Imiquimod (maleate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.074683
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0675808
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0582577
FMNL2 formin-like 2 0.0578444
AHNAK AHNAK nucleoprotein 0.0546435
SNX14 sorting nexin 14 0.0460465
NAV2 neuron navigator 2 0.0452008
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0430885
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0387693
ATP13A3 ATPase type 13A3 0.0325608
CD109 CD109 molecule 0.0317725
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0306419
FNDC3B fibronectin type III domain containing 3B 0.0293874
USP3 ubiquitin specific peptidase 3 0.0287143
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0280236
ADAM17 ADAM metallopeptidase domain 17 0.0279166
H1-0 H1.0 linker histone 0.0264441
JMJD1C jumonji domain containing 1C 0.0252532
ANKRD11 ankyrin repeat domain 11 0.0249038
RPL4 ribosomal protein L4 0.0244912
HMGA2 high mobility group AT-hook 2 0.0240185
ARHGAP32 Rho GTPase activating protein 32 0.0237872
PICALM phosphatidylinositol binding clathrin assembly protein 0.0236921
CTBP2 C-terminal binding protein 2 0.0234211
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0232453
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0232188
NHSL1 NHS-like 1 0.0225531
ADGRG6 adhesion G protein-coupled receptor G6 0.022463
ZCCHC7 zinc finger, CCHC domain containing 7 0.0224371
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0223734
SPAG9 sperm associated antigen 9 0.0223104
THSD4 thrombospondin, type I, domain containing 4 0.0217708
GRK5 G protein-coupled receptor kinase 5 0.0215218
SLC35F3 solute carrier family 35, member F3 0.0210708
ZEB1 zinc finger E-box binding homeobox 1 0.0209741
FLOT1 flotillin 1 0.0206349
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0206098
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0205589
ECT2 epithelial cell transforming 2 0.0205512
LCORL ligand dependent nuclear receptor corepressor-like 0.0204801
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0202607
RASA2 RAS p21 protein activator 2 0.0200631
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0200604
TPD52 tumor protein D52 0.0197767
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0196882
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0196248
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0194843
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0191513
DGKD diacylglycerol kinase, delta 130kDa 0.0190686
SBF2 SET binding factor 2 0.0190253
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0190197
PDE10A phosphodiesterase 10A 0.0189612
COG5 component of oligomeric golgi complex 5 0.0189319
SPIRE1 spire-type actin nucleation factor 1 0.0185343
PSD3 pleckstrin and Sec7 domain containing 3 0.0177111
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0175094
TRA2A transformer 2 alpha homolog (Drosophila) 0.0174811
RAB1A RAB1A, member RAS oncogene family 0.0172348
MEMO1 mediator of cell motility 1 0.01723
YAP1 Yes-associated protein 1 0.0172052
SSH1 slingshot protein phosphatase 1 0.0171977
MYO10 myosin X 0.0171636
TFG TRK-fused gene 0.0170832
WAC WW domain containing adaptor with coiled-coil 0.0169516
SPRED2 sprouty-related, EVH1 domain containing 2 0.0166355
PDE8A phosphodiesterase 8A 0.0161085
MAP1B microtubule-associated protein 1B 0.0160689
BIRC2 baculoviral IAP repeat containing 2 0.0160588
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.015908
SEC24A SEC24 family member A 0.0158548
HP1BP3 heterochromatin protein 1, binding protein 3 0.0157387
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.015321
TM4SF1 transmembrane 4 L six family member 1 0.0152946
ESYT2 extended synaptotagmin-like protein 2 0.0152826
TPX2 TPX2, microtubule-associated 0.0151688
KDM6A lysine (K)-specific demethylase 6A 0.0151039
GOLGA4 golgin A4 0.0150063
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0147449
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0146917
BIRC6 baculoviral IAP repeat containing 6 0.0146796
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0146421
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0145631
SNX9 sorting nexin 9 0.0145074
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0144204
FOSL1 FOS-like antigen 1 0.0143496
RRM2 ribonucleotide reductase M2 0.014321
CDK17 cyclin-dependent kinase 17 0.0143091
PTK2 protein tyrosine kinase 2 0.0143048
ARL8B ADP-ribosylation factor-like 8B 0.0142842
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0142613
KCMF1 potassium channel modulatory factor 1 0.0142366
PUM2 pumilio RNA-binding family member 2 0.0141795
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0141635
PDIA4 protein disulfide isomerase family A, member 4 0.014147
MAST2 microtubule associated serine/threonine kinase 2 0.0141342
ATXN2 ataxin 2 0.0140092
TM9SF3 transmembrane 9 superfamily member 3 0.0140069
FNIP1 folliculin interacting protein 1 0.0139947
ARL5B ADP-ribosylation factor-like 5B 0.0138905
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0137054

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.234606
VIM vimentin -0.226973
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122725
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0905271
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0743933
TMSB10 thymosin beta 10 -0.0722362
RPLP2 ribosomal protein, large, P2 -0.0716622
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0693315
CD44 CD44 molecule (Indian blood group) -0.0644823
SAMD4B sterile alpha motif domain containing 4B -0.0617446
RPS3 ribosomal protein S3 -0.0594046
PTMA prothymosin, alpha -0.0570396
SFTPA2 surfactant protein A2 -0.0560068
RPLP1 ribosomal protein, large, P1 -0.0548926
RPS12 ribosomal protein S12 -0.0527269
MT2A metallothionein 2A -0.0524262
KTN1 kinectin 1 (kinesin receptor) -0.0498992
ZFP36 ZFP36 ring finger protein -0.0489964
RPS2 ribosomal protein S2 -0.0487253
ACTN4 actinin, alpha 4 -0.0479324
RPL35A ribosomal protein L35a -0.0459621
ZNF780B zinc finger protein 780B -0.0426356
ACTG1 actin gamma 1 -0.0421331
RPL37A ribosomal protein L37a -0.0399232
S100A6 S100 calcium binding protein A6 -0.0395945
RPS8 ribosomal protein S8 -0.0387922
RPS6 ribosomal protein S6 -0.0386766
FBL fibrillarin -0.037992
LOC112694756 uncharaterized LOC112694756 -0.037814
NAP1L1 nucleosome assembly protein 1-like 1 -0.0367268
RPL38 ribosomal protein L38 -0.0363125
RPL28 ribosomal protein L28 -0.035427
RPL7 ribosomal protein L7 -0.0346914
LMNA lamin A/C -0.0341485
B2M beta-2-microglobulin -0.0340585
RPS19 ribosomal protein S19 -0.0332785
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0329769
SMAD3 SMAD family member 3 -0.0314573
RPL26 ribosomal protein L26 -0.031027
RPL12 ribosomal protein L12 -0.0306998
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0306949
WWTR1 WW domain containing transcription regulator 1 -0.0303945
SEPTIN9 septin 9 -0.0301935
RPL36A ribosomal protein L36a -0.029842
CANX calnexin -0.0297782
IFITM3 interferon induced transmembrane protein 3 -0.0296279
ASPH aspartate beta-hydroxylase -0.0296259
RPL11 ribosomal protein L11 -0.0293113
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0293051
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.0281532
PHF14 PHD finger protein 14 -0.0278025
EEF2 eukaryotic translation elongation factor 2 -0.0277066
TXNRD1 thioredoxin reductase 1 -0.0274577
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0264801
RPS13 ribosomal protein S13 -0.026319
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -0.0261176
PRRC2C proline-rich coiled-coil 2C -0.0259968
RPS29 ribosomal protein S29 -0.0258743
EIF1 eukaryotic translation initiation factor 1 -0.0258159
FTL ferritin, light polypeptide -0.0255766
RBM39 RNA binding motif protein 39 -0.0255477
ATP5F1B ATP synthase F1 subunit beta -0.025333
RPS24 ribosomal protein S24 -0.0253141
MORF4L2 mortality factor 4 like 2 -0.0245682
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245022
OSMR oncostatin M receptor -0.024467
RPL9 ribosomal protein L9 -0.0243141
CTSD cathepsin D -0.0242796
ZBTB20 zinc finger and BTB domain containing 20 -0.0242476
HLA-B major histocompatibility complex, class I, B -0.0239293
RBM25 RNA binding motif protein 25 -0.0236932
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0236304
EGR1 early growth response 1 -0.0235843
RPS17 ribosomal protein S17 -0.0234299
PFN1 profilin 1 -0.0232971
GOLGB1 golgin B1 -0.023145
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0231131
RPS14 ribosomal protein S14 -0.0230001
NACA nascent polypeptide-associated complex alpha subunit -0.0229039
RPL23 ribosomal protein L23 -0.0228401
DSTN destrin (actin depolymerizing factor) -0.0225293
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0223929
DSCAM Down syndrome cell adhesion molecule -0.0222894
PCBP2 poly(rC) binding protein 2 -0.0221414
RPS27 ribosomal protein S27 -0.0220154
RPS5 ribosomal protein S5 -0.02189
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0217433
RPL31 ribosomal protein L31 -0.0214651
RPL30 ribosomal protein L30 -0.0213892
BRD2 bromodomain containing 2 -0.0213185
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0211093
CSNK1A1 casein kinase 1, alpha 1 -0.0210721
ASTN2 astrotactin 2 -0.0209392
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0209204
BPTF bromodomain PHD finger transcription factor -0.0208459
PKM pyruvate kinase, muscle -0.0207631
WSB1 WD repeat and SOCS box containing 1 -0.0205025
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.020478
SRSF11 serine/arginine-rich splicing factor 11 -0.0204343
CARD18 caspase recruitment domain family, member 18 -0.0204132