribosomal protein L35a | -0.0857933 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0830751 |
| EFNA5 | ephrin-A5 | -0.0784549 |
| ERBIN | erbb2 interacting protein | -0.0774732 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0659507 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0606842 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0596523 |
| TMEM165 | transmembrane protein 165 | -0.057684 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0574276 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0570114 |
| HLA-B | major histocompatibility complex, class I, B | -0.0546979 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0543805 |
| RBM47 | RNA binding motif protein 47 | -0.0540984 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0521541 |
| MYO1E | myosin IE | -0.04986 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.048415 |
| TPM4 | tropomyosin 4 | -0.0480584 |
| RNF213 | ring finger protein 213 | -0.0477906 |
| HLA-A | major histocompatibility complex, class I, A | -0.0468074 |
| CSTB | cystatin B (stefin B) | -0.0465348 |
| VEGFA | vascular endothelial growth factor A | -0.0455951 |
| LMO7 | LIM domain 7 | -0.0452522 |
| MX2 | MX dynamin-like GTPase 2 | -0.0448468 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0441651 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0427587 |
| GOLGB1 | golgin B1 | -0.0423883 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0422636 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0412357 |
| ETV6 | ets variant 6 | -0.0412087 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.040761 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0404754 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.039895 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0398481 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0397295 |
| RPLP1 | ribosomal protein, large, P1 | -0.0394942 |
| JUP | junction plakoglobin | -0.0393795 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0389777 |
| RAI14 | retinoic acid induced 14 | -0.038923 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0387666 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.038766 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0386855 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0384738 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0383162 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0374297 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0372208 |
| ANKRD17 | ankyrin repeat domain 17 | -0.037126 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0370283 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0367848 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0359507 |
| RPS19 | ribosomal protein S19 | -0.0357994 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0356279 |
| PLSCR1 | phospholipid scramblase 1 | -0.035345 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0352617 |
| TXNIP | thioredoxin interacting protein | -0.0351035 |
| S100A9 | S100 calcium binding protein A9 | -0.0347117 |
| ATXN1 | ataxin 1 | -0.0346066 |
| RPLP2 | ribosomal protein, large, P2 | -0.0345286 |
| OCLN | occludin | -0.0343627 |
| RCOR1 | REST corepressor 1 | -0.0342441 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0340566 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0339101 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0336852 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0334317 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.032764 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0327485 |
| RPS6 | ribosomal protein S6 | -0.0327323 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0325474 |
| SVIL | supervillin | -0.0324726 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0324107 |
| RPL34 | ribosomal protein L34 | -0.0322888 |
| RPL23 | ribosomal protein L23 | -0.0322034 |
| RBM25 | RNA binding motif protein 25 | -0.0320845 |
| LMNA | lamin A/C | -0.0320799 |
| FBXO34 | F-box protein 34 | -0.0320674 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0320485 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0317056 |
| MX1 | MX dynamin-like GTPase 1 | -0.03159 |
| FNIP1 | folliculin interacting protein 1 | -0.0314077 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0311114 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0311074 |
| RRBP1 | ribosome binding protein 1 | -0.0310236 |
| RAD51B | RAD51 paralog B | -0.0310086 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0308533 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0308366 |
| MYO6 | myosin VI | -0.0307618 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0306663 |
| VCL | vinculin | -0.0305457 |
