Imiquimod (maleate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.195144
ASPH aspartate beta-hydroxylase 0.155708
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.149825
NAMPT nicotinamide phosphoribosyltransferase 0.116683
NEK7 NIMA-related kinase 7 0.0833971
TRIO trio Rho guanine nucleotide exchange factor 0.0831893
TXNRD1 thioredoxin reductase 1 0.0749392
NRCAM neuronal cell adhesion molecule 0.0710892
PSD3 pleckstrin and Sec7 domain containing 3 0.0698155
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0664125
GDA guanine deaminase 0.0621388
FNDC3B fibronectin type III domain containing 3B 0.0582677
RTN4 reticulon 4 0.0581383
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0573112
KYNU kynureninase 0.052225
PCBP3 poly(rC) binding protein 3 0.0506791
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0504025
OGA O-GlcNAcase 0.048751
GRAMD1B GRAM domain containing 1B 0.0482107
SAMD4A sterile alpha motif domain containing 4A 0.0466608
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0465119
DST dystonin 0.0462113
ERRFI1 ERBB receptor feedback inhibitor 1 0.0456901
CTSC cathepsin C 0.0442795
MYOF myoferlin 0.043659
AGFG1 ArfGAP with FG repeats 1 0.0425544
TNPO1 transportin 1 0.0420965
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.041571
COL8A1 collagen, type VIII, alpha 1 0.0410128
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0408596
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0407973
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0376844
ELL2 elongation factor, RNA polymerase II, 2 0.0360225
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0359358
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0356639
LIMCH1 LIM and calponin homology domains 1 0.0355615
MFF mitochondrial fission factor 0.0345835
ZNF292 zinc finger protein 292 0.033829
CARD16 caspase recruitment domain family, member 16 0.0327686
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0324787
ARHGAP29 Rho GTPase activating protein 29 0.0323554
RNF145 ring finger protein 145 0.0323157
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0320099
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0313622
ANKRD28 ankyrin repeat domain 28 0.0312811
USP9X ubiquitin specific peptidase 9, X-linked 0.0312102
BCAR3 breast cancer anti-estrogen resistance 3 0.0307732
KDM6A lysine (K)-specific demethylase 6A 0.0307728
ENAH enabled homolog (Drosophila) 0.0305897
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0304482
BIRC6 baculoviral IAP repeat containing 6 0.0301686
PTEN phosphatase and tensin homolog 0.0300903
PUM2 pumilio RNA-binding family member 2 0.0298418
COL4A6 collagen, type IV, alpha 6 0.0296774
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0292938
BRWD3 bromodomain and WD repeat domain containing 3 0.0288894
NCKAP1 NCK-associated protein 1 0.0283527
DOCK4 dedicator of cytokinesis 4 0.0276483
NBAS neuroblastoma amplified sequence 0.0275306
KMT2E lysine (K)-specific methyltransferase 2E 0.0269651
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.026877
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0268195
PRRC2C proline-rich coiled-coil 2C 0.0267997
PTK2 protein tyrosine kinase 2 0.0265678
CUL3 cullin 3 0.0265184
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0264502
TM4SF1 transmembrane 4 L six family member 1 0.0263832
GLS2 glutaminase 2 (liver, mitochondrial) 0.0262637
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0260614
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0259685
ATP13A3 ATPase type 13A3 0.0258966
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0257911
MBNL1 muscleblind-like splicing regulator 1 0.0257367
WDFY2 WD repeat and FYVE domain containing 2 0.0253562
CDK6 cyclin-dependent kinase 6 0.0249996
CD109 CD109 molecule 0.0248421
WDR43 WD repeat domain 43 0.024663
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0245182
ADAM9 ADAM metallopeptidase domain 9 0.0241282
RLIM ring finger protein, LIM domain interacting 0.0240335
HSPA8 heat shock 70kDa protein 8 0.0239724
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0239575
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0239544
CENPF centromere protein F, 350/400kDa 0.0239184
ANLN anillin, actin binding protein 0.0236919
RBM39 RNA binding motif protein 39 0.0236705
PARD3 par-3 family cell polarity regulator 0.0235376
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0233921
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0231456
BDNF brain-derived neurotrophic factor 0.0230484
ZFC3H1 zinc finger, C3H1-type containing 0.0228924
HELZ helicase with zinc finger 0.0228858
MKI67 marker of proliferation Ki-67 0.0226624
ADAM17 ADAM metallopeptidase domain 17 0.0225239
JMJD1C jumonji domain containing 1C 0.0225083
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0225015
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0224641
MED13L mediator complex subunit 13-like 0.022434
TSC22D2 TSC22 domain family, member 2 0.022415
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0223979

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.353387
FN1 fibronectin 1 -0.222356
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.15426
VIM vimentin -0.14887
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11436
RPS6 ribosomal protein S6 -0.0944728
TMSB10 thymosin beta 10 -0.0920691
TPT1 tumor protein, translationally-controlled 1 -0.0907658
RPLP1 ribosomal protein, large, P1 -0.084181
IGFBP3 insulin-like growth factor binding protein 3 -0.0828267
RPL35A ribosomal protein L35a -0.066682
FTL ferritin, light polypeptide -0.063888
RPL31 ribosomal protein L31 -0.0545961
FTH1 ferritin, heavy polypeptide 1 -0.054458
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0543063
PTMA prothymosin, alpha -0.0508303
RPS19 ribosomal protein S19 -0.0506864
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0504125
RPS8 ribosomal protein S8 -0.0503182
S100A6 S100 calcium binding protein A6 -0.0495336
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0476443
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0454765
WARS1 tryptophanyl-tRNA synthetase 1 -0.0451443
HLA-A major histocompatibility complex, class I, A -0.0435532
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.043493
RPS24 ribosomal protein S24 -0.0417612
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0412816
RPS23 ribosomal protein S23 -0.0411087
RPL37A ribosomal protein L37a -0.0405251
P3H2 prolyl 3-hydroxylase 2 -0.0401953
EGR1 early growth response 1 -0.0401087
NDRG1 N-myc downstream regulated 1 -0.0398835
RPS12 ribosomal protein S12 -0.0398675
RPL26 ribosomal protein L26 -0.0395169
RPL9 ribosomal protein L9 -0.0390707
PDIA3 protein disulfide isomerase family A, member 3 -0.0388727
RPL36A ribosomal protein L36a -0.0385941
RPL34 ribosomal protein L34 -0.0384644
RPS27 ribosomal protein S27 -0.0380882
IL6 interleukin 6 -0.0377658
SOX4 SRY (sex determining region Y)-box 4 -0.0366116
HLA-B major histocompatibility complex, class I, B -0.0365891
RPLP0 ribosomal protein, large, P0 -0.0358655
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.035575
RPL37 ribosomal protein L37 -0.0353421
RPL12 ribosomal protein L12 -0.0350195
LSAMP limbic system-associated membrane protein -0.0346371
S100A10 S100 calcium binding protein A10 -0.0345562
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0343624
CDH13 cadherin 13 -0.0343495
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0339259
GNAS GNAS complex locus -0.0332914
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0322792
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0319625
RPS29 ribosomal protein S29 -0.0319338
RPS14 ribosomal protein S14 -0.0318611
POTEF POTE ankyrin domain family, member F -0.0313747
EEF2 eukaryotic translation elongation factor 2 -0.031367
MAP7 microtubule-associated protein 7 -0.0313151
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0312175
B2M beta-2-microglobulin -0.0310958
RPL38 ribosomal protein L38 -0.0307183
RPL36 ribosomal protein L36 -0.030282
BTG1 B-cell translocation gene 1, anti-proliferative -0.0299905
PRKN parkin RBR E3 ubiquitin protein ligase -0.0297708
RPL7A ribosomal protein L7a -0.0296903
WSB1 WD repeat and SOCS box containing 1 -0.0295811
MT2A metallothionein 2A -0.0293772
RPL23 ribosomal protein L23 -0.0287484
BASP1 brain abundant, membrane attached signal protein 1 -0.0286576
RPS16 ribosomal protein S16 -0.0282023
CTSL cathepsin L -0.0275457
RPS3 ribosomal protein S3 -0.0274641
RPS13 ribosomal protein S13 -0.0272795
LMNA lamin A/C -0.0270313
RPS4X ribosomal protein S4, X-linked -0.0269761
RHOB ras homolog family member B -0.0267347
RACK1 receptor for activated C kinase 1 -0.0266986
FNDC3A fibronectin type III domain containing 3A -0.0266977
CUX1 cut-like homeobox 1 -0.0266587
RPS25 ribosomal protein S25 -0.0265801
RPLP2 ribosomal protein, large, P2 -0.0263375
OASL 2'-5'-oligoadenylate synthetase-like -0.0261753
RPL19 ribosomal protein L19 -0.0260892
LAMA5 laminin, alpha 5 -0.0258573
RPL11 ribosomal protein L11 -0.0255923
NBEAL1 neurobeachin-like 1 -0.0253448
CANX calnexin -0.0251602
MCL1 myeloid cell leukemia 1 -0.0250692
SQSTM1 sequestosome 1 -0.0250538
ASTN2 astrotactin 2 -0.0242108
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0241482
RPS27A ribosomal protein S27a -0.0239091
ACTG1 actin gamma 1 -0.0228351
LOC102724023 ES1 protein homolog, mitochondrial -0.0224424
RPS28 ribosomal protein S28 -0.0224002
RPS21 ribosomal protein S21 -0.0220306
EIF1 eukaryotic translation initiation factor 1 -0.0220206
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0219123
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0218465