Imiquimod (maleate)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.135673
FNDC3B fibronectin type III domain containing 3B 0.11931
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.100945
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.09973
PGK1 phosphoglycerate kinase 1 0.0943393
ZNF292 zinc finger protein 292 0.0832762
NAMPT nicotinamide phosphoribosyltransferase 0.0748318
CENPF centromere protein F, 350/400kDa 0.0695236
MCTP2 multiple C2 domains, transmembrane 2 0.0635465
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0601769
NAV2 neuron navigator 2 0.0582383
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0494404
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0491719
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0478849
KDM3A lysine (K)-specific demethylase 3A 0.0472013
TFG TRK-fused gene 0.0468594
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0462948
DSCAM Down syndrome cell adhesion molecule 0.0443721
PDE4D phosphodiesterase 4D, cAMP-specific 0.0440917
ANLN anillin, actin binding protein 0.0433679
FAM13A family with sequence similarity 13, member A 0.0432377
XPO1 exportin 1 0.0431162
USP3 ubiquitin specific peptidase 3 0.0416475
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0404227
RLF rearranged L-myc fusion 0.0403156
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0389769
CD109 CD109 molecule 0.0377724
RBM39 RNA binding motif protein 39 0.0371997
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0360323
SPAG9 sperm associated antigen 9 0.0359799
YEATS2 YEATS domain containing 2 0.0355692
ELL2 elongation factor, RNA polymerase II, 2 0.035073
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0348289
BRWD3 bromodomain and WD repeat domain containing 3 0.0347575
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0346836
AFAP1 actin filament associated protein 1 0.0339476
OGA O-GlcNAcase 0.0333172
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0325941
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0325671
KMT2E lysine (K)-specific methyltransferase 2E 0.0320379
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0317822
AHNAK AHNAK nucleoprotein 0.0317533
MYH9 myosin, heavy chain 9, non-muscle 0.0316442
ESYT2 extended synaptotagmin-like protein 2 0.031466
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0310584
MEF2A myocyte enhancer factor 2A 0.0304144
CEMIP cell migration inducing protein, hyaluronan binding 0.0303395
NGLY1 N-glycanase 1 0.0302929
DOCK7 dedicator of cytokinesis 7 0.0297228
ANKRD11 ankyrin repeat domain 11 0.0296144
ZMYND8 zinc finger, MYND-type containing 8 0.0296075
H1-0 H1.0 linker histone 0.0295268
BBX bobby sox homolog (Drosophila) 0.0295132
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0295088
RB1CC1 RB1-inducible coiled-coil 1 0.0289502
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0285076
SNAP25 synaptosomal-associated protein, 25kDa 0.0282863
FOXJ3 forkhead box J3 0.0282352
RYBP RING1 and YY1 binding protein 0.0278704
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0278034
MYOF myoferlin 0.0278024
ZNF148 zinc finger protein 148 0.0277237
SEPTIN7 septin 7 0.027676
NBAS neuroblastoma amplified sequence 0.0276285
ZEB2 zinc finger E-box binding homeobox 2 0.0275153
BIRC6 baculoviral IAP repeat containing 6 0.0274419
PUM2 pumilio RNA-binding family member 2 0.0272052
MAP4 microtubule-associated protein 4 0.0267918
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0267702
USP37 ubiquitin specific peptidase 37 0.0266677
MACF1 microtubule-actin crosslinking factor 1 0.0265799
NCKAP1 NCK-associated protein 1 0.0265158
HELZ helicase with zinc finger 0.0263876
USP9X ubiquitin specific peptidase 9, X-linked 0.0263321
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0263075
TPX2 TPX2, microtubule-associated 0.0262416
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0260176
RAD21 RAD21 homolog (S. pombe) 0.0259529
MKI67 marker of proliferation Ki-67 0.0257711
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0255375
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0254894
ARHGAP35 Rho GTPase activating protein 35 0.0254569
SUCO SUN domain containing ossification factor 0.0253454
APP amyloid beta (A4) precursor protein 0.0251735
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0250784
SETD5 SET domain containing 5 0.0250626
KDM6A lysine (K)-specific demethylase 6A 0.0250096
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0247226
ATP13A3 ATPase type 13A3 0.0245559
TRIO trio Rho guanine nucleotide exchange factor 0.0244615
PPME1 protein phosphatase methylesterase 1 0.0240631
ITCH itchy E3 ubiquitin protein ligase 0.0236881
NUP58 nucleoporin 58 0.0236592
CENPE centromere protein E, 312kDa 0.0234126
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0233686
CKAP5 cytoskeleton associated protein 5 0.0232808
ARRDC3 arrestin domain containing 3 0.0232142
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0231901
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0231517
TP53BP1 tumor protein p53 binding protein 1 0.023151

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.257075
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.171092
MT2A metallothionein 2A -0.127664
FTL ferritin, light polypeptide -0.10928
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0871784
TMSB10 thymosin beta 10 -0.0827114
NDRG1 N-myc downstream regulated 1 -0.0655488
B2M beta-2-microglobulin -0.0642474
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0568158
EGR1 early growth response 1 -0.0543984
COL6A1 collagen, type VI, alpha 1 -0.0515863
RAB7A RAB7A, member RAS oncogene family -0.0465265
COL1A1 collagen, type I, alpha 1 -0.0459353
HLA-B major histocompatibility complex, class I, B -0.044552
IFI6 interferon, alpha-inducible protein 6 -0.0440822
IGFBP3 insulin-like growth factor binding protein 3 -0.0428891
RPS19 ribosomal protein S19 -0.0419185
POTEF POTE ankyrin domain family, member F -0.0414224
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0408873
EXT1 exostosin glycosyltransferase 1 -0.0408419
PSD3 pleckstrin and Sec7 domain containing 3 -0.0403002
COL5A1 collagen, type V, alpha 1 -0.0399248
IFITM3 interferon induced transmembrane protein 3 -0.0392138
RPLP1 ribosomal protein, large, P1 -0.0391191
NAV1 neuron navigator 1 -0.0370409
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0368807
VEGFA vascular endothelial growth factor A -0.0352288
COL6A2 collagen, type VI, alpha 2 -0.034689
RPL23 ribosomal protein L23 -0.0346079
RPS21 ribosomal protein S21 -0.033209
RPL37A ribosomal protein L37a -0.0329408
FRMD4A FERM domain containing 4A -0.0324739
TGFBI transforming growth factor, beta-induced, 68kDa -0.0320255
TIMP1 TIMP metallopeptidase inhibitor 1 -0.031514
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0309872
TNNC1 troponin C type 1 (slow) -0.0308047
RPL28 ribosomal protein L28 -0.0307164
RPS3 ribosomal protein S3 -0.0298906
COL5A3 collagen, type V, alpha 3 -0.0296951
RPS8 ribosomal protein S8 -0.0295033
HPCAL1 hippocalcin-like 1 -0.0287722
RPL31 ribosomal protein L31 -0.02834
PFN1 profilin 1 -0.0283254
RPLP2 ribosomal protein, large, P2 -0.0275385
RPL35A ribosomal protein L35a -0.0274585
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0272236
EIF1 eukaryotic translation initiation factor 1 -0.0271204
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0271128
SHISA5 shisa family member 5 -0.0270766
GLIS3 GLIS family zinc finger 3 -0.0270755
TGFB1 transforming growth factor, beta 1 -0.0269475
RPL34 ribosomal protein L34 -0.0266144
CDH13 cadherin 13 -0.0264849
RPS12 ribosomal protein S12 -0.0260403
VCL vinculin -0.0256643
LOC102724023 ES1 protein homolog, mitochondrial -0.0254714
RPS23 ribosomal protein S23 -0.0249332
RPS17 ribosomal protein S17 -0.0249238
SEC61G Sec61 gamma subunit -0.0244833
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.024448
FTH1 ferritin, heavy polypeptide 1 -0.0239678
COL1A2 collagen, type I, alpha 2 -0.0234481
MCL1 myeloid cell leukemia 1 -0.0234221
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0234131
RPL11 ribosomal protein L11 -0.0230897
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0229533
RPS29 ribosomal protein S29 -0.0229475
RPL12 ribosomal protein L12 -0.0225366
S100A9 S100 calcium binding protein A9 -0.0220702
RPS16 ribosomal protein S16 -0.021742
HLA-C major histocompatibility complex, class I, C -0.02154
HLA-A major histocompatibility complex, class I, A -0.0214197
RPL32 ribosomal protein L32 -0.0211096
RPS13 ribosomal protein S13 -0.0210312
LOC112694756 uncharaterized LOC112694756 -0.0206729
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0206179
RPL18 ribosomal protein L18 -0.020541
S100A6 S100 calcium binding protein A6 -0.0203717
RPL9 ribosomal protein L9 -0.0203654
INTS6 integrator complex subunit 6 -0.0201856
TPI1 triosephosphate isomerase 1 -0.0200221
MYADM myeloid-associated differentiation marker -0.0200151
LOX lysyl oxidase -0.0199044
S100A10 S100 calcium binding protein A10 -0.0198801
ECE1 endothelin converting enzyme 1 -0.0193936
RPL26 ribosomal protein L26 -0.0193214
SERF2 small EDRK-rich factor 2 -0.0192722
CCDC138 coiled-coil domain containing 138 -0.0188504
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0186208
TPT1 tumor protein, translationally-controlled 1 -0.0185875
MT1X metallothionein 1X -0.0185431
INHBA inhibin, beta A -0.0184763
SLC38A2 solute carrier family 38, member 2 -0.0182298
RPS25 ribosomal protein S25 -0.0178011
S100A11 S100 calcium binding protein A11 -0.0177875
RPL36 ribosomal protein L36 -0.0177851
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.017659
IFI44L interferon-induced protein 44-like -0.0176583
ACTG1 actin gamma 1 -0.0175314
RPL19 ribosomal protein L19 -0.0174552